Eintrag weiter verarbeiten
Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro
Gespeichert in:
| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Blood, 102, 2003, 6, S. 2240-2242 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Oehler, Leopold Jaeger, Eva Eser, Alexander Sillaber, Christian Gisslinger, Heinz Geissler, Klaus Oehler, Leopold Jaeger, Eva Eser, Alexander Sillaber, Christian Gisslinger, Heinz Geissler, Klaus |
|---|---|
| author |
Oehler, Leopold Jaeger, Eva Eser, Alexander Sillaber, Christian Gisslinger, Heinz Geissler, Klaus |
| spellingShingle |
Oehler, Leopold Jaeger, Eva Eser, Alexander Sillaber, Christian Gisslinger, Heinz Geissler, Klaus Blood Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro Cell Biology Hematology Immunology Biochemistry |
| author_sort |
oehler, leopold |
| spelling |
Oehler, Leopold Jaeger, Eva Eser, Alexander Sillaber, Christian Gisslinger, Heinz Geissler, Klaus 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2003-03-0676 <jats:title>Abstract</jats:title> <jats:p>The overproduction of red blood cells in patients with polycythemia vera (PV) is reflected in vitro by the formation of erythroid burst-forming units (BFU-Es) in the absence of exogenous erythropoietin. In contrast to other myeloproliferative disorders, the molecular mechanism of PV is unknown and no specific chromosomal abnormality has been described. We speculated that imatinib mesylate may reverse the pathological overproduction of red cells by inhibition of autonomous erythropoiesis. In the present study, imatinib mesylate was found to either block or strongly inhibit autonomous BFU-E formation in vitro in all patients tested. Moreover, autonomous BFU-E growth was also markedly reduced by exposure of PV cells to imatinib mesylate prior to cultivation in semisolid medium. The profound effect of imatinib mesylate on autonomous erythropoiesis suggests the involvement of an as yet unidentified kinase in the pathogenesis of PV and should provide the rationale for a forthcoming clinical trial.</jats:p> Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro Blood |
| doi_str_mv |
10.1182/blood-2003-03-0676 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Medizin Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDAzLTAzLTA2NzY |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDAzLTAzLTA2NzY |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
American Society of Hematology, 2003 |
| imprint_str_mv |
American Society of Hematology, 2003 |
| issn |
0006-4971 1528-0020 |
| issn_str_mv |
0006-4971 1528-0020 |
| language |
English |
| mega_collection |
American Society of Hematology (CrossRef) |
| match_str |
oehler2003imatinibmesylateinhibitsautonomouserythropoiesisinpatientswithpolycythemiaverainvitro |
| publishDateSort |
2003 |
| publisher |
American Society of Hematology |
| recordtype |
ai |
| record_format |
ai |
| series |
Blood |
| source_id |
49 |
| title |
Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_unstemmed |
Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_full |
Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_fullStr |
Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_full_unstemmed |
Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_short |
Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_sort |
imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2003-03-0676 |
| publishDate |
2003 |
| physical |
2240-2242 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>The overproduction of red blood cells in patients with polycythemia vera (PV) is reflected in vitro by the formation of erythroid burst-forming units (BFU-Es) in the absence of exogenous erythropoietin. In contrast to other myeloproliferative disorders, the molecular mechanism of PV is unknown and no specific chromosomal abnormality has been described. We speculated that imatinib mesylate may reverse the pathological overproduction of red cells by inhibition of autonomous erythropoiesis. In the present study, imatinib mesylate was found to either block or strongly inhibit autonomous BFU-E formation in vitro in all patients tested. Moreover, autonomous BFU-E growth was also markedly reduced by exposure of PV cells to imatinib mesylate prior to cultivation in semisolid medium. The profound effect of imatinib mesylate on autonomous erythropoiesis suggests the involvement of an as yet unidentified kinase in the pathogenesis of PV and should provide the rationale for a forthcoming clinical trial.</jats:p> |
| container_issue |
6 |
| container_start_page |
2240 |
| container_title |
Blood |
| container_volume |
102 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792339299826401284 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:45:53.189Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Imatinib+mesylate+inhibits+autonomous+erythropoiesis+in+patients+with+polycythemia+vera+in+vitro&rft.date=2003-09-15&genre=article&issn=1528-0020&volume=102&issue=6&spage=2240&epage=2242&pages=2240-2242&jtitle=Blood&atitle=Imatinib+mesylate+inhibits+autonomous+erythropoiesis+in+patients+with+polycythemia+vera+in+vitro&aulast=Geissler&aufirst=Klaus&rft_id=info%3Adoi%2F10.1182%2Fblood-2003-03-0676&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792339299826401284 |
| author | Oehler, Leopold, Jaeger, Eva, Eser, Alexander, Sillaber, Christian, Gisslinger, Heinz, Geissler, Klaus |
| author_facet | Oehler, Leopold, Jaeger, Eva, Eser, Alexander, Sillaber, Christian, Gisslinger, Heinz, Geissler, Klaus, Oehler, Leopold, Jaeger, Eva, Eser, Alexander, Sillaber, Christian, Gisslinger, Heinz, Geissler, Klaus |
| author_sort | oehler, leopold |
| container_issue | 6 |
| container_start_page | 2240 |
| container_title | Blood |
| container_volume | 102 |
| description | <jats:title>Abstract</jats:title> <jats:p>The overproduction of red blood cells in patients with polycythemia vera (PV) is reflected in vitro by the formation of erythroid burst-forming units (BFU-Es) in the absence of exogenous erythropoietin. In contrast to other myeloproliferative disorders, the molecular mechanism of PV is unknown and no specific chromosomal abnormality has been described. We speculated that imatinib mesylate may reverse the pathological overproduction of red cells by inhibition of autonomous erythropoiesis. In the present study, imatinib mesylate was found to either block or strongly inhibit autonomous BFU-E formation in vitro in all patients tested. Moreover, autonomous BFU-E growth was also markedly reduced by exposure of PV cells to imatinib mesylate prior to cultivation in semisolid medium. The profound effect of imatinib mesylate on autonomous erythropoiesis suggests the involvement of an as yet unidentified kinase in the pathogenesis of PV and should provide the rationale for a forthcoming clinical trial.</jats:p> |
| doi_str_mv | 10.1182/blood-2003-03-0676 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDAzLTAzLTA2NzY |
| imprint | American Society of Hematology, 2003 |
| imprint_str_mv | American Society of Hematology, 2003 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0006-4971, 1528-0020 |
| issn_str_mv | 0006-4971, 1528-0020 |
| language | English |
| last_indexed | 2024-03-01T15:45:53.189Z |
| match_str | oehler2003imatinibmesylateinhibitsautonomouserythropoiesisinpatientswithpolycythemiaverainvitro |
| mega_collection | American Society of Hematology (CrossRef) |
| physical | 2240-2242 |
| publishDate | 2003 |
| publishDateSort | 2003 |
| publisher | American Society of Hematology |
| record_format | ai |
| recordtype | ai |
| series | Blood |
| source_id | 49 |
| spelling | Oehler, Leopold Jaeger, Eva Eser, Alexander Sillaber, Christian Gisslinger, Heinz Geissler, Klaus 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2003-03-0676 <jats:title>Abstract</jats:title> <jats:p>The overproduction of red blood cells in patients with polycythemia vera (PV) is reflected in vitro by the formation of erythroid burst-forming units (BFU-Es) in the absence of exogenous erythropoietin. In contrast to other myeloproliferative disorders, the molecular mechanism of PV is unknown and no specific chromosomal abnormality has been described. We speculated that imatinib mesylate may reverse the pathological overproduction of red cells by inhibition of autonomous erythropoiesis. In the present study, imatinib mesylate was found to either block or strongly inhibit autonomous BFU-E formation in vitro in all patients tested. Moreover, autonomous BFU-E growth was also markedly reduced by exposure of PV cells to imatinib mesylate prior to cultivation in semisolid medium. The profound effect of imatinib mesylate on autonomous erythropoiesis suggests the involvement of an as yet unidentified kinase in the pathogenesis of PV and should provide the rationale for a forthcoming clinical trial.</jats:p> Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro Blood |
| spellingShingle | Oehler, Leopold, Jaeger, Eva, Eser, Alexander, Sillaber, Christian, Gisslinger, Heinz, Geissler, Klaus, Blood, Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_full | Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_fullStr | Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_full_unstemmed | Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_short | Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_sort | imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| title_unstemmed | Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2003-03-0676 |