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Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease
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| Zeitschriftentitel: | Stroke |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Stroke, 46, 2015, 5, S. 1250-1256 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Saura, Hiroaki Ogasawara, Kuniaki Beppu, Takaaki Yoshida, Koji Kobayashi, Masakazu Yoshida, Kenji Terasaki, Kazunori Takai, Yoshihiro Ogawa, Akira Saura, Hiroaki Ogasawara, Kuniaki Beppu, Takaaki Yoshida, Koji Kobayashi, Masakazu Yoshida, Kenji Terasaki, Kazunori Takai, Yoshihiro Ogawa, Akira |
|---|---|
| author |
Saura, Hiroaki Ogasawara, Kuniaki Beppu, Takaaki Yoshida, Koji Kobayashi, Masakazu Yoshida, Kenji Terasaki, Kazunori Takai, Yoshihiro Ogawa, Akira |
| spellingShingle |
Saura, Hiroaki Ogasawara, Kuniaki Beppu, Takaaki Yoshida, Koji Kobayashi, Masakazu Yoshida, Kenji Terasaki, Kazunori Takai, Yoshihiro Ogawa, Akira Stroke Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| author_sort |
saura, hiroaki |
| spelling |
Saura, Hiroaki Ogasawara, Kuniaki Beppu, Takaaki Yoshida, Koji Kobayashi, Masakazu Yoshida, Kenji Terasaki, Kazunori Takai, Yoshihiro Ogawa, Akira 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/strokeaha.114.008238 <jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p> Positron emission tomography (PET) with radiolabeled 2-nitroimidazoles directly detects hypoxic but viable tissue present in an acute ischemic area in the human brain. This study using PET with 1-(2- <jats:sup>18</jats:sup> F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole ( <jats:sup>18</jats:sup> F-FRP170) aimed to determine whether tissue with an abnormally elevated uptake of <jats:sup>18</jats:sup> F-FRP170 exists in human chronic cerebral ischemia because of unilateral atherosclerotic major cerebral artery steno-occlusive disease. </jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p> <jats:sup>18</jats:sup> F-FRP170 PET was performed, and cerebral blood flow and metabolism were assessed using <jats:sup>15</jats:sup> O-gas PET in 20 healthy subjects and 52 patients. A region of interest (ROI) was automatically placed in 3 segments of the middle cerebral artery territory in both cerebral hemispheres with a 3-dimensional stereotaxic ROI template using SPM2, and each PET value was determined in each ROI. The ratio of values in the affected versus contralateral hemispheres was calculated for the <jats:sup>18</jats:sup> F-FRP170 PET image. </jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> A significant correlation was observed between oxygen extraction fraction and <jats:sup>18</jats:sup> F-FRP170 ratios ( <jats:italic>ρ</jats:italic> =0.509; <jats:italic>P</jats:italic> <0.0001) in a total of 156 ROIs in 52 patients. The specificity and positive-predictive value for a combination of an elevated oxygen extraction fraction and a moderately reduced cerebral oxygen metabolism for detection of an abnormally elevated <jats:sup>18</jats:sup> F-FRP170 ratio (19 ROIs: 12%) were significantly greater than those for the individual categories (elevated oxygen extraction fraction, moderately reduced cerebral oxygen metabolism, or reduced cerebral blood flow). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p> Tissues with abnormally elevated uptake of <jats:sup>18</jats:sup> F-FRP170 exist in human chronic cerebral ischemia characterized by a combination of misery perfusion and moderately reduced oxygen metabolism because of unilateral atherosclerotic major cerebral artery steno-occlusive disease. </jats:p> </jats:sec> Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease Stroke |
| doi_str_mv |
10.1161/strokeaha.114.008238 |
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Medizin |
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Ovid Technologies (Wolters Kluwer Health), 2015 |
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Ovid Technologies (Wolters Kluwer Health), 2015 |
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1524-4628 0039-2499 |
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Ovid Technologies (Wolters Kluwer Health) |
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Stroke |
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49 |
| title |
Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_unstemmed |
Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_full |
Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_fullStr |
Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_full_unstemmed |
Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_short |
Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_sort |
hypoxic viable tissue in human chronic cerebral ischemia because of unilateral major cerebral artery steno-occlusive disease |
| topic |
Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| url |
http://dx.doi.org/10.1161/strokeaha.114.008238 |
| publishDate |
2015 |
| physical |
1250-1256 |
| description |
<jats:sec>
<jats:title>Background and Purpose—</jats:title>
<jats:p>
Positron emission tomography (PET) with radiolabeled 2-nitroimidazoles directly detects hypoxic but viable tissue present in an acute ischemic area in the human brain. This study using PET with 1-(2-
<jats:sup>18</jats:sup>
F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole (
<jats:sup>18</jats:sup>
F-FRP170) aimed to determine whether tissue with an abnormally elevated uptake of
<jats:sup>18</jats:sup>
F-FRP170 exists in human chronic cerebral ischemia because of unilateral atherosclerotic major cerebral artery steno-occlusive disease.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods—</jats:title>
<jats:p>
<jats:sup>18</jats:sup>
F-FRP170 PET was performed, and cerebral blood flow and metabolism were assessed using
<jats:sup>15</jats:sup>
O-gas PET in 20 healthy subjects and 52 patients. A region of interest (ROI) was automatically placed in 3 segments of the middle cerebral artery territory in both cerebral hemispheres with a 3-dimensional stereotaxic ROI template using SPM2, and each PET value was determined in each ROI. The ratio of values in the affected versus contralateral hemispheres was calculated for the
<jats:sup>18</jats:sup>
F-FRP170 PET image.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results—</jats:title>
<jats:p>
A significant correlation was observed between oxygen extraction fraction and
<jats:sup>18</jats:sup>
F-FRP170 ratios (
<jats:italic>ρ</jats:italic>
=0.509;
<jats:italic>P</jats:italic>
<0.0001) in a total of 156 ROIs in 52 patients. The specificity and positive-predictive value for a combination of an elevated oxygen extraction fraction and a moderately reduced cerebral oxygen metabolism for detection of an abnormally elevated
<jats:sup>18</jats:sup>
F-FRP170 ratio (19 ROIs: 12%) were significantly greater than those for the individual categories (elevated oxygen extraction fraction, moderately reduced cerebral oxygen metabolism, or reduced cerebral blood flow).
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions—</jats:title>
<jats:p>
Tissues with abnormally elevated uptake of
<jats:sup>18</jats:sup>
F-FRP170 exist in human chronic cerebral ischemia characterized by a combination of misery perfusion and moderately reduced oxygen metabolism because of unilateral atherosclerotic major cerebral artery steno-occlusive disease.
</jats:p>
</jats:sec> |
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| author | Saura, Hiroaki, Ogasawara, Kuniaki, Beppu, Takaaki, Yoshida, Koji, Kobayashi, Masakazu, Yoshida, Kenji, Terasaki, Kazunori, Takai, Yoshihiro, Ogawa, Akira |
| author_facet | Saura, Hiroaki, Ogasawara, Kuniaki, Beppu, Takaaki, Yoshida, Koji, Kobayashi, Masakazu, Yoshida, Kenji, Terasaki, Kazunori, Takai, Yoshihiro, Ogawa, Akira, Saura, Hiroaki, Ogasawara, Kuniaki, Beppu, Takaaki, Yoshida, Koji, Kobayashi, Masakazu, Yoshida, Kenji, Terasaki, Kazunori, Takai, Yoshihiro, Ogawa, Akira |
| author_sort | saura, hiroaki |
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| description | <jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p> Positron emission tomography (PET) with radiolabeled 2-nitroimidazoles directly detects hypoxic but viable tissue present in an acute ischemic area in the human brain. This study using PET with 1-(2- <jats:sup>18</jats:sup> F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole ( <jats:sup>18</jats:sup> F-FRP170) aimed to determine whether tissue with an abnormally elevated uptake of <jats:sup>18</jats:sup> F-FRP170 exists in human chronic cerebral ischemia because of unilateral atherosclerotic major cerebral artery steno-occlusive disease. </jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p> <jats:sup>18</jats:sup> F-FRP170 PET was performed, and cerebral blood flow and metabolism were assessed using <jats:sup>15</jats:sup> O-gas PET in 20 healthy subjects and 52 patients. A region of interest (ROI) was automatically placed in 3 segments of the middle cerebral artery territory in both cerebral hemispheres with a 3-dimensional stereotaxic ROI template using SPM2, and each PET value was determined in each ROI. The ratio of values in the affected versus contralateral hemispheres was calculated for the <jats:sup>18</jats:sup> F-FRP170 PET image. </jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> A significant correlation was observed between oxygen extraction fraction and <jats:sup>18</jats:sup> F-FRP170 ratios ( <jats:italic>ρ</jats:italic> =0.509; <jats:italic>P</jats:italic> <0.0001) in a total of 156 ROIs in 52 patients. The specificity and positive-predictive value for a combination of an elevated oxygen extraction fraction and a moderately reduced cerebral oxygen metabolism for detection of an abnormally elevated <jats:sup>18</jats:sup> F-FRP170 ratio (19 ROIs: 12%) were significantly greater than those for the individual categories (elevated oxygen extraction fraction, moderately reduced cerebral oxygen metabolism, or reduced cerebral blood flow). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p> Tissues with abnormally elevated uptake of <jats:sup>18</jats:sup> F-FRP170 exist in human chronic cerebral ischemia characterized by a combination of misery perfusion and moderately reduced oxygen metabolism because of unilateral atherosclerotic major cerebral artery steno-occlusive disease. </jats:p> </jats:sec> |
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| spelling | Saura, Hiroaki Ogasawara, Kuniaki Beppu, Takaaki Yoshida, Koji Kobayashi, Masakazu Yoshida, Kenji Terasaki, Kazunori Takai, Yoshihiro Ogawa, Akira 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/strokeaha.114.008238 <jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p> Positron emission tomography (PET) with radiolabeled 2-nitroimidazoles directly detects hypoxic but viable tissue present in an acute ischemic area in the human brain. This study using PET with 1-(2- <jats:sup>18</jats:sup> F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole ( <jats:sup>18</jats:sup> F-FRP170) aimed to determine whether tissue with an abnormally elevated uptake of <jats:sup>18</jats:sup> F-FRP170 exists in human chronic cerebral ischemia because of unilateral atherosclerotic major cerebral artery steno-occlusive disease. </jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p> <jats:sup>18</jats:sup> F-FRP170 PET was performed, and cerebral blood flow and metabolism were assessed using <jats:sup>15</jats:sup> O-gas PET in 20 healthy subjects and 52 patients. A region of interest (ROI) was automatically placed in 3 segments of the middle cerebral artery territory in both cerebral hemispheres with a 3-dimensional stereotaxic ROI template using SPM2, and each PET value was determined in each ROI. The ratio of values in the affected versus contralateral hemispheres was calculated for the <jats:sup>18</jats:sup> F-FRP170 PET image. </jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> A significant correlation was observed between oxygen extraction fraction and <jats:sup>18</jats:sup> F-FRP170 ratios ( <jats:italic>ρ</jats:italic> =0.509; <jats:italic>P</jats:italic> <0.0001) in a total of 156 ROIs in 52 patients. The specificity and positive-predictive value for a combination of an elevated oxygen extraction fraction and a moderately reduced cerebral oxygen metabolism for detection of an abnormally elevated <jats:sup>18</jats:sup> F-FRP170 ratio (19 ROIs: 12%) were significantly greater than those for the individual categories (elevated oxygen extraction fraction, moderately reduced cerebral oxygen metabolism, or reduced cerebral blood flow). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p> Tissues with abnormally elevated uptake of <jats:sup>18</jats:sup> F-FRP170 exist in human chronic cerebral ischemia characterized by a combination of misery perfusion and moderately reduced oxygen metabolism because of unilateral atherosclerotic major cerebral artery steno-occlusive disease. </jats:p> </jats:sec> Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease Stroke |
| spellingShingle | Saura, Hiroaki, Ogasawara, Kuniaki, Beppu, Takaaki, Yoshida, Koji, Kobayashi, Masakazu, Yoshida, Kenji, Terasaki, Kazunori, Takai, Yoshihiro, Ogawa, Akira, Stroke, Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease, Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| title | Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_full | Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_fullStr | Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_full_unstemmed | Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_short | Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| title_sort | hypoxic viable tissue in human chronic cerebral ischemia because of unilateral major cerebral artery steno-occlusive disease |
| title_unstemmed | Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease |
| topic | Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| url | http://dx.doi.org/10.1161/strokeaha.114.008238 |