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Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 22, 2013, 12, S. 2345-2353 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
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| Schlagwörter: |
| author_facet |
Guan, Hong-Bo Wu, Qi-Jun Gong, Ting-Ting Guan, Hong-Bo Wu, Qi-Jun Gong, Ting-Ting |
|---|---|
| author |
Guan, Hong-Bo Wu, Qi-Jun Gong, Ting-Ting |
| spellingShingle |
Guan, Hong-Bo Wu, Qi-Jun Gong, Ting-Ting Cancer Epidemiology, Biomarkers & Prevention Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies Oncology Epidemiology |
| author_sort |
guan, hong-bo |
| spelling |
Guan, Hong-Bo Wu, Qi-Jun Gong, Ting-Ting 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-13-0759-t <jats:title>Abstract</jats:title> <jats:p>Background: Observational studies have reported conflicting results between parity and kidney cancer risk. To our knowledge, a comprehensive and quantitative assessment of the association between parity and kidney cancer has not been reported. Thus, we conducted a systematic review and dose–response meta-analysis of published epidemiologic studies to summarize the evidence of this association.</jats:p> <jats:p>Methods: Relevant published studies of parity and kidney cancer were identified using MEDLINE (PubMed) database through end of June 2013. Two authors independently assessed eligibility and extracted data. Six prospective and eight case–control studies reported relative risk (RR) estimates and 95% confidence intervals (CI) of kidney cancer associated with parity or parity number. Fixed- or random-effects models were used to estimate summary relative risk.</jats:p> <jats:p>Results: The summary relative risk of kidney cancer for the parity versus nulliparous was 1.23 (95% CI, 1.10–1.36; Q = 12.41; P = 0.413; I2 = 3.3%). In addition, significant association was also found for the highest versus lowest parity number, with summary RR = 1.36 (95% CI, 1.19–1.56; Q = 8.24; P = 0.766; I2 = 0%). In the dose–response analysis, the summary per one live birth relative risk was 1.08 (95% CI: 1.05–1.10; Q = 9.34; P = 0.500; I2 = 0%), also indicating the positive effect of parity on kidney cancer risk. No evidence of publication bias and significant heterogeneity between subgroups was detected by meta-regression analyses.</jats:p> <jats:p>Conclusions: In summary, findings from this meta-analysis suggest that ever parity and higher parity number is significantly associated with increased risk of kidney cancer.</jats:p> <jats:p>Impact: The present results suggest a positive association between parity and kidney cancer risk. Cancer Epidemiol Biomarkers Prev; 22(12); 2345–53. ©2013 AACR.</jats:p> Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies Cancer Epidemiology, Biomarkers & Prevention |
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10.1158/1055-9965.epi-13-0759-t |
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American Association for Cancer Research (AACR), 2013 |
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American Association for Cancer Research (AACR), 2013 |
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1538-7755 1055-9965 |
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Cancer Epidemiology, Biomarkers & Prevention |
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| title |
Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_unstemmed |
Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_full |
Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_fullStr |
Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_full_unstemmed |
Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_short |
Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_sort |
parity and kidney cancer risk: evidence from epidemiologic studies |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-13-0759-t |
| publishDate |
2013 |
| physical |
2345-2353 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Background: Observational studies have reported conflicting results between parity and kidney cancer risk. To our knowledge, a comprehensive and quantitative assessment of the association between parity and kidney cancer has not been reported. Thus, we conducted a systematic review and dose–response meta-analysis of published epidemiologic studies to summarize the evidence of this association.</jats:p>
<jats:p>Methods: Relevant published studies of parity and kidney cancer were identified using MEDLINE (PubMed) database through end of June 2013. Two authors independently assessed eligibility and extracted data. Six prospective and eight case–control studies reported relative risk (RR) estimates and 95% confidence intervals (CI) of kidney cancer associated with parity or parity number. Fixed- or random-effects models were used to estimate summary relative risk.</jats:p>
<jats:p>Results: The summary relative risk of kidney cancer for the parity versus nulliparous was 1.23 (95% CI, 1.10–1.36; Q = 12.41; P = 0.413; I2 = 3.3%). In addition, significant association was also found for the highest versus lowest parity number, with summary RR = 1.36 (95% CI, 1.19–1.56; Q = 8.24; P = 0.766; I2 = 0%). In the dose–response analysis, the summary per one live birth relative risk was 1.08 (95% CI: 1.05–1.10; Q = 9.34; P = 0.500; I2 = 0%), also indicating the positive effect of parity on kidney cancer risk. No evidence of publication bias and significant heterogeneity between subgroups was detected by meta-regression analyses.</jats:p>
<jats:p>Conclusions: In summary, findings from this meta-analysis suggest that ever parity and higher parity number is significantly associated with increased risk of kidney cancer.</jats:p>
<jats:p>Impact: The present results suggest a positive association between parity and kidney cancer risk. Cancer Epidemiol Biomarkers Prev; 22(12); 2345–53. ©2013 AACR.</jats:p> |
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| author | Guan, Hong-Bo, Wu, Qi-Jun, Gong, Ting-Ting |
| author_facet | Guan, Hong-Bo, Wu, Qi-Jun, Gong, Ting-Ting, Guan, Hong-Bo, Wu, Qi-Jun, Gong, Ting-Ting |
| author_sort | guan, hong-bo |
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| description | <jats:title>Abstract</jats:title> <jats:p>Background: Observational studies have reported conflicting results between parity and kidney cancer risk. To our knowledge, a comprehensive and quantitative assessment of the association between parity and kidney cancer has not been reported. Thus, we conducted a systematic review and dose–response meta-analysis of published epidemiologic studies to summarize the evidence of this association.</jats:p> <jats:p>Methods: Relevant published studies of parity and kidney cancer were identified using MEDLINE (PubMed) database through end of June 2013. Two authors independently assessed eligibility and extracted data. Six prospective and eight case–control studies reported relative risk (RR) estimates and 95% confidence intervals (CI) of kidney cancer associated with parity or parity number. Fixed- or random-effects models were used to estimate summary relative risk.</jats:p> <jats:p>Results: The summary relative risk of kidney cancer for the parity versus nulliparous was 1.23 (95% CI, 1.10–1.36; Q = 12.41; P = 0.413; I2 = 3.3%). In addition, significant association was also found for the highest versus lowest parity number, with summary RR = 1.36 (95% CI, 1.19–1.56; Q = 8.24; P = 0.766; I2 = 0%). In the dose–response analysis, the summary per one live birth relative risk was 1.08 (95% CI: 1.05–1.10; Q = 9.34; P = 0.500; I2 = 0%), also indicating the positive effect of parity on kidney cancer risk. No evidence of publication bias and significant heterogeneity between subgroups was detected by meta-regression analyses.</jats:p> <jats:p>Conclusions: In summary, findings from this meta-analysis suggest that ever parity and higher parity number is significantly associated with increased risk of kidney cancer.</jats:p> <jats:p>Impact: The present results suggest a positive association between parity and kidney cancer risk. Cancer Epidemiol Biomarkers Prev; 22(12); 2345–53. ©2013 AACR.</jats:p> |
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| imprint | American Association for Cancer Research (AACR), 2013 |
| imprint_str_mv | American Association for Cancer Research (AACR), 2013 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
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| spelling | Guan, Hong-Bo Wu, Qi-Jun Gong, Ting-Ting 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-13-0759-t <jats:title>Abstract</jats:title> <jats:p>Background: Observational studies have reported conflicting results between parity and kidney cancer risk. To our knowledge, a comprehensive and quantitative assessment of the association between parity and kidney cancer has not been reported. Thus, we conducted a systematic review and dose–response meta-analysis of published epidemiologic studies to summarize the evidence of this association.</jats:p> <jats:p>Methods: Relevant published studies of parity and kidney cancer were identified using MEDLINE (PubMed) database through end of June 2013. Two authors independently assessed eligibility and extracted data. Six prospective and eight case–control studies reported relative risk (RR) estimates and 95% confidence intervals (CI) of kidney cancer associated with parity or parity number. Fixed- or random-effects models were used to estimate summary relative risk.</jats:p> <jats:p>Results: The summary relative risk of kidney cancer for the parity versus nulliparous was 1.23 (95% CI, 1.10–1.36; Q = 12.41; P = 0.413; I2 = 3.3%). In addition, significant association was also found for the highest versus lowest parity number, with summary RR = 1.36 (95% CI, 1.19–1.56; Q = 8.24; P = 0.766; I2 = 0%). In the dose–response analysis, the summary per one live birth relative risk was 1.08 (95% CI: 1.05–1.10; Q = 9.34; P = 0.500; I2 = 0%), also indicating the positive effect of parity on kidney cancer risk. No evidence of publication bias and significant heterogeneity between subgroups was detected by meta-regression analyses.</jats:p> <jats:p>Conclusions: In summary, findings from this meta-analysis suggest that ever parity and higher parity number is significantly associated with increased risk of kidney cancer.</jats:p> <jats:p>Impact: The present results suggest a positive association between parity and kidney cancer risk. Cancer Epidemiol Biomarkers Prev; 22(12); 2345–53. ©2013 AACR.</jats:p> Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Guan, Hong-Bo, Wu, Qi-Jun, Gong, Ting-Ting, Cancer Epidemiology, Biomarkers & Prevention, Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies, Oncology, Epidemiology |
| title | Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_full | Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_fullStr | Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_full_unstemmed | Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_short | Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| title_sort | parity and kidney cancer risk: evidence from epidemiologic studies |
| title_unstemmed | Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-13-0759-t |