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Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , |
| In: | Blood, 115, 2010, 9, S. 1765-1767 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
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| Schlagwörter: |
| author_facet |
Prasad, Rashmi B. Hosking, Fay J. Vijayakrishnan, Jayaram Papaemmanuil, Elli Koehler, Rolf Greaves, Mel Sheridan, Eamonn Gast, Andreas Kinsey, Sally E. Lightfoot, Tracy Roman, Eve Taylor, Malcolm Pritchard-Jones, Kathy Stanulla, Martin Schrappe, Martin Bartram, Claus R. Houlston, Richard S. Kumar, Rajiv Hemminki, Kari Prasad, Rashmi B. Hosking, Fay J. Vijayakrishnan, Jayaram Papaemmanuil, Elli Koehler, Rolf Greaves, Mel Sheridan, Eamonn Gast, Andreas Kinsey, Sally E. Lightfoot, Tracy Roman, Eve Taylor, Malcolm Pritchard-Jones, Kathy Stanulla, Martin Schrappe, Martin Bartram, Claus R. Houlston, Richard S. Kumar, Rajiv Hemminki, Kari |
|---|---|
| author |
Prasad, Rashmi B. Hosking, Fay J. Vijayakrishnan, Jayaram Papaemmanuil, Elli Koehler, Rolf Greaves, Mel Sheridan, Eamonn Gast, Andreas Kinsey, Sally E. Lightfoot, Tracy Roman, Eve Taylor, Malcolm Pritchard-Jones, Kathy Stanulla, Martin Schrappe, Martin Bartram, Claus R. Houlston, Richard S. Kumar, Rajiv Hemminki, Kari |
| spellingShingle |
Prasad, Rashmi B. Hosking, Fay J. Vijayakrishnan, Jayaram Papaemmanuil, Elli Koehler, Rolf Greaves, Mel Sheridan, Eamonn Gast, Andreas Kinsey, Sally E. Lightfoot, Tracy Roman, Eve Taylor, Malcolm Pritchard-Jones, Kathy Stanulla, Martin Schrappe, Martin Bartram, Claus R. Houlston, Richard S. Kumar, Rajiv Hemminki, Kari Blood Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood Cell Biology Hematology Immunology Biochemistry |
| author_sort |
prasad, rashmi b. |
| spelling |
Prasad, Rashmi B. Hosking, Fay J. Vijayakrishnan, Jayaram Papaemmanuil, Elli Koehler, Rolf Greaves, Mel Sheridan, Eamonn Gast, Andreas Kinsey, Sally E. Lightfoot, Tracy Roman, Eve Taylor, Malcolm Pritchard-Jones, Kathy Stanulla, Martin Schrappe, Martin Bartram, Claus R. Houlston, Richard S. Kumar, Rajiv Hemminki, Kari 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2009-09-241513 <jats:title>Abstract</jats:title> <jats:p>Recent genome-wide association data have implicated genetic variation at 7p12.2 (IKZF1), 10q21.2 (ARIDB5), and 14q11.2 (CEBPE) in the etiology of B-cell childhood acute lymphoblastic leukemia (ALL). To verify and further examine the relationship between these variants and ALL risk, we genotyped 1384 cases of precursor B-cell childhood ALL and 1877 controls from Germany and the United Kingdom. The combined data provided statistically significant support for an association between genotype at each of these loci and ALL risk; odds ratios (OR), 1.69 (P = 7.51 ×10−22), 1.80 (P = 5.90 × 10−28), and 1.27 (P = 4.90 × 10−6), respectively. Furthermore, the risk of ALL increases with an increasing numbers of variant alleles for the 3 loci (ORper-allele = 1.53, 95% confidence interval, 1.44-1.62; Ptrend = 3.49 × 10−42), consistent with a polygenic model of disease susceptibility. These data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases.</jats:p> Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood Blood |
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10.1182/blood-2009-09-241513 |
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| title |
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_unstemmed |
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_full |
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_fullStr |
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_full_unstemmed |
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_short |
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_sort |
verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor b-cell acute lymphoblastic leukemia of childhood |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2009-09-241513 |
| publishDate |
2010 |
| physical |
1765-1767 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Recent genome-wide association data have implicated genetic variation at 7p12.2 (IKZF1), 10q21.2 (ARIDB5), and 14q11.2 (CEBPE) in the etiology of B-cell childhood acute lymphoblastic leukemia (ALL). To verify and further examine the relationship between these variants and ALL risk, we genotyped 1384 cases of precursor B-cell childhood ALL and 1877 controls from Germany and the United Kingdom. The combined data provided statistically significant support for an association between genotype at each of these loci and ALL risk; odds ratios (OR), 1.69 (P = 7.51 ×10−22), 1.80 (P = 5.90 × 10−28), and 1.27 (P = 4.90 × 10−6), respectively. Furthermore, the risk of ALL increases with an increasing numbers of variant alleles for the 3 loci (ORper-allele = 1.53, 95% confidence interval, 1.44-1.62; Ptrend = 3.49 × 10−42), consistent with a polygenic model of disease susceptibility. These data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases.</jats:p> |
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| author | Prasad, Rashmi B., Hosking, Fay J., Vijayakrishnan, Jayaram, Papaemmanuil, Elli, Koehler, Rolf, Greaves, Mel, Sheridan, Eamonn, Gast, Andreas, Kinsey, Sally E., Lightfoot, Tracy, Roman, Eve, Taylor, Malcolm, Pritchard-Jones, Kathy, Stanulla, Martin, Schrappe, Martin, Bartram, Claus R., Houlston, Richard S., Kumar, Rajiv, Hemminki, Kari |
| author_facet | Prasad, Rashmi B., Hosking, Fay J., Vijayakrishnan, Jayaram, Papaemmanuil, Elli, Koehler, Rolf, Greaves, Mel, Sheridan, Eamonn, Gast, Andreas, Kinsey, Sally E., Lightfoot, Tracy, Roman, Eve, Taylor, Malcolm, Pritchard-Jones, Kathy, Stanulla, Martin, Schrappe, Martin, Bartram, Claus R., Houlston, Richard S., Kumar, Rajiv, Hemminki, Kari, Prasad, Rashmi B., Hosking, Fay J., Vijayakrishnan, Jayaram, Papaemmanuil, Elli, Koehler, Rolf, Greaves, Mel, Sheridan, Eamonn, Gast, Andreas, Kinsey, Sally E., Lightfoot, Tracy, Roman, Eve, Taylor, Malcolm, Pritchard-Jones, Kathy, Stanulla, Martin, Schrappe, Martin, Bartram, Claus R., Houlston, Richard S., Kumar, Rajiv, Hemminki, Kari |
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| description | <jats:title>Abstract</jats:title> <jats:p>Recent genome-wide association data have implicated genetic variation at 7p12.2 (IKZF1), 10q21.2 (ARIDB5), and 14q11.2 (CEBPE) in the etiology of B-cell childhood acute lymphoblastic leukemia (ALL). To verify and further examine the relationship between these variants and ALL risk, we genotyped 1384 cases of precursor B-cell childhood ALL and 1877 controls from Germany and the United Kingdom. The combined data provided statistically significant support for an association between genotype at each of these loci and ALL risk; odds ratios (OR), 1.69 (P = 7.51 ×10−22), 1.80 (P = 5.90 × 10−28), and 1.27 (P = 4.90 × 10−6), respectively. Furthermore, the risk of ALL increases with an increasing numbers of variant alleles for the 3 loci (ORper-allele = 1.53, 95% confidence interval, 1.44-1.62; Ptrend = 3.49 × 10−42), consistent with a polygenic model of disease susceptibility. These data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases.</jats:p> |
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| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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| spelling | Prasad, Rashmi B. Hosking, Fay J. Vijayakrishnan, Jayaram Papaemmanuil, Elli Koehler, Rolf Greaves, Mel Sheridan, Eamonn Gast, Andreas Kinsey, Sally E. Lightfoot, Tracy Roman, Eve Taylor, Malcolm Pritchard-Jones, Kathy Stanulla, Martin Schrappe, Martin Bartram, Claus R. Houlston, Richard S. Kumar, Rajiv Hemminki, Kari 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2009-09-241513 <jats:title>Abstract</jats:title> <jats:p>Recent genome-wide association data have implicated genetic variation at 7p12.2 (IKZF1), 10q21.2 (ARIDB5), and 14q11.2 (CEBPE) in the etiology of B-cell childhood acute lymphoblastic leukemia (ALL). To verify and further examine the relationship between these variants and ALL risk, we genotyped 1384 cases of precursor B-cell childhood ALL and 1877 controls from Germany and the United Kingdom. The combined data provided statistically significant support for an association between genotype at each of these loci and ALL risk; odds ratios (OR), 1.69 (P = 7.51 ×10−22), 1.80 (P = 5.90 × 10−28), and 1.27 (P = 4.90 × 10−6), respectively. Furthermore, the risk of ALL increases with an increasing numbers of variant alleles for the 3 loci (ORper-allele = 1.53, 95% confidence interval, 1.44-1.62; Ptrend = 3.49 × 10−42), consistent with a polygenic model of disease susceptibility. These data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases.</jats:p> Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood Blood |
| spellingShingle | Prasad, Rashmi B., Hosking, Fay J., Vijayakrishnan, Jayaram, Papaemmanuil, Elli, Koehler, Rolf, Greaves, Mel, Sheridan, Eamonn, Gast, Andreas, Kinsey, Sally E., Lightfoot, Tracy, Roman, Eve, Taylor, Malcolm, Pritchard-Jones, Kathy, Stanulla, Martin, Schrappe, Martin, Bartram, Claus R., Houlston, Richard S., Kumar, Rajiv, Hemminki, Kari, Blood, Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_full | Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_fullStr | Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_full_unstemmed | Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_short | Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| title_sort | verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor b-cell acute lymphoblastic leukemia of childhood |
| title_unstemmed | Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2009-09-241513 |