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Comparison of three antimicrobial strategies in diabetic foot infections post-amputation
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| Zeitschriftentitel: | Therapeutic Advances in Infectious Disease |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Therapeutic Advances in Infectious Disease, 6, 2019, S. 204993611986454 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Shah, Samarth P. Negrete, Ana Self, Timothy Bergeron, Jaclyn Twilla, Jennifer D. Shah, Samarth P. Negrete, Ana Self, Timothy Bergeron, Jaclyn Twilla, Jennifer D. |
|---|---|
| author |
Shah, Samarth P. Negrete, Ana Self, Timothy Bergeron, Jaclyn Twilla, Jennifer D. |
| spellingShingle |
Shah, Samarth P. Negrete, Ana Self, Timothy Bergeron, Jaclyn Twilla, Jennifer D. Therapeutic Advances in Infectious Disease Comparison of three antimicrobial strategies in diabetic foot infections post-amputation Pharmacology (medical) Infectious Diseases |
| author_sort |
shah, samarth p. |
| spelling |
Shah, Samarth P. Negrete, Ana Self, Timothy Bergeron, Jaclyn Twilla, Jennifer D. 2049-9361 2049-937X SAGE Publications Pharmacology (medical) Infectious Diseases http://dx.doi.org/10.1177/2049936119864542 <jats:sec><jats:title>Background:</jats:title><jats:p> The 2012 Infectious Disease Society of America (IDSA) guidelines recommend antimicrobial treatment of diabetic foot infections (DFIs) post-amputation, but the optimal route and duration are poorly defined. </jats:p></jats:sec><jats:sec><jats:title>Objective:</jats:title><jats:p> The objective of this study was to determine whether the selection of a specific antimicrobial treatment modality affected hospital and patient outcomes. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> This was a retrospective review of hospital admissions of adults admitted to ourhealthcare system with a primary diagnosis of DFIs post-amputation. The groups were separated into patients who received intravenous antimicrobials (IV), oral antimicrobials (PO), or no antimicrobials (NA). Outcomes included average length of stay among others. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Of the 200 patients screened, 120 patients were included (IV n = 72; PO n = 20; NA n = 28). No statistically significant differences were identified in average LOS (IV = 9.97 ± 5.85, PO = 8.83 ± 7.37, NA = 9.33 ± 5.91 days; p = 0.73). However, post-operative (post-op) LOS was significantly shorter in the PO group (PO = 3.43 ± 2.56, IV = 7.34 ± 5.95, NA = 5.81 ± 4.18 days; p = 0.0001). </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> The results of our study indicate that a PO antimicrobial treatment strategy post amputation for DFIs has the potential to decrease post-op LOS without increasing the risk of readmission. Based on the results of our study, we feel consideration should be given to transition to oral antimicrobials soon after amputation to facilitate discharge and decrease the utilization of intravenous antimicrobials. </jats:p></jats:sec> Comparison of three antimicrobial strategies in diabetic foot infections post-amputation Therapeutic Advances in Infectious Disease |
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| title |
Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_unstemmed |
Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_full |
Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_fullStr |
Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_full_unstemmed |
Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_short |
Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_sort |
comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| topic |
Pharmacology (medical) Infectious Diseases |
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http://dx.doi.org/10.1177/2049936119864542 |
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<jats:sec><jats:title>Background:</jats:title><jats:p> The 2012 Infectious Disease Society of America (IDSA) guidelines recommend antimicrobial treatment of diabetic foot infections (DFIs) post-amputation, but the optimal route and duration are poorly defined. </jats:p></jats:sec><jats:sec><jats:title>Objective:</jats:title><jats:p> The objective of this study was to determine whether the selection of a specific antimicrobial treatment modality affected hospital and patient outcomes. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> This was a retrospective review of hospital admissions of adults admitted to ourhealthcare system with a primary diagnosis of DFIs post-amputation. The groups were separated into patients who received intravenous antimicrobials (IV), oral antimicrobials (PO), or no antimicrobials (NA). Outcomes included average length of stay among others. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Of the 200 patients screened, 120 patients were included (IV n = 72; PO n = 20; NA n = 28). No statistically significant differences were identified in average LOS (IV = 9.97 ± 5.85, PO = 8.83 ± 7.37, NA = 9.33 ± 5.91 days; p = 0.73). However, post-operative (post-op) LOS was significantly shorter in the PO group (PO = 3.43 ± 2.56, IV = 7.34 ± 5.95, NA = 5.81 ± 4.18 days; p = 0.0001). </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> The results of our study indicate that a PO antimicrobial treatment strategy post amputation for DFIs has the potential to decrease post-op LOS without increasing the risk of readmission. Based on the results of our study, we feel consideration should be given to transition to oral antimicrobials soon after amputation to facilitate discharge and decrease the utilization of intravenous antimicrobials. </jats:p></jats:sec> |
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| description | <jats:sec><jats:title>Background:</jats:title><jats:p> The 2012 Infectious Disease Society of America (IDSA) guidelines recommend antimicrobial treatment of diabetic foot infections (DFIs) post-amputation, but the optimal route and duration are poorly defined. </jats:p></jats:sec><jats:sec><jats:title>Objective:</jats:title><jats:p> The objective of this study was to determine whether the selection of a specific antimicrobial treatment modality affected hospital and patient outcomes. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> This was a retrospective review of hospital admissions of adults admitted to ourhealthcare system with a primary diagnosis of DFIs post-amputation. The groups were separated into patients who received intravenous antimicrobials (IV), oral antimicrobials (PO), or no antimicrobials (NA). Outcomes included average length of stay among others. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Of the 200 patients screened, 120 patients were included (IV n = 72; PO n = 20; NA n = 28). No statistically significant differences were identified in average LOS (IV = 9.97 ± 5.85, PO = 8.83 ± 7.37, NA = 9.33 ± 5.91 days; p = 0.73). However, post-operative (post-op) LOS was significantly shorter in the PO group (PO = 3.43 ± 2.56, IV = 7.34 ± 5.95, NA = 5.81 ± 4.18 days; p = 0.0001). </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> The results of our study indicate that a PO antimicrobial treatment strategy post amputation for DFIs has the potential to decrease post-op LOS without increasing the risk of readmission. Based on the results of our study, we feel consideration should be given to transition to oral antimicrobials soon after amputation to facilitate discharge and decrease the utilization of intravenous antimicrobials. </jats:p></jats:sec> |
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| spelling | Shah, Samarth P. Negrete, Ana Self, Timothy Bergeron, Jaclyn Twilla, Jennifer D. 2049-9361 2049-937X SAGE Publications Pharmacology (medical) Infectious Diseases http://dx.doi.org/10.1177/2049936119864542 <jats:sec><jats:title>Background:</jats:title><jats:p> The 2012 Infectious Disease Society of America (IDSA) guidelines recommend antimicrobial treatment of diabetic foot infections (DFIs) post-amputation, but the optimal route and duration are poorly defined. </jats:p></jats:sec><jats:sec><jats:title>Objective:</jats:title><jats:p> The objective of this study was to determine whether the selection of a specific antimicrobial treatment modality affected hospital and patient outcomes. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> This was a retrospective review of hospital admissions of adults admitted to ourhealthcare system with a primary diagnosis of DFIs post-amputation. The groups were separated into patients who received intravenous antimicrobials (IV), oral antimicrobials (PO), or no antimicrobials (NA). Outcomes included average length of stay among others. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Of the 200 patients screened, 120 patients were included (IV n = 72; PO n = 20; NA n = 28). No statistically significant differences were identified in average LOS (IV = 9.97 ± 5.85, PO = 8.83 ± 7.37, NA = 9.33 ± 5.91 days; p = 0.73). However, post-operative (post-op) LOS was significantly shorter in the PO group (PO = 3.43 ± 2.56, IV = 7.34 ± 5.95, NA = 5.81 ± 4.18 days; p = 0.0001). </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> The results of our study indicate that a PO antimicrobial treatment strategy post amputation for DFIs has the potential to decrease post-op LOS without increasing the risk of readmission. Based on the results of our study, we feel consideration should be given to transition to oral antimicrobials soon after amputation to facilitate discharge and decrease the utilization of intravenous antimicrobials. </jats:p></jats:sec> Comparison of three antimicrobial strategies in diabetic foot infections post-amputation Therapeutic Advances in Infectious Disease |
| spellingShingle | Shah, Samarth P., Negrete, Ana, Self, Timothy, Bergeron, Jaclyn, Twilla, Jennifer D., Therapeutic Advances in Infectious Disease, Comparison of three antimicrobial strategies in diabetic foot infections post-amputation, Pharmacology (medical), Infectious Diseases |
| title | Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_full | Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_fullStr | Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_full_unstemmed | Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_short | Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_sort | comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| title_unstemmed | Comparison of three antimicrobial strategies in diabetic foot infections post-amputation |
| topic | Pharmacology (medical), Infectious Diseases |
| url | http://dx.doi.org/10.1177/2049936119864542 |