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Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase
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| Zeitschriftentitel: | Cancer Prevention Research |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Cancer Prevention Research, 2, 2009, 4, S. 301-309 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
|
| Schlagwörter: |
| author_facet |
Fay, Judith R. Steele, Vernon Crowell, James A. Fay, Judith R. Steele, Vernon Crowell, James A. |
|---|---|
| author |
Fay, Judith R. Steele, Vernon Crowell, James A. |
| spellingShingle |
Fay, Judith R. Steele, Vernon Crowell, James A. Cancer Prevention Research Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase Cancer Research Oncology |
| author_sort |
fay, judith r. |
| spelling |
Fay, Judith R. Steele, Vernon Crowell, James A. 1940-6207 1940-6215 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1940-6207.capr-08-0166 <jats:title>Abstract</jats:title> <jats:p>Caloric restriction has long been recognized as an extremely effective cancer preventive. Current population demographics suggest that caloric excess and obesity will lead to increased cancer incidence, underscoring the need to elucidate the molecular mechanisms that couple dysregulated energy homeostasis to aberrant cell growth. The AMP-activated protein kinase (AMPK) is a critical monitor of cellular energy status, largely studied for its importance in metabolic regulation. AMPK also controls processes relevant to tumor development, including cell cycle progression, protein synthesis, cell growth, and survival. Several tumor suppressors impinge on AMPK signaling, and activation of the kinase inhibits tumor growth. However, AMPK can also promote cancer in some settings, necessitating a more complete understanding of the complexities of this signaling network. Because dysregulated energy balance is a nexus for multiple chronic diseases of aging, drugs that target these pathways may find broad utility in aging populations.</jats:p> Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase Cancer Prevention Research |
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American Association for Cancer Research (AACR), 2009 |
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American Association for Cancer Research (AACR), 2009 |
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1940-6207 1940-6215 |
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2009 |
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American Association for Cancer Research (AACR) |
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Cancer Prevention Research |
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49 |
| title |
Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_unstemmed |
Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_full |
Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_fullStr |
Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_full_unstemmed |
Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_short |
Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_sort |
energy homeostasis and cancer prevention: the amp-activated protein kinase |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1158/1940-6207.capr-08-0166 |
| publishDate |
2009 |
| physical |
301-309 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Caloric restriction has long been recognized as an extremely effective cancer preventive. Current population demographics suggest that caloric excess and obesity will lead to increased cancer incidence, underscoring the need to elucidate the molecular mechanisms that couple dysregulated energy homeostasis to aberrant cell growth. The AMP-activated protein kinase (AMPK) is a critical monitor of cellular energy status, largely studied for its importance in metabolic regulation. AMPK also controls processes relevant to tumor development, including cell cycle progression, protein synthesis, cell growth, and survival. Several tumor suppressors impinge on AMPK signaling, and activation of the kinase inhibits tumor growth. However, AMPK can also promote cancer in some settings, necessitating a more complete understanding of the complexities of this signaling network. Because dysregulated energy balance is a nexus for multiple chronic diseases of aging, drugs that target these pathways may find broad utility in aging populations.</jats:p> |
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| author | Fay, Judith R., Steele, Vernon, Crowell, James A. |
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| author_sort | fay, judith r. |
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| container_title | Cancer Prevention Research |
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| description | <jats:title>Abstract</jats:title> <jats:p>Caloric restriction has long been recognized as an extremely effective cancer preventive. Current population demographics suggest that caloric excess and obesity will lead to increased cancer incidence, underscoring the need to elucidate the molecular mechanisms that couple dysregulated energy homeostasis to aberrant cell growth. The AMP-activated protein kinase (AMPK) is a critical monitor of cellular energy status, largely studied for its importance in metabolic regulation. AMPK also controls processes relevant to tumor development, including cell cycle progression, protein synthesis, cell growth, and survival. Several tumor suppressors impinge on AMPK signaling, and activation of the kinase inhibits tumor growth. However, AMPK can also promote cancer in some settings, necessitating a more complete understanding of the complexities of this signaling network. Because dysregulated energy balance is a nexus for multiple chronic diseases of aging, drugs that target these pathways may find broad utility in aging populations.</jats:p> |
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| imprint | American Association for Cancer Research (AACR), 2009 |
| imprint_str_mv | American Association for Cancer Research (AACR), 2009 |
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| physical | 301-309 |
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| series | Cancer Prevention Research |
| source_id | 49 |
| spelling | Fay, Judith R. Steele, Vernon Crowell, James A. 1940-6207 1940-6215 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1940-6207.capr-08-0166 <jats:title>Abstract</jats:title> <jats:p>Caloric restriction has long been recognized as an extremely effective cancer preventive. Current population demographics suggest that caloric excess and obesity will lead to increased cancer incidence, underscoring the need to elucidate the molecular mechanisms that couple dysregulated energy homeostasis to aberrant cell growth. The AMP-activated protein kinase (AMPK) is a critical monitor of cellular energy status, largely studied for its importance in metabolic regulation. AMPK also controls processes relevant to tumor development, including cell cycle progression, protein synthesis, cell growth, and survival. Several tumor suppressors impinge on AMPK signaling, and activation of the kinase inhibits tumor growth. However, AMPK can also promote cancer in some settings, necessitating a more complete understanding of the complexities of this signaling network. Because dysregulated energy balance is a nexus for multiple chronic diseases of aging, drugs that target these pathways may find broad utility in aging populations.</jats:p> Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase Cancer Prevention Research |
| spellingShingle | Fay, Judith R., Steele, Vernon, Crowell, James A., Cancer Prevention Research, Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase, Cancer Research, Oncology |
| title | Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_full | Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_fullStr | Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_full_unstemmed | Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_short | Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| title_sort | energy homeostasis and cancer prevention: the amp-activated protein kinase |
| title_unstemmed | Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1158/1940-6207.capr-08-0166 |