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Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study: A Serial Magnetic Resonance Imaging Stud...
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| Zeitschriftentitel: | Stroke |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Stroke, 44, 2013, 4, S. 1144-1146 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Li, Na Worthmann, Hans Heeren, Meike Schuppner, Ramona Deb-Chatterji, Milani Tryc, Anita B. Bueltmann, Eva Lanfermann, Heinrich Donnerstag, Frank Weissenborn, Karin Raab, Peter Li, Na Worthmann, Hans Heeren, Meike Schuppner, Ramona Deb-Chatterji, Milani Tryc, Anita B. Bueltmann, Eva Lanfermann, Heinrich Donnerstag, Frank Weissenborn, Karin Raab, Peter |
|---|---|
| author |
Li, Na Worthmann, Hans Heeren, Meike Schuppner, Ramona Deb-Chatterji, Milani Tryc, Anita B. Bueltmann, Eva Lanfermann, Heinrich Donnerstag, Frank Weissenborn, Karin Raab, Peter |
| spellingShingle |
Li, Na Worthmann, Hans Heeren, Meike Schuppner, Ramona Deb-Chatterji, Milani Tryc, Anita B. Bueltmann, Eva Lanfermann, Heinrich Donnerstag, Frank Weissenborn, Karin Raab, Peter Stroke Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| author_sort |
li, na |
| spelling |
Li, Na Worthmann, Hans Heeren, Meike Schuppner, Ramona Deb-Chatterji, Milani Tryc, Anita B. Bueltmann, Eva Lanfermann, Heinrich Donnerstag, Frank Weissenborn, Karin Raab, Peter 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/strokeaha.111.000056 <jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>Knowledge about cytotoxic edema (CE) in intracerebral hemorrhage is still limited. We aimed to analyze its presence, temporal pattern, and prognostic meaning.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p>Twenty-one patients with primary intracerebral hemorrhage underwent magnetic resonance imaging at days 1, 3, and 7 after symptom onset. CE was identified using diffusion-weighted imaging. Hematoma and perihematomal edema volumes were measured on fluid-attenuated inversion recovery images. National Institutes of Health Stroke Scale score was assessed at admission and with each magnetic resonance imaging. Clinical outcome was assessed by modified Rankin scale at 90 days.</jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> CE appeared in half of the patients within the first 24 hours. The apparent diffusion coefficient values decreased until day 3 and were significantly reversed from days 3 through 7 ( <jats:italic>P</jats:italic> <0.01). Patients with CE showed significantly faster perihematomal edema growth from day 0 to 1 ( <jats:italic>P</jats:italic> =0.036) than those without. Larger 3-day perihematomal edema volume ( <jats:italic>P</jats:italic> =0.02) and presence of CE on day 3 ( <jats:italic>P</jats:italic> =0.07) were associated with poor clinical outcome. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>CE is associated with stroke severity, perihematomal edema volume, and poor outcome. It is considered to indicate ongoing neuronal injury and, thus, might emerge as new treatment target.</jats:p> </jats:sec> A Serial Magnetic Resonance Imaging Study Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study Stroke |
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10.1161/strokeaha.111.000056 |
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Ovid Technologies (Wolters Kluwer Health), 2013 |
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| title_sub |
A Serial Magnetic Resonance Imaging Study |
| title |
Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_unstemmed |
Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_full |
Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_fullStr |
Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_full_unstemmed |
Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_short |
Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_sort |
temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage : a serial magnetic resonance imaging study |
| topic |
Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| url |
http://dx.doi.org/10.1161/strokeaha.111.000056 |
| publishDate |
2013 |
| physical |
1144-1146 |
| description |
<jats:sec>
<jats:title>Background and Purpose—</jats:title>
<jats:p>Knowledge about cytotoxic edema (CE) in intracerebral hemorrhage is still limited. We aimed to analyze its presence, temporal pattern, and prognostic meaning.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods—</jats:title>
<jats:p>Twenty-one patients with primary intracerebral hemorrhage underwent magnetic resonance imaging at days 1, 3, and 7 after symptom onset. CE was identified using diffusion-weighted imaging. Hematoma and perihematomal edema volumes were measured on fluid-attenuated inversion recovery images. National Institutes of Health Stroke Scale score was assessed at admission and with each magnetic resonance imaging. Clinical outcome was assessed by modified Rankin scale at 90 days.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results—</jats:title>
<jats:p>
CE appeared in half of the patients within the first 24 hours. The apparent diffusion coefficient values decreased until day 3 and were significantly reversed from days 3 through 7 (
<jats:italic>P</jats:italic>
<0.01). Patients with CE showed significantly faster perihematomal edema growth from day 0 to 1 (
<jats:italic>P</jats:italic>
=0.036) than those without. Larger 3-day perihematomal edema volume (
<jats:italic>P</jats:italic>
=0.02) and presence of CE on day 3 (
<jats:italic>P</jats:italic>
=0.07) were associated with poor clinical outcome.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions—</jats:title>
<jats:p>CE is associated with stroke severity, perihematomal edema volume, and poor outcome. It is considered to indicate ongoing neuronal injury and, thus, might emerge as new treatment target.</jats:p>
</jats:sec> |
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| author | Li, Na, Worthmann, Hans, Heeren, Meike, Schuppner, Ramona, Deb-Chatterji, Milani, Tryc, Anita B., Bueltmann, Eva, Lanfermann, Heinrich, Donnerstag, Frank, Weissenborn, Karin, Raab, Peter |
| author_facet | Li, Na, Worthmann, Hans, Heeren, Meike, Schuppner, Ramona, Deb-Chatterji, Milani, Tryc, Anita B., Bueltmann, Eva, Lanfermann, Heinrich, Donnerstag, Frank, Weissenborn, Karin, Raab, Peter, Li, Na, Worthmann, Hans, Heeren, Meike, Schuppner, Ramona, Deb-Chatterji, Milani, Tryc, Anita B., Bueltmann, Eva, Lanfermann, Heinrich, Donnerstag, Frank, Weissenborn, Karin, Raab, Peter |
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| description | <jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>Knowledge about cytotoxic edema (CE) in intracerebral hemorrhage is still limited. We aimed to analyze its presence, temporal pattern, and prognostic meaning.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p>Twenty-one patients with primary intracerebral hemorrhage underwent magnetic resonance imaging at days 1, 3, and 7 after symptom onset. CE was identified using diffusion-weighted imaging. Hematoma and perihematomal edema volumes were measured on fluid-attenuated inversion recovery images. National Institutes of Health Stroke Scale score was assessed at admission and with each magnetic resonance imaging. Clinical outcome was assessed by modified Rankin scale at 90 days.</jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> CE appeared in half of the patients within the first 24 hours. The apparent diffusion coefficient values decreased until day 3 and were significantly reversed from days 3 through 7 ( <jats:italic>P</jats:italic> <0.01). Patients with CE showed significantly faster perihematomal edema growth from day 0 to 1 ( <jats:italic>P</jats:italic> =0.036) than those without. Larger 3-day perihematomal edema volume ( <jats:italic>P</jats:italic> =0.02) and presence of CE on day 3 ( <jats:italic>P</jats:italic> =0.07) were associated with poor clinical outcome. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>CE is associated with stroke severity, perihematomal edema volume, and poor outcome. It is considered to indicate ongoing neuronal injury and, thus, might emerge as new treatment target.</jats:p> </jats:sec> |
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| imprint_str_mv | Ovid Technologies (Wolters Kluwer Health), 2013 |
| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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| spelling | Li, Na Worthmann, Hans Heeren, Meike Schuppner, Ramona Deb-Chatterji, Milani Tryc, Anita B. Bueltmann, Eva Lanfermann, Heinrich Donnerstag, Frank Weissenborn, Karin Raab, Peter 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/strokeaha.111.000056 <jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>Knowledge about cytotoxic edema (CE) in intracerebral hemorrhage is still limited. We aimed to analyze its presence, temporal pattern, and prognostic meaning.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p>Twenty-one patients with primary intracerebral hemorrhage underwent magnetic resonance imaging at days 1, 3, and 7 after symptom onset. CE was identified using diffusion-weighted imaging. Hematoma and perihematomal edema volumes were measured on fluid-attenuated inversion recovery images. National Institutes of Health Stroke Scale score was assessed at admission and with each magnetic resonance imaging. Clinical outcome was assessed by modified Rankin scale at 90 days.</jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> CE appeared in half of the patients within the first 24 hours. The apparent diffusion coefficient values decreased until day 3 and were significantly reversed from days 3 through 7 ( <jats:italic>P</jats:italic> <0.01). Patients with CE showed significantly faster perihematomal edema growth from day 0 to 1 ( <jats:italic>P</jats:italic> =0.036) than those without. Larger 3-day perihematomal edema volume ( <jats:italic>P</jats:italic> =0.02) and presence of CE on day 3 ( <jats:italic>P</jats:italic> =0.07) were associated with poor clinical outcome. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>CE is associated with stroke severity, perihematomal edema volume, and poor outcome. It is considered to indicate ongoing neuronal injury and, thus, might emerge as new treatment target.</jats:p> </jats:sec> A Serial Magnetic Resonance Imaging Study Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study Stroke |
| spellingShingle | Li, Na, Worthmann, Hans, Heeren, Meike, Schuppner, Ramona, Deb-Chatterji, Milani, Tryc, Anita B., Bueltmann, Eva, Lanfermann, Heinrich, Donnerstag, Frank, Weissenborn, Karin, Raab, Peter, Stroke, Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study, Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| title | Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_full | Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_fullStr | Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_full_unstemmed | Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_short | Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| title_sort | temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage : a serial magnetic resonance imaging study |
| title_sub | A Serial Magnetic Resonance Imaging Study |
| title_unstemmed | Temporal Pattern of Cytotoxic Edema in the Perihematomal Region After Intracerebral Hemorrhage : A Serial Magnetic Resonance Imaging Study |
| topic | Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| url | http://dx.doi.org/10.1161/strokeaha.111.000056 |