Eintrag weiter verarbeiten
A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology
Gespeichert in:
| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | Blood, 133, 2019, 9, S. 967-977 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
de Vries, Paul S. Sabater-Lleal, Maria Huffman, Jennifer E. Marten, Jonathan Song, Ci Pankratz, Nathan Bartz, Traci M. de Haan, Hugoline G. Delgado, Graciela E. Eicher, John D. Martinez-Perez, Angel Ward-Caviness, Cavin K. Brody, Jennifer A. Chen, Ming-Huei de Maat, Moniek P. M. Frånberg, Mattias Gill, Dipender Kleber, Marcus E. Rivadeneira, Fernando Soria, José Manuel Tang, Weihong Tofler, Geoffrey H. Uitterlinden, André G. van Hylckama Vlieg, Astrid Seshadri, Sudha Boerwinkle, Eric Davies, Neil M. Giese, Anne-Katrin Ikram, M. Kamran Kittner, Steven J. McKnight, Barbara Psaty, Bruce M. Reiner, Alex P. Sargurupremraj, Muralidharan Taylor, Kent D. Fornage, Myriam Hamsten, Anders März, Winfried Rosendaal, Frits R. Souto, Juan Carlos Dehghan, Abbas Johnson, Andrew D. Morrison, Alanna C. O'Donnell, Christopher J. Smith, Nicholas L. de Vries, Paul S. Sabater-Lleal, Maria Huffman, Jennifer E. Marten, Jonathan Song, Ci Pankratz, Nathan Bartz, Traci M. de Haan, Hugoline G. Delgado, Graciela E. Eicher, John D. Martinez-Perez, Angel Ward-Caviness, Cavin K. Brody, Jennifer A. Chen, Ming-Huei de Maat, Moniek P. M. Frånberg, Mattias Gill, Dipender Kleber, Marcus E. Rivadeneira, Fernando Soria, José Manuel Tang, Weihong Tofler, Geoffrey H. Uitterlinden, André G. van Hylckama Vlieg, Astrid Seshadri, Sudha Boerwinkle, Eric Davies, Neil M. Giese, Anne-Katrin Ikram, M. Kamran Kittner, Steven J. McKnight, Barbara Psaty, Bruce M. Reiner, Alex P. Sargurupremraj, Muralidharan Taylor, Kent D. Fornage, Myriam Hamsten, Anders März, Winfried Rosendaal, Frits R. Souto, Juan Carlos Dehghan, Abbas Johnson, Andrew D. Morrison, Alanna C. O'Donnell, Christopher J. Smith, Nicholas L. |
|---|---|
| author |
de Vries, Paul S. Sabater-Lleal, Maria Huffman, Jennifer E. Marten, Jonathan Song, Ci Pankratz, Nathan Bartz, Traci M. de Haan, Hugoline G. Delgado, Graciela E. Eicher, John D. Martinez-Perez, Angel Ward-Caviness, Cavin K. Brody, Jennifer A. Chen, Ming-Huei de Maat, Moniek P. M. Frånberg, Mattias Gill, Dipender Kleber, Marcus E. Rivadeneira, Fernando Soria, José Manuel Tang, Weihong Tofler, Geoffrey H. Uitterlinden, André G. van Hylckama Vlieg, Astrid Seshadri, Sudha Boerwinkle, Eric Davies, Neil M. Giese, Anne-Katrin Ikram, M. Kamran Kittner, Steven J. McKnight, Barbara Psaty, Bruce M. Reiner, Alex P. Sargurupremraj, Muralidharan Taylor, Kent D. Fornage, Myriam Hamsten, Anders März, Winfried Rosendaal, Frits R. Souto, Juan Carlos Dehghan, Abbas Johnson, Andrew D. Morrison, Alanna C. O'Donnell, Christopher J. Smith, Nicholas L. |
| spellingShingle |
de Vries, Paul S. Sabater-Lleal, Maria Huffman, Jennifer E. Marten, Jonathan Song, Ci Pankratz, Nathan Bartz, Traci M. de Haan, Hugoline G. Delgado, Graciela E. Eicher, John D. Martinez-Perez, Angel Ward-Caviness, Cavin K. Brody, Jennifer A. Chen, Ming-Huei de Maat, Moniek P. M. Frånberg, Mattias Gill, Dipender Kleber, Marcus E. Rivadeneira, Fernando Soria, José Manuel Tang, Weihong Tofler, Geoffrey H. Uitterlinden, André G. van Hylckama Vlieg, Astrid Seshadri, Sudha Boerwinkle, Eric Davies, Neil M. Giese, Anne-Katrin Ikram, M. Kamran Kittner, Steven J. McKnight, Barbara Psaty, Bruce M. Reiner, Alex P. Sargurupremraj, Muralidharan Taylor, Kent D. Fornage, Myriam Hamsten, Anders März, Winfried Rosendaal, Frits R. Souto, Juan Carlos Dehghan, Abbas Johnson, Andrew D. Morrison, Alanna C. O'Donnell, Christopher J. Smith, Nicholas L. Blood A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology Cell Biology Hematology Immunology Biochemistry |
| author_sort |
de vries, paul s. |
| spelling |
de Vries, Paul S. Sabater-Lleal, Maria Huffman, Jennifer E. Marten, Jonathan Song, Ci Pankratz, Nathan Bartz, Traci M. de Haan, Hugoline G. Delgado, Graciela E. Eicher, John D. Martinez-Perez, Angel Ward-Caviness, Cavin K. Brody, Jennifer A. Chen, Ming-Huei de Maat, Moniek P. M. Frånberg, Mattias Gill, Dipender Kleber, Marcus E. Rivadeneira, Fernando Soria, José Manuel Tang, Weihong Tofler, Geoffrey H. Uitterlinden, André G. van Hylckama Vlieg, Astrid Seshadri, Sudha Boerwinkle, Eric Davies, Neil M. Giese, Anne-Katrin Ikram, M. Kamran Kittner, Steven J. McKnight, Barbara Psaty, Bruce M. Reiner, Alex P. Sargurupremraj, Muralidharan Taylor, Kent D. Fornage, Myriam Hamsten, Anders März, Winfried Rosendaal, Frits R. Souto, Juan Carlos Dehghan, Abbas Johnson, Andrew D. Morrison, Alanna C. O'Donnell, Christopher J. Smith, Nicholas L. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2018-05-849240 <jats:title>Abstract</jats:title> <jats:p>Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combined for a trans-ancestry meta-analysis. Our primary analysis included the 7 studies that measured FVII activity, and a secondary analysis included all 9 studies. We provided functional genomic validation for newly identified significant loci by silencing candidate genes in a human liver cell line (HuH7) using small-interfering RNA and then measuring F7 messenger RNA and FVII protein expression. Lastly, we used meta-analysis results to perform Mendelian randomization analysis to estimate the causal effect of FVII activity on coronary artery disease, ischemic stroke (IS), and venous thromboembolism. We identified 2 novel (REEP3 and JAZF1-AS1) and 6 known loci associated with FVII activity, explaining 19.0% of the phenotypic variance. Adding FVII antigen data to the meta-analysis did not result in the discovery of further loci. Silencing REEP3 in HuH7 cells upregulated FVII, whereas silencing JAZF1 downregulated FVII. Mendelian randomization analyses suggest that FVII activity has a positive causal effect on the risk of IS. Variants at REEP3 and JAZF1 contribute to FVII activity by regulating F7 expression levels. FVII activity appears to contribute to the etiology of IS in the general population.</jats:p> A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology Blood |
| doi_str_mv |
10.1182/blood-2018-05-849240 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Medizin Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDE4LTA1LTg0OTI0MA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDE4LTA1LTg0OTI0MA |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
American Society of Hematology, 2019 |
| imprint_str_mv |
American Society of Hematology, 2019 |
| issn |
0006-4971 1528-0020 |
| issn_str_mv |
0006-4971 1528-0020 |
| language |
English |
| mega_collection |
American Society of Hematology (CrossRef) |
| match_str |
devries2019agenomewideassociationstudyidentifiesnewlociforfactorviiandimplicatesfactorviiinischemicstrokeetiology |
| publishDateSort |
2019 |
| publisher |
American Society of Hematology |
| recordtype |
ai |
| record_format |
ai |
| series |
Blood |
| source_id |
49 |
| title |
A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_unstemmed |
A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_full |
A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_fullStr |
A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_full_unstemmed |
A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_short |
A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_sort |
a genome-wide association study identifies new loci for factor vii and implicates factor vii in ischemic stroke etiology |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2018-05-849240 |
| publishDate |
2019 |
| physical |
967-977 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combined for a trans-ancestry meta-analysis. Our primary analysis included the 7 studies that measured FVII activity, and a secondary analysis included all 9 studies. We provided functional genomic validation for newly identified significant loci by silencing candidate genes in a human liver cell line (HuH7) using small-interfering RNA and then measuring F7 messenger RNA and FVII protein expression. Lastly, we used meta-analysis results to perform Mendelian randomization analysis to estimate the causal effect of FVII activity on coronary artery disease, ischemic stroke (IS), and venous thromboembolism. We identified 2 novel (REEP3 and JAZF1-AS1) and 6 known loci associated with FVII activity, explaining 19.0% of the phenotypic variance. Adding FVII antigen data to the meta-analysis did not result in the discovery of further loci. Silencing REEP3 in HuH7 cells upregulated FVII, whereas silencing JAZF1 downregulated FVII. Mendelian randomization analyses suggest that FVII activity has a positive causal effect on the risk of IS. Variants at REEP3 and JAZF1 contribute to FVII activity by regulating F7 expression levels. FVII activity appears to contribute to the etiology of IS in the general population.</jats:p> |
| container_issue |
9 |
| container_start_page |
967 |
| container_title |
Blood |
| container_volume |
133 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792347829522399246 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:01:05.438Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=A+genome-wide+association+study+identifies+new+loci+for+factor+VII+and+implicates+factor+VII+in+ischemic+stroke+etiology&rft.date=2019-02-28&genre=article&issn=1528-0020&volume=133&issue=9&spage=967&epage=977&pages=967-977&jtitle=Blood&atitle=A+genome-wide+association+study+identifies+new+loci+for+factor+VII+and+implicates+factor+VII+in+ischemic+stroke+etiology&aulast=Smith&aufirst=Nicholas+L.&rft_id=info%3Adoi%2F10.1182%2Fblood-2018-05-849240&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792347829522399246 |
| author | de Vries, Paul S., Sabater-Lleal, Maria, Huffman, Jennifer E., Marten, Jonathan, Song, Ci, Pankratz, Nathan, Bartz, Traci M., de Haan, Hugoline G., Delgado, Graciela E., Eicher, John D., Martinez-Perez, Angel, Ward-Caviness, Cavin K., Brody, Jennifer A., Chen, Ming-Huei, de Maat, Moniek P. M., Frånberg, Mattias, Gill, Dipender, Kleber, Marcus E., Rivadeneira, Fernando, Soria, José Manuel, Tang, Weihong, Tofler, Geoffrey H., Uitterlinden, André G., van Hylckama Vlieg, Astrid, Seshadri, Sudha, Boerwinkle, Eric, Davies, Neil M., Giese, Anne-Katrin, Ikram, M. Kamran, Kittner, Steven J., McKnight, Barbara, Psaty, Bruce M., Reiner, Alex P., Sargurupremraj, Muralidharan, Taylor, Kent D., Fornage, Myriam, Hamsten, Anders, März, Winfried, Rosendaal, Frits R., Souto, Juan Carlos, Dehghan, Abbas, Johnson, Andrew D., Morrison, Alanna C., O'Donnell, Christopher J., Smith, Nicholas L. |
| author_facet | de Vries, Paul S., Sabater-Lleal, Maria, Huffman, Jennifer E., Marten, Jonathan, Song, Ci, Pankratz, Nathan, Bartz, Traci M., de Haan, Hugoline G., Delgado, Graciela E., Eicher, John D., Martinez-Perez, Angel, Ward-Caviness, Cavin K., Brody, Jennifer A., Chen, Ming-Huei, de Maat, Moniek P. M., Frånberg, Mattias, Gill, Dipender, Kleber, Marcus E., Rivadeneira, Fernando, Soria, José Manuel, Tang, Weihong, Tofler, Geoffrey H., Uitterlinden, André G., van Hylckama Vlieg, Astrid, Seshadri, Sudha, Boerwinkle, Eric, Davies, Neil M., Giese, Anne-Katrin, Ikram, M. Kamran, Kittner, Steven J., McKnight, Barbara, Psaty, Bruce M., Reiner, Alex P., Sargurupremraj, Muralidharan, Taylor, Kent D., Fornage, Myriam, Hamsten, Anders, März, Winfried, Rosendaal, Frits R., Souto, Juan Carlos, Dehghan, Abbas, Johnson, Andrew D., Morrison, Alanna C., O'Donnell, Christopher J., Smith, Nicholas L., de Vries, Paul S., Sabater-Lleal, Maria, Huffman, Jennifer E., Marten, Jonathan, Song, Ci, Pankratz, Nathan, Bartz, Traci M., de Haan, Hugoline G., Delgado, Graciela E., Eicher, John D., Martinez-Perez, Angel, Ward-Caviness, Cavin K., Brody, Jennifer A., Chen, Ming-Huei, de Maat, Moniek P. M., Frånberg, Mattias, Gill, Dipender, Kleber, Marcus E., Rivadeneira, Fernando, Soria, José Manuel, Tang, Weihong, Tofler, Geoffrey H., Uitterlinden, André G., van Hylckama Vlieg, Astrid, Seshadri, Sudha, Boerwinkle, Eric, Davies, Neil M., Giese, Anne-Katrin, Ikram, M. Kamran, Kittner, Steven J., McKnight, Barbara, Psaty, Bruce M., Reiner, Alex P., Sargurupremraj, Muralidharan, Taylor, Kent D., Fornage, Myriam, Hamsten, Anders, März, Winfried, Rosendaal, Frits R., Souto, Juan Carlos, Dehghan, Abbas, Johnson, Andrew D., Morrison, Alanna C., O'Donnell, Christopher J., Smith, Nicholas L. |
| author_sort | de vries, paul s. |
| container_issue | 9 |
| container_start_page | 967 |
| container_title | Blood |
| container_volume | 133 |
| description | <jats:title>Abstract</jats:title> <jats:p>Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combined for a trans-ancestry meta-analysis. Our primary analysis included the 7 studies that measured FVII activity, and a secondary analysis included all 9 studies. We provided functional genomic validation for newly identified significant loci by silencing candidate genes in a human liver cell line (HuH7) using small-interfering RNA and then measuring F7 messenger RNA and FVII protein expression. Lastly, we used meta-analysis results to perform Mendelian randomization analysis to estimate the causal effect of FVII activity on coronary artery disease, ischemic stroke (IS), and venous thromboembolism. We identified 2 novel (REEP3 and JAZF1-AS1) and 6 known loci associated with FVII activity, explaining 19.0% of the phenotypic variance. Adding FVII antigen data to the meta-analysis did not result in the discovery of further loci. Silencing REEP3 in HuH7 cells upregulated FVII, whereas silencing JAZF1 downregulated FVII. Mendelian randomization analyses suggest that FVII activity has a positive causal effect on the risk of IS. Variants at REEP3 and JAZF1 contribute to FVII activity by regulating F7 expression levels. FVII activity appears to contribute to the etiology of IS in the general population.</jats:p> |
| doi_str_mv | 10.1182/blood-2018-05-849240 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDE4LTA1LTg0OTI0MA |
| imprint | American Society of Hematology, 2019 |
| imprint_str_mv | American Society of Hematology, 2019 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0006-4971, 1528-0020 |
| issn_str_mv | 0006-4971, 1528-0020 |
| language | English |
| last_indexed | 2024-03-01T18:01:05.438Z |
| match_str | devries2019agenomewideassociationstudyidentifiesnewlociforfactorviiandimplicatesfactorviiinischemicstrokeetiology |
| mega_collection | American Society of Hematology (CrossRef) |
| physical | 967-977 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | American Society of Hematology |
| record_format | ai |
| recordtype | ai |
| series | Blood |
| source_id | 49 |
| spelling | de Vries, Paul S. Sabater-Lleal, Maria Huffman, Jennifer E. Marten, Jonathan Song, Ci Pankratz, Nathan Bartz, Traci M. de Haan, Hugoline G. Delgado, Graciela E. Eicher, John D. Martinez-Perez, Angel Ward-Caviness, Cavin K. Brody, Jennifer A. Chen, Ming-Huei de Maat, Moniek P. M. Frånberg, Mattias Gill, Dipender Kleber, Marcus E. Rivadeneira, Fernando Soria, José Manuel Tang, Weihong Tofler, Geoffrey H. Uitterlinden, André G. van Hylckama Vlieg, Astrid Seshadri, Sudha Boerwinkle, Eric Davies, Neil M. Giese, Anne-Katrin Ikram, M. Kamran Kittner, Steven J. McKnight, Barbara Psaty, Bruce M. Reiner, Alex P. Sargurupremraj, Muralidharan Taylor, Kent D. Fornage, Myriam Hamsten, Anders März, Winfried Rosendaal, Frits R. Souto, Juan Carlos Dehghan, Abbas Johnson, Andrew D. Morrison, Alanna C. O'Donnell, Christopher J. Smith, Nicholas L. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2018-05-849240 <jats:title>Abstract</jats:title> <jats:p>Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combined for a trans-ancestry meta-analysis. Our primary analysis included the 7 studies that measured FVII activity, and a secondary analysis included all 9 studies. We provided functional genomic validation for newly identified significant loci by silencing candidate genes in a human liver cell line (HuH7) using small-interfering RNA and then measuring F7 messenger RNA and FVII protein expression. Lastly, we used meta-analysis results to perform Mendelian randomization analysis to estimate the causal effect of FVII activity on coronary artery disease, ischemic stroke (IS), and venous thromboembolism. We identified 2 novel (REEP3 and JAZF1-AS1) and 6 known loci associated with FVII activity, explaining 19.0% of the phenotypic variance. Adding FVII antigen data to the meta-analysis did not result in the discovery of further loci. Silencing REEP3 in HuH7 cells upregulated FVII, whereas silencing JAZF1 downregulated FVII. Mendelian randomization analyses suggest that FVII activity has a positive causal effect on the risk of IS. Variants at REEP3 and JAZF1 contribute to FVII activity by regulating F7 expression levels. FVII activity appears to contribute to the etiology of IS in the general population.</jats:p> A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology Blood |
| spellingShingle | de Vries, Paul S., Sabater-Lleal, Maria, Huffman, Jennifer E., Marten, Jonathan, Song, Ci, Pankratz, Nathan, Bartz, Traci M., de Haan, Hugoline G., Delgado, Graciela E., Eicher, John D., Martinez-Perez, Angel, Ward-Caviness, Cavin K., Brody, Jennifer A., Chen, Ming-Huei, de Maat, Moniek P. M., Frånberg, Mattias, Gill, Dipender, Kleber, Marcus E., Rivadeneira, Fernando, Soria, José Manuel, Tang, Weihong, Tofler, Geoffrey H., Uitterlinden, André G., van Hylckama Vlieg, Astrid, Seshadri, Sudha, Boerwinkle, Eric, Davies, Neil M., Giese, Anne-Katrin, Ikram, M. Kamran, Kittner, Steven J., McKnight, Barbara, Psaty, Bruce M., Reiner, Alex P., Sargurupremraj, Muralidharan, Taylor, Kent D., Fornage, Myriam, Hamsten, Anders, März, Winfried, Rosendaal, Frits R., Souto, Juan Carlos, Dehghan, Abbas, Johnson, Andrew D., Morrison, Alanna C., O'Donnell, Christopher J., Smith, Nicholas L., Blood, A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology, Cell Biology, Hematology, Immunology, Biochemistry |
| title | A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_full | A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_fullStr | A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_full_unstemmed | A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_short | A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| title_sort | a genome-wide association study identifies new loci for factor vii and implicates factor vii in ischemic stroke etiology |
| title_unstemmed | A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2018-05-849240 |