Eintrag weiter verarbeiten
The homeoprotein Hex is required for hemangioblast differentiation
Gespeichert in:
| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Blood, 102, 2003, 7, S. 2428-2435 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Guo, Ying Chan, Rebecca Ramsey, Heather Li, Weiming Xie, Xiaodong Shelley, William C. Martinez-Barbera, Juan Pedro Bort, Bernardo Zaret, Kenneth Yoder, Mervin Hromas, Robert Guo, Ying Chan, Rebecca Ramsey, Heather Li, Weiming Xie, Xiaodong Shelley, William C. Martinez-Barbera, Juan Pedro Bort, Bernardo Zaret, Kenneth Yoder, Mervin Hromas, Robert |
|---|---|
| author |
Guo, Ying Chan, Rebecca Ramsey, Heather Li, Weiming Xie, Xiaodong Shelley, William C. Martinez-Barbera, Juan Pedro Bort, Bernardo Zaret, Kenneth Yoder, Mervin Hromas, Robert |
| spellingShingle |
Guo, Ying Chan, Rebecca Ramsey, Heather Li, Weiming Xie, Xiaodong Shelley, William C. Martinez-Barbera, Juan Pedro Bort, Bernardo Zaret, Kenneth Yoder, Mervin Hromas, Robert Blood The homeoprotein Hex is required for hemangioblast differentiation Cell Biology Hematology Immunology Biochemistry |
| author_sort |
guo, ying |
| spelling |
Guo, Ying Chan, Rebecca Ramsey, Heather Li, Weiming Xie, Xiaodong Shelley, William C. Martinez-Barbera, Juan Pedro Bort, Bernardo Zaret, Kenneth Yoder, Mervin Hromas, Robert 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2003-02-0634 <jats:title>Abstract</jats:title><jats:p>The first hematopoietic and endothelial progenitors are derived from a common embryonic precursor termed the hemangioblast. The genetic cascades that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are largely unknown. In general, much of embryonic development is coordinately regulated by temporal and spatial expression of transcription factors, such as the Homeobox (Hox) gene family. We and others isolated a divergent homeobox gene termed Hex (or Prh) that is preferentially expressed in hematopoietic and endothelial cells. Using in vitro Hex-/- embryonic stem (ES) cell differentiation, in vivo yolk sac hematopoietic progenitor assays, and chimeric mouse analysis, we found that Hex is required for differentiation of the hemangioblast to definitive embryonic hematopoietic progenitors and to a lesser extent endothelial cells. Therefore, Hex is a novel regulator of hemangioblast differentiation to hematopoietic and endothelial cells. (Blood. 2003;102:2428-2435)</jats:p> The homeoprotein Hex is required for hemangioblast differentiation Blood |
| doi_str_mv |
10.1182/blood-2003-02-0634 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin Chemie und Pharmazie Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDAzLTAyLTA2MzQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDAzLTAyLTA2MzQ |
| institution |
DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 |
| imprint |
American Society of Hematology, 2003 |
| imprint_str_mv |
American Society of Hematology, 2003 |
| issn |
0006-4971 1528-0020 |
| issn_str_mv |
0006-4971 1528-0020 |
| language |
English |
| mega_collection |
American Society of Hematology (CrossRef) |
| match_str |
guo2003thehomeoproteinhexisrequiredforhemangioblastdifferentiation |
| publishDateSort |
2003 |
| publisher |
American Society of Hematology |
| recordtype |
ai |
| record_format |
ai |
| series |
Blood |
| source_id |
49 |
| title |
The homeoprotein Hex is required for hemangioblast differentiation |
| title_unstemmed |
The homeoprotein Hex is required for hemangioblast differentiation |
| title_full |
The homeoprotein Hex is required for hemangioblast differentiation |
| title_fullStr |
The homeoprotein Hex is required for hemangioblast differentiation |
| title_full_unstemmed |
The homeoprotein Hex is required for hemangioblast differentiation |
| title_short |
The homeoprotein Hex is required for hemangioblast differentiation |
| title_sort |
the homeoprotein hex is required for hemangioblast differentiation |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2003-02-0634 |
| publishDate |
2003 |
| physical |
2428-2435 |
| description |
<jats:title>Abstract</jats:title><jats:p>The first hematopoietic and endothelial progenitors are derived from a common embryonic precursor termed the hemangioblast. The genetic cascades that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are largely unknown. In general, much of embryonic development is coordinately regulated by temporal and spatial expression of transcription factors, such as the Homeobox (Hox) gene family. We and others isolated a divergent homeobox gene termed Hex (or Prh) that is preferentially expressed in hematopoietic and endothelial cells. Using in vitro Hex-/- embryonic stem (ES) cell differentiation, in vivo yolk sac hematopoietic progenitor assays, and chimeric mouse analysis, we found that Hex is required for differentiation of the hemangioblast to definitive embryonic hematopoietic progenitors and to a lesser extent endothelial cells. Therefore, Hex is a novel regulator of hemangioblast differentiation to hematopoietic and endothelial cells. (Blood. 2003;102:2428-2435)</jats:p> |
| container_issue |
7 |
| container_start_page |
2428 |
| container_title |
Blood |
| container_volume |
102 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792336126337351681 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:54:43.818Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=The+homeoprotein+Hex+is+required+for+hemangioblast+differentiation&rft.date=2003-10-01&genre=article&issn=1528-0020&volume=102&issue=7&spage=2428&epage=2435&pages=2428-2435&jtitle=Blood&atitle=The+homeoprotein+Hex+is+required+for+hemangioblast+differentiation&aulast=Hromas&aufirst=Robert&rft_id=info%3Adoi%2F10.1182%2Fblood-2003-02-0634&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792336126337351681 |
| author | Guo, Ying, Chan, Rebecca, Ramsey, Heather, Li, Weiming, Xie, Xiaodong, Shelley, William C., Martinez-Barbera, Juan Pedro, Bort, Bernardo, Zaret, Kenneth, Yoder, Mervin, Hromas, Robert |
| author_facet | Guo, Ying, Chan, Rebecca, Ramsey, Heather, Li, Weiming, Xie, Xiaodong, Shelley, William C., Martinez-Barbera, Juan Pedro, Bort, Bernardo, Zaret, Kenneth, Yoder, Mervin, Hromas, Robert, Guo, Ying, Chan, Rebecca, Ramsey, Heather, Li, Weiming, Xie, Xiaodong, Shelley, William C., Martinez-Barbera, Juan Pedro, Bort, Bernardo, Zaret, Kenneth, Yoder, Mervin, Hromas, Robert |
| author_sort | guo, ying |
| container_issue | 7 |
| container_start_page | 2428 |
| container_title | Blood |
| container_volume | 102 |
| description | <jats:title>Abstract</jats:title><jats:p>The first hematopoietic and endothelial progenitors are derived from a common embryonic precursor termed the hemangioblast. The genetic cascades that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are largely unknown. In general, much of embryonic development is coordinately regulated by temporal and spatial expression of transcription factors, such as the Homeobox (Hox) gene family. We and others isolated a divergent homeobox gene termed Hex (or Prh) that is preferentially expressed in hematopoietic and endothelial cells. Using in vitro Hex-/- embryonic stem (ES) cell differentiation, in vivo yolk sac hematopoietic progenitor assays, and chimeric mouse analysis, we found that Hex is required for differentiation of the hemangioblast to definitive embryonic hematopoietic progenitors and to a lesser extent endothelial cells. Therefore, Hex is a novel regulator of hemangioblast differentiation to hematopoietic and endothelial cells. (Blood. 2003;102:2428-2435)</jats:p> |
| doi_str_mv | 10.1182/blood-2003-02-0634 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin, Chemie und Pharmazie, Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDAzLTAyLTA2MzQ |
| imprint | American Society of Hematology, 2003 |
| imprint_str_mv | American Society of Hematology, 2003 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
| issn | 0006-4971, 1528-0020 |
| issn_str_mv | 0006-4971, 1528-0020 |
| language | English |
| last_indexed | 2024-03-01T14:54:43.818Z |
| match_str | guo2003thehomeoproteinhexisrequiredforhemangioblastdifferentiation |
| mega_collection | American Society of Hematology (CrossRef) |
| physical | 2428-2435 |
| publishDate | 2003 |
| publishDateSort | 2003 |
| publisher | American Society of Hematology |
| record_format | ai |
| recordtype | ai |
| series | Blood |
| source_id | 49 |
| spelling | Guo, Ying Chan, Rebecca Ramsey, Heather Li, Weiming Xie, Xiaodong Shelley, William C. Martinez-Barbera, Juan Pedro Bort, Bernardo Zaret, Kenneth Yoder, Mervin Hromas, Robert 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2003-02-0634 <jats:title>Abstract</jats:title><jats:p>The first hematopoietic and endothelial progenitors are derived from a common embryonic precursor termed the hemangioblast. The genetic cascades that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are largely unknown. In general, much of embryonic development is coordinately regulated by temporal and spatial expression of transcription factors, such as the Homeobox (Hox) gene family. We and others isolated a divergent homeobox gene termed Hex (or Prh) that is preferentially expressed in hematopoietic and endothelial cells. Using in vitro Hex-/- embryonic stem (ES) cell differentiation, in vivo yolk sac hematopoietic progenitor assays, and chimeric mouse analysis, we found that Hex is required for differentiation of the hemangioblast to definitive embryonic hematopoietic progenitors and to a lesser extent endothelial cells. Therefore, Hex is a novel regulator of hemangioblast differentiation to hematopoietic and endothelial cells. (Blood. 2003;102:2428-2435)</jats:p> The homeoprotein Hex is required for hemangioblast differentiation Blood |
| spellingShingle | Guo, Ying, Chan, Rebecca, Ramsey, Heather, Li, Weiming, Xie, Xiaodong, Shelley, William C., Martinez-Barbera, Juan Pedro, Bort, Bernardo, Zaret, Kenneth, Yoder, Mervin, Hromas, Robert, Blood, The homeoprotein Hex is required for hemangioblast differentiation, Cell Biology, Hematology, Immunology, Biochemistry |
| title | The homeoprotein Hex is required for hemangioblast differentiation |
| title_full | The homeoprotein Hex is required for hemangioblast differentiation |
| title_fullStr | The homeoprotein Hex is required for hemangioblast differentiation |
| title_full_unstemmed | The homeoprotein Hex is required for hemangioblast differentiation |
| title_short | The homeoprotein Hex is required for hemangioblast differentiation |
| title_sort | the homeoprotein hex is required for hemangioblast differentiation |
| title_unstemmed | The homeoprotein Hex is required for hemangioblast differentiation |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2003-02-0634 |