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New insights into the structural basis of integrin activation
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Blood, 102, 2003, 4, S. 1155-1159 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
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Xiong, Jian-Ping Stehle, Thilo Goodman, Simon L. Arnaout, M. Amin Xiong, Jian-Ping Stehle, Thilo Goodman, Simon L. Arnaout, M. Amin |
|---|---|
| author |
Xiong, Jian-Ping Stehle, Thilo Goodman, Simon L. Arnaout, M. Amin |
| spellingShingle |
Xiong, Jian-Ping Stehle, Thilo Goodman, Simon L. Arnaout, M. Amin Blood New insights into the structural basis of integrin activation Cell Biology Hematology Immunology Biochemistry |
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xiong, jian-ping |
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Xiong, Jian-Ping Stehle, Thilo Goodman, Simon L. Arnaout, M. Amin 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2003-01-0334 <jats:title>Abstract</jats:title><jats:p>Integrins are cell adhesion receptors that communicate biochemical and mechanical signals in a bidirectional manner across the plasma membrane and thus influence most cellular functions. Intracellular signals switch integrins into a ligand-competent state as a result of elicited conformational changes in the integrin ectodomain. Binding of extracellular ligands induces, in turn, structural changes that convey distinct signals to the cell interior. The structural basis of this bidirectional signaling has been the focus of intensive study for the past 3 decades. In this perspective, we develop a new hypothesis for integrin activation based on recent crystallographic, electron microscopic, and biochemical studies.</jats:p> New insights into the structural basis of integrin activation Blood |
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American Society of Hematology, 2003 |
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New insights into the structural basis of integrin activation |
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New insights into the structural basis of integrin activation |
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New insights into the structural basis of integrin activation |
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New insights into the structural basis of integrin activation |
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New insights into the structural basis of integrin activation |
| title_short |
New insights into the structural basis of integrin activation |
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new insights into the structural basis of integrin activation |
| topic |
Cell Biology Hematology Immunology Biochemistry |
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http://dx.doi.org/10.1182/blood-2003-01-0334 |
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2003 |
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1155-1159 |
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<jats:title>Abstract</jats:title><jats:p>Integrins are cell adhesion receptors that communicate biochemical and mechanical signals in a bidirectional manner across the plasma membrane and thus influence most cellular functions. Intracellular signals switch integrins into a ligand-competent state as a result of elicited conformational changes in the integrin ectodomain. Binding of extracellular ligands induces, in turn, structural changes that convey distinct signals to the cell interior. The structural basis of this bidirectional signaling has been the focus of intensive study for the past 3 decades. In this perspective, we develop a new hypothesis for integrin activation based on recent crystallographic, electron microscopic, and biochemical studies.</jats:p> |
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| author | Xiong, Jian-Ping, Stehle, Thilo, Goodman, Simon L., Arnaout, M. Amin |
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| description | <jats:title>Abstract</jats:title><jats:p>Integrins are cell adhesion receptors that communicate biochemical and mechanical signals in a bidirectional manner across the plasma membrane and thus influence most cellular functions. Intracellular signals switch integrins into a ligand-competent state as a result of elicited conformational changes in the integrin ectodomain. Binding of extracellular ligands induces, in turn, structural changes that convey distinct signals to the cell interior. The structural basis of this bidirectional signaling has been the focus of intensive study for the past 3 decades. In this perspective, we develop a new hypothesis for integrin activation based on recent crystallographic, electron microscopic, and biochemical studies.</jats:p> |
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| imprint | American Society of Hematology, 2003 |
| imprint_str_mv | American Society of Hematology, 2003 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| spelling | Xiong, Jian-Ping Stehle, Thilo Goodman, Simon L. Arnaout, M. Amin 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2003-01-0334 <jats:title>Abstract</jats:title><jats:p>Integrins are cell adhesion receptors that communicate biochemical and mechanical signals in a bidirectional manner across the plasma membrane and thus influence most cellular functions. Intracellular signals switch integrins into a ligand-competent state as a result of elicited conformational changes in the integrin ectodomain. Binding of extracellular ligands induces, in turn, structural changes that convey distinct signals to the cell interior. The structural basis of this bidirectional signaling has been the focus of intensive study for the past 3 decades. In this perspective, we develop a new hypothesis for integrin activation based on recent crystallographic, electron microscopic, and biochemical studies.</jats:p> New insights into the structural basis of integrin activation Blood |
| spellingShingle | Xiong, Jian-Ping, Stehle, Thilo, Goodman, Simon L., Arnaout, M. Amin, Blood, New insights into the structural basis of integrin activation, Cell Biology, Hematology, Immunology, Biochemistry |
| title | New insights into the structural basis of integrin activation |
| title_full | New insights into the structural basis of integrin activation |
| title_fullStr | New insights into the structural basis of integrin activation |
| title_full_unstemmed | New insights into the structural basis of integrin activation |
| title_short | New insights into the structural basis of integrin activation |
| title_sort | new insights into the structural basis of integrin activation |
| title_unstemmed | New insights into the structural basis of integrin activation |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2003-01-0334 |