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Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Blood, 112, 2008, 4, S. 990-998 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
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| Schlagwörter: |
| author_facet |
Devine, Steven M. Vij, Ravi Rettig, Michael Todt, Laura McGlauchlen, Kiley Fisher, Nicholas Devine, Hollie Link, Daniel C. Calandra, Gary Bridger, Gary Westervelt, Peter DiPersio, John F. Devine, Steven M. Vij, Ravi Rettig, Michael Todt, Laura McGlauchlen, Kiley Fisher, Nicholas Devine, Hollie Link, Daniel C. Calandra, Gary Bridger, Gary Westervelt, Peter DiPersio, John F. |
|---|---|
| author |
Devine, Steven M. Vij, Ravi Rettig, Michael Todt, Laura McGlauchlen, Kiley Fisher, Nicholas Devine, Hollie Link, Daniel C. Calandra, Gary Bridger, Gary Westervelt, Peter DiPersio, John F. |
| spellingShingle |
Devine, Steven M. Vij, Ravi Rettig, Michael Todt, Laura McGlauchlen, Kiley Fisher, Nicholas Devine, Hollie Link, Daniel C. Calandra, Gary Bridger, Gary Westervelt, Peter DiPersio, John F. Blood Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction Cell Biology Hematology Immunology Biochemistry |
| author_sort |
devine, steven m. |
| spelling |
Devine, Steven M. Vij, Ravi Rettig, Michael Todt, Laura McGlauchlen, Kiley Fisher, Nicholas Devine, Hollie Link, Daniel C. Calandra, Gary Bridger, Gary Westervelt, Peter DiPersio, John F. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2007-12-130179 <jats:title>Abstract</jats:title> <jats:p>Allografts from HLA-matched sibling donors were mobilized and collected without granulocyte colony-stimulating factor (G-CSF) using AMD3100, a direct antagonist of CXCR4/stromal-derived factor 1 (SDF-1/CXCL12). Donors (N = 25) were treated with AMD3100 at a dose of 240 μg/kg by subcutaneous injection, and leukapheresis was then initiated just 4 hours later. Two-thirds of the donors collected an allograft with a CD34+ cell dose sufficient for transplantation after just one dose of AMD3100. No donor experienced more than grade 1 toxicity. After a myeloablative regimen, 20 patients with hematologic malignancies received allografts collected after AMD3100 alone. All patients engrafted neutrophils (median day 10) and platelets (median day 12) promptly. Acute graft-versus-host disease (GVHD) grades 2 through 4 occurred in 35% of patients. One patient died due to complications related to acute GVHD. No unexpected adverse events were observed in any of the recipients. All 14 patients surviving in remission have robust trilineage hematopoiesis and are transfusion-free with a median follow-up of 277 days (range, 139-964 days). Direct antagonism of CXCR4 by AMD3100 may provide a more rapid and possibly less toxic and cumbersome alternative to traditional G-CSF–based mobilization in normal donors. This trial was registered as no. NCT00241358 at www.ClinicalTrials.gov.</jats:p> Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction Blood |
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10.1182/blood-2007-12-130179 |
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American Society of Hematology, 2008 |
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American Society of Hematology, 2008 |
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| title |
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_unstemmed |
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_full |
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_fullStr |
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_full_unstemmed |
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_short |
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_sort |
rapid mobilization of functional donor hematopoietic cells without g-csf using amd3100, an antagonist of the cxcr4/sdf-1 interaction |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2007-12-130179 |
| publishDate |
2008 |
| physical |
990-998 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Allografts from HLA-matched sibling donors were mobilized and collected without granulocyte colony-stimulating factor (G-CSF) using AMD3100, a direct antagonist of CXCR4/stromal-derived factor 1 (SDF-1/CXCL12). Donors (N = 25) were treated with AMD3100 at a dose of 240 μg/kg by subcutaneous injection, and leukapheresis was then initiated just 4 hours later. Two-thirds of the donors collected an allograft with a CD34+ cell dose sufficient for transplantation after just one dose of AMD3100. No donor experienced more than grade 1 toxicity. After a myeloablative regimen, 20 patients with hematologic malignancies received allografts collected after AMD3100 alone. All patients engrafted neutrophils (median day 10) and platelets (median day 12) promptly. Acute graft-versus-host disease (GVHD) grades 2 through 4 occurred in 35% of patients. One patient died due to complications related to acute GVHD. No unexpected adverse events were observed in any of the recipients. All 14 patients surviving in remission have robust trilineage hematopoiesis and are transfusion-free with a median follow-up of 277 days (range, 139-964 days). Direct antagonism of CXCR4 by AMD3100 may provide a more rapid and possibly less toxic and cumbersome alternative to traditional G-CSF–based mobilization in normal donors. This trial was registered as no. NCT00241358 at www.ClinicalTrials.gov.</jats:p> |
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| author | Devine, Steven M., Vij, Ravi, Rettig, Michael, Todt, Laura, McGlauchlen, Kiley, Fisher, Nicholas, Devine, Hollie, Link, Daniel C., Calandra, Gary, Bridger, Gary, Westervelt, Peter, DiPersio, John F. |
| author_facet | Devine, Steven M., Vij, Ravi, Rettig, Michael, Todt, Laura, McGlauchlen, Kiley, Fisher, Nicholas, Devine, Hollie, Link, Daniel C., Calandra, Gary, Bridger, Gary, Westervelt, Peter, DiPersio, John F., Devine, Steven M., Vij, Ravi, Rettig, Michael, Todt, Laura, McGlauchlen, Kiley, Fisher, Nicholas, Devine, Hollie, Link, Daniel C., Calandra, Gary, Bridger, Gary, Westervelt, Peter, DiPersio, John F. |
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| description | <jats:title>Abstract</jats:title> <jats:p>Allografts from HLA-matched sibling donors were mobilized and collected without granulocyte colony-stimulating factor (G-CSF) using AMD3100, a direct antagonist of CXCR4/stromal-derived factor 1 (SDF-1/CXCL12). Donors (N = 25) were treated with AMD3100 at a dose of 240 μg/kg by subcutaneous injection, and leukapheresis was then initiated just 4 hours later. Two-thirds of the donors collected an allograft with a CD34+ cell dose sufficient for transplantation after just one dose of AMD3100. No donor experienced more than grade 1 toxicity. After a myeloablative regimen, 20 patients with hematologic malignancies received allografts collected after AMD3100 alone. All patients engrafted neutrophils (median day 10) and platelets (median day 12) promptly. Acute graft-versus-host disease (GVHD) grades 2 through 4 occurred in 35% of patients. One patient died due to complications related to acute GVHD. No unexpected adverse events were observed in any of the recipients. All 14 patients surviving in remission have robust trilineage hematopoiesis and are transfusion-free with a median follow-up of 277 days (range, 139-964 days). Direct antagonism of CXCR4 by AMD3100 may provide a more rapid and possibly less toxic and cumbersome alternative to traditional G-CSF–based mobilization in normal donors. This trial was registered as no. NCT00241358 at www.ClinicalTrials.gov.</jats:p> |
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| imprint | American Society of Hematology, 2008 |
| imprint_str_mv | American Society of Hematology, 2008 |
| institution | DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| spelling | Devine, Steven M. Vij, Ravi Rettig, Michael Todt, Laura McGlauchlen, Kiley Fisher, Nicholas Devine, Hollie Link, Daniel C. Calandra, Gary Bridger, Gary Westervelt, Peter DiPersio, John F. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2007-12-130179 <jats:title>Abstract</jats:title> <jats:p>Allografts from HLA-matched sibling donors were mobilized and collected without granulocyte colony-stimulating factor (G-CSF) using AMD3100, a direct antagonist of CXCR4/stromal-derived factor 1 (SDF-1/CXCL12). Donors (N = 25) were treated with AMD3100 at a dose of 240 μg/kg by subcutaneous injection, and leukapheresis was then initiated just 4 hours later. Two-thirds of the donors collected an allograft with a CD34+ cell dose sufficient for transplantation after just one dose of AMD3100. No donor experienced more than grade 1 toxicity. After a myeloablative regimen, 20 patients with hematologic malignancies received allografts collected after AMD3100 alone. All patients engrafted neutrophils (median day 10) and platelets (median day 12) promptly. Acute graft-versus-host disease (GVHD) grades 2 through 4 occurred in 35% of patients. One patient died due to complications related to acute GVHD. No unexpected adverse events were observed in any of the recipients. All 14 patients surviving in remission have robust trilineage hematopoiesis and are transfusion-free with a median follow-up of 277 days (range, 139-964 days). Direct antagonism of CXCR4 by AMD3100 may provide a more rapid and possibly less toxic and cumbersome alternative to traditional G-CSF–based mobilization in normal donors. This trial was registered as no. NCT00241358 at www.ClinicalTrials.gov.</jats:p> Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction Blood |
| spellingShingle | Devine, Steven M., Vij, Ravi, Rettig, Michael, Todt, Laura, McGlauchlen, Kiley, Fisher, Nicholas, Devine, Hollie, Link, Daniel C., Calandra, Gary, Bridger, Gary, Westervelt, Peter, DiPersio, John F., Blood, Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_full | Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_fullStr | Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_full_unstemmed | Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_short | Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| title_sort | rapid mobilization of functional donor hematopoietic cells without g-csf using amd3100, an antagonist of the cxcr4/sdf-1 interaction |
| title_unstemmed | Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2007-12-130179 |