Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria

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Bibliographische Detailangaben
Zeitschriftentitel:	Journal of Innate Immunity
Personen und Körperschaften:	Binsker, Ulrike, Kohler, Thomas P., Hammerschmidt, Sven
In:	Journal of Innate Immunity, 11, 2019, 4, S. 303-315
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	S. Karger AG
Schlagwörter:	Immunology and Allergy

Details
Zusammenfassung:	<jats:p>A successful colonization of different compartments of the human host requires multifactorial contacts between bacterial surface proteins and host factors. Extracellular matrix proteins and matricellular proteins such as thrombospondin-1 play a pivotal role as adhesive substrates to ensure a strong interaction with pathobionts like the Gram-positive <i>Streptococcus pneumoniae</i> and <i>Staphylococcus aureus.</i> The human glycoprotein thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the bloodstream during bacteremia. Human platelets secrete thrombospondin-1, which is then acquired by invading pathogens to facilitate colonization and immune evasion. Gram-positive bacteria express a broad spectrum of surface-exposed proteins, some of which also recognize thrombospondin-1. This review highlights the importance of thrombospondin-1 as an adhesion substrate to facilitate colonization, and we summarize the variety of thrombospondin-1-binding proteins of <i>S. pneumoniae</i> and <i>S. aureus</i>.</jats:p>
Umfang:	303-315
ISSN:	1662-811X 1662-8128
DOI:	10.1159/000496033