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IL-10–producing macrophages preferentially clear early apoptotic cells
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Blood, 107, 2006, 12, S. 4930-4937 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Xu, Wei Roos, Anja Schlagwein, Nicole Woltman, Andrea M. Daha, Mohamed R. van Kooten, Cees Xu, Wei Roos, Anja Schlagwein, Nicole Woltman, Andrea M. Daha, Mohamed R. van Kooten, Cees |
|---|---|
| author |
Xu, Wei Roos, Anja Schlagwein, Nicole Woltman, Andrea M. Daha, Mohamed R. van Kooten, Cees |
| spellingShingle |
Xu, Wei Roos, Anja Schlagwein, Nicole Woltman, Andrea M. Daha, Mohamed R. van Kooten, Cees Blood IL-10–producing macrophages preferentially clear early apoptotic cells Cell Biology Hematology Immunology Biochemistry |
| author_sort |
xu, wei |
| spelling |
Xu, Wei Roos, Anja Schlagwein, Nicole Woltman, Andrea M. Daha, Mohamed R. van Kooten, Cees 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2005-10-4144 <jats:title>Abstract</jats:title><jats:p>Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage colony-stimulating factor (M-CSF)–driven macrophages (Mø2s) are potent phagocytes that have the unique capacity to preferentially bind and ingest early apoptotic cells. This macrophage subset has intrinsic anti-inflammatory properties, characterized by high interleukin-10 (IL-10) production in the absence of proinflammatory cytokines, such as IL-6 and tumor necrosis factor-α (TNF-α). Importantly, whereas the IL-6 and TNF-α production by granulocyte-macrophage (GM)–CSF–driven macrophages (Mø1s) is inhibited upon uptake of apoptotic cells, the anti-inflammatory status of Mø2 is retained during phagocytosis. Mø2s were shown to use CD14 to tether apoptotic cells, whereas recognition of phosphatidylserine (PS) contributed to uptake of early apoptotic cells. Mø2s showed more potent macropinocytosis compared with dendritic cells (DCs) and Mø1s, and uptake of apoptotic cells was inhibited by a macropinocytosis inhibitor. Our studies suggest that, under steady-state conditions, IL-10–producing Mø2s are prominently involved in the clearance of early apoptotic cells.</jats:p> IL-10–producing macrophages preferentially clear early apoptotic cells Blood |
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10.1182/blood-2005-10-4144 |
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American Society of Hematology, 2006 |
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American Society of Hematology, 2006 |
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| title |
IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_unstemmed |
IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_full |
IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_fullStr |
IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_full_unstemmed |
IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_short |
IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_sort |
il-10–producing macrophages preferentially clear early apoptotic cells |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2005-10-4144 |
| publishDate |
2006 |
| physical |
4930-4937 |
| description |
<jats:title>Abstract</jats:title><jats:p>Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage colony-stimulating factor (M-CSF)–driven macrophages (Mø2s) are potent phagocytes that have the unique capacity to preferentially bind and ingest early apoptotic cells. This macrophage subset has intrinsic anti-inflammatory properties, characterized by high interleukin-10 (IL-10) production in the absence of proinflammatory cytokines, such as IL-6 and tumor necrosis factor-α (TNF-α). Importantly, whereas the IL-6 and TNF-α production by granulocyte-macrophage (GM)–CSF–driven macrophages (Mø1s) is inhibited upon uptake of apoptotic cells, the anti-inflammatory status of Mø2 is retained during phagocytosis. Mø2s were shown to use CD14 to tether apoptotic cells, whereas recognition of phosphatidylserine (PS) contributed to uptake of early apoptotic cells. Mø2s showed more potent macropinocytosis compared with dendritic cells (DCs) and Mø1s, and uptake of apoptotic cells was inhibited by a macropinocytosis inhibitor. Our studies suggest that, under steady-state conditions, IL-10–producing Mø2s are prominently involved in the clearance of early apoptotic cells.</jats:p> |
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| author | Xu, Wei, Roos, Anja, Schlagwein, Nicole, Woltman, Andrea M., Daha, Mohamed R., van Kooten, Cees |
| author_facet | Xu, Wei, Roos, Anja, Schlagwein, Nicole, Woltman, Andrea M., Daha, Mohamed R., van Kooten, Cees, Xu, Wei, Roos, Anja, Schlagwein, Nicole, Woltman, Andrea M., Daha, Mohamed R., van Kooten, Cees |
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| description | <jats:title>Abstract</jats:title><jats:p>Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage colony-stimulating factor (M-CSF)–driven macrophages (Mø2s) are potent phagocytes that have the unique capacity to preferentially bind and ingest early apoptotic cells. This macrophage subset has intrinsic anti-inflammatory properties, characterized by high interleukin-10 (IL-10) production in the absence of proinflammatory cytokines, such as IL-6 and tumor necrosis factor-α (TNF-α). Importantly, whereas the IL-6 and TNF-α production by granulocyte-macrophage (GM)–CSF–driven macrophages (Mø1s) is inhibited upon uptake of apoptotic cells, the anti-inflammatory status of Mø2 is retained during phagocytosis. Mø2s were shown to use CD14 to tether apoptotic cells, whereas recognition of phosphatidylserine (PS) contributed to uptake of early apoptotic cells. Mø2s showed more potent macropinocytosis compared with dendritic cells (DCs) and Mø1s, and uptake of apoptotic cells was inhibited by a macropinocytosis inhibitor. Our studies suggest that, under steady-state conditions, IL-10–producing Mø2s are prominently involved in the clearance of early apoptotic cells.</jats:p> |
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| imprint | American Society of Hematology, 2006 |
| imprint_str_mv | American Society of Hematology, 2006 |
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| spelling | Xu, Wei Roos, Anja Schlagwein, Nicole Woltman, Andrea M. Daha, Mohamed R. van Kooten, Cees 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2005-10-4144 <jats:title>Abstract</jats:title><jats:p>Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage colony-stimulating factor (M-CSF)–driven macrophages (Mø2s) are potent phagocytes that have the unique capacity to preferentially bind and ingest early apoptotic cells. This macrophage subset has intrinsic anti-inflammatory properties, characterized by high interleukin-10 (IL-10) production in the absence of proinflammatory cytokines, such as IL-6 and tumor necrosis factor-α (TNF-α). Importantly, whereas the IL-6 and TNF-α production by granulocyte-macrophage (GM)–CSF–driven macrophages (Mø1s) is inhibited upon uptake of apoptotic cells, the anti-inflammatory status of Mø2 is retained during phagocytosis. Mø2s were shown to use CD14 to tether apoptotic cells, whereas recognition of phosphatidylserine (PS) contributed to uptake of early apoptotic cells. Mø2s showed more potent macropinocytosis compared with dendritic cells (DCs) and Mø1s, and uptake of apoptotic cells was inhibited by a macropinocytosis inhibitor. Our studies suggest that, under steady-state conditions, IL-10–producing Mø2s are prominently involved in the clearance of early apoptotic cells.</jats:p> IL-10–producing macrophages preferentially clear early apoptotic cells Blood |
| spellingShingle | Xu, Wei, Roos, Anja, Schlagwein, Nicole, Woltman, Andrea M., Daha, Mohamed R., van Kooten, Cees, Blood, IL-10–producing macrophages preferentially clear early apoptotic cells, Cell Biology, Hematology, Immunology, Biochemistry |
| title | IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_full | IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_fullStr | IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_full_unstemmed | IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_short | IL-10–producing macrophages preferentially clear early apoptotic cells |
| title_sort | il-10–producing macrophages preferentially clear early apoptotic cells |
| title_unstemmed | IL-10–producing macrophages preferentially clear early apoptotic cells |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2005-10-4144 |