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Multimodal Regulation of Cardiac Myocyte Proliferation
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| Zeitschriftentitel: | Circulation Research |
|---|---|
| Personen und Körperschaften: | , |
| In: | Circulation Research, 121, 2017, 3, S. 293-309 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
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Yuan, Xuejun Braun, Thomas Yuan, Xuejun Braun, Thomas |
|---|---|
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Yuan, Xuejun Braun, Thomas |
| spellingShingle |
Yuan, Xuejun Braun, Thomas Circulation Research Multimodal Regulation of Cardiac Myocyte Proliferation Cardiology and Cardiovascular Medicine Physiology |
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yuan, xuejun |
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Yuan, Xuejun Braun, Thomas 0009-7330 1524-4571 Ovid Technologies (Wolters Kluwer Health) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1161/circresaha.117.308428 <jats:p>Efficient cardiac regeneration is closely associated with the ability of cardiac myocytes to proliferate. Fetal or neonatal mouse hearts containing proliferating cardiac myocytes regenerate even extensive injuries, whereas adult hearts containing mostly post-mitotic cardiac myocytes have lost this ability. The same correlation is seen in some homoiotherm species such as teleost fish and urodelian amphibians leading to the hypothesis that cardiac myocyte proliferation is a major driver of heart regeneration. Although cardiomyocyte proliferation might not be the only prerequisite to restore full organ function after cardiac damage, induction of cardiac myocyte proliferation is an attractive therapeutic option to cure the injured heart and prevent heart failure. To (re)initiate cardiac myocyte proliferation in adult mammalian hearts, a thorough understanding of the molecular circuitry governing cardiac myocyte cell cycle regulation is required. Here, we review the current knowledge in the field focusing on the withdrawal of cardiac myocytes from the cell cycle during the transition from neonatal to adult stages.</jats:p> Multimodal Regulation of Cardiac Myocyte Proliferation Circulation Research |
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| title |
Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_unstemmed |
Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_full |
Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_fullStr |
Multimodal Regulation of Cardiac Myocyte Proliferation |
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Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_short |
Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_sort |
multimodal regulation of cardiac myocyte proliferation |
| topic |
Cardiology and Cardiovascular Medicine Physiology |
| url |
http://dx.doi.org/10.1161/circresaha.117.308428 |
| publishDate |
2017 |
| physical |
293-309 |
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<jats:p>Efficient cardiac regeneration is closely associated with the ability of cardiac myocytes to proliferate. Fetal or neonatal mouse hearts containing proliferating cardiac myocytes regenerate even extensive injuries, whereas adult hearts containing mostly post-mitotic cardiac myocytes have lost this ability. The same correlation is seen in some homoiotherm species such as teleost fish and urodelian amphibians leading to the hypothesis that cardiac myocyte proliferation is a major driver of heart regeneration. Although cardiomyocyte proliferation might not be the only prerequisite to restore full organ function after cardiac damage, induction of cardiac myocyte proliferation is an attractive therapeutic option to cure the injured heart and prevent heart failure. To (re)initiate cardiac myocyte proliferation in adult mammalian hearts, a thorough understanding of the molecular circuitry governing cardiac myocyte cell cycle regulation is required. Here, we review the current knowledge in the field focusing on the withdrawal of cardiac myocytes from the cell cycle during the transition from neonatal to adult stages.</jats:p> |
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| description | <jats:p>Efficient cardiac regeneration is closely associated with the ability of cardiac myocytes to proliferate. Fetal or neonatal mouse hearts containing proliferating cardiac myocytes regenerate even extensive injuries, whereas adult hearts containing mostly post-mitotic cardiac myocytes have lost this ability. The same correlation is seen in some homoiotherm species such as teleost fish and urodelian amphibians leading to the hypothesis that cardiac myocyte proliferation is a major driver of heart regeneration. Although cardiomyocyte proliferation might not be the only prerequisite to restore full organ function after cardiac damage, induction of cardiac myocyte proliferation is an attractive therapeutic option to cure the injured heart and prevent heart failure. To (re)initiate cardiac myocyte proliferation in adult mammalian hearts, a thorough understanding of the molecular circuitry governing cardiac myocyte cell cycle regulation is required. Here, we review the current knowledge in the field focusing on the withdrawal of cardiac myocytes from the cell cycle during the transition from neonatal to adult stages.</jats:p> |
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| physical | 293-309 |
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| spelling | Yuan, Xuejun Braun, Thomas 0009-7330 1524-4571 Ovid Technologies (Wolters Kluwer Health) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1161/circresaha.117.308428 <jats:p>Efficient cardiac regeneration is closely associated with the ability of cardiac myocytes to proliferate. Fetal or neonatal mouse hearts containing proliferating cardiac myocytes regenerate even extensive injuries, whereas adult hearts containing mostly post-mitotic cardiac myocytes have lost this ability. The same correlation is seen in some homoiotherm species such as teleost fish and urodelian amphibians leading to the hypothesis that cardiac myocyte proliferation is a major driver of heart regeneration. Although cardiomyocyte proliferation might not be the only prerequisite to restore full organ function after cardiac damage, induction of cardiac myocyte proliferation is an attractive therapeutic option to cure the injured heart and prevent heart failure. To (re)initiate cardiac myocyte proliferation in adult mammalian hearts, a thorough understanding of the molecular circuitry governing cardiac myocyte cell cycle regulation is required. Here, we review the current knowledge in the field focusing on the withdrawal of cardiac myocytes from the cell cycle during the transition from neonatal to adult stages.</jats:p> Multimodal Regulation of Cardiac Myocyte Proliferation Circulation Research |
| spellingShingle | Yuan, Xuejun, Braun, Thomas, Circulation Research, Multimodal Regulation of Cardiac Myocyte Proliferation, Cardiology and Cardiovascular Medicine, Physiology |
| title | Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_full | Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_fullStr | Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_full_unstemmed | Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_short | Multimodal Regulation of Cardiac Myocyte Proliferation |
| title_sort | multimodal regulation of cardiac myocyte proliferation |
| title_unstemmed | Multimodal Regulation of Cardiac Myocyte Proliferation |
| topic | Cardiology and Cardiovascular Medicine, Physiology |
| url | http://dx.doi.org/10.1161/circresaha.117.308428 |