Eintrag weiter verarbeiten
Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer
Gespeichert in:
| Zeitschriftentitel: | Clinical Cancer Research |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Clinical Cancer Research, 10, 2004, 16, S. 5299-5312 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
|
| Schlagwörter: |
| author_facet |
Chu, Roland L. Post, Dawn E. Khuri, Fadlo R. Van Meir, Erwin G. Chu, Roland L. Post, Dawn E. Khuri, Fadlo R. Van Meir, Erwin G. |
|---|---|
| author |
Chu, Roland L. Post, Dawn E. Khuri, Fadlo R. Van Meir, Erwin G. |
| spellingShingle |
Chu, Roland L. Post, Dawn E. Khuri, Fadlo R. Van Meir, Erwin G. Clinical Cancer Research Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer Cancer Research Oncology |
| author_sort |
chu, roland l. |
| spelling |
Chu, Roland L. Post, Dawn E. Khuri, Fadlo R. Van Meir, Erwin G. 1078-0432 1557-3265 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1078-0432.ccr-0349-03 <jats:title>Abstract</jats:title> <jats:p>Oncolytic virotherapy is the use of genetically engineered viruses that specifically target and destroy tumor cells via their cytolytic replication cycle. Viral-mediated tumor destruction is propagated through infection of nearby tumor cells by the newly released progeny. Each cycle should amplify the number of oncolytic viruses available for infection. Our understanding of the life cycles of cytolytic viruses has allowed manipulation of their genome to selectively kill tumor cells over normal tissue. Because the mechanism of tumor destruction is different, oncolytic virotherapy should work synergistically with current modes of treatment such as chemotherapy and radiation therapy. This article focuses on oncolytic adenoviruses that have been created and tested in preclinical and clinical trials in combination with chemotherapy, radiation therapy, and gene therapy.</jats:p> Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer Clinical Cancer Research |
| doi_str_mv |
10.1158/1078-0432.ccr-0349-03 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8xMDc4LTA0MzIuY2NyLTAzNDktMDM |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8xMDc4LTA0MzIuY2NyLTAzNDktMDM |
| institution |
DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 |
| imprint |
American Association for Cancer Research (AACR), 2004 |
| imprint_str_mv |
American Association for Cancer Research (AACR), 2004 |
| issn |
1078-0432 1557-3265 |
| issn_str_mv |
1078-0432 1557-3265 |
| language |
English |
| mega_collection |
American Association for Cancer Research (AACR) (CrossRef) |
| match_str |
chu2004useofreplicatingoncolyticadenovirusesincombinationtherapyforcancer |
| publishDateSort |
2004 |
| publisher |
American Association for Cancer Research (AACR) |
| recordtype |
ai |
| record_format |
ai |
| series |
Clinical Cancer Research |
| source_id |
49 |
| title |
Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_unstemmed |
Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_full |
Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_fullStr |
Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_full_unstemmed |
Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_short |
Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_sort |
use of replicating oncolytic adenoviruses in combination therapy for cancer |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1158/1078-0432.ccr-0349-03 |
| publishDate |
2004 |
| physical |
5299-5312 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Oncolytic virotherapy is the use of genetically engineered viruses that specifically target and destroy tumor cells via their cytolytic replication cycle. Viral-mediated tumor destruction is propagated through infection of nearby tumor cells by the newly released progeny. Each cycle should amplify the number of oncolytic viruses available for infection. Our understanding of the life cycles of cytolytic viruses has allowed manipulation of their genome to selectively kill tumor cells over normal tissue. Because the mechanism of tumor destruction is different, oncolytic virotherapy should work synergistically with current modes of treatment such as chemotherapy and radiation therapy. This article focuses on oncolytic adenoviruses that have been created and tested in preclinical and clinical trials in combination with chemotherapy, radiation therapy, and gene therapy.</jats:p> |
| container_issue |
16 |
| container_start_page |
5299 |
| container_title |
Clinical Cancer Research |
| container_volume |
10 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792346467179954183 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:38:58.392Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Use+of+Replicating+Oncolytic+Adenoviruses+in+Combination+Therapy+for+Cancer&rft.date=2004-08-15&genre=article&issn=1557-3265&volume=10&issue=16&spage=5299&epage=5312&pages=5299-5312&jtitle=Clinical+Cancer+Research&atitle=Use+of+Replicating+Oncolytic+Adenoviruses+in+Combination+Therapy+for+Cancer&aulast=Van+Meir&aufirst=Erwin+G.&rft_id=info%3Adoi%2F10.1158%2F1078-0432.ccr-0349-03&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792346467179954183 |
| author | Chu, Roland L., Post, Dawn E., Khuri, Fadlo R., Van Meir, Erwin G. |
| author_facet | Chu, Roland L., Post, Dawn E., Khuri, Fadlo R., Van Meir, Erwin G., Chu, Roland L., Post, Dawn E., Khuri, Fadlo R., Van Meir, Erwin G. |
| author_sort | chu, roland l. |
| container_issue | 16 |
| container_start_page | 5299 |
| container_title | Clinical Cancer Research |
| container_volume | 10 |
| description | <jats:title>Abstract</jats:title> <jats:p>Oncolytic virotherapy is the use of genetically engineered viruses that specifically target and destroy tumor cells via their cytolytic replication cycle. Viral-mediated tumor destruction is propagated through infection of nearby tumor cells by the newly released progeny. Each cycle should amplify the number of oncolytic viruses available for infection. Our understanding of the life cycles of cytolytic viruses has allowed manipulation of their genome to selectively kill tumor cells over normal tissue. Because the mechanism of tumor destruction is different, oncolytic virotherapy should work synergistically with current modes of treatment such as chemotherapy and radiation therapy. This article focuses on oncolytic adenoviruses that have been created and tested in preclinical and clinical trials in combination with chemotherapy, radiation therapy, and gene therapy.</jats:p> |
| doi_str_mv | 10.1158/1078-0432.ccr-0349-03 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8xMDc4LTA0MzIuY2NyLTAzNDktMDM |
| imprint | American Association for Cancer Research (AACR), 2004 |
| imprint_str_mv | American Association for Cancer Research (AACR), 2004 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14 |
| issn | 1078-0432, 1557-3265 |
| issn_str_mv | 1078-0432, 1557-3265 |
| language | English |
| last_indexed | 2024-03-01T17:38:58.392Z |
| match_str | chu2004useofreplicatingoncolyticadenovirusesincombinationtherapyforcancer |
| mega_collection | American Association for Cancer Research (AACR) (CrossRef) |
| physical | 5299-5312 |
| publishDate | 2004 |
| publishDateSort | 2004 |
| publisher | American Association for Cancer Research (AACR) |
| record_format | ai |
| recordtype | ai |
| series | Clinical Cancer Research |
| source_id | 49 |
| spelling | Chu, Roland L. Post, Dawn E. Khuri, Fadlo R. Van Meir, Erwin G. 1078-0432 1557-3265 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1078-0432.ccr-0349-03 <jats:title>Abstract</jats:title> <jats:p>Oncolytic virotherapy is the use of genetically engineered viruses that specifically target and destroy tumor cells via their cytolytic replication cycle. Viral-mediated tumor destruction is propagated through infection of nearby tumor cells by the newly released progeny. Each cycle should amplify the number of oncolytic viruses available for infection. Our understanding of the life cycles of cytolytic viruses has allowed manipulation of their genome to selectively kill tumor cells over normal tissue. Because the mechanism of tumor destruction is different, oncolytic virotherapy should work synergistically with current modes of treatment such as chemotherapy and radiation therapy. This article focuses on oncolytic adenoviruses that have been created and tested in preclinical and clinical trials in combination with chemotherapy, radiation therapy, and gene therapy.</jats:p> Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer Clinical Cancer Research |
| spellingShingle | Chu, Roland L., Post, Dawn E., Khuri, Fadlo R., Van Meir, Erwin G., Clinical Cancer Research, Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer, Cancer Research, Oncology |
| title | Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_full | Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_fullStr | Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_full_unstemmed | Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_short | Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| title_sort | use of replicating oncolytic adenoviruses in combination therapy for cancer |
| title_unstemmed | Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1158/1078-0432.ccr-0349-03 |