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A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy.
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| Zeitschriftentitel: | Stroke |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Stroke, 19, 1988, 10, S. 1262-1266 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Molnár, L Hegedüs, K Fekete, I Molnár, L Hegedüs, K Fekete, I |
|---|---|
| author |
Molnár, L Hegedüs, K Fekete, I |
| spellingShingle |
Molnár, L Hegedüs, K Fekete, I Stroke A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| author_sort |
molnár, l |
| spelling |
Molnár, L Hegedüs, K Fekete, I 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/01.str.19.10.1262 <jats:p>An artificial ball removable by an attached fiber was injected into the middle cerebral artery (MCA) of 16 rabbits, allowing the study of transient (5, 10, 15, or 30 minutes) cerebral ischemia without craniectomy. Measurements of available oxygen (aO2) in the ischemic core (the ventral part of the temporal area) followed by histologic examination verified the embolization. Electroencephalographic power spectra and steady (direct current) potentials were recorded bilaterally on the convexity remote from the actual lesion but still supplied by the MCA. Local cerebral blood flow and aO2 in the border zone between the anterior cerebral artery and the occluded MCA were measured. Embolization caused typical ischemic changes ipsilaterally and alterations characteristic of diaschisis contralaterally. Extreme border zone hyperemia developed without significant aO2 changes in the same region. Restoration of circulation via the circle of Willis induced gradual normalization. Our model for controlled embolization and recirculation proved suitable for detailed studies of the complex changes in brain function caused by transient ischemia.</jats:p> A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. Stroke |
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| title |
A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_unstemmed |
A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_full |
A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_fullStr |
A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_full_unstemmed |
A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_short |
A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_sort |
a new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| topic |
Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| url |
http://dx.doi.org/10.1161/01.str.19.10.1262 |
| publishDate |
1988 |
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1262-1266 |
| description |
<jats:p>An artificial ball removable by an attached fiber was injected into the middle cerebral artery (MCA) of 16 rabbits, allowing the study of transient (5, 10, 15, or 30 minutes) cerebral ischemia without craniectomy. Measurements of available oxygen (aO2) in the ischemic core (the ventral part of the temporal area) followed by histologic examination verified the embolization. Electroencephalographic power spectra and steady (direct current) potentials were recorded bilaterally on the convexity remote from the actual lesion but still supplied by the MCA. Local cerebral blood flow and aO2 in the border zone between the anterior cerebral artery and the occluded MCA were measured. Embolization caused typical ischemic changes ipsilaterally and alterations characteristic of diaschisis contralaterally. Extreme border zone hyperemia developed without significant aO2 changes in the same region. Restoration of circulation via the circle of Willis induced gradual normalization. Our model for controlled embolization and recirculation proved suitable for detailed studies of the complex changes in brain function caused by transient ischemia.</jats:p> |
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| author | Molnár, L, Hegedüs, K, Fekete, I |
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| description | <jats:p>An artificial ball removable by an attached fiber was injected into the middle cerebral artery (MCA) of 16 rabbits, allowing the study of transient (5, 10, 15, or 30 minutes) cerebral ischemia without craniectomy. Measurements of available oxygen (aO2) in the ischemic core (the ventral part of the temporal area) followed by histologic examination verified the embolization. Electroencephalographic power spectra and steady (direct current) potentials were recorded bilaterally on the convexity remote from the actual lesion but still supplied by the MCA. Local cerebral blood flow and aO2 in the border zone between the anterior cerebral artery and the occluded MCA were measured. Embolization caused typical ischemic changes ipsilaterally and alterations characteristic of diaschisis contralaterally. Extreme border zone hyperemia developed without significant aO2 changes in the same region. Restoration of circulation via the circle of Willis induced gradual normalization. Our model for controlled embolization and recirculation proved suitable for detailed studies of the complex changes in brain function caused by transient ischemia.</jats:p> |
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| spelling | Molnár, L Hegedüs, K Fekete, I 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/01.str.19.10.1262 <jats:p>An artificial ball removable by an attached fiber was injected into the middle cerebral artery (MCA) of 16 rabbits, allowing the study of transient (5, 10, 15, or 30 minutes) cerebral ischemia without craniectomy. Measurements of available oxygen (aO2) in the ischemic core (the ventral part of the temporal area) followed by histologic examination verified the embolization. Electroencephalographic power spectra and steady (direct current) potentials were recorded bilaterally on the convexity remote from the actual lesion but still supplied by the MCA. Local cerebral blood flow and aO2 in the border zone between the anterior cerebral artery and the occluded MCA were measured. Embolization caused typical ischemic changes ipsilaterally and alterations characteristic of diaschisis contralaterally. Extreme border zone hyperemia developed without significant aO2 changes in the same region. Restoration of circulation via the circle of Willis induced gradual normalization. Our model for controlled embolization and recirculation proved suitable for detailed studies of the complex changes in brain function caused by transient ischemia.</jats:p> A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. Stroke |
| spellingShingle | Molnár, L, Hegedüs, K, Fekete, I, Stroke, A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy., Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| title | A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_full | A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_fullStr | A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_full_unstemmed | A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_short | A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_sort | a new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| title_unstemmed | A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. |
| topic | Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| url | http://dx.doi.org/10.1161/01.str.19.10.1262 |