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IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Blood, 113, 2009, 13, S. 2999-3007 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
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| Schlagwörter: |
| author_facet |
Azevedo, Rita I. Soares, Maria Vieira D. Barata, João T. Tendeiro, Rita Serra-Caetano, Ana Victorino, Rui M. M. Sousa, Ana E. Azevedo, Rita I. Soares, Maria Vieira D. Barata, João T. Tendeiro, Rita Serra-Caetano, Ana Victorino, Rui M. M. Sousa, Ana E. |
|---|---|
| author |
Azevedo, Rita I. Soares, Maria Vieira D. Barata, João T. Tendeiro, Rita Serra-Caetano, Ana Victorino, Rui M. M. Sousa, Ana E. |
| spellingShingle |
Azevedo, Rita I. Soares, Maria Vieira D. Barata, João T. Tendeiro, Rita Serra-Caetano, Ana Victorino, Rui M. M. Sousa, Ana E. Blood IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner Cell Biology Hematology Immunology Biochemistry |
| author_sort |
azevedo, rita i. |
| spelling |
Azevedo, Rita I. Soares, Maria Vieira D. Barata, João T. Tendeiro, Rita Serra-Caetano, Ana Victorino, Rui M. M. Sousa, Ana E. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2008-07-166223 <jats:title>Abstract</jats:title><jats:p>The CD31+ subset of human naive CD4+ T cells is thought to contain the population of cells that have recently emigrated from the thymus, while their CD31− counterparts have been proposed to originate from CD31+ cells after homeostatic cell division. Naive T-cell maintenance is known to involve homeostatic cytokines such as interleukin-7 (IL-7). It remains to be investigated what role this cytokine has in the homeostasis of naive CD4+ T-cell subsets defined by CD31 expression. We provide evidence that IL-7 exerts a preferential proliferative effect on CD31+ naive CD4+ T cells from adult peripheral blood compared with the CD31− subset. IL-7–driven proliferation did not result in loss of CD31 expression, suggesting that CD31+ naive CD4+ T cells can undergo cytokine-driven homeostatic proliferation while preserving CD31. Furthermore, IL-7 sustained or increased CD31 expression even in nonproliferating cells. Both proliferation and CD31 maintenance were dependent on the activation of phosphoinositide 3-kinase (PI3K) signaling. Taken together, our data suggest that during adulthood CD31+ naive CD4+ T cells are maintained by IL-7 and that IL-7–based therapies may exert a preferential effect on this population.</jats:p> IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner Blood |
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10.1182/blood-2008-07-166223 |
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American Society of Hematology, 2009 |
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American Society of Hematology, 2009 |
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1528-0020 0006-4971 |
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| title |
IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_unstemmed |
IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_full |
IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_fullStr |
IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_full_unstemmed |
IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_short |
IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_sort |
il-7 sustains cd31 expression in human naive cd4+ t cells and preferentially expands the cd31+ subset in a pi3k-dependent manner |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2008-07-166223 |
| publishDate |
2009 |
| physical |
2999-3007 |
| description |
<jats:title>Abstract</jats:title><jats:p>The CD31+ subset of human naive CD4+ T cells is thought to contain the population of cells that have recently emigrated from the thymus, while their CD31− counterparts have been proposed to originate from CD31+ cells after homeostatic cell division. Naive T-cell maintenance is known to involve homeostatic cytokines such as interleukin-7 (IL-7). It remains to be investigated what role this cytokine has in the homeostasis of naive CD4+ T-cell subsets defined by CD31 expression. We provide evidence that IL-7 exerts a preferential proliferative effect on CD31+ naive CD4+ T cells from adult peripheral blood compared with the CD31− subset. IL-7–driven proliferation did not result in loss of CD31 expression, suggesting that CD31+ naive CD4+ T cells can undergo cytokine-driven homeostatic proliferation while preserving CD31. Furthermore, IL-7 sustained or increased CD31 expression even in nonproliferating cells. Both proliferation and CD31 maintenance were dependent on the activation of phosphoinositide 3-kinase (PI3K) signaling. Taken together, our data suggest that during adulthood CD31+ naive CD4+ T cells are maintained by IL-7 and that IL-7–based therapies may exert a preferential effect on this population.</jats:p> |
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| author | Azevedo, Rita I., Soares, Maria Vieira D., Barata, João T., Tendeiro, Rita, Serra-Caetano, Ana, Victorino, Rui M. M., Sousa, Ana E. |
| author_facet | Azevedo, Rita I., Soares, Maria Vieira D., Barata, João T., Tendeiro, Rita, Serra-Caetano, Ana, Victorino, Rui M. M., Sousa, Ana E., Azevedo, Rita I., Soares, Maria Vieira D., Barata, João T., Tendeiro, Rita, Serra-Caetano, Ana, Victorino, Rui M. M., Sousa, Ana E. |
| author_sort | azevedo, rita i. |
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| description | <jats:title>Abstract</jats:title><jats:p>The CD31+ subset of human naive CD4+ T cells is thought to contain the population of cells that have recently emigrated from the thymus, while their CD31− counterparts have been proposed to originate from CD31+ cells after homeostatic cell division. Naive T-cell maintenance is known to involve homeostatic cytokines such as interleukin-7 (IL-7). It remains to be investigated what role this cytokine has in the homeostasis of naive CD4+ T-cell subsets defined by CD31 expression. We provide evidence that IL-7 exerts a preferential proliferative effect on CD31+ naive CD4+ T cells from adult peripheral blood compared with the CD31− subset. IL-7–driven proliferation did not result in loss of CD31 expression, suggesting that CD31+ naive CD4+ T cells can undergo cytokine-driven homeostatic proliferation while preserving CD31. Furthermore, IL-7 sustained or increased CD31 expression even in nonproliferating cells. Both proliferation and CD31 maintenance were dependent on the activation of phosphoinositide 3-kinase (PI3K) signaling. Taken together, our data suggest that during adulthood CD31+ naive CD4+ T cells are maintained by IL-7 and that IL-7–based therapies may exert a preferential effect on this population.</jats:p> |
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| imprint | American Society of Hematology, 2009 |
| imprint_str_mv | American Society of Hematology, 2009 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1528-0020, 0006-4971 |
| issn_str_mv | 1528-0020, 0006-4971 |
| language | English |
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| spelling | Azevedo, Rita I. Soares, Maria Vieira D. Barata, João T. Tendeiro, Rita Serra-Caetano, Ana Victorino, Rui M. M. Sousa, Ana E. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2008-07-166223 <jats:title>Abstract</jats:title><jats:p>The CD31+ subset of human naive CD4+ T cells is thought to contain the population of cells that have recently emigrated from the thymus, while their CD31− counterparts have been proposed to originate from CD31+ cells after homeostatic cell division. Naive T-cell maintenance is known to involve homeostatic cytokines such as interleukin-7 (IL-7). It remains to be investigated what role this cytokine has in the homeostasis of naive CD4+ T-cell subsets defined by CD31 expression. We provide evidence that IL-7 exerts a preferential proliferative effect on CD31+ naive CD4+ T cells from adult peripheral blood compared with the CD31− subset. IL-7–driven proliferation did not result in loss of CD31 expression, suggesting that CD31+ naive CD4+ T cells can undergo cytokine-driven homeostatic proliferation while preserving CD31. Furthermore, IL-7 sustained or increased CD31 expression even in nonproliferating cells. Both proliferation and CD31 maintenance were dependent on the activation of phosphoinositide 3-kinase (PI3K) signaling. Taken together, our data suggest that during adulthood CD31+ naive CD4+ T cells are maintained by IL-7 and that IL-7–based therapies may exert a preferential effect on this population.</jats:p> IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner Blood |
| spellingShingle | Azevedo, Rita I., Soares, Maria Vieira D., Barata, João T., Tendeiro, Rita, Serra-Caetano, Ana, Victorino, Rui M. M., Sousa, Ana E., Blood, IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner, Cell Biology, Hematology, Immunology, Biochemistry |
| title | IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_full | IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_fullStr | IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_full_unstemmed | IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_short | IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| title_sort | il-7 sustains cd31 expression in human naive cd4+ t cells and preferentially expands the cd31+ subset in a pi3k-dependent manner |
| title_unstemmed | IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2008-07-166223 |