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A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma
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Zeitschriftentitel: | Clinical Cancer Research |
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Personen und Körperschaften: | , , , , , , , , |
In: | Clinical Cancer Research, 15, 2009, 23, S. 7429-7433 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
American Association for Cancer Research (AACR)
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Schlagwörter: |
author_facet |
Lan, Qing Cawthon, Richard Shen, Min Weinstein, Stephanie J. Virtamo, Jarmo Lim, Unhee Hosgood, H. Dean Albanes, Demetrius Rothman, Nathaniel Lan, Qing Cawthon, Richard Shen, Min Weinstein, Stephanie J. Virtamo, Jarmo Lim, Unhee Hosgood, H. Dean Albanes, Demetrius Rothman, Nathaniel |
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author |
Lan, Qing Cawthon, Richard Shen, Min Weinstein, Stephanie J. Virtamo, Jarmo Lim, Unhee Hosgood, H. Dean Albanes, Demetrius Rothman, Nathaniel |
spellingShingle |
Lan, Qing Cawthon, Richard Shen, Min Weinstein, Stephanie J. Virtamo, Jarmo Lim, Unhee Hosgood, H. Dean Albanes, Demetrius Rothman, Nathaniel Clinical Cancer Research A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma Cancer Research Oncology |
author_sort |
lan, qing |
spelling |
Lan, Qing Cawthon, Richard Shen, Min Weinstein, Stephanie J. Virtamo, Jarmo Lim, Unhee Hosgood, H. Dean Albanes, Demetrius Rothman, Nathaniel 1078-0432 1557-3265 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1078-0432.ccr-09-0845 <jats:title>Abstract</jats:title> <jats:p>Purpose: Telomere length plays an important role in the maintenance of chromosomal stability and in tumorigenesis. We hypothesized that telomere length in peripheral WBC DNA obtained from healthy individuals would be a predictor of future risk of developing non-Hodgkin lymphoma.</jats:p> <jats:p>Experimental Design: Using a new assay to measure relative telomere length, monochrome multiplex quantitative PCR, which strongly correlates with telomere length measured by Southern blot (Spearman r = 0.91, P &lt; 0.0001) and has high precision (coefficient of variation = 7%), we compared telomere length in peripheral WBC DNA in 107 incident male non-Hodgkin lymphoma cases and 107 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort.</jats:p> <jats:p>Results: Median (10th, 90th percentile) telomere length was 1.10 (0.79, 1.43) in cases and 1.02 (0.78, 1.26) in controls (P = 0.0017, Wilcoxon sign test). There was a strong dose-response relationship between quartiles of telomere length and risk of non-Hodgkin lymphoma overall [odds ratios (95% confidence intervals) by quartile: 1.0; 1.1 (0.4-2.7); 1.8 (0.7-4.9); and 3.6 (1.4-8.9); P trend = 0.003], and this association was similar across the most common non-Hodgkin lymphoma subtypes present in this study.</jats:p> <jats:p>Conclusion: These results suggest that longer telomere length may be a potential predictor for future risk of non-Hodgkin lymphoma. (Clin Cancer Res 2009;15(23):7429–33)</jats:p> A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma Clinical Cancer Research |
doi_str_mv |
10.1158/1078-0432.ccr-09-0845 |
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Medizin |
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ElectronicArticle |
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American Association for Cancer Research (AACR), 2009 |
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American Association for Cancer Research (AACR), 2009 |
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1078-0432 1557-3265 |
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American Association for Cancer Research (AACR) |
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title |
A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_unstemmed |
A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_full |
A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_fullStr |
A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_full_unstemmed |
A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_short |
A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_sort |
a prospective study of telomere length measured by monochrome multiplex quantitative pcr and risk of non-hodgkin lymphoma |
topic |
Cancer Research Oncology |
url |
http://dx.doi.org/10.1158/1078-0432.ccr-09-0845 |
publishDate |
2009 |
physical |
7429-7433 |
description |
<jats:title>Abstract</jats:title>
<jats:p>Purpose: Telomere length plays an important role in the maintenance of chromosomal stability and in tumorigenesis. We hypothesized that telomere length in peripheral WBC DNA obtained from healthy individuals would be a predictor of future risk of developing non-Hodgkin lymphoma.</jats:p>
<jats:p>Experimental Design: Using a new assay to measure relative telomere length, monochrome multiplex quantitative PCR, which strongly correlates with telomere length measured by Southern blot (Spearman r = 0.91, P &lt; 0.0001) and has high precision (coefficient of variation = 7%), we compared telomere length in peripheral WBC DNA in 107 incident male non-Hodgkin lymphoma cases and 107 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort.</jats:p>
<jats:p>Results: Median (10th, 90th percentile) telomere length was 1.10 (0.79, 1.43) in cases and 1.02 (0.78, 1.26) in controls (P = 0.0017, Wilcoxon sign test). There was a strong dose-response relationship between quartiles of telomere length and risk of non-Hodgkin lymphoma overall [odds ratios (95% confidence intervals) by quartile: 1.0; 1.1 (0.4-2.7); 1.8 (0.7-4.9); and 3.6 (1.4-8.9); P trend = 0.003], and this association was similar across the most common non-Hodgkin lymphoma subtypes present in this study.</jats:p>
<jats:p>Conclusion: These results suggest that longer telomere length may be a potential predictor for future risk of non-Hodgkin lymphoma. (Clin Cancer Res 2009;15(23):7429–33)</jats:p> |
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author | Lan, Qing, Cawthon, Richard, Shen, Min, Weinstein, Stephanie J., Virtamo, Jarmo, Lim, Unhee, Hosgood, H. Dean, Albanes, Demetrius, Rothman, Nathaniel |
author_facet | Lan, Qing, Cawthon, Richard, Shen, Min, Weinstein, Stephanie J., Virtamo, Jarmo, Lim, Unhee, Hosgood, H. Dean, Albanes, Demetrius, Rothman, Nathaniel, Lan, Qing, Cawthon, Richard, Shen, Min, Weinstein, Stephanie J., Virtamo, Jarmo, Lim, Unhee, Hosgood, H. Dean, Albanes, Demetrius, Rothman, Nathaniel |
author_sort | lan, qing |
container_issue | 23 |
container_start_page | 7429 |
container_title | Clinical Cancer Research |
container_volume | 15 |
description | <jats:title>Abstract</jats:title> <jats:p>Purpose: Telomere length plays an important role in the maintenance of chromosomal stability and in tumorigenesis. We hypothesized that telomere length in peripheral WBC DNA obtained from healthy individuals would be a predictor of future risk of developing non-Hodgkin lymphoma.</jats:p> <jats:p>Experimental Design: Using a new assay to measure relative telomere length, monochrome multiplex quantitative PCR, which strongly correlates with telomere length measured by Southern blot (Spearman r = 0.91, P &lt; 0.0001) and has high precision (coefficient of variation = 7%), we compared telomere length in peripheral WBC DNA in 107 incident male non-Hodgkin lymphoma cases and 107 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort.</jats:p> <jats:p>Results: Median (10th, 90th percentile) telomere length was 1.10 (0.79, 1.43) in cases and 1.02 (0.78, 1.26) in controls (P = 0.0017, Wilcoxon sign test). There was a strong dose-response relationship between quartiles of telomere length and risk of non-Hodgkin lymphoma overall [odds ratios (95% confidence intervals) by quartile: 1.0; 1.1 (0.4-2.7); 1.8 (0.7-4.9); and 3.6 (1.4-8.9); P trend = 0.003], and this association was similar across the most common non-Hodgkin lymphoma subtypes present in this study.</jats:p> <jats:p>Conclusion: These results suggest that longer telomere length may be a potential predictor for future risk of non-Hodgkin lymphoma. (Clin Cancer Res 2009;15(23):7429–33)</jats:p> |
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spelling | Lan, Qing Cawthon, Richard Shen, Min Weinstein, Stephanie J. Virtamo, Jarmo Lim, Unhee Hosgood, H. Dean Albanes, Demetrius Rothman, Nathaniel 1078-0432 1557-3265 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1078-0432.ccr-09-0845 <jats:title>Abstract</jats:title> <jats:p>Purpose: Telomere length plays an important role in the maintenance of chromosomal stability and in tumorigenesis. We hypothesized that telomere length in peripheral WBC DNA obtained from healthy individuals would be a predictor of future risk of developing non-Hodgkin lymphoma.</jats:p> <jats:p>Experimental Design: Using a new assay to measure relative telomere length, monochrome multiplex quantitative PCR, which strongly correlates with telomere length measured by Southern blot (Spearman r = 0.91, P &lt; 0.0001) and has high precision (coefficient of variation = 7%), we compared telomere length in peripheral WBC DNA in 107 incident male non-Hodgkin lymphoma cases and 107 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort.</jats:p> <jats:p>Results: Median (10th, 90th percentile) telomere length was 1.10 (0.79, 1.43) in cases and 1.02 (0.78, 1.26) in controls (P = 0.0017, Wilcoxon sign test). There was a strong dose-response relationship between quartiles of telomere length and risk of non-Hodgkin lymphoma overall [odds ratios (95% confidence intervals) by quartile: 1.0; 1.1 (0.4-2.7); 1.8 (0.7-4.9); and 3.6 (1.4-8.9); P trend = 0.003], and this association was similar across the most common non-Hodgkin lymphoma subtypes present in this study.</jats:p> <jats:p>Conclusion: These results suggest that longer telomere length may be a potential predictor for future risk of non-Hodgkin lymphoma. (Clin Cancer Res 2009;15(23):7429–33)</jats:p> A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma Clinical Cancer Research |
spellingShingle | Lan, Qing, Cawthon, Richard, Shen, Min, Weinstein, Stephanie J., Virtamo, Jarmo, Lim, Unhee, Hosgood, H. Dean, Albanes, Demetrius, Rothman, Nathaniel, Clinical Cancer Research, A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma, Cancer Research, Oncology |
title | A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_full | A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_fullStr | A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_full_unstemmed | A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_short | A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
title_sort | a prospective study of telomere length measured by monochrome multiplex quantitative pcr and risk of non-hodgkin lymphoma |
title_unstemmed | A Prospective Study of Telomere Length Measured by Monochrome Multiplex Quantitative PCR and Risk of Non-Hodgkin Lymphoma |
topic | Cancer Research, Oncology |
url | http://dx.doi.org/10.1158/1078-0432.ccr-09-0845 |