A nonsense mutation in IKBKB causes combined immunodeficiency

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Bibliographische Detailangaben
Zeitschriftentitel:	Blood
Personen und Körperschaften:	Mousallem, Talal, Yang, Jialong, Urban, Thomas J., Wang, Hongxia, Adeli, Mehdi, Parrott, Roberta E., Roberts, Joseph L., Goldstein, David B., Buckley, Rebecca H., Zhong, Xiao-Ping
In:	Blood, 124, 2014, 13, S. 2046-2050
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society of Hematology
Schlagwörter:	Cell Biology Hematology Immunology Biochemistry

Details
Zusammenfassung:	<jats:title>Key Points</jats:title><jats:p>A nonsense mutation in IKBKB caused the absence of IKKβ and a lack of T- and B-cell activation through their antigen receptors. IKKβ is not necessary for development of T or B lymphocytes but is important for their activation and for the development/function of NK cells.</jats:p>
Umfang:	2046-2050
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood-2014-04-571265