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Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Blood, 97, 2001, 8, S. 2401-2405 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
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| Schlagwörter: |
| author_facet |
Seitz, Volkhard Hummel, Michael Anagnostopoulos, Ioannis Stein, Harald Seitz, Volkhard Hummel, Michael Anagnostopoulos, Ioannis Stein, Harald |
|---|---|
| author |
Seitz, Volkhard Hummel, Michael Anagnostopoulos, Ioannis Stein, Harald |
| spellingShingle |
Seitz, Volkhard Hummel, Michael Anagnostopoulos, Ioannis Stein, Harald Blood Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type Cell Biology Hematology Immunology Biochemistry |
| author_sort |
seitz, volkhard |
| spelling |
Seitz, Volkhard Hummel, Michael Anagnostopoulos, Ioannis Stein, Harald 1528-0020 0006-4971 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood.v97.8.2401 <jats:title>Abstract</jats:title> <jats:p>BCL-6 is essential for germinal center formation and thus for affinity maturation of immunoglobulin (Ig) genes by somatic mutations. The 5′-noncoding region of the BCL-6gene is even a target for the mutation machinery. Translocations of theBCL-6 gene to heterologous promoters and mutations of its 5′-noncoding regulatory region were reported to be potential mechanisms for deregulating BCL-6 expression and for playing a role in the genesis of non-Hodgkin lymphoma. In line with this hypothesis is the observation that B-cell lymphoma with somatic mutations, such as diffuse large B-cell lymphoma and follicular lymphoma, also carryBCL-6 mutations, some of which are recurrently detectable. Classic Hodgkin disease (cHD) is also derived from B cells with high loads of somatic mutations and thus a further candidate forBCL-6 mutations. To determine the presence and potential role of BCL-6 mutations in cHD, the 5′-noncodingBCL-6 proportion of single Hodgkin and Reed-Sternberg (HRS) cells from 6 cases of cHD and 6 cases of HD-derived cell lines was analyzed. All B-cell–derived HD cases and cell lines harboredBCL-6 mutations. In contrast, both T-cell–derived HD cases and cell lines were devoid of BCL-6 mutations. With only one exception, there were no lymphoma-specific recurrentBCL-6 mutations detected, and BCL-6 protein was absent from the HRS cells of most cases. In conclusion, (1) somaticBCL-6 mutations are restricted to cHD cases of B-cell origin, and (2) the BCL-6 mutations represent mostly irrelevant somatic base substitutions without consequences for BCL-6 protein expression and the pathogenesis of cHD.</jats:p> Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type Blood |
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10.1182/blood.v97.8.2401 |
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Online Free |
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Biologie Medizin Chemie und Pharmazie |
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American Society of Hematology, 2001 |
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American Society of Hematology, 2001 |
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1528-0020 0006-4971 |
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2001 |
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49 |
| title |
Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_unstemmed |
Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_full |
Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_fullStr |
Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_full_unstemmed |
Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_short |
Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_sort |
analysis of bcl-6 mutations in classic hodgkin disease of the b- and t-cell type |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood.v97.8.2401 |
| publishDate |
2001 |
| physical |
2401-2405 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>BCL-6 is essential for germinal center formation and thus for affinity maturation of immunoglobulin (Ig) genes by somatic mutations. The 5′-noncoding region of the BCL-6gene is even a target for the mutation machinery. Translocations of theBCL-6 gene to heterologous promoters and mutations of its 5′-noncoding regulatory region were reported to be potential mechanisms for deregulating BCL-6 expression and for playing a role in the genesis of non-Hodgkin lymphoma. In line with this hypothesis is the observation that B-cell lymphoma with somatic mutations, such as diffuse large B-cell lymphoma and follicular lymphoma, also carryBCL-6 mutations, some of which are recurrently detectable. Classic Hodgkin disease (cHD) is also derived from B cells with high loads of somatic mutations and thus a further candidate forBCL-6 mutations. To determine the presence and potential role of BCL-6 mutations in cHD, the 5′-noncodingBCL-6 proportion of single Hodgkin and Reed-Sternberg (HRS) cells from 6 cases of cHD and 6 cases of HD-derived cell lines was analyzed. All B-cell–derived HD cases and cell lines harboredBCL-6 mutations. In contrast, both T-cell–derived HD cases and cell lines were devoid of BCL-6 mutations. With only one exception, there were no lymphoma-specific recurrentBCL-6 mutations detected, and BCL-6 protein was absent from the HRS cells of most cases. In conclusion, (1) somaticBCL-6 mutations are restricted to cHD cases of B-cell origin, and (2) the BCL-6 mutations represent mostly irrelevant somatic base substitutions without consequences for BCL-6 protein expression and the pathogenesis of cHD.</jats:p> |
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| author | Seitz, Volkhard, Hummel, Michael, Anagnostopoulos, Ioannis, Stein, Harald |
| author_facet | Seitz, Volkhard, Hummel, Michael, Anagnostopoulos, Ioannis, Stein, Harald, Seitz, Volkhard, Hummel, Michael, Anagnostopoulos, Ioannis, Stein, Harald |
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| description | <jats:title>Abstract</jats:title> <jats:p>BCL-6 is essential for germinal center formation and thus for affinity maturation of immunoglobulin (Ig) genes by somatic mutations. The 5′-noncoding region of the BCL-6gene is even a target for the mutation machinery. Translocations of theBCL-6 gene to heterologous promoters and mutations of its 5′-noncoding regulatory region were reported to be potential mechanisms for deregulating BCL-6 expression and for playing a role in the genesis of non-Hodgkin lymphoma. In line with this hypothesis is the observation that B-cell lymphoma with somatic mutations, such as diffuse large B-cell lymphoma and follicular lymphoma, also carryBCL-6 mutations, some of which are recurrently detectable. Classic Hodgkin disease (cHD) is also derived from B cells with high loads of somatic mutations and thus a further candidate forBCL-6 mutations. To determine the presence and potential role of BCL-6 mutations in cHD, the 5′-noncodingBCL-6 proportion of single Hodgkin and Reed-Sternberg (HRS) cells from 6 cases of cHD and 6 cases of HD-derived cell lines was analyzed. All B-cell–derived HD cases and cell lines harboredBCL-6 mutations. In contrast, both T-cell–derived HD cases and cell lines were devoid of BCL-6 mutations. With only one exception, there were no lymphoma-specific recurrentBCL-6 mutations detected, and BCL-6 protein was absent from the HRS cells of most cases. In conclusion, (1) somaticBCL-6 mutations are restricted to cHD cases of B-cell origin, and (2) the BCL-6 mutations represent mostly irrelevant somatic base substitutions without consequences for BCL-6 protein expression and the pathogenesis of cHD.</jats:p> |
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| imprint | American Society of Hematology, 2001 |
| imprint_str_mv | American Society of Hematology, 2001 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| spelling | Seitz, Volkhard Hummel, Michael Anagnostopoulos, Ioannis Stein, Harald 1528-0020 0006-4971 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood.v97.8.2401 <jats:title>Abstract</jats:title> <jats:p>BCL-6 is essential for germinal center formation and thus for affinity maturation of immunoglobulin (Ig) genes by somatic mutations. The 5′-noncoding region of the BCL-6gene is even a target for the mutation machinery. Translocations of theBCL-6 gene to heterologous promoters and mutations of its 5′-noncoding regulatory region were reported to be potential mechanisms for deregulating BCL-6 expression and for playing a role in the genesis of non-Hodgkin lymphoma. In line with this hypothesis is the observation that B-cell lymphoma with somatic mutations, such as diffuse large B-cell lymphoma and follicular lymphoma, also carryBCL-6 mutations, some of which are recurrently detectable. Classic Hodgkin disease (cHD) is also derived from B cells with high loads of somatic mutations and thus a further candidate forBCL-6 mutations. To determine the presence and potential role of BCL-6 mutations in cHD, the 5′-noncodingBCL-6 proportion of single Hodgkin and Reed-Sternberg (HRS) cells from 6 cases of cHD and 6 cases of HD-derived cell lines was analyzed. All B-cell–derived HD cases and cell lines harboredBCL-6 mutations. In contrast, both T-cell–derived HD cases and cell lines were devoid of BCL-6 mutations. With only one exception, there were no lymphoma-specific recurrentBCL-6 mutations detected, and BCL-6 protein was absent from the HRS cells of most cases. In conclusion, (1) somaticBCL-6 mutations are restricted to cHD cases of B-cell origin, and (2) the BCL-6 mutations represent mostly irrelevant somatic base substitutions without consequences for BCL-6 protein expression and the pathogenesis of cHD.</jats:p> Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type Blood |
| spellingShingle | Seitz, Volkhard, Hummel, Michael, Anagnostopoulos, Ioannis, Stein, Harald, Blood, Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_full | Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_fullStr | Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_full_unstemmed | Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_short | Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| title_sort | analysis of bcl-6 mutations in classic hodgkin disease of the b- and t-cell type |
| title_unstemmed | Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood.v97.8.2401 |