Eintrag weiter verarbeiten
New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls
Gespeichert in:
| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Blood, 108, 2006, 1, S. 200-202 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Hao, Zhifang Guo, Caiying Jiang, Xi Krueger, Susan Pietri, Thomas Dufour, Sylvie Cone, Robert E. O'Rourke, James Hao, Zhifang Guo, Caiying Jiang, Xi Krueger, Susan Pietri, Thomas Dufour, Sylvie Cone, Robert E. O'Rourke, James |
|---|---|
| author |
Hao, Zhifang Guo, Caiying Jiang, Xi Krueger, Susan Pietri, Thomas Dufour, Sylvie Cone, Robert E. O'Rourke, James |
| spellingShingle |
Hao, Zhifang Guo, Caiying Jiang, Xi Krueger, Susan Pietri, Thomas Dufour, Sylvie Cone, Robert E. O'Rourke, James Blood New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls Cell Biology Hematology Immunology Biochemistry |
| author_sort |
hao, zhifang |
| spelling |
Hao, Zhifang Guo, Caiying Jiang, Xi Krueger, Susan Pietri, Thomas Dufour, Sylvie Cone, Robert E. O'Rourke, James 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2005-12-4884 <jats:p>Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant source of vessel wall t-PA. To visualize fine embedded axons independent of endothelium, we created a transgenic mouse whose expressions of the t-PA promoter and enhanced green fluorescent protein are confined to sympathetic neurons and other neural crest derivatives. Confocal images reveal the extension of t-PA axons to arterioles serving heart, brain, kidney, lung, mesentery, and skin; plus aortic, carotid, and mesenteric artery walls. Ganglion neurons and adrenal chromaffin cells also show strong expressions. These new sightings confirm the existence of a system of t-PA axons that is prominent in arterioles, and compatible with the release of neural t-PA into their walls. (Blood. 2006;108:200-202)</jats:p> New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls Blood |
| doi_str_mv |
10.1182/blood-2005-12-4884 |
| facet_avail |
Online Free |
| finc_class_facet |
Chemie und Pharmazie Biologie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDA1LTEyLTQ4ODQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDA1LTEyLTQ4ODQ |
| institution |
DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 DE-Gla1 DE-Zi4 DE-15 |
| imprint |
American Society of Hematology, 2006 |
| imprint_str_mv |
American Society of Hematology, 2006 |
| issn |
1528-0020 0006-4971 |
| issn_str_mv |
1528-0020 0006-4971 |
| language |
English |
| mega_collection |
American Society of Hematology (CrossRef) |
| match_str |
hao2006newtransgenicevidenceforasystemofsympatheticaxonsabletoexpresstissueplasminogenactivatortpawithinarterialarteriolarwalls |
| publishDateSort |
2006 |
| publisher |
American Society of Hematology |
| recordtype |
ai |
| record_format |
ai |
| series |
Blood |
| source_id |
49 |
| title |
New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_unstemmed |
New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_full |
New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_fullStr |
New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_full_unstemmed |
New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_short |
New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_sort |
new transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-pa) within arterial/arteriolar walls |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2005-12-4884 |
| publishDate |
2006 |
| physical |
200-202 |
| description |
<jats:p>Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant source of vessel wall t-PA. To visualize fine embedded axons independent of endothelium, we created a transgenic mouse whose expressions of the t-PA promoter and enhanced green fluorescent protein are confined to sympathetic neurons and other neural crest derivatives. Confocal images reveal the extension of t-PA axons to arterioles serving heart, brain, kidney, lung, mesentery, and skin; plus aortic, carotid, and mesenteric artery walls. Ganglion neurons and adrenal chromaffin cells also show strong expressions. These new sightings confirm the existence of a system of t-PA axons that is prominent in arterioles, and compatible with the release of neural t-PA into their walls. (Blood. 2006;108:200-202)</jats:p> |
| container_issue |
1 |
| container_start_page |
200 |
| container_title |
Blood |
| container_volume |
108 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792335828217757696 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:50:44.192Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=New+transgenic+evidence+for+a+system+of+sympathetic+axons+able+to+express+tissue+plasminogen+activator+%28t-PA%29+within+arterial%2Farteriolar+walls&rft.date=2006-07-01&genre=article&issn=1528-0020&volume=108&issue=1&spage=200&epage=202&pages=200-202&jtitle=Blood&atitle=New+transgenic+evidence+for+a+system+of+sympathetic+axons+able+to+express+tissue+plasminogen+activator+%28t-PA%29+within+arterial%2Farteriolar+walls&aulast=O%27Rourke&aufirst=James&rft_id=info%3Adoi%2F10.1182%2Fblood-2005-12-4884&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792335828217757696 |
| author | Hao, Zhifang, Guo, Caiying, Jiang, Xi, Krueger, Susan, Pietri, Thomas, Dufour, Sylvie, Cone, Robert E., O'Rourke, James |
| author_facet | Hao, Zhifang, Guo, Caiying, Jiang, Xi, Krueger, Susan, Pietri, Thomas, Dufour, Sylvie, Cone, Robert E., O'Rourke, James, Hao, Zhifang, Guo, Caiying, Jiang, Xi, Krueger, Susan, Pietri, Thomas, Dufour, Sylvie, Cone, Robert E., O'Rourke, James |
| author_sort | hao, zhifang |
| container_issue | 1 |
| container_start_page | 200 |
| container_title | Blood |
| container_volume | 108 |
| description | <jats:p>Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant source of vessel wall t-PA. To visualize fine embedded axons independent of endothelium, we created a transgenic mouse whose expressions of the t-PA promoter and enhanced green fluorescent protein are confined to sympathetic neurons and other neural crest derivatives. Confocal images reveal the extension of t-PA axons to arterioles serving heart, brain, kidney, lung, mesentery, and skin; plus aortic, carotid, and mesenteric artery walls. Ganglion neurons and adrenal chromaffin cells also show strong expressions. These new sightings confirm the existence of a system of t-PA axons that is prominent in arterioles, and compatible with the release of neural t-PA into their walls. (Blood. 2006;108:200-202)</jats:p> |
| doi_str_mv | 10.1182/blood-2005-12-4884 |
| facet_avail | Online, Free |
| finc_class_facet | Chemie und Pharmazie, Biologie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDA1LTEyLTQ4ODQ |
| imprint | American Society of Hematology, 2006 |
| imprint_str_mv | American Society of Hematology, 2006 |
| institution | DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15 |
| issn | 1528-0020, 0006-4971 |
| issn_str_mv | 1528-0020, 0006-4971 |
| language | English |
| last_indexed | 2024-03-01T14:50:44.192Z |
| match_str | hao2006newtransgenicevidenceforasystemofsympatheticaxonsabletoexpresstissueplasminogenactivatortpawithinarterialarteriolarwalls |
| mega_collection | American Society of Hematology (CrossRef) |
| physical | 200-202 |
| publishDate | 2006 |
| publishDateSort | 2006 |
| publisher | American Society of Hematology |
| record_format | ai |
| recordtype | ai |
| series | Blood |
| source_id | 49 |
| spelling | Hao, Zhifang Guo, Caiying Jiang, Xi Krueger, Susan Pietri, Thomas Dufour, Sylvie Cone, Robert E. O'Rourke, James 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2005-12-4884 <jats:p>Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant source of vessel wall t-PA. To visualize fine embedded axons independent of endothelium, we created a transgenic mouse whose expressions of the t-PA promoter and enhanced green fluorescent protein are confined to sympathetic neurons and other neural crest derivatives. Confocal images reveal the extension of t-PA axons to arterioles serving heart, brain, kidney, lung, mesentery, and skin; plus aortic, carotid, and mesenteric artery walls. Ganglion neurons and adrenal chromaffin cells also show strong expressions. These new sightings confirm the existence of a system of t-PA axons that is prominent in arterioles, and compatible with the release of neural t-PA into their walls. (Blood. 2006;108:200-202)</jats:p> New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls Blood |
| spellingShingle | Hao, Zhifang, Guo, Caiying, Jiang, Xi, Krueger, Susan, Pietri, Thomas, Dufour, Sylvie, Cone, Robert E., O'Rourke, James, Blood, New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls, Cell Biology, Hematology, Immunology, Biochemistry |
| title | New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_full | New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_fullStr | New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_full_unstemmed | New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_short | New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| title_sort | new transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-pa) within arterial/arteriolar walls |
| title_unstemmed | New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2005-12-4884 |