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Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection
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| Zeitschriftentitel: | Journal of Innate Immunity |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Journal of Innate Immunity, 12, 2020, 2, S. 131-141 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
S. Karger AG
|
| Schlagwörter: |
| author_facet |
van den Broek, Bryan van der Flier, Michiel de Groot, Ronald de Jonge, Marien I. Langereis, Jeroen D. van den Broek, Bryan van der Flier, Michiel de Groot, Ronald de Jonge, Marien I. Langereis, Jeroen D. |
|---|---|
| author |
van den Broek, Bryan van der Flier, Michiel de Groot, Ronald de Jonge, Marien I. Langereis, Jeroen D. |
| spellingShingle |
van den Broek, Bryan van der Flier, Michiel de Groot, Ronald de Jonge, Marien I. Langereis, Jeroen D. Journal of Innate Immunity Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection Immunology and Allergy |
| author_sort |
van den broek, bryan |
| spelling |
van den Broek, Bryan van der Flier, Michiel de Groot, Ronald de Jonge, Marien I. Langereis, Jeroen D. 1662-811X 1662-8128 S. Karger AG Immunology and Allergy http://dx.doi.org/10.1159/000500545 <jats:p><i>Streptococcus pneumoniae</i> and <i>Neisseria meningitidis</i> are pathogens that frequently colonize the nasopharynx in an asymptomatic manner but are also a cause of invasive bacterial infections mainly in young children. The complement system plays a crucial role in humoral immunity, complementing the ability of antibodies to clear microbes, thereby protecting the host against bacterial infections, including <i>S. pneumoniae</i> and <i>N. meningitidis</i>. While it is widely accepted that complement deficiencies due to rare genetic variants increase the risk for invasive bacterial infection, not much is known about the common genetic variants in the complement system in relation to disease susceptibility. In this review, we provide an overview of the effects of common genetic variants on complement activation and on complement-mediated inflammation.</jats:p> Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection Journal of Innate Immunity |
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S. Karger AG, 2020 |
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| title |
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_unstemmed |
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_full |
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_fullStr |
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_full_unstemmed |
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_short |
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_sort |
common genetic variants in the complement system and their potential link with disease susceptibility and outcome of invasive bacterial infection |
| topic |
Immunology and Allergy |
| url |
http://dx.doi.org/10.1159/000500545 |
| publishDate |
2020 |
| physical |
131-141 |
| description |
<jats:p><i>Streptococcus pneumoniae</i> and <i>Neisseria meningitidis</i> are pathogens that frequently colonize the nasopharynx in an asymptomatic manner but are also a cause of invasive bacterial infections mainly in young children. The complement system plays a crucial role in humoral immunity, complementing the ability of antibodies to clear microbes, thereby protecting the host against bacterial infections, including <i>S. pneumoniae</i> and <i>N. meningitidis</i>. While it is widely accepted that complement deficiencies due to rare genetic variants increase the risk for invasive bacterial infection, not much is known about the common genetic variants in the complement system in relation to disease susceptibility. In this review, we provide an overview of the effects of common genetic variants on complement activation and on complement-mediated inflammation.</jats:p> |
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| author | van den Broek, Bryan, van der Flier, Michiel, de Groot, Ronald, de Jonge, Marien I., Langereis, Jeroen D. |
| author_facet | van den Broek, Bryan, van der Flier, Michiel, de Groot, Ronald, de Jonge, Marien I., Langereis, Jeroen D., van den Broek, Bryan, van der Flier, Michiel, de Groot, Ronald, de Jonge, Marien I., Langereis, Jeroen D. |
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| description | <jats:p><i>Streptococcus pneumoniae</i> and <i>Neisseria meningitidis</i> are pathogens that frequently colonize the nasopharynx in an asymptomatic manner but are also a cause of invasive bacterial infections mainly in young children. The complement system plays a crucial role in humoral immunity, complementing the ability of antibodies to clear microbes, thereby protecting the host against bacterial infections, including <i>S. pneumoniae</i> and <i>N. meningitidis</i>. While it is widely accepted that complement deficiencies due to rare genetic variants increase the risk for invasive bacterial infection, not much is known about the common genetic variants in the complement system in relation to disease susceptibility. In this review, we provide an overview of the effects of common genetic variants on complement activation and on complement-mediated inflammation.</jats:p> |
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| spelling | van den Broek, Bryan van der Flier, Michiel de Groot, Ronald de Jonge, Marien I. Langereis, Jeroen D. 1662-811X 1662-8128 S. Karger AG Immunology and Allergy http://dx.doi.org/10.1159/000500545 <jats:p><i>Streptococcus pneumoniae</i> and <i>Neisseria meningitidis</i> are pathogens that frequently colonize the nasopharynx in an asymptomatic manner but are also a cause of invasive bacterial infections mainly in young children. The complement system plays a crucial role in humoral immunity, complementing the ability of antibodies to clear microbes, thereby protecting the host against bacterial infections, including <i>S. pneumoniae</i> and <i>N. meningitidis</i>. While it is widely accepted that complement deficiencies due to rare genetic variants increase the risk for invasive bacterial infection, not much is known about the common genetic variants in the complement system in relation to disease susceptibility. In this review, we provide an overview of the effects of common genetic variants on complement activation and on complement-mediated inflammation.</jats:p> Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection Journal of Innate Immunity |
| spellingShingle | van den Broek, Bryan, van der Flier, Michiel, de Groot, Ronald, de Jonge, Marien I., Langereis, Jeroen D., Journal of Innate Immunity, Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection, Immunology and Allergy |
| title | Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_full | Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_fullStr | Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_full_unstemmed | Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_short | Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| title_sort | common genetic variants in the complement system and their potential link with disease susceptibility and outcome of invasive bacterial infection |
| title_unstemmed | Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection |
| topic | Immunology and Allergy |
| url | http://dx.doi.org/10.1159/000500545 |