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| author_facet |
Casu, Carla Nemeth, Elizabeta Rivella, Stefano Casu, Carla Nemeth, Elizabeta Rivella, Stefano |
|---|---|
| author |
Casu, Carla Nemeth, Elizabeta Rivella, Stefano |
| spellingShingle |
Casu, Carla Nemeth, Elizabeta Rivella, Stefano Blood Hepcidin agonists as therapeutic tools Cell Biology Hematology Immunology Biochemistry |
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casu, carla |
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Casu, Carla Nemeth, Elizabeta Rivella, Stefano 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2017-11-737411 <jats:title>Abstract</jats:title> <jats:p>Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron absorption, and could improve the treatment of hemochromatosis, β-thalassemia, polycythemia vera, and other disorders in which disrupted iron homeostasis causes or contributes to disease. Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease. This review highlights the preclinical studies that support the development of hepcidin agonists for the treatment of these disorders.</jats:p> Hepcidin agonists as therapeutic tools Blood |
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10.1182/blood-2017-11-737411 |
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Biologie Medizin Chemie und Pharmazie |
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American Society of Hematology, 2018 |
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American Society of Hematology, 2018 |
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0006-4971 1528-0020 |
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0006-4971 1528-0020 |
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2018 |
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American Society of Hematology |
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| title |
Hepcidin agonists as therapeutic tools |
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Hepcidin agonists as therapeutic tools |
| title_full |
Hepcidin agonists as therapeutic tools |
| title_fullStr |
Hepcidin agonists as therapeutic tools |
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Hepcidin agonists as therapeutic tools |
| title_short |
Hepcidin agonists as therapeutic tools |
| title_sort |
hepcidin agonists as therapeutic tools |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2017-11-737411 |
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2018 |
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1790-1794 |
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<jats:title>Abstract</jats:title>
<jats:p>Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron absorption, and could improve the treatment of hemochromatosis, β-thalassemia, polycythemia vera, and other disorders in which disrupted iron homeostasis causes or contributes to disease. Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease. This review highlights the preclinical studies that support the development of hepcidin agonists for the treatment of these disorders.</jats:p> |
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| author | Casu, Carla, Nemeth, Elizabeta, Rivella, Stefano |
| author_facet | Casu, Carla, Nemeth, Elizabeta, Rivella, Stefano, Casu, Carla, Nemeth, Elizabeta, Rivella, Stefano |
| author_sort | casu, carla |
| container_issue | 16 |
| container_start_page | 1790 |
| container_title | Blood |
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| description | <jats:title>Abstract</jats:title> <jats:p>Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron absorption, and could improve the treatment of hemochromatosis, β-thalassemia, polycythemia vera, and other disorders in which disrupted iron homeostasis causes or contributes to disease. Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease. This review highlights the preclinical studies that support the development of hepcidin agonists for the treatment of these disorders.</jats:p> |
| doi_str_mv | 10.1182/blood-2017-11-737411 |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDE3LTExLTczNzQxMQ |
| imprint | American Society of Hematology, 2018 |
| imprint_str_mv | American Society of Hematology, 2018 |
| institution | DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
| issn | 0006-4971, 1528-0020 |
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| language | English |
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| publishDate | 2018 |
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| series | Blood |
| source_id | 49 |
| spelling | Casu, Carla Nemeth, Elizabeta Rivella, Stefano 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2017-11-737411 <jats:title>Abstract</jats:title> <jats:p>Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron absorption, and could improve the treatment of hemochromatosis, β-thalassemia, polycythemia vera, and other disorders in which disrupted iron homeostasis causes or contributes to disease. Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease. This review highlights the preclinical studies that support the development of hepcidin agonists for the treatment of these disorders.</jats:p> Hepcidin agonists as therapeutic tools Blood |
| spellingShingle | Casu, Carla, Nemeth, Elizabeta, Rivella, Stefano, Blood, Hepcidin agonists as therapeutic tools, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Hepcidin agonists as therapeutic tools |
| title_full | Hepcidin agonists as therapeutic tools |
| title_fullStr | Hepcidin agonists as therapeutic tools |
| title_full_unstemmed | Hepcidin agonists as therapeutic tools |
| title_short | Hepcidin agonists as therapeutic tools |
| title_sort | hepcidin agonists as therapeutic tools |
| title_unstemmed | Hepcidin agonists as therapeutic tools |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2017-11-737411 |