Eintrag weiter verarbeiten
Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention
Gespeichert in:
| Zeitschriftentitel: | Journal of the American Heart Association |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Journal of the American Heart Association, 8, 2019, 14 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Zafrir, Barak Adawi, Salim Khalaily, Marah Jaffe, Ronen Eitan, Amnon Barnett‐Griness, Ofra Saliba, Walid Zafrir, Barak Adawi, Salim Khalaily, Marah Jaffe, Ronen Eitan, Amnon Barnett‐Griness, Ofra Saliba, Walid |
|---|---|
| author |
Zafrir, Barak Adawi, Salim Khalaily, Marah Jaffe, Ronen Eitan, Amnon Barnett‐Griness, Ofra Saliba, Walid |
| spellingShingle |
Zafrir, Barak Adawi, Salim Khalaily, Marah Jaffe, Ronen Eitan, Amnon Barnett‐Griness, Ofra Saliba, Walid Journal of the American Heart Association Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention Cardiology and Cardiovascular Medicine |
| author_sort |
zafrir, barak |
| spelling |
Zafrir, Barak Adawi, Salim Khalaily, Marah Jaffe, Ronen Eitan, Amnon Barnett‐Griness, Ofra Saliba, Walid 2047-9980 Ovid Technologies (Wolters Kluwer Health) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/jaha.119.012433 <jats:sec xml:lang="en"><jats:title>Background</jats:title><jats:p xml:lang="en">A risk score for secondary prevention after myocardial infarction (Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention [TRS2P]), based on 9 established clinical factors, was recently developed from the<jats:styled-content style="fixed-case">TRA</jats:styled-content>2°P‐<jats:styled-content style="fixed-case">TIMI</jats:styled-content>50 (Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events) trial. We aimed to evaluate the performance of<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P for predicting long‐term outcomes in real‐world patients presenting for coronary angiography.</jats:p></jats:sec><jats:sec xml:lang="en"><jats:title>Methods and Results</jats:title><jats:p xml:lang="en">A retrospective analysis of 13 593 patients referred to angiography for the assessment or treatment of coronary disease was performed. Risk stratification for 10‐year major adverse cardiovascular events was performed using the<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, divided into 6 categories (0 to ≥5 points), and in relation to the presenting coronary syndrome. All clinical variables, except prior coronary artery bypass grafting, were independent risk predictors. The annualized incidence rate of major adverse cardiovascular events increased in a graded manner with increasing<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, ranging from 1.65 to 16.6 per 100 person‐years (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub><0.001). Compared with the lowest‐risk group (risk indicators=0), the hazard ratios (95% CIs) for 10‐year major adverse cardiovascular events were 1.60 (95% CI, 1.36–1.89), 2.58 (95% CI, 2.21–3.02), 4.31 (95% CI, 3.69–5.05), 6.43 (95% CI, 5.47–7.56), and 10.03 (95% CI, 8.52–11.81), in those with 1, 2, 3, 4 and ≥5 risk indicators, respectively. Risk gradation was consistent among individual clinical end points.<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P showed reasonable discrimination with C‐statistics of 0.693 for major adverse cardiovascular events and 0.758 for mortality. The graded relationship between the risk score and event rates was observed in both patients presenting with acute and nonacute coronary syndromes.</jats:p></jats:sec><jats:sec xml:lang="en"><jats:title>Conclusions</jats:title><jats:p xml:lang="en">The use of<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, a simple risk score based on routinely collected variables, enables risk stratification in patients undergoing coronary angiography. Its predictive value was demonstrated in a real‐world setting with long‐term follow‐up and regardless of the acuity of coronary presentation.</jats:p></jats:sec> Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention Journal of the American Heart Association |
| doi_str_mv |
10.1161/jaha.119.012433 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2MS9qYWhhLjExOS4wMTI0MzM |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2MS9qYWhhLjExOS4wMTI0MzM |
| institution |
DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 |
| imprint |
Ovid Technologies (Wolters Kluwer Health), 2019 |
| imprint_str_mv |
Ovid Technologies (Wolters Kluwer Health), 2019 |
| issn |
2047-9980 |
| issn_str_mv |
2047-9980 |
| language |
English |
| mega_collection |
Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| match_str |
zafrir2019longtermriskstratificationofpatientsundergoingcoronaryangiographyaccordingtothethrombolysisinmyocardialinfarctionriskscoreforsecondaryprevention |
| publishDateSort |
2019 |
| publisher |
Ovid Technologies (Wolters Kluwer Health) |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of the American Heart Association |
| source_id |
49 |
| title |
Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_unstemmed |
Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_full |
Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_fullStr |
Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_full_unstemmed |
Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_short |
Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_sort |
long‐term risk stratification of patients undergoing coronary angiography according to the thrombolysis in myocardial infarction risk score for secondary prevention |
| topic |
Cardiology and Cardiovascular Medicine |
| url |
http://dx.doi.org/10.1161/jaha.119.012433 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:sec xml:lang="en"><jats:title>Background</jats:title><jats:p xml:lang="en">A risk score for secondary prevention after myocardial infarction (Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention [TRS2P]), based on 9 established clinical factors, was recently developed from the<jats:styled-content style="fixed-case">TRA</jats:styled-content>2°P‐<jats:styled-content style="fixed-case">TIMI</jats:styled-content>50 (Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events) trial. We aimed to evaluate the performance of<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P for predicting long‐term outcomes in real‐world patients presenting for coronary angiography.</jats:p></jats:sec><jats:sec xml:lang="en"><jats:title>Methods and Results</jats:title><jats:p xml:lang="en">A retrospective analysis of 13 593 patients referred to angiography for the assessment or treatment of coronary disease was performed. Risk stratification for 10‐year major adverse cardiovascular events was performed using the<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, divided into 6 categories (0 to ≥5 points), and in relation to the presenting coronary syndrome. All clinical variables, except prior coronary artery bypass grafting, were independent risk predictors. The annualized incidence rate of major adverse cardiovascular events increased in a graded manner with increasing<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, ranging from 1.65 to 16.6 per 100 person‐years (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub><0.001). Compared with the lowest‐risk group (risk indicators=0), the hazard ratios (95% CIs) for 10‐year major adverse cardiovascular events were 1.60 (95% CI, 1.36–1.89), 2.58 (95% CI, 2.21–3.02), 4.31 (95% CI, 3.69–5.05), 6.43 (95% CI, 5.47–7.56), and 10.03 (95% CI, 8.52–11.81), in those with 1, 2, 3, 4 and ≥5 risk indicators, respectively. Risk gradation was consistent among individual clinical end points.<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P showed reasonable discrimination with C‐statistics of 0.693 for major adverse cardiovascular events and 0.758 for mortality. The graded relationship between the risk score and event rates was observed in both patients presenting with acute and nonacute coronary syndromes.</jats:p></jats:sec><jats:sec xml:lang="en"><jats:title>Conclusions</jats:title><jats:p xml:lang="en">The use of<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, a simple risk score based on routinely collected variables, enables risk stratification in patients undergoing coronary angiography. Its predictive value was demonstrated in a real‐world setting with long‐term follow‐up and regardless of the acuity of coronary presentation.</jats:p></jats:sec> |
| container_issue |
14 |
| container_start_page |
0 |
| container_title |
Journal of the American Heart Association |
| container_volume |
8 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792340857853050889 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:10:41.65Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Long%E2%80%90Term+Risk+Stratification+of+Patients+Undergoing+Coronary+Angiography+According+to+the+Thrombolysis+in+Myocardial+Infarction%C2%A0Risk+Score+for+Secondary+Prevention&rft.date=2019-07-16&genre=article&issn=2047-9980&volume=8&issue=14&jtitle=Journal+of+the+American+Heart+Association&atitle=Long%E2%80%90Term+Risk+Stratification+of+Patients+Undergoing+Coronary+Angiography+According+to+the+Thrombolysis+in+Myocardial+Infarction%C2%A0Risk+Score+for+Secondary+Prevention&aulast=Saliba&aufirst=Walid&rft_id=info%3Adoi%2F10.1161%2Fjaha.119.012433&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792340857853050889 |
| author | Zafrir, Barak, Adawi, Salim, Khalaily, Marah, Jaffe, Ronen, Eitan, Amnon, Barnett‐Griness, Ofra, Saliba, Walid |
| author_facet | Zafrir, Barak, Adawi, Salim, Khalaily, Marah, Jaffe, Ronen, Eitan, Amnon, Barnett‐Griness, Ofra, Saliba, Walid, Zafrir, Barak, Adawi, Salim, Khalaily, Marah, Jaffe, Ronen, Eitan, Amnon, Barnett‐Griness, Ofra, Saliba, Walid |
| author_sort | zafrir, barak |
| container_issue | 14 |
| container_start_page | 0 |
| container_title | Journal of the American Heart Association |
| container_volume | 8 |
| description | <jats:sec xml:lang="en"><jats:title>Background</jats:title><jats:p xml:lang="en">A risk score for secondary prevention after myocardial infarction (Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention [TRS2P]), based on 9 established clinical factors, was recently developed from the<jats:styled-content style="fixed-case">TRA</jats:styled-content>2°P‐<jats:styled-content style="fixed-case">TIMI</jats:styled-content>50 (Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events) trial. We aimed to evaluate the performance of<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P for predicting long‐term outcomes in real‐world patients presenting for coronary angiography.</jats:p></jats:sec><jats:sec xml:lang="en"><jats:title>Methods and Results</jats:title><jats:p xml:lang="en">A retrospective analysis of 13 593 patients referred to angiography for the assessment or treatment of coronary disease was performed. Risk stratification for 10‐year major adverse cardiovascular events was performed using the<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, divided into 6 categories (0 to ≥5 points), and in relation to the presenting coronary syndrome. All clinical variables, except prior coronary artery bypass grafting, were independent risk predictors. The annualized incidence rate of major adverse cardiovascular events increased in a graded manner with increasing<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, ranging from 1.65 to 16.6 per 100 person‐years (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub><0.001). Compared with the lowest‐risk group (risk indicators=0), the hazard ratios (95% CIs) for 10‐year major adverse cardiovascular events were 1.60 (95% CI, 1.36–1.89), 2.58 (95% CI, 2.21–3.02), 4.31 (95% CI, 3.69–5.05), 6.43 (95% CI, 5.47–7.56), and 10.03 (95% CI, 8.52–11.81), in those with 1, 2, 3, 4 and ≥5 risk indicators, respectively. Risk gradation was consistent among individual clinical end points.<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P showed reasonable discrimination with C‐statistics of 0.693 for major adverse cardiovascular events and 0.758 for mortality. The graded relationship between the risk score and event rates was observed in both patients presenting with acute and nonacute coronary syndromes.</jats:p></jats:sec><jats:sec xml:lang="en"><jats:title>Conclusions</jats:title><jats:p xml:lang="en">The use of<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, a simple risk score based on routinely collected variables, enables risk stratification in patients undergoing coronary angiography. Its predictive value was demonstrated in a real‐world setting with long‐term follow‐up and regardless of the acuity of coronary presentation.</jats:p></jats:sec> |
| doi_str_mv | 10.1161/jaha.119.012433 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2MS9qYWhhLjExOS4wMTI0MzM |
| imprint | Ovid Technologies (Wolters Kluwer Health), 2019 |
| imprint_str_mv | Ovid Technologies (Wolters Kluwer Health), 2019 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
| issn | 2047-9980 |
| issn_str_mv | 2047-9980 |
| language | English |
| last_indexed | 2024-03-01T16:10:41.65Z |
| match_str | zafrir2019longtermriskstratificationofpatientsundergoingcoronaryangiographyaccordingtothethrombolysisinmyocardialinfarctionriskscoreforsecondaryprevention |
| mega_collection | Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| physical | |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Ovid Technologies (Wolters Kluwer Health) |
| record_format | ai |
| recordtype | ai |
| series | Journal of the American Heart Association |
| source_id | 49 |
| spelling | Zafrir, Barak Adawi, Salim Khalaily, Marah Jaffe, Ronen Eitan, Amnon Barnett‐Griness, Ofra Saliba, Walid 2047-9980 Ovid Technologies (Wolters Kluwer Health) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/jaha.119.012433 <jats:sec xml:lang="en"><jats:title>Background</jats:title><jats:p xml:lang="en">A risk score for secondary prevention after myocardial infarction (Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention [TRS2P]), based on 9 established clinical factors, was recently developed from the<jats:styled-content style="fixed-case">TRA</jats:styled-content>2°P‐<jats:styled-content style="fixed-case">TIMI</jats:styled-content>50 (Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events) trial. We aimed to evaluate the performance of<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P for predicting long‐term outcomes in real‐world patients presenting for coronary angiography.</jats:p></jats:sec><jats:sec xml:lang="en"><jats:title>Methods and Results</jats:title><jats:p xml:lang="en">A retrospective analysis of 13 593 patients referred to angiography for the assessment or treatment of coronary disease was performed. Risk stratification for 10‐year major adverse cardiovascular events was performed using the<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, divided into 6 categories (0 to ≥5 points), and in relation to the presenting coronary syndrome. All clinical variables, except prior coronary artery bypass grafting, were independent risk predictors. The annualized incidence rate of major adverse cardiovascular events increased in a graded manner with increasing<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, ranging from 1.65 to 16.6 per 100 person‐years (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub><0.001). Compared with the lowest‐risk group (risk indicators=0), the hazard ratios (95% CIs) for 10‐year major adverse cardiovascular events were 1.60 (95% CI, 1.36–1.89), 2.58 (95% CI, 2.21–3.02), 4.31 (95% CI, 3.69–5.05), 6.43 (95% CI, 5.47–7.56), and 10.03 (95% CI, 8.52–11.81), in those with 1, 2, 3, 4 and ≥5 risk indicators, respectively. Risk gradation was consistent among individual clinical end points.<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P showed reasonable discrimination with C‐statistics of 0.693 for major adverse cardiovascular events and 0.758 for mortality. The graded relationship between the risk score and event rates was observed in both patients presenting with acute and nonacute coronary syndromes.</jats:p></jats:sec><jats:sec xml:lang="en"><jats:title>Conclusions</jats:title><jats:p xml:lang="en">The use of<jats:styled-content style="fixed-case">TRS</jats:styled-content>2P, a simple risk score based on routinely collected variables, enables risk stratification in patients undergoing coronary angiography. Its predictive value was demonstrated in a real‐world setting with long‐term follow‐up and regardless of the acuity of coronary presentation.</jats:p></jats:sec> Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention Journal of the American Heart Association |
| spellingShingle | Zafrir, Barak, Adawi, Salim, Khalaily, Marah, Jaffe, Ronen, Eitan, Amnon, Barnett‐Griness, Ofra, Saliba, Walid, Journal of the American Heart Association, Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention, Cardiology and Cardiovascular Medicine |
| title | Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_full | Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_fullStr | Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_full_unstemmed | Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_short | Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| title_sort | long‐term risk stratification of patients undergoing coronary angiography according to the thrombolysis in myocardial infarction risk score for secondary prevention |
| title_unstemmed | Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention |
| topic | Cardiology and Cardiovascular Medicine |
| url | http://dx.doi.org/10.1161/jaha.119.012433 |