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Evaluation of published single nucleotide polymorphisms associated with acute GVHD
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Blood, 119, 2012, 22, S. 5311-5319 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Chien, Jason W. Zhang, Xinyi Cindy Fan, Wenhong Wang, Hongwei Zhao, Lue Ping Martin, Paul J. Storer, Barry E. Boeckh, Michael Warren, Edus H. Hansen, John A. Chien, Jason W. Zhang, Xinyi Cindy Fan, Wenhong Wang, Hongwei Zhao, Lue Ping Martin, Paul J. Storer, Barry E. Boeckh, Michael Warren, Edus H. Hansen, John A. |
|---|---|
| author |
Chien, Jason W. Zhang, Xinyi Cindy Fan, Wenhong Wang, Hongwei Zhao, Lue Ping Martin, Paul J. Storer, Barry E. Boeckh, Michael Warren, Edus H. Hansen, John A. |
| spellingShingle |
Chien, Jason W. Zhang, Xinyi Cindy Fan, Wenhong Wang, Hongwei Zhao, Lue Ping Martin, Paul J. Storer, Barry E. Boeckh, Michael Warren, Edus H. Hansen, John A. Blood Evaluation of published single nucleotide polymorphisms associated with acute GVHD Cell Biology Hematology Immunology Biochemistry |
| author_sort |
chien, jason w. |
| spelling |
Chien, Jason W. Zhang, Xinyi Cindy Fan, Wenhong Wang, Hongwei Zhao, Lue Ping Martin, Paul J. Storer, Barry E. Boeckh, Michael Warren, Edus H. Hansen, John A. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2011-09-371153 <jats:p>Candidate genetic associations with acute GVHD (aGVHD) were evaluated with the use of genotyped and imputed single-nucleotide polymorphism data from genome-wide scans of 1298 allogeneic hematopoietic cell transplantation (HCT) donors and recipients. Of 40 previously reported candidate SNPs, 6 were successfully genotyped, and 10 were imputed and passed criteria for analysis. Patient and donor genotypes were assessed for association with grades IIb-IV and III-IV aGVHD, stratified by donor type, in univariate and multivariate allelic, recessive and dominant models. Use of imputed genotypes to replicate previous IL10 associations was validated. Similar to previous publications, the IL6 donor genotype for rs1800795 was associated with a 20%-50% increased risk for grade IIb-IV aGVHD after unrelated HCT in the allelic (adjusted P = .011) and recessive (adjusted P = .0013) models. The donor genotype was associated with a 60% increase in risk for grade III-IV aGVHD after related HCT (adjusted P = .028). Other associations were found for IL2, CTLA4, HPSE, and MTHFR but were inconsistent with original publications. These results illustrate the advantages of using imputed single-nucleotide polymorphism data in genetic analyses and demonstrate the importance of validation in genetic association studies.</jats:p> Evaluation of published single nucleotide polymorphisms associated with acute GVHD Blood |
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10.1182/blood-2011-09-371153 |
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American Society of Hematology, 2012 |
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| title |
Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_unstemmed |
Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_full |
Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_fullStr |
Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_full_unstemmed |
Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_short |
Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_sort |
evaluation of published single nucleotide polymorphisms associated with acute gvhd |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2011-09-371153 |
| publishDate |
2012 |
| physical |
5311-5319 |
| description |
<jats:p>Candidate genetic associations with acute GVHD (aGVHD) were evaluated with the use of genotyped and imputed single-nucleotide polymorphism data from genome-wide scans of 1298 allogeneic hematopoietic cell transplantation (HCT) donors and recipients. Of 40 previously reported candidate SNPs, 6 were successfully genotyped, and 10 were imputed and passed criteria for analysis. Patient and donor genotypes were assessed for association with grades IIb-IV and III-IV aGVHD, stratified by donor type, in univariate and multivariate allelic, recessive and dominant models. Use of imputed genotypes to replicate previous IL10 associations was validated. Similar to previous publications, the IL6 donor genotype for rs1800795 was associated with a 20%-50% increased risk for grade IIb-IV aGVHD after unrelated HCT in the allelic (adjusted P = .011) and recessive (adjusted P = .0013) models. The donor genotype was associated with a 60% increase in risk for grade III-IV aGVHD after related HCT (adjusted P = .028). Other associations were found for IL2, CTLA4, HPSE, and MTHFR but were inconsistent with original publications. These results illustrate the advantages of using imputed single-nucleotide polymorphism data in genetic analyses and demonstrate the importance of validation in genetic association studies.</jats:p> |
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| author | Chien, Jason W., Zhang, Xinyi Cindy, Fan, Wenhong, Wang, Hongwei, Zhao, Lue Ping, Martin, Paul J., Storer, Barry E., Boeckh, Michael, Warren, Edus H., Hansen, John A. |
| author_facet | Chien, Jason W., Zhang, Xinyi Cindy, Fan, Wenhong, Wang, Hongwei, Zhao, Lue Ping, Martin, Paul J., Storer, Barry E., Boeckh, Michael, Warren, Edus H., Hansen, John A., Chien, Jason W., Zhang, Xinyi Cindy, Fan, Wenhong, Wang, Hongwei, Zhao, Lue Ping, Martin, Paul J., Storer, Barry E., Boeckh, Michael, Warren, Edus H., Hansen, John A. |
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| description | <jats:p>Candidate genetic associations with acute GVHD (aGVHD) were evaluated with the use of genotyped and imputed single-nucleotide polymorphism data from genome-wide scans of 1298 allogeneic hematopoietic cell transplantation (HCT) donors and recipients. Of 40 previously reported candidate SNPs, 6 were successfully genotyped, and 10 were imputed and passed criteria for analysis. Patient and donor genotypes were assessed for association with grades IIb-IV and III-IV aGVHD, stratified by donor type, in univariate and multivariate allelic, recessive and dominant models. Use of imputed genotypes to replicate previous IL10 associations was validated. Similar to previous publications, the IL6 donor genotype for rs1800795 was associated with a 20%-50% increased risk for grade IIb-IV aGVHD after unrelated HCT in the allelic (adjusted P = .011) and recessive (adjusted P = .0013) models. The donor genotype was associated with a 60% increase in risk for grade III-IV aGVHD after related HCT (adjusted P = .028). Other associations were found for IL2, CTLA4, HPSE, and MTHFR but were inconsistent with original publications. These results illustrate the advantages of using imputed single-nucleotide polymorphism data in genetic analyses and demonstrate the importance of validation in genetic association studies.</jats:p> |
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| imprint_str_mv | American Society of Hematology, 2012 |
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| spelling | Chien, Jason W. Zhang, Xinyi Cindy Fan, Wenhong Wang, Hongwei Zhao, Lue Ping Martin, Paul J. Storer, Barry E. Boeckh, Michael Warren, Edus H. Hansen, John A. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2011-09-371153 <jats:p>Candidate genetic associations with acute GVHD (aGVHD) were evaluated with the use of genotyped and imputed single-nucleotide polymorphism data from genome-wide scans of 1298 allogeneic hematopoietic cell transplantation (HCT) donors and recipients. Of 40 previously reported candidate SNPs, 6 were successfully genotyped, and 10 were imputed and passed criteria for analysis. Patient and donor genotypes were assessed for association with grades IIb-IV and III-IV aGVHD, stratified by donor type, in univariate and multivariate allelic, recessive and dominant models. Use of imputed genotypes to replicate previous IL10 associations was validated. Similar to previous publications, the IL6 donor genotype for rs1800795 was associated with a 20%-50% increased risk for grade IIb-IV aGVHD after unrelated HCT in the allelic (adjusted P = .011) and recessive (adjusted P = .0013) models. The donor genotype was associated with a 60% increase in risk for grade III-IV aGVHD after related HCT (adjusted P = .028). Other associations were found for IL2, CTLA4, HPSE, and MTHFR but were inconsistent with original publications. These results illustrate the advantages of using imputed single-nucleotide polymorphism data in genetic analyses and demonstrate the importance of validation in genetic association studies.</jats:p> Evaluation of published single nucleotide polymorphisms associated with acute GVHD Blood |
| spellingShingle | Chien, Jason W., Zhang, Xinyi Cindy, Fan, Wenhong, Wang, Hongwei, Zhao, Lue Ping, Martin, Paul J., Storer, Barry E., Boeckh, Michael, Warren, Edus H., Hansen, John A., Blood, Evaluation of published single nucleotide polymorphisms associated with acute GVHD, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_full | Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_fullStr | Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_full_unstemmed | Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_short | Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| title_sort | evaluation of published single nucleotide polymorphisms associated with acute gvhd |
| title_unstemmed | Evaluation of published single nucleotide polymorphisms associated with acute GVHD |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2011-09-371153 |