Eintrag weiter verarbeiten
Verfügbar über Online-Ressource

Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.

Gespeichert in:

Bibliographische Detailangaben
Zeitschriftentitel: Blood
Personen und Körperschaften: Karakas, Zeynep
In: Blood, 114, 2009, 22, S. 4746-4746
Format: E-Article
Sprache: Englisch
veröffentlicht:
American Society of Hematology
Schlagwörter:
Cell Biology
Hematology
Immunology
Biochemistry
author_facet Karakas, Zeynep
Karakas, Zeynep
author Karakas, Zeynep
spellingShingle Karakas, Zeynep
Blood
Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
Cell Biology
Hematology
Immunology
Biochemistry
author_sort karakas, zeynep
spelling Karakas, Zeynep 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood.v114.22.4746.4746 <jats:title>Abstract</jats:title> <jats:p>Abstract 4746</jats:p> <jats:p>DEFECTIVE NATURAL KILLER ACTIVITY IMPROVED BY IL-2 STIMULATION INDEPENDENT OF CD16 AND NKG2D RECEPTORS IN PATIENTS WITH THALASSEMIA MAJOR</jats:p> <jats:p>Zeynep Karakaρ1,Belkýs Atasever2, Serap Erdem Kuruca3, Batu Erman2, Agaoglu Leyla1Istanbul Faculty of Medicine, Department of Pediatrics, Istanbul University, Istanbul, TurkeyFaculty of Engineering and Natural Sciences, Biological Sciences &amp; Bioengineering Program, Sabanci University, Istanbul, Turkey3 Istanbul Faculty of Medicine, Department of Physiology, Istanbul University, Istanbul, Turkiye</jats:p> <jats:sec> <jats:title>BACKGROUND</jats:title> <jats:p>Natural killer (NK) cells account for up to 15% of blood lymphocytes. Functional NK cells are found in the spleen. The function of NK cells is to recognize and kill virus infected cells and certain tumor cells. The mechanism of recognition is not fully understood, but it involves both activating and inhibitory receptors. CD 16 and NKG2D are receptors involved in two of the activation pathways of NK cells. NK cells use a variety of different mechanism to kill their targets. These include direct cell-cell signalling via surface molecules, and indirect signalling via cytokins. A decreased level of natural killer (NK) activity is one of the various immunological abnormalities in patients with thalassemia major.</jats:p> </jats:sec> <jats:sec> <jats:title>AIM</jats:title> <jats:p>This study aims to evaluate the relationship between NK cytotoxicity and CD 16 and NKG2D receptors, and effect of IL-2 stimulation in patients with thalassemia major.</jats:p> </jats:sec> <jats:sec> <jats:title>PATIENTS AND METHODS</jats:title> <jats:p>The study includes 26 patients with thalassemia major (TM) with age ranged 7-35 (median age was 18, 17 of them were female and 9 male), and sex and age matched 16 normal healthy subjects as controls. Fourteen of the patients were splenectomized. Patients regulary chelated with deferasirox (n:16), deferipron (n: 8) and desferroxamin (n: 2). NK cells were isolated from PBMC of subjects by using RosetteSep. Before and after the IL2 incubation; CD16, NKG2D receptors are examined in NK cells of both b-thalassemia major patients and controls by flow cytometry and we analyzed cytolytic function of NK cells against K562 cells. The cytotoxic activity of NK cells was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Ratios of NK cells /K562 cells (Efector:Target (E:T)) were 1:1, 10:1 and 20:1.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>NK cytotoxicity was found to be lower at E:T ratios of 1:1 and 10:1 in patients with thalassemia major when compared to controls(p &lt; 0.05). Patients with above 18 years old had significantly lower NK activity than below 18 years old. Sex, presence of splenectomy and chelation type did not effect on NK activity (p&gt;0.05). NK cytotoxicity significantly increased by IL-2 stimulation in 26 patients at E:T ratio of 10:1 (p&lt;0.05). But the increase was still less than the control. There was no significantly statistically difference between CD16 and NKG2D receptor levels compared with patients and controls. Patient's CD 16 receptor levels did not change after incubation with IL-2. NKG2D receptor levels of control NK cells significantly increased after IL-2 incubation (2021.66 / 1675.79/molecule, p&lt;0.003). We detected significantly increased levels of NKG2D after IL-2 incubation in patients with splenectomy than patients without splenectomy (1834.80 / 901.41/molecule, p&lt;0.005).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSION</jats:title> <jats:p>IL-2 may have potential therapeutic effect to improve the defective NK activity in patients with thalassaemia major. Increasing effect of IL-2 stimulation on NK activity may be independent than NKG2D receptor pattern. Defective NK cell functions can be partially restored by interleukin IL-2.</jats:p> <jats:p>This study was supported by Istanbul University Research Fund.</jats:p> </jats:sec> <jats:sec> <jats:title>Disclosures:</jats:title> <jats:p>No relevant conflicts of interest to declare.</jats:p> </jats:sec> Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR. Blood
doi_str_mv 10.1182/blood.v114.22.4746.4746
facet_avail Online
Free
finc_class_facet Biologie
Medizin
Chemie und Pharmazie
format ElectronicArticle
fullrecord blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC52MTE0LjIyLjQ3NDYuNDc0Ng
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC52MTE0LjIyLjQ3NDYuNDc0Ng
institution DE-Pl11
DE-Rs1
DE-105
DE-14
DE-Ch1
DE-L229
DE-D275
DE-Bn3
DE-Brt1
DE-Zwi2
DE-D161
DE-Gla1
DE-Zi4
DE-15
imprint American Society of Hematology, 2009
imprint_str_mv American Society of Hematology, 2009
issn 0006-4971
1528-0020
issn_str_mv 0006-4971
1528-0020
language English
mega_collection American Society of Hematology (CrossRef)
match_str karakas2009defectivenaturalkilleractivityimprovedbyil2stimulationindependentofcd16andnkg2dreceptorsinpatientswiththalassemiamajor
publishDateSort 2009
publisher American Society of Hematology
recordtype ai
record_format ai
series Blood
source_id 49
title Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_unstemmed Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_full Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_fullStr Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_full_unstemmed Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_short Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_sort defective natural killer activity improved by il-2 stimulation independent of cd16 and nkg2d receptors in patients with thalassemia major.
topic Cell Biology
Hematology
Immunology
Biochemistry
url http://dx.doi.org/10.1182/blood.v114.22.4746.4746
publishDate 2009
physical 4746-4746
description <jats:title>Abstract</jats:title> <jats:p>Abstract 4746</jats:p> <jats:p>DEFECTIVE NATURAL KILLER ACTIVITY IMPROVED BY IL-2 STIMULATION INDEPENDENT OF CD16 AND NKG2D RECEPTORS IN PATIENTS WITH THALASSEMIA MAJOR</jats:p> <jats:p>Zeynep Karakaρ1,Belkýs Atasever2, Serap Erdem Kuruca3, Batu Erman2, Agaoglu Leyla1Istanbul Faculty of Medicine, Department of Pediatrics, Istanbul University, Istanbul, TurkeyFaculty of Engineering and Natural Sciences, Biological Sciences &amp; Bioengineering Program, Sabanci University, Istanbul, Turkey3 Istanbul Faculty of Medicine, Department of Physiology, Istanbul University, Istanbul, Turkiye</jats:p> <jats:sec> <jats:title>BACKGROUND</jats:title> <jats:p>Natural killer (NK) cells account for up to 15% of blood lymphocytes. Functional NK cells are found in the spleen. The function of NK cells is to recognize and kill virus infected cells and certain tumor cells. The mechanism of recognition is not fully understood, but it involves both activating and inhibitory receptors. CD 16 and NKG2D are receptors involved in two of the activation pathways of NK cells. NK cells use a variety of different mechanism to kill their targets. These include direct cell-cell signalling via surface molecules, and indirect signalling via cytokins. A decreased level of natural killer (NK) activity is one of the various immunological abnormalities in patients with thalassemia major.</jats:p> </jats:sec> <jats:sec> <jats:title>AIM</jats:title> <jats:p>This study aims to evaluate the relationship between NK cytotoxicity and CD 16 and NKG2D receptors, and effect of IL-2 stimulation in patients with thalassemia major.</jats:p> </jats:sec> <jats:sec> <jats:title>PATIENTS AND METHODS</jats:title> <jats:p>The study includes 26 patients with thalassemia major (TM) with age ranged 7-35 (median age was 18, 17 of them were female and 9 male), and sex and age matched 16 normal healthy subjects as controls. Fourteen of the patients were splenectomized. Patients regulary chelated with deferasirox (n:16), deferipron (n: 8) and desferroxamin (n: 2). NK cells were isolated from PBMC of subjects by using RosetteSep. Before and after the IL2 incubation; CD16, NKG2D receptors are examined in NK cells of both b-thalassemia major patients and controls by flow cytometry and we analyzed cytolytic function of NK cells against K562 cells. The cytotoxic activity of NK cells was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Ratios of NK cells /K562 cells (Efector:Target (E:T)) were 1:1, 10:1 and 20:1.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>NK cytotoxicity was found to be lower at E:T ratios of 1:1 and 10:1 in patients with thalassemia major when compared to controls(p &lt; 0.05). Patients with above 18 years old had significantly lower NK activity than below 18 years old. Sex, presence of splenectomy and chelation type did not effect on NK activity (p&gt;0.05). NK cytotoxicity significantly increased by IL-2 stimulation in 26 patients at E:T ratio of 10:1 (p&lt;0.05). But the increase was still less than the control. There was no significantly statistically difference between CD16 and NKG2D receptor levels compared with patients and controls. Patient's CD 16 receptor levels did not change after incubation with IL-2. NKG2D receptor levels of control NK cells significantly increased after IL-2 incubation (2021.66 / 1675.79/molecule, p&lt;0.003). We detected significantly increased levels of NKG2D after IL-2 incubation in patients with splenectomy than patients without splenectomy (1834.80 / 901.41/molecule, p&lt;0.005).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSION</jats:title> <jats:p>IL-2 may have potential therapeutic effect to improve the defective NK activity in patients with thalassaemia major. Increasing effect of IL-2 stimulation on NK activity may be independent than NKG2D receptor pattern. Defective NK cell functions can be partially restored by interleukin IL-2.</jats:p> <jats:p>This study was supported by Istanbul University Research Fund.</jats:p> </jats:sec> <jats:sec> <jats:title>Disclosures:</jats:title> <jats:p>No relevant conflicts of interest to declare.</jats:p> </jats:sec>
container_issue 22
container_start_page 4746
container_title Blood
container_volume 114
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
_version_ 1792322468492345348
geogr_code not assigned
last_indexed 2024-03-01T11:18:21.234Z
geogr_code_person not assigned
openURL url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Defective+NATURAL+Killer+ACTIVITY+Improved+by+IL-2+Stimulation+Independent+of+CD16+and+NKG2D+Receptors+IN+PATIENTS+with+THALASSEMIA+MAJOR.&rft.date=2009-11-20&genre=article&issn=1528-0020&volume=114&issue=22&spage=4746&epage=4746&pages=4746-4746&jtitle=Blood&atitle=Defective+NATURAL+Killer+ACTIVITY+Improved+by+IL-2+Stimulation+Independent+of+CD16+and+NKG2D+Receptors+IN+PATIENTS+with+THALASSEMIA+MAJOR.&aulast=Karakas&aufirst=Zeynep&rft_id=info%3Adoi%2F10.1182%2Fblood.v114.22.4746.4746&rft.language%5B0%5D=eng
SOLR
_version_ 1792322468492345348
author Karakas, Zeynep
author_facet Karakas, Zeynep, Karakas, Zeynep
author_sort karakas, zeynep
container_issue 22
container_start_page 4746
container_title Blood
container_volume 114
description <jats:title>Abstract</jats:title> <jats:p>Abstract 4746</jats:p> <jats:p>DEFECTIVE NATURAL KILLER ACTIVITY IMPROVED BY IL-2 STIMULATION INDEPENDENT OF CD16 AND NKG2D RECEPTORS IN PATIENTS WITH THALASSEMIA MAJOR</jats:p> <jats:p>Zeynep Karakaρ1,Belkýs Atasever2, Serap Erdem Kuruca3, Batu Erman2, Agaoglu Leyla1Istanbul Faculty of Medicine, Department of Pediatrics, Istanbul University, Istanbul, TurkeyFaculty of Engineering and Natural Sciences, Biological Sciences &amp; Bioengineering Program, Sabanci University, Istanbul, Turkey3 Istanbul Faculty of Medicine, Department of Physiology, Istanbul University, Istanbul, Turkiye</jats:p> <jats:sec> <jats:title>BACKGROUND</jats:title> <jats:p>Natural killer (NK) cells account for up to 15% of blood lymphocytes. Functional NK cells are found in the spleen. The function of NK cells is to recognize and kill virus infected cells and certain tumor cells. The mechanism of recognition is not fully understood, but it involves both activating and inhibitory receptors. CD 16 and NKG2D are receptors involved in two of the activation pathways of NK cells. NK cells use a variety of different mechanism to kill their targets. These include direct cell-cell signalling via surface molecules, and indirect signalling via cytokins. A decreased level of natural killer (NK) activity is one of the various immunological abnormalities in patients with thalassemia major.</jats:p> </jats:sec> <jats:sec> <jats:title>AIM</jats:title> <jats:p>This study aims to evaluate the relationship between NK cytotoxicity and CD 16 and NKG2D receptors, and effect of IL-2 stimulation in patients with thalassemia major.</jats:p> </jats:sec> <jats:sec> <jats:title>PATIENTS AND METHODS</jats:title> <jats:p>The study includes 26 patients with thalassemia major (TM) with age ranged 7-35 (median age was 18, 17 of them were female and 9 male), and sex and age matched 16 normal healthy subjects as controls. Fourteen of the patients were splenectomized. Patients regulary chelated with deferasirox (n:16), deferipron (n: 8) and desferroxamin (n: 2). NK cells were isolated from PBMC of subjects by using RosetteSep. Before and after the IL2 incubation; CD16, NKG2D receptors are examined in NK cells of both b-thalassemia major patients and controls by flow cytometry and we analyzed cytolytic function of NK cells against K562 cells. The cytotoxic activity of NK cells was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Ratios of NK cells /K562 cells (Efector:Target (E:T)) were 1:1, 10:1 and 20:1.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>NK cytotoxicity was found to be lower at E:T ratios of 1:1 and 10:1 in patients with thalassemia major when compared to controls(p &lt; 0.05). Patients with above 18 years old had significantly lower NK activity than below 18 years old. Sex, presence of splenectomy and chelation type did not effect on NK activity (p&gt;0.05). NK cytotoxicity significantly increased by IL-2 stimulation in 26 patients at E:T ratio of 10:1 (p&lt;0.05). But the increase was still less than the control. There was no significantly statistically difference between CD16 and NKG2D receptor levels compared with patients and controls. Patient's CD 16 receptor levels did not change after incubation with IL-2. NKG2D receptor levels of control NK cells significantly increased after IL-2 incubation (2021.66 / 1675.79/molecule, p&lt;0.003). We detected significantly increased levels of NKG2D after IL-2 incubation in patients with splenectomy than patients without splenectomy (1834.80 / 901.41/molecule, p&lt;0.005).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSION</jats:title> <jats:p>IL-2 may have potential therapeutic effect to improve the defective NK activity in patients with thalassaemia major. Increasing effect of IL-2 stimulation on NK activity may be independent than NKG2D receptor pattern. Defective NK cell functions can be partially restored by interleukin IL-2.</jats:p> <jats:p>This study was supported by Istanbul University Research Fund.</jats:p> </jats:sec> <jats:sec> <jats:title>Disclosures:</jats:title> <jats:p>No relevant conflicts of interest to declare.</jats:p> </jats:sec>
doi_str_mv 10.1182/blood.v114.22.4746.4746
facet_avail Online, Free
finc_class_facet Biologie, Medizin, Chemie und Pharmazie
format ElectronicArticle
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
geogr_code not assigned
geogr_code_person not assigned
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC52MTE0LjIyLjQ3NDYuNDc0Ng
imprint American Society of Hematology, 2009
imprint_str_mv American Society of Hematology, 2009
institution DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15
issn 0006-4971, 1528-0020
issn_str_mv 0006-4971, 1528-0020
language English
last_indexed 2024-03-01T11:18:21.234Z
match_str karakas2009defectivenaturalkilleractivityimprovedbyil2stimulationindependentofcd16andnkg2dreceptorsinpatientswiththalassemiamajor
mega_collection American Society of Hematology (CrossRef)
physical 4746-4746
publishDate 2009
publishDateSort 2009
publisher American Society of Hematology
record_format ai
recordtype ai
series Blood
source_id 49
spelling Karakas, Zeynep 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood.v114.22.4746.4746 <jats:title>Abstract</jats:title> <jats:p>Abstract 4746</jats:p> <jats:p>DEFECTIVE NATURAL KILLER ACTIVITY IMPROVED BY IL-2 STIMULATION INDEPENDENT OF CD16 AND NKG2D RECEPTORS IN PATIENTS WITH THALASSEMIA MAJOR</jats:p> <jats:p>Zeynep Karakaρ1,Belkýs Atasever2, Serap Erdem Kuruca3, Batu Erman2, Agaoglu Leyla1Istanbul Faculty of Medicine, Department of Pediatrics, Istanbul University, Istanbul, TurkeyFaculty of Engineering and Natural Sciences, Biological Sciences &amp; Bioengineering Program, Sabanci University, Istanbul, Turkey3 Istanbul Faculty of Medicine, Department of Physiology, Istanbul University, Istanbul, Turkiye</jats:p> <jats:sec> <jats:title>BACKGROUND</jats:title> <jats:p>Natural killer (NK) cells account for up to 15% of blood lymphocytes. Functional NK cells are found in the spleen. The function of NK cells is to recognize and kill virus infected cells and certain tumor cells. The mechanism of recognition is not fully understood, but it involves both activating and inhibitory receptors. CD 16 and NKG2D are receptors involved in two of the activation pathways of NK cells. NK cells use a variety of different mechanism to kill their targets. These include direct cell-cell signalling via surface molecules, and indirect signalling via cytokins. A decreased level of natural killer (NK) activity is one of the various immunological abnormalities in patients with thalassemia major.</jats:p> </jats:sec> <jats:sec> <jats:title>AIM</jats:title> <jats:p>This study aims to evaluate the relationship between NK cytotoxicity and CD 16 and NKG2D receptors, and effect of IL-2 stimulation in patients with thalassemia major.</jats:p> </jats:sec> <jats:sec> <jats:title>PATIENTS AND METHODS</jats:title> <jats:p>The study includes 26 patients with thalassemia major (TM) with age ranged 7-35 (median age was 18, 17 of them were female and 9 male), and sex and age matched 16 normal healthy subjects as controls. Fourteen of the patients were splenectomized. Patients regulary chelated with deferasirox (n:16), deferipron (n: 8) and desferroxamin (n: 2). NK cells were isolated from PBMC of subjects by using RosetteSep. Before and after the IL2 incubation; CD16, NKG2D receptors are examined in NK cells of both b-thalassemia major patients and controls by flow cytometry and we analyzed cytolytic function of NK cells against K562 cells. The cytotoxic activity of NK cells was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Ratios of NK cells /K562 cells (Efector:Target (E:T)) were 1:1, 10:1 and 20:1.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>NK cytotoxicity was found to be lower at E:T ratios of 1:1 and 10:1 in patients with thalassemia major when compared to controls(p &lt; 0.05). Patients with above 18 years old had significantly lower NK activity than below 18 years old. Sex, presence of splenectomy and chelation type did not effect on NK activity (p&gt;0.05). NK cytotoxicity significantly increased by IL-2 stimulation in 26 patients at E:T ratio of 10:1 (p&lt;0.05). But the increase was still less than the control. There was no significantly statistically difference between CD16 and NKG2D receptor levels compared with patients and controls. Patient's CD 16 receptor levels did not change after incubation with IL-2. NKG2D receptor levels of control NK cells significantly increased after IL-2 incubation (2021.66 / 1675.79/molecule, p&lt;0.003). We detected significantly increased levels of NKG2D after IL-2 incubation in patients with splenectomy than patients without splenectomy (1834.80 / 901.41/molecule, p&lt;0.005).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSION</jats:title> <jats:p>IL-2 may have potential therapeutic effect to improve the defective NK activity in patients with thalassaemia major. Increasing effect of IL-2 stimulation on NK activity may be independent than NKG2D receptor pattern. Defective NK cell functions can be partially restored by interleukin IL-2.</jats:p> <jats:p>This study was supported by Istanbul University Research Fund.</jats:p> </jats:sec> <jats:sec> <jats:title>Disclosures:</jats:title> <jats:p>No relevant conflicts of interest to declare.</jats:p> </jats:sec> Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR. Blood
spellingShingle Karakas, Zeynep, Blood, Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR., Cell Biology, Hematology, Immunology, Biochemistry
title Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_full Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_fullStr Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_full_unstemmed Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_short Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
title_sort defective natural killer activity improved by il-2 stimulation independent of cd16 and nkg2d receptors in patients with thalassemia major.
title_unstemmed Defective NATURAL Killer ACTIVITY Improved by IL-2 Stimulation Independent of CD16 and NKG2D Receptors IN PATIENTS with THALASSEMIA MAJOR.
topic Cell Biology, Hematology, Immunology, Biochemistry
url http://dx.doi.org/10.1182/blood.v114.22.4746.4746