Eintrag weiter verarbeiten
The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism
Gespeichert in:
| Zeitschriftentitel: | Scandinavian Journal of Surgery |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Scandinavian Journal of Surgery, 97, 2008, 3, S. 248-253 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
| author_facet |
Volpe, C. Enberg, U. Sjögren, A. Wahrenberg, H. Jacobsson, H. Törring, O. Hamberger, B. Thorén, M. Volpe, C. Enberg, U. Sjögren, A. Wahrenberg, H. Jacobsson, H. Törring, O. Hamberger, B. Thorén, M. |
|---|---|
| author |
Volpe, C. Enberg, U. Sjögren, A. Wahrenberg, H. Jacobsson, H. Törring, O. Hamberger, B. Thorén, M. |
| spellingShingle |
Volpe, C. Enberg, U. Sjögren, A. Wahrenberg, H. Jacobsson, H. Törring, O. Hamberger, B. Thorén, M. Scandinavian Journal of Surgery The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism Surgery |
| author_sort |
volpe, c. |
| spelling |
Volpe, C. Enberg, U. Sjögren, A. Wahrenberg, H. Jacobsson, H. Törring, O. Hamberger, B. Thorén, M. 1457-4969 1799-7267 SAGE Publications Surgery http://dx.doi.org/10.1177/145749690809700308 <jats:sec><jats:title>Background and Aims:</jats:title><jats:p> Differentiation between the two major subgroups of primary aldosteronism, bilateral hyperplasia and aldosterone producing adenoma is essential since therapy in the former is medical and in the latter surgical. The aim of the present study was to evaluate the clinical utility of adrenocortical scintigraphy in the management of primary aldosteronism. </jats:p></jats:sec><jats:sec><jats:title>Material and Methods:</jats:title><jats:p> [<jats:sup>131</jats:sup>I] norcholesterol (NP-59) scintigraphy with dexamethasone suppression for subclassification and lateralization of primary aldosteronism was evaluated in 49 patients with long-term follow-up after diagnosis and treatment </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Thirty-three patients with the diagnosis of aldosterone producing adenoma were operated with adrenalectomy. Preoperative scintigraphy showed lateralized isotope uptake in 27/33 patients while 6 showed no uptake. Twenty-two were cured and three significantly improved. Thus, in 25/33 (76%), scintigraphy showed the correct side as the patients benefited of surgery. Two patients did not improve. Fourteen patients with a probable diagnosis of bilateral hyperplasia had normal scintigraphies. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> In the present retrospective study we found limited sensitivity of NP-59 scintigraphy. However, when a lateralized scintigraphic uptake is achieved it has a high accuracy. Scintigraphy may be used as an adjunct in cases where adrenal venous sampling is inconclusive. </jats:p></jats:sec> The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism Scandinavian Journal of Surgery |
| doi_str_mv |
10.1177/145749690809700308 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8xNDU3NDk2OTA4MDk3MDAzMDg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8xNDU3NDk2OTA4MDk3MDAzMDg |
| institution |
DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 |
| imprint |
SAGE Publications, 2008 |
| imprint_str_mv |
SAGE Publications, 2008 |
| issn |
1799-7267 1457-4969 |
| issn_str_mv |
1799-7267 1457-4969 |
| language |
English |
| mega_collection |
SAGE Publications (CrossRef) |
| match_str |
volpe2008theroleofadrenalscintigraphyinthepreoperativemanagementofprimaryaldosteronism |
| publishDateSort |
2008 |
| publisher |
SAGE Publications |
| recordtype |
ai |
| record_format |
ai |
| series |
Scandinavian Journal of Surgery |
| source_id |
49 |
| title |
The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_unstemmed |
The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_full |
The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_fullStr |
The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_full_unstemmed |
The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_short |
The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_sort |
the role of adrenal scintigraphy in the preoperative management of primary aldosteronism |
| topic |
Surgery |
| url |
http://dx.doi.org/10.1177/145749690809700308 |
| publishDate |
2008 |
| physical |
248-253 |
| description |
<jats:sec><jats:title>Background and Aims:</jats:title><jats:p> Differentiation between the two major subgroups of primary aldosteronism, bilateral hyperplasia and aldosterone producing adenoma is essential since therapy in the former is medical and in the latter surgical. The aim of the present study was to evaluate the clinical utility of adrenocortical scintigraphy in the management of primary aldosteronism. </jats:p></jats:sec><jats:sec><jats:title>Material and Methods:</jats:title><jats:p> [<jats:sup>131</jats:sup>I] norcholesterol (NP-59) scintigraphy with dexamethasone suppression for subclassification and lateralization of primary aldosteronism was evaluated in 49 patients with long-term follow-up after diagnosis and treatment </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Thirty-three patients with the diagnosis of aldosterone producing adenoma were operated with adrenalectomy. Preoperative scintigraphy showed lateralized isotope uptake in 27/33 patients while 6 showed no uptake. Twenty-two were cured and three significantly improved. Thus, in 25/33 (76%), scintigraphy showed the correct side as the patients benefited of surgery. Two patients did not improve. Fourteen patients with a probable diagnosis of bilateral hyperplasia had normal scintigraphies. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> In the present retrospective study we found limited sensitivity of NP-59 scintigraphy. However, when a lateralized scintigraphic uptake is achieved it has a high accuracy. Scintigraphy may be used as an adjunct in cases where adrenal venous sampling is inconclusive. </jats:p></jats:sec> |
| container_issue |
3 |
| container_start_page |
248 |
| container_title |
Scandinavian Journal of Surgery |
| container_volume |
97 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792337051486519304 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:09:50.396Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=The+Role+of+Adrenal+Scintigraphy+in+the+Preoperative+Management+of+Primary+Aldosteronism&rft.date=2008-09-01&genre=article&issn=1799-7267&volume=97&issue=3&spage=248&epage=253&pages=248-253&jtitle=Scandinavian+Journal+of+Surgery&atitle=The+Role+of+Adrenal+Scintigraphy+in+the+Preoperative+Management+of+Primary+Aldosteronism&aulast=Thor%C3%A9n&aufirst=M.&rft_id=info%3Adoi%2F10.1177%2F145749690809700308&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792337051486519304 |
| author | Volpe, C., Enberg, U., Sjögren, A., Wahrenberg, H., Jacobsson, H., Törring, O., Hamberger, B., Thorén, M. |
| author_facet | Volpe, C., Enberg, U., Sjögren, A., Wahrenberg, H., Jacobsson, H., Törring, O., Hamberger, B., Thorén, M., Volpe, C., Enberg, U., Sjögren, A., Wahrenberg, H., Jacobsson, H., Törring, O., Hamberger, B., Thorén, M. |
| author_sort | volpe, c. |
| container_issue | 3 |
| container_start_page | 248 |
| container_title | Scandinavian Journal of Surgery |
| container_volume | 97 |
| description | <jats:sec><jats:title>Background and Aims:</jats:title><jats:p> Differentiation between the two major subgroups of primary aldosteronism, bilateral hyperplasia and aldosterone producing adenoma is essential since therapy in the former is medical and in the latter surgical. The aim of the present study was to evaluate the clinical utility of adrenocortical scintigraphy in the management of primary aldosteronism. </jats:p></jats:sec><jats:sec><jats:title>Material and Methods:</jats:title><jats:p> [<jats:sup>131</jats:sup>I] norcholesterol (NP-59) scintigraphy with dexamethasone suppression for subclassification and lateralization of primary aldosteronism was evaluated in 49 patients with long-term follow-up after diagnosis and treatment </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Thirty-three patients with the diagnosis of aldosterone producing adenoma were operated with adrenalectomy. Preoperative scintigraphy showed lateralized isotope uptake in 27/33 patients while 6 showed no uptake. Twenty-two were cured and three significantly improved. Thus, in 25/33 (76%), scintigraphy showed the correct side as the patients benefited of surgery. Two patients did not improve. Fourteen patients with a probable diagnosis of bilateral hyperplasia had normal scintigraphies. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> In the present retrospective study we found limited sensitivity of NP-59 scintigraphy. However, when a lateralized scintigraphic uptake is achieved it has a high accuracy. Scintigraphy may be used as an adjunct in cases where adrenal venous sampling is inconclusive. </jats:p></jats:sec> |
| doi_str_mv | 10.1177/145749690809700308 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8xNDU3NDk2OTA4MDk3MDAzMDg |
| imprint | SAGE Publications, 2008 |
| imprint_str_mv | SAGE Publications, 2008 |
| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
| issn | 1799-7267, 1457-4969 |
| issn_str_mv | 1799-7267, 1457-4969 |
| language | English |
| last_indexed | 2024-03-01T15:09:50.396Z |
| match_str | volpe2008theroleofadrenalscintigraphyinthepreoperativemanagementofprimaryaldosteronism |
| mega_collection | SAGE Publications (CrossRef) |
| physical | 248-253 |
| publishDate | 2008 |
| publishDateSort | 2008 |
| publisher | SAGE Publications |
| record_format | ai |
| recordtype | ai |
| series | Scandinavian Journal of Surgery |
| source_id | 49 |
| spelling | Volpe, C. Enberg, U. Sjögren, A. Wahrenberg, H. Jacobsson, H. Törring, O. Hamberger, B. Thorén, M. 1457-4969 1799-7267 SAGE Publications Surgery http://dx.doi.org/10.1177/145749690809700308 <jats:sec><jats:title>Background and Aims:</jats:title><jats:p> Differentiation between the two major subgroups of primary aldosteronism, bilateral hyperplasia and aldosterone producing adenoma is essential since therapy in the former is medical and in the latter surgical. The aim of the present study was to evaluate the clinical utility of adrenocortical scintigraphy in the management of primary aldosteronism. </jats:p></jats:sec><jats:sec><jats:title>Material and Methods:</jats:title><jats:p> [<jats:sup>131</jats:sup>I] norcholesterol (NP-59) scintigraphy with dexamethasone suppression for subclassification and lateralization of primary aldosteronism was evaluated in 49 patients with long-term follow-up after diagnosis and treatment </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Thirty-three patients with the diagnosis of aldosterone producing adenoma were operated with adrenalectomy. Preoperative scintigraphy showed lateralized isotope uptake in 27/33 patients while 6 showed no uptake. Twenty-two were cured and three significantly improved. Thus, in 25/33 (76%), scintigraphy showed the correct side as the patients benefited of surgery. Two patients did not improve. Fourteen patients with a probable diagnosis of bilateral hyperplasia had normal scintigraphies. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> In the present retrospective study we found limited sensitivity of NP-59 scintigraphy. However, when a lateralized scintigraphic uptake is achieved it has a high accuracy. Scintigraphy may be used as an adjunct in cases where adrenal venous sampling is inconclusive. </jats:p></jats:sec> The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism Scandinavian Journal of Surgery |
| spellingShingle | Volpe, C., Enberg, U., Sjögren, A., Wahrenberg, H., Jacobsson, H., Törring, O., Hamberger, B., Thorén, M., Scandinavian Journal of Surgery, The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism, Surgery |
| title | The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_full | The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_fullStr | The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_full_unstemmed | The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_short | The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| title_sort | the role of adrenal scintigraphy in the preoperative management of primary aldosteronism |
| title_unstemmed | The Role of Adrenal Scintigraphy in the Preoperative Management of Primary Aldosteronism |
| topic | Surgery |
| url | http://dx.doi.org/10.1177/145749690809700308 |