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Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology
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| Zeitschriftentitel: | Molecular Cancer Therapeutics |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Molecular Cancer Therapeutics, 4, 2005, 11, S. 1645-1652 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
|
| Schlagwörter: |
| author_facet |
Laheru, Dan A. Pardoll, Drew M. Jaffee, Elizabeth M. Laheru, Dan A. Pardoll, Drew M. Jaffee, Elizabeth M. |
|---|---|
| author |
Laheru, Dan A. Pardoll, Drew M. Jaffee, Elizabeth M. |
| spellingShingle |
Laheru, Dan A. Pardoll, Drew M. Jaffee, Elizabeth M. Molecular Cancer Therapeutics Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology Cancer Research Oncology |
| author_sort |
laheru, dan a. |
| spelling |
Laheru, Dan A. Pardoll, Drew M. Jaffee, Elizabeth M. 1535-7163 1538-8514 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1535-7163.mct-05-0151 <jats:title>Abstract</jats:title> <jats:p>Recent advances in our understanding of the complex signaling pathways involved in immune system regulation, along with analyses of genetic differences between tumors and their normal cellular counterparts, have accelerated development of immune-based strategies for cancer treatment and prevention. More clinically relevant animal models have shown that successful immune-based strategies will require the integration of interventions that target specific tumor antigens with regulators of the antitumor immune response. Immunotherapy for cancer is at a critical crossroad, as therapeutics designed to target cancer-associated antigens and regulatory signaling molecules enter clinical trials. We outline here a paradigm for early-stage clinical development of immunotherapy combinations that use vaccines to drive tumor antigen-specific responses while simultaneously targeting immune regulatory pathways.</jats:p> Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology Molecular Cancer Therapeutics |
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American Association for Cancer Research (AACR), 2005 |
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American Association for Cancer Research (AACR), 2005 |
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| title |
Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_unstemmed |
Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_full |
Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_fullStr |
Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_full_unstemmed |
Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_short |
Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_sort |
genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1158/1535-7163.mct-05-0151 |
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2005 |
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1645-1652 |
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<jats:title>Abstract</jats:title>
<jats:p>Recent advances in our understanding of the complex signaling pathways involved in immune system regulation, along with analyses of genetic differences between tumors and their normal cellular counterparts, have accelerated development of immune-based strategies for cancer treatment and prevention. More clinically relevant animal models have shown that successful immune-based strategies will require the integration of interventions that target specific tumor antigens with regulators of the antitumor immune response. Immunotherapy for cancer is at a critical crossroad, as therapeutics designed to target cancer-associated antigens and regulatory signaling molecules enter clinical trials. We outline here a paradigm for early-stage clinical development of immunotherapy combinations that use vaccines to drive tumor antigen-specific responses while simultaneously targeting immune regulatory pathways.</jats:p> |
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| author | Laheru, Dan A., Pardoll, Drew M., Jaffee, Elizabeth M. |
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| description | <jats:title>Abstract</jats:title> <jats:p>Recent advances in our understanding of the complex signaling pathways involved in immune system regulation, along with analyses of genetic differences between tumors and their normal cellular counterparts, have accelerated development of immune-based strategies for cancer treatment and prevention. More clinically relevant animal models have shown that successful immune-based strategies will require the integration of interventions that target specific tumor antigens with regulators of the antitumor immune response. Immunotherapy for cancer is at a critical crossroad, as therapeutics designed to target cancer-associated antigens and regulatory signaling molecules enter clinical trials. We outline here a paradigm for early-stage clinical development of immunotherapy combinations that use vaccines to drive tumor antigen-specific responses while simultaneously targeting immune regulatory pathways.</jats:p> |
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| spelling | Laheru, Dan A. Pardoll, Drew M. Jaffee, Elizabeth M. 1535-7163 1538-8514 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1535-7163.mct-05-0151 <jats:title>Abstract</jats:title> <jats:p>Recent advances in our understanding of the complex signaling pathways involved in immune system regulation, along with analyses of genetic differences between tumors and their normal cellular counterparts, have accelerated development of immune-based strategies for cancer treatment and prevention. More clinically relevant animal models have shown that successful immune-based strategies will require the integration of interventions that target specific tumor antigens with regulators of the antitumor immune response. Immunotherapy for cancer is at a critical crossroad, as therapeutics designed to target cancer-associated antigens and regulatory signaling molecules enter clinical trials. We outline here a paradigm for early-stage clinical development of immunotherapy combinations that use vaccines to drive tumor antigen-specific responses while simultaneously targeting immune regulatory pathways.</jats:p> Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology Molecular Cancer Therapeutics |
| spellingShingle | Laheru, Dan A., Pardoll, Drew M., Jaffee, Elizabeth M., Molecular Cancer Therapeutics, Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology, Cancer Research, Oncology |
| title | Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_full | Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_fullStr | Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_full_unstemmed | Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_short | Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_sort | genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| title_unstemmed | Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1158/1535-7163.mct-05-0151 |