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Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and surviva...
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | Blood, 112, 2008, 4, S. 1539-1542 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
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| Schlagwörter: |
| author_facet |
Choi, Sung W. Kitko, Carrie L. Braun, Thomas Paczesny, Sophie Yanik, Gregory Mineishi, Shin Krijanovski, Oleg Jones, Dawn Whitfield, Joel Cooke, Kenneth Hutchinson, Raymond J. Ferrara, James L. M. Levine, John E. Choi, Sung W. Kitko, Carrie L. Braun, Thomas Paczesny, Sophie Yanik, Gregory Mineishi, Shin Krijanovski, Oleg Jones, Dawn Whitfield, Joel Cooke, Kenneth Hutchinson, Raymond J. Ferrara, James L. M. Levine, John E. |
|---|---|
| author |
Choi, Sung W. Kitko, Carrie L. Braun, Thomas Paczesny, Sophie Yanik, Gregory Mineishi, Shin Krijanovski, Oleg Jones, Dawn Whitfield, Joel Cooke, Kenneth Hutchinson, Raymond J. Ferrara, James L. M. Levine, John E. |
| spellingShingle |
Choi, Sung W. Kitko, Carrie L. Braun, Thomas Paczesny, Sophie Yanik, Gregory Mineishi, Shin Krijanovski, Oleg Jones, Dawn Whitfield, Joel Cooke, Kenneth Hutchinson, Raymond J. Ferrara, James L. M. Levine, John E. Blood Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival Cell Biology Hematology Immunology Biochemistry |
| author_sort |
choi, sung w. |
| spelling |
Choi, Sung W. Kitko, Carrie L. Braun, Thomas Paczesny, Sophie Yanik, Gregory Mineishi, Shin Krijanovski, Oleg Jones, Dawn Whitfield, Joel Cooke, Kenneth Hutchinson, Raymond J. Ferrara, James L. M. Levine, John E. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2008-02-138867 <jats:title>Abstract</jats:title> <jats:p>Acute graft-versus-host disease (GVHD) remains a significant cause of mortality after hematopoietic cell transplantation (HCT). Tumor necrosis factor–alpha (TNF-α) mediates GVHD by amplifying donor immune responses to host tissues and by direct toxicity to target organs. We measured TNF receptor 1 (TNFR1) as a surrogate marker for TNF-α in 438 recipients of myeloablative HCT before transplantation and at day 7 after transplantation. Increases in TNFR1 levels more than or equal to 2.5 baseline correlated with eventual development of GVHD grade 2 to 4 (58% vs 32%, P < .001) and with treatment-related mortality (39% vs 17%, P < .001). In a multivariate analysis including age, degree of HLA match, donor type, recipient and donor sex, disease, and status at HCT, the increase in TNFR1 level at day 7 remained a significant predictor for outcome. Measurement of TNFR1 levels early after transplantation provides independent information in advance of important clinical outcomes, such as GVHD and death.</jats:p> Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival Blood |
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10.1182/blood-2008-02-138867 |
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Biologie Medizin Chemie und Pharmazie |
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American Society of Hematology, 2008 |
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American Society of Hematology, 2008 |
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0006-4971 1528-0020 |
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0006-4971 1528-0020 |
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| title |
Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_unstemmed |
Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_full |
Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_fullStr |
Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_full_unstemmed |
Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_short |
Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_sort |
change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of gvhd and survival |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2008-02-138867 |
| publishDate |
2008 |
| physical |
1539-1542 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Acute graft-versus-host disease (GVHD) remains a significant cause of mortality after hematopoietic cell transplantation (HCT). Tumor necrosis factor–alpha (TNF-α) mediates GVHD by amplifying donor immune responses to host tissues and by direct toxicity to target organs. We measured TNF receptor 1 (TNFR1) as a surrogate marker for TNF-α in 438 recipients of myeloablative HCT before transplantation and at day 7 after transplantation. Increases in TNFR1 levels more than or equal to 2.5 baseline correlated with eventual development of GVHD grade 2 to 4 (58% vs 32%, P < .001) and with treatment-related mortality (39% vs 17%, P < .001). In a multivariate analysis including age, degree of HLA match, donor type, recipient and donor sex, disease, and status at HCT, the increase in TNFR1 level at day 7 remained a significant predictor for outcome. Measurement of TNFR1 levels early after transplantation provides independent information in advance of important clinical outcomes, such as GVHD and death.</jats:p> |
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| author | Choi, Sung W., Kitko, Carrie L., Braun, Thomas, Paczesny, Sophie, Yanik, Gregory, Mineishi, Shin, Krijanovski, Oleg, Jones, Dawn, Whitfield, Joel, Cooke, Kenneth, Hutchinson, Raymond J., Ferrara, James L. M., Levine, John E. |
| author_facet | Choi, Sung W., Kitko, Carrie L., Braun, Thomas, Paczesny, Sophie, Yanik, Gregory, Mineishi, Shin, Krijanovski, Oleg, Jones, Dawn, Whitfield, Joel, Cooke, Kenneth, Hutchinson, Raymond J., Ferrara, James L. M., Levine, John E., Choi, Sung W., Kitko, Carrie L., Braun, Thomas, Paczesny, Sophie, Yanik, Gregory, Mineishi, Shin, Krijanovski, Oleg, Jones, Dawn, Whitfield, Joel, Cooke, Kenneth, Hutchinson, Raymond J., Ferrara, James L. M., Levine, John E. |
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| description | <jats:title>Abstract</jats:title> <jats:p>Acute graft-versus-host disease (GVHD) remains a significant cause of mortality after hematopoietic cell transplantation (HCT). Tumor necrosis factor–alpha (TNF-α) mediates GVHD by amplifying donor immune responses to host tissues and by direct toxicity to target organs. We measured TNF receptor 1 (TNFR1) as a surrogate marker for TNF-α in 438 recipients of myeloablative HCT before transplantation and at day 7 after transplantation. Increases in TNFR1 levels more than or equal to 2.5 baseline correlated with eventual development of GVHD grade 2 to 4 (58% vs 32%, P < .001) and with treatment-related mortality (39% vs 17%, P < .001). In a multivariate analysis including age, degree of HLA match, donor type, recipient and donor sex, disease, and status at HCT, the increase in TNFR1 level at day 7 remained a significant predictor for outcome. Measurement of TNFR1 levels early after transplantation provides independent information in advance of important clinical outcomes, such as GVHD and death.</jats:p> |
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| imprint_str_mv | American Society of Hematology, 2008 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14 |
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| language | English |
| last_indexed | 2024-03-01T17:01:15.943Z |
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| spelling | Choi, Sung W. Kitko, Carrie L. Braun, Thomas Paczesny, Sophie Yanik, Gregory Mineishi, Shin Krijanovski, Oleg Jones, Dawn Whitfield, Joel Cooke, Kenneth Hutchinson, Raymond J. Ferrara, James L. M. Levine, John E. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2008-02-138867 <jats:title>Abstract</jats:title> <jats:p>Acute graft-versus-host disease (GVHD) remains a significant cause of mortality after hematopoietic cell transplantation (HCT). Tumor necrosis factor–alpha (TNF-α) mediates GVHD by amplifying donor immune responses to host tissues and by direct toxicity to target organs. We measured TNF receptor 1 (TNFR1) as a surrogate marker for TNF-α in 438 recipients of myeloablative HCT before transplantation and at day 7 after transplantation. Increases in TNFR1 levels more than or equal to 2.5 baseline correlated with eventual development of GVHD grade 2 to 4 (58% vs 32%, P < .001) and with treatment-related mortality (39% vs 17%, P < .001). In a multivariate analysis including age, degree of HLA match, donor type, recipient and donor sex, disease, and status at HCT, the increase in TNFR1 level at day 7 remained a significant predictor for outcome. Measurement of TNFR1 levels early after transplantation provides independent information in advance of important clinical outcomes, such as GVHD and death.</jats:p> Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival Blood |
| spellingShingle | Choi, Sung W., Kitko, Carrie L., Braun, Thomas, Paczesny, Sophie, Yanik, Gregory, Mineishi, Shin, Krijanovski, Oleg, Jones, Dawn, Whitfield, Joel, Cooke, Kenneth, Hutchinson, Raymond J., Ferrara, James L. M., Levine, John E., Blood, Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_full | Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_fullStr | Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_full_unstemmed | Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_short | Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| title_sort | change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of gvhd and survival |
| title_unstemmed | Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2008-02-138867 |