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Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats...
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| Zeitschriftentitel: | Journal of the American Heart Association |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Journal of the American Heart Association, 5, 2016, 10 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Huang, Hefei Li, Xiaolong Zheng, Shuo Chen, Yue Chen, Caiyu Wang, Jialiang Tong, Haipeng Zhou, Lin Yang, Jian Zeng, Chunyu Huang, Hefei Li, Xiaolong Zheng, Shuo Chen, Yue Chen, Caiyu Wang, Jialiang Tong, Haipeng Zhou, Lin Yang, Jian Zeng, Chunyu |
|---|---|
| author |
Huang, Hefei Li, Xiaolong Zheng, Shuo Chen, Yue Chen, Caiyu Wang, Jialiang Tong, Haipeng Zhou, Lin Yang, Jian Zeng, Chunyu |
| spellingShingle |
Huang, Hefei Li, Xiaolong Zheng, Shuo Chen, Yue Chen, Caiyu Wang, Jialiang Tong, Haipeng Zhou, Lin Yang, Jian Zeng, Chunyu Journal of the American Heart Association Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats Cardiology and Cardiovascular Medicine |
| author_sort |
huang, hefei |
| spelling |
Huang, Hefei Li, Xiaolong Zheng, Shuo Chen, Yue Chen, Caiyu Wang, Jialiang Tong, Haipeng Zhou, Lin Yang, Jian Zeng, Chunyu 2047-9980 Ovid Technologies (Wolters Kluwer Health) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/jaha.116.004028 <jats:sec xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en"> G protein–coupled receptor kinase type 4 ( <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4) plays a vital role in the long‐term control of blood pressure (BP) and sodium excretion by regulating renal G protein–coupled receptor phosphorylation, including dopamine type 1 receptor (D <jats:sub>1</jats:sub> R). Ultrasound‐targeted microbubble destruction ( <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ) is a promising method for gene delivery. Whether this method can deliver <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 small interfering RNA (si <jats:styled-content style="fixed-case">RNA)</jats:styled-content> and lower BP is not known. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en"> BP, 24‐hour sodium excretion, and urine volume were measured after <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ‐targeted <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 si <jats:styled-content style="fixed-case">RNA</jats:styled-content> delivery to the kidney in spontaneously hypertensive rats. The expression levels of <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 and D <jats:sub>1</jats:sub> R were determined by immunoblotting. The phosphorylation of D <jats:sub>1</jats:sub> R was investigated using immunoprecipitation. The present study revealed that <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ‐mediated renal <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 si <jats:styled-content style="fixed-case">RNA</jats:styled-content> delivery efficiently reduced <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 expression and lowered BP in spontaneously hypertensive rats, accompanied by increased sodium excretion. The increased sodium excretion might be accounted for by the <jats:styled-content style="fixed-case">UTMD</jats:styled-content> regulation of D <jats:sub>1</jats:sub> R phosphorylation and function in spontaneously hypertensive rats. Further analysis showed that, although <jats:styled-content style="fixed-case">UTMD</jats:styled-content> had no effect on D <jats:sub>1</jats:sub> R expression, it reduced D <jats:sub>1</jats:sub> R phosphorylation in spontaneously hypertensive rats kidneys and consequently increased D <jats:sub>1</jats:sub> R‐mediated natriuresis and diuresis. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en"> Taken together, these study results indicate that <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ‐targeted <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 si <jats:styled-content style="fixed-case">RNA</jats:styled-content> delivery to the kidney effectively reduces D <jats:sub>1</jats:sub> R phosphorylation by inhibiting renal <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 expression, improving D <jats:sub>1</jats:sub> R‐mediated natriuresis and diuresis, and lowering BP, which may provide a promising novel strategy for gene therapy for hypertension. </jats:p> </jats:sec> Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats Journal of the American Heart Association |
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2016 |
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Ovid Technologies (Wolters Kluwer Health) |
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ai |
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Journal of the American Heart Association |
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| title |
Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_unstemmed |
Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_full |
Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_fullStr |
Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_full_unstemmed |
Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_short |
Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_sort |
downregulation of renal g protein–coupled receptor kinase type 4 expression via ultrasound‐targeted microbubble destruction lowers blood pressure in spontaneously hypertensive rats |
| topic |
Cardiology and Cardiovascular Medicine |
| url |
http://dx.doi.org/10.1161/jaha.116.004028 |
| publishDate |
2016 |
| physical |
|
| description |
<jats:sec xml:lang="en">
<jats:title>Background</jats:title>
<jats:p xml:lang="en">
G protein–coupled receptor kinase type 4 (
<jats:styled-content style="fixed-case">GRK</jats:styled-content>
4) plays a vital role in the long‐term control of blood pressure (BP) and sodium excretion by regulating renal G protein–coupled receptor phosphorylation, including dopamine type 1 receptor (D
<jats:sub>1</jats:sub>
R). Ultrasound‐targeted microbubble destruction (
<jats:styled-content style="fixed-case">UTMD</jats:styled-content>
) is a promising method for gene delivery. Whether this method can deliver
<jats:styled-content style="fixed-case">GRK</jats:styled-content>
4 small interfering RNA (si
<jats:styled-content style="fixed-case">RNA)</jats:styled-content>
and lower BP is not known.
</jats:p>
</jats:sec>
<jats:sec xml:lang="en">
<jats:title>Methods and Results</jats:title>
<jats:p xml:lang="en">
BP, 24‐hour sodium excretion, and urine volume were measured after
<jats:styled-content style="fixed-case">UTMD</jats:styled-content>
‐targeted
<jats:styled-content style="fixed-case">GRK</jats:styled-content>
4 si
<jats:styled-content style="fixed-case">RNA</jats:styled-content>
delivery to the kidney in spontaneously hypertensive rats. The expression levels of
<jats:styled-content style="fixed-case">GRK</jats:styled-content>
4 and D
<jats:sub>1</jats:sub>
R were determined by immunoblotting. The phosphorylation of D
<jats:sub>1</jats:sub>
R was investigated using immunoprecipitation. The present study revealed that
<jats:styled-content style="fixed-case">UTMD</jats:styled-content>
‐mediated renal
<jats:styled-content style="fixed-case">GRK</jats:styled-content>
4 si
<jats:styled-content style="fixed-case">RNA</jats:styled-content>
delivery efficiently reduced
<jats:styled-content style="fixed-case">GRK</jats:styled-content>
4 expression and lowered BP in spontaneously hypertensive rats, accompanied by increased sodium excretion. The increased sodium excretion might be accounted for by the
<jats:styled-content style="fixed-case">UTMD</jats:styled-content>
regulation of D
<jats:sub>1</jats:sub>
R phosphorylation and function in spontaneously hypertensive rats. Further analysis showed that, although
<jats:styled-content style="fixed-case">UTMD</jats:styled-content>
had no effect on D
<jats:sub>1</jats:sub>
R expression, it reduced D
<jats:sub>1</jats:sub>
R phosphorylation in spontaneously hypertensive rats kidneys and consequently increased D
<jats:sub>1</jats:sub>
R‐mediated natriuresis and diuresis.
</jats:p>
</jats:sec>
<jats:sec xml:lang="en">
<jats:title>Conclusions</jats:title>
<jats:p xml:lang="en">
Taken together, these study results indicate that
<jats:styled-content style="fixed-case">UTMD</jats:styled-content>
‐targeted
<jats:styled-content style="fixed-case">GRK</jats:styled-content>
4 si
<jats:styled-content style="fixed-case">RNA</jats:styled-content>
delivery to the kidney effectively reduces D
<jats:sub>1</jats:sub>
R phosphorylation by inhibiting renal
<jats:styled-content style="fixed-case">GRK</jats:styled-content>
4 expression, improving D
<jats:sub>1</jats:sub>
R‐mediated natriuresis and diuresis, and lowering BP, which may provide a promising novel strategy for gene therapy for hypertension.
</jats:p>
</jats:sec> |
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| description | <jats:sec xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en"> G protein–coupled receptor kinase type 4 ( <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4) plays a vital role in the long‐term control of blood pressure (BP) and sodium excretion by regulating renal G protein–coupled receptor phosphorylation, including dopamine type 1 receptor (D <jats:sub>1</jats:sub> R). Ultrasound‐targeted microbubble destruction ( <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ) is a promising method for gene delivery. Whether this method can deliver <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 small interfering RNA (si <jats:styled-content style="fixed-case">RNA)</jats:styled-content> and lower BP is not known. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en"> BP, 24‐hour sodium excretion, and urine volume were measured after <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ‐targeted <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 si <jats:styled-content style="fixed-case">RNA</jats:styled-content> delivery to the kidney in spontaneously hypertensive rats. The expression levels of <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 and D <jats:sub>1</jats:sub> R were determined by immunoblotting. The phosphorylation of D <jats:sub>1</jats:sub> R was investigated using immunoprecipitation. The present study revealed that <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ‐mediated renal <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 si <jats:styled-content style="fixed-case">RNA</jats:styled-content> delivery efficiently reduced <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 expression and lowered BP in spontaneously hypertensive rats, accompanied by increased sodium excretion. The increased sodium excretion might be accounted for by the <jats:styled-content style="fixed-case">UTMD</jats:styled-content> regulation of D <jats:sub>1</jats:sub> R phosphorylation and function in spontaneously hypertensive rats. Further analysis showed that, although <jats:styled-content style="fixed-case">UTMD</jats:styled-content> had no effect on D <jats:sub>1</jats:sub> R expression, it reduced D <jats:sub>1</jats:sub> R phosphorylation in spontaneously hypertensive rats kidneys and consequently increased D <jats:sub>1</jats:sub> R‐mediated natriuresis and diuresis. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en"> Taken together, these study results indicate that <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ‐targeted <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 si <jats:styled-content style="fixed-case">RNA</jats:styled-content> delivery to the kidney effectively reduces D <jats:sub>1</jats:sub> R phosphorylation by inhibiting renal <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 expression, improving D <jats:sub>1</jats:sub> R‐mediated natriuresis and diuresis, and lowering BP, which may provide a promising novel strategy for gene therapy for hypertension. </jats:p> </jats:sec> |
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| spelling | Huang, Hefei Li, Xiaolong Zheng, Shuo Chen, Yue Chen, Caiyu Wang, Jialiang Tong, Haipeng Zhou, Lin Yang, Jian Zeng, Chunyu 2047-9980 Ovid Technologies (Wolters Kluwer Health) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/jaha.116.004028 <jats:sec xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en"> G protein–coupled receptor kinase type 4 ( <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4) plays a vital role in the long‐term control of blood pressure (BP) and sodium excretion by regulating renal G protein–coupled receptor phosphorylation, including dopamine type 1 receptor (D <jats:sub>1</jats:sub> R). Ultrasound‐targeted microbubble destruction ( <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ) is a promising method for gene delivery. Whether this method can deliver <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 small interfering RNA (si <jats:styled-content style="fixed-case">RNA)</jats:styled-content> and lower BP is not known. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en"> BP, 24‐hour sodium excretion, and urine volume were measured after <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ‐targeted <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 si <jats:styled-content style="fixed-case">RNA</jats:styled-content> delivery to the kidney in spontaneously hypertensive rats. The expression levels of <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 and D <jats:sub>1</jats:sub> R were determined by immunoblotting. The phosphorylation of D <jats:sub>1</jats:sub> R was investigated using immunoprecipitation. The present study revealed that <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ‐mediated renal <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 si <jats:styled-content style="fixed-case">RNA</jats:styled-content> delivery efficiently reduced <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 expression and lowered BP in spontaneously hypertensive rats, accompanied by increased sodium excretion. The increased sodium excretion might be accounted for by the <jats:styled-content style="fixed-case">UTMD</jats:styled-content> regulation of D <jats:sub>1</jats:sub> R phosphorylation and function in spontaneously hypertensive rats. Further analysis showed that, although <jats:styled-content style="fixed-case">UTMD</jats:styled-content> had no effect on D <jats:sub>1</jats:sub> R expression, it reduced D <jats:sub>1</jats:sub> R phosphorylation in spontaneously hypertensive rats kidneys and consequently increased D <jats:sub>1</jats:sub> R‐mediated natriuresis and diuresis. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en"> Taken together, these study results indicate that <jats:styled-content style="fixed-case">UTMD</jats:styled-content> ‐targeted <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 si <jats:styled-content style="fixed-case">RNA</jats:styled-content> delivery to the kidney effectively reduces D <jats:sub>1</jats:sub> R phosphorylation by inhibiting renal <jats:styled-content style="fixed-case">GRK</jats:styled-content> 4 expression, improving D <jats:sub>1</jats:sub> R‐mediated natriuresis and diuresis, and lowering BP, which may provide a promising novel strategy for gene therapy for hypertension. </jats:p> </jats:sec> Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats Journal of the American Heart Association |
| spellingShingle | Huang, Hefei, Li, Xiaolong, Zheng, Shuo, Chen, Yue, Chen, Caiyu, Wang, Jialiang, Tong, Haipeng, Zhou, Lin, Yang, Jian, Zeng, Chunyu, Journal of the American Heart Association, Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats, Cardiology and Cardiovascular Medicine |
| title | Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_full | Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_fullStr | Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_full_unstemmed | Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_short | Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| title_sort | downregulation of renal g protein–coupled receptor kinase type 4 expression via ultrasound‐targeted microbubble destruction lowers blood pressure in spontaneously hypertensive rats |
| title_unstemmed | Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats |
| topic | Cardiology and Cardiovascular Medicine |
| url | http://dx.doi.org/10.1161/jaha.116.004028 |