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Pattern Recognition Receptors in Immune Disorders Affecting the Skin
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| Zeitschriftentitel: | Journal of Innate Immunity |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Journal of Innate Immunity, 4, 2012, 3, S. 225-240 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
S. Karger AG
|
| Schlagwörter: |
| author_facet |
de Koning, Heleen D. Simon, Anna Zeeuwen, Patrick L.J.M. Schalkwijk, Joost de Koning, Heleen D. Simon, Anna Zeeuwen, Patrick L.J.M. Schalkwijk, Joost |
|---|---|
| author |
de Koning, Heleen D. Simon, Anna Zeeuwen, Patrick L.J.M. Schalkwijk, Joost |
| spellingShingle |
de Koning, Heleen D. Simon, Anna Zeeuwen, Patrick L.J.M. Schalkwijk, Joost Journal of Innate Immunity Pattern Recognition Receptors in Immune Disorders Affecting the Skin Immunology and Allergy |
| author_sort |
de koning, heleen d. |
| spelling |
de Koning, Heleen D. Simon, Anna Zeeuwen, Patrick L.J.M. Schalkwijk, Joost 1662-811X 1662-8128 S. Karger AG Immunology and Allergy http://dx.doi.org/10.1159/000335900 <jats:p>Pattern recognition receptors (PRRs) evolved to protect organisms against pathogens, but excessive signaling can induce immune responses that are harmful to the host. Putative PRR dysfunction is associated with numerous immune disorders that affect the skin, such as systemic lupus erythematosus, cryopyrin-associated periodic syndrome, and primary inflammatory skin diseases including psoriasis and atopic dermatitis. As yet, the evidence is often confined to genetic association studies without additional proof of a causal relationship. However, insight into the role of PRRs in the pathophysiology of some disorders has already resulted in new therapeutic approaches based on immunomodulation of PRRs.</jats:p> Pattern Recognition Receptors in Immune Disorders Affecting the Skin Journal of Innate Immunity |
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2012 |
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S. Karger AG |
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Journal of Innate Immunity |
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49 |
| title |
Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
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Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
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Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
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Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
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Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
| title_short |
Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
| title_sort |
pattern recognition receptors in immune disorders affecting the skin |
| topic |
Immunology and Allergy |
| url |
http://dx.doi.org/10.1159/000335900 |
| publishDate |
2012 |
| physical |
225-240 |
| description |
<jats:p>Pattern recognition receptors (PRRs) evolved to protect organisms against pathogens, but excessive signaling can induce immune responses that are harmful to the host. Putative PRR dysfunction is associated with numerous immune disorders that affect the skin, such as systemic lupus erythematosus, cryopyrin-associated periodic syndrome, and primary inflammatory skin diseases including psoriasis and atopic dermatitis. As yet, the evidence is often confined to genetic association studies without additional proof of a causal relationship. However, insight into the role of PRRs in the pathophysiology of some disorders has already resulted in new therapeutic approaches based on immunomodulation of PRRs.</jats:p> |
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| author | de Koning, Heleen D., Simon, Anna, Zeeuwen, Patrick L.J.M., Schalkwijk, Joost |
| author_facet | de Koning, Heleen D., Simon, Anna, Zeeuwen, Patrick L.J.M., Schalkwijk, Joost, de Koning, Heleen D., Simon, Anna, Zeeuwen, Patrick L.J.M., Schalkwijk, Joost |
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| description | <jats:p>Pattern recognition receptors (PRRs) evolved to protect organisms against pathogens, but excessive signaling can induce immune responses that are harmful to the host. Putative PRR dysfunction is associated with numerous immune disorders that affect the skin, such as systemic lupus erythematosus, cryopyrin-associated periodic syndrome, and primary inflammatory skin diseases including psoriasis and atopic dermatitis. As yet, the evidence is often confined to genetic association studies without additional proof of a causal relationship. However, insight into the role of PRRs in the pathophysiology of some disorders has already resulted in new therapeutic approaches based on immunomodulation of PRRs.</jats:p> |
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| institution | DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| physical | 225-240 |
| publishDate | 2012 |
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| series | Journal of Innate Immunity |
| source_id | 49 |
| spelling | de Koning, Heleen D. Simon, Anna Zeeuwen, Patrick L.J.M. Schalkwijk, Joost 1662-811X 1662-8128 S. Karger AG Immunology and Allergy http://dx.doi.org/10.1159/000335900 <jats:p>Pattern recognition receptors (PRRs) evolved to protect organisms against pathogens, but excessive signaling can induce immune responses that are harmful to the host. Putative PRR dysfunction is associated with numerous immune disorders that affect the skin, such as systemic lupus erythematosus, cryopyrin-associated periodic syndrome, and primary inflammatory skin diseases including psoriasis and atopic dermatitis. As yet, the evidence is often confined to genetic association studies without additional proof of a causal relationship. However, insight into the role of PRRs in the pathophysiology of some disorders has already resulted in new therapeutic approaches based on immunomodulation of PRRs.</jats:p> Pattern Recognition Receptors in Immune Disorders Affecting the Skin Journal of Innate Immunity |
| spellingShingle | de Koning, Heleen D., Simon, Anna, Zeeuwen, Patrick L.J.M., Schalkwijk, Joost, Journal of Innate Immunity, Pattern Recognition Receptors in Immune Disorders Affecting the Skin, Immunology and Allergy |
| title | Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
| title_full | Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
| title_fullStr | Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
| title_full_unstemmed | Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
| title_short | Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
| title_sort | pattern recognition receptors in immune disorders affecting the skin |
| title_unstemmed | Pattern Recognition Receptors in Immune Disorders Affecting the Skin |
| topic | Immunology and Allergy |
| url | http://dx.doi.org/10.1159/000335900 |