Eintrag weiter verarbeiten
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia
Gespeichert in:
| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , |
| In: | Blood, 106, 2005, 9, S. 3142-3149 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Xu, Rongzhen Yu, Yingzi Zheng, Shu Zhao, Xiaoying Dong, Qinghua He, Zhiwen Liang, Yun Lu, Qinghua Fang, Yongmin Gan, Xiaoxian Xu, Xiaohua Zhang, Suzhan Dong, Qi Zhang, Xiaohong Feng, Gen-Sheng Xu, Rongzhen Yu, Yingzi Zheng, Shu Zhao, Xiaoying Dong, Qinghua He, Zhiwen Liang, Yun Lu, Qinghua Fang, Yongmin Gan, Xiaoxian Xu, Xiaohua Zhang, Suzhan Dong, Qi Zhang, Xiaohong Feng, Gen-Sheng |
|---|---|
| author |
Xu, Rongzhen Yu, Yingzi Zheng, Shu Zhao, Xiaoying Dong, Qinghua He, Zhiwen Liang, Yun Lu, Qinghua Fang, Yongmin Gan, Xiaoxian Xu, Xiaohua Zhang, Suzhan Dong, Qi Zhang, Xiaohong Feng, Gen-Sheng |
| spellingShingle |
Xu, Rongzhen Yu, Yingzi Zheng, Shu Zhao, Xiaoying Dong, Qinghua He, Zhiwen Liang, Yun Lu, Qinghua Fang, Yongmin Gan, Xiaoxian Xu, Xiaohua Zhang, Suzhan Dong, Qi Zhang, Xiaohong Feng, Gen-Sheng Blood Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia Cell Biology Hematology Immunology Biochemistry |
| author_sort |
xu, rongzhen |
| spelling |
Xu, Rongzhen Yu, Yingzi Zheng, Shu Zhao, Xiaoying Dong, Qinghua He, Zhiwen Liang, Yun Lu, Qinghua Fang, Yongmin Gan, Xiaoxian Xu, Xiaohua Zhang, Suzhan Dong, Qi Zhang, Xiaohong Feng, Gen-Sheng 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2004-10-4057 <jats:title>Abstract</jats:title><jats:p>Shp2 tyrosine phosphatase plays a critical role in hematopoiesis, and dominant active mutations have been detected in the human gene PTPN11, encoding Shp2, in child leukemia patients. We report here that although no such mutations were detected in 44 adult leukemia patients screened, Shp2 expression levels were significantly elevated in primary leukemia cells and leukemia cell lines, as compared with normal hematopoietic progenitor cells. The Shp2 protein amounts correlated well with the hyperproliferative capacity but were inversely associated with the differentiation degree of leukemia cells. Suppression of Shp2 expression induced apoptosis and inhibition of leukemic cell clonogenic growth. Notably, the majority of Shp2 was preferentially localized to the plasma membrane and was constitutively phosphorylated on tyrosine in leukemia cells, and also in normal hematopoietic cells following mitogenic stimulation. Based on these results, we propose that aberrantly increased expression of Shp2 may contribute, collaboratively with other factors, to leukemogenesis.</jats:p> Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia Blood |
| doi_str_mv |
10.1182/blood-2004-10-4057 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Medizin Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDA0LTEwLTQwNTc |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDA0LTEwLTQwNTc |
| institution |
DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 |
| imprint |
American Society of Hematology, 2005 |
| imprint_str_mv |
American Society of Hematology, 2005 |
| issn |
1528-0020 0006-4971 |
| issn_str_mv |
1528-0020 0006-4971 |
| language |
English |
| mega_collection |
American Society of Hematology (CrossRef) |
| match_str |
xu2005overexpressionofshp2tyrosinephosphataseisimplicatedinleukemogenesisinadulthumanleukemia |
| publishDateSort |
2005 |
| publisher |
American Society of Hematology |
| recordtype |
ai |
| record_format |
ai |
| series |
Blood |
| source_id |
49 |
| title |
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_unstemmed |
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_full |
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_fullStr |
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_full_unstemmed |
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_short |
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_sort |
overexpression of shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2004-10-4057 |
| publishDate |
2005 |
| physical |
3142-3149 |
| description |
<jats:title>Abstract</jats:title><jats:p>Shp2 tyrosine phosphatase plays a critical role in hematopoiesis, and dominant active mutations have been detected in the human gene PTPN11, encoding Shp2, in child leukemia patients. We report here that although no such mutations were detected in 44 adult leukemia patients screened, Shp2 expression levels were significantly elevated in primary leukemia cells and leukemia cell lines, as compared with normal hematopoietic progenitor cells. The Shp2 protein amounts correlated well with the hyperproliferative capacity but were inversely associated with the differentiation degree of leukemia cells. Suppression of Shp2 expression induced apoptosis and inhibition of leukemic cell clonogenic growth. Notably, the majority of Shp2 was preferentially localized to the plasma membrane and was constitutively phosphorylated on tyrosine in leukemia cells, and also in normal hematopoietic cells following mitogenic stimulation. Based on these results, we propose that aberrantly increased expression of Shp2 may contribute, collaboratively with other factors, to leukemogenesis.</jats:p> |
| container_issue |
9 |
| container_start_page |
3142 |
| container_title |
Blood |
| container_volume |
106 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792344332302286857 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:05:55.047Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Overexpression+of+Shp2+tyrosine+phosphatase+is+implicated+in+leukemogenesis+in+adult+human+leukemia&rft.date=2005-11-01&genre=article&issn=1528-0020&volume=106&issue=9&spage=3142&epage=3149&pages=3142-3149&jtitle=Blood&atitle=Overexpression+of+Shp2+tyrosine+phosphatase+is+implicated+in+leukemogenesis+in+adult+human+leukemia&aulast=Feng&aufirst=Gen-Sheng&rft_id=info%3Adoi%2F10.1182%2Fblood-2004-10-4057&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792344332302286857 |
| author | Xu, Rongzhen, Yu, Yingzi, Zheng, Shu, Zhao, Xiaoying, Dong, Qinghua, He, Zhiwen, Liang, Yun, Lu, Qinghua, Fang, Yongmin, Gan, Xiaoxian, Xu, Xiaohua, Zhang, Suzhan, Dong, Qi, Zhang, Xiaohong, Feng, Gen-Sheng |
| author_facet | Xu, Rongzhen, Yu, Yingzi, Zheng, Shu, Zhao, Xiaoying, Dong, Qinghua, He, Zhiwen, Liang, Yun, Lu, Qinghua, Fang, Yongmin, Gan, Xiaoxian, Xu, Xiaohua, Zhang, Suzhan, Dong, Qi, Zhang, Xiaohong, Feng, Gen-Sheng, Xu, Rongzhen, Yu, Yingzi, Zheng, Shu, Zhao, Xiaoying, Dong, Qinghua, He, Zhiwen, Liang, Yun, Lu, Qinghua, Fang, Yongmin, Gan, Xiaoxian, Xu, Xiaohua, Zhang, Suzhan, Dong, Qi, Zhang, Xiaohong, Feng, Gen-Sheng |
| author_sort | xu, rongzhen |
| container_issue | 9 |
| container_start_page | 3142 |
| container_title | Blood |
| container_volume | 106 |
| description | <jats:title>Abstract</jats:title><jats:p>Shp2 tyrosine phosphatase plays a critical role in hematopoiesis, and dominant active mutations have been detected in the human gene PTPN11, encoding Shp2, in child leukemia patients. We report here that although no such mutations were detected in 44 adult leukemia patients screened, Shp2 expression levels were significantly elevated in primary leukemia cells and leukemia cell lines, as compared with normal hematopoietic progenitor cells. The Shp2 protein amounts correlated well with the hyperproliferative capacity but were inversely associated with the differentiation degree of leukemia cells. Suppression of Shp2 expression induced apoptosis and inhibition of leukemic cell clonogenic growth. Notably, the majority of Shp2 was preferentially localized to the plasma membrane and was constitutively phosphorylated on tyrosine in leukemia cells, and also in normal hematopoietic cells following mitogenic stimulation. Based on these results, we propose that aberrantly increased expression of Shp2 may contribute, collaboratively with other factors, to leukemogenesis.</jats:p> |
| doi_str_mv | 10.1182/blood-2004-10-4057 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC0yMDA0LTEwLTQwNTc |
| imprint | American Society of Hematology, 2005 |
| imprint_str_mv | American Society of Hematology, 2005 |
| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
| issn | 1528-0020, 0006-4971 |
| issn_str_mv | 1528-0020, 0006-4971 |
| language | English |
| last_indexed | 2024-03-01T17:05:55.047Z |
| match_str | xu2005overexpressionofshp2tyrosinephosphataseisimplicatedinleukemogenesisinadulthumanleukemia |
| mega_collection | American Society of Hematology (CrossRef) |
| physical | 3142-3149 |
| publishDate | 2005 |
| publishDateSort | 2005 |
| publisher | American Society of Hematology |
| record_format | ai |
| recordtype | ai |
| series | Blood |
| source_id | 49 |
| spelling | Xu, Rongzhen Yu, Yingzi Zheng, Shu Zhao, Xiaoying Dong, Qinghua He, Zhiwen Liang, Yun Lu, Qinghua Fang, Yongmin Gan, Xiaoxian Xu, Xiaohua Zhang, Suzhan Dong, Qi Zhang, Xiaohong Feng, Gen-Sheng 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2004-10-4057 <jats:title>Abstract</jats:title><jats:p>Shp2 tyrosine phosphatase plays a critical role in hematopoiesis, and dominant active mutations have been detected in the human gene PTPN11, encoding Shp2, in child leukemia patients. We report here that although no such mutations were detected in 44 adult leukemia patients screened, Shp2 expression levels were significantly elevated in primary leukemia cells and leukemia cell lines, as compared with normal hematopoietic progenitor cells. The Shp2 protein amounts correlated well with the hyperproliferative capacity but were inversely associated with the differentiation degree of leukemia cells. Suppression of Shp2 expression induced apoptosis and inhibition of leukemic cell clonogenic growth. Notably, the majority of Shp2 was preferentially localized to the plasma membrane and was constitutively phosphorylated on tyrosine in leukemia cells, and also in normal hematopoietic cells following mitogenic stimulation. Based on these results, we propose that aberrantly increased expression of Shp2 may contribute, collaboratively with other factors, to leukemogenesis.</jats:p> Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia Blood |
| spellingShingle | Xu, Rongzhen, Yu, Yingzi, Zheng, Shu, Zhao, Xiaoying, Dong, Qinghua, He, Zhiwen, Liang, Yun, Lu, Qinghua, Fang, Yongmin, Gan, Xiaoxian, Xu, Xiaohua, Zhang, Suzhan, Dong, Qi, Zhang, Xiaohong, Feng, Gen-Sheng, Blood, Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_full | Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_fullStr | Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_full_unstemmed | Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_short | Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_sort | overexpression of shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| title_unstemmed | Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2004-10-4057 |