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Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 21, 2012, 8, S. 1385-1387 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
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| Schlagwörter: |
| author_facet |
Sung, Hyuna Zhang, Ben Choi, Ji-Yeob Long, Jirong Park, Sue K. Yoo, Keun-Young Noh, Dong-Young Ahn, Sei-Hyun Zheng, Wei Kang, Daehee Sung, Hyuna Zhang, Ben Choi, Ji-Yeob Long, Jirong Park, Sue K. Yoo, Keun-Young Noh, Dong-Young Ahn, Sei-Hyun Zheng, Wei Kang, Daehee |
|---|---|
| author |
Sung, Hyuna Zhang, Ben Choi, Ji-Yeob Long, Jirong Park, Sue K. Yoo, Keun-Young Noh, Dong-Young Ahn, Sei-Hyun Zheng, Wei Kang, Daehee |
| spellingShingle |
Sung, Hyuna Zhang, Ben Choi, Ji-Yeob Long, Jirong Park, Sue K. Yoo, Keun-Young Noh, Dong-Young Ahn, Sei-Hyun Zheng, Wei Kang, Daehee Cancer Epidemiology, Biomarkers & Prevention Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women Oncology Epidemiology |
| author_sort |
sung, hyuna |
| spelling |
Sung, Hyuna Zhang, Ben Choi, Ji-Yeob Long, Jirong Park, Sue K. Yoo, Keun-Young Noh, Dong-Young Ahn, Sei-Hyun Zheng, Wei Kang, Daehee 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-12-0600 <jats:title>Abstract</jats:title> <jats:p>Background: Although the role of miRNA in cancer development and progression has been well established, the association between genetic variants in miRNA biogenesis pathway genes and breast cancer risk has been yet unclear.</jats:p> <jats:p>Methods: We analyzed data from two genome-wide association studies conducted in East Asian women including 5,066 cases and 4,337 controls. Among the single-nucleotide polymorphisms (SNP), which were directly genotyped or imputed, we selected 237 SNPs in 32 genes involved in miRNA biogenesis pathway and its regulation.</jats:p> <jats:p>Results: Although eight SNPs were nominally associated with breast cancer risk in combined samples (P &lt; 0.05), none of them were significant after adjustment for multiple comparisons.</jats:p> <jats:p>Conclusions: The common genetic variants in miRNA biogenesis pathway genes may not be associated with breast cancer risk.</jats:p> <jats:p>Impact: This study suggests no association between the polymorphisms in miRNA biogenesis pathway genes and breast cancer risk. Studies with large sample size and more genetic variants should be warranted to adequately evaluate the potential association. Cancer Epidemiol Biomarkers Prev; 21(8); 1385–7. ©2012 AACR.</jats:p> Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women Cancer Epidemiology, Biomarkers & Prevention |
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American Association for Cancer Research (AACR), 2012 |
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American Association for Cancer Research (AACR), 2012 |
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1055-9965 1538-7755 |
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2012 |
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Cancer Epidemiology, Biomarkers & Prevention |
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| title |
Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_unstemmed |
Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_full |
Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_fullStr |
Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_full_unstemmed |
Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_short |
Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_sort |
common genetic variants in the microrna biogenesis pathway are not associated with breast cancer risk in asian women |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-12-0600 |
| publishDate |
2012 |
| physical |
1385-1387 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Background: Although the role of miRNA in cancer development and progression has been well established, the association between genetic variants in miRNA biogenesis pathway genes and breast cancer risk has been yet unclear.</jats:p>
<jats:p>Methods: We analyzed data from two genome-wide association studies conducted in East Asian women including 5,066 cases and 4,337 controls. Among the single-nucleotide polymorphisms (SNP), which were directly genotyped or imputed, we selected 237 SNPs in 32 genes involved in miRNA biogenesis pathway and its regulation.</jats:p>
<jats:p>Results: Although eight SNPs were nominally associated with breast cancer risk in combined samples (P &lt; 0.05), none of them were significant after adjustment for multiple comparisons.</jats:p>
<jats:p>Conclusions: The common genetic variants in miRNA biogenesis pathway genes may not be associated with breast cancer risk.</jats:p>
<jats:p>Impact: This study suggests no association between the polymorphisms in miRNA biogenesis pathway genes and breast cancer risk. Studies with large sample size and more genetic variants should be warranted to adequately evaluate the potential association. Cancer Epidemiol Biomarkers Prev; 21(8); 1385–7. ©2012 AACR.</jats:p> |
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| author | Sung, Hyuna, Zhang, Ben, Choi, Ji-Yeob, Long, Jirong, Park, Sue K., Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Zheng, Wei, Kang, Daehee |
| author_facet | Sung, Hyuna, Zhang, Ben, Choi, Ji-Yeob, Long, Jirong, Park, Sue K., Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Zheng, Wei, Kang, Daehee, Sung, Hyuna, Zhang, Ben, Choi, Ji-Yeob, Long, Jirong, Park, Sue K., Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Zheng, Wei, Kang, Daehee |
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| description | <jats:title>Abstract</jats:title> <jats:p>Background: Although the role of miRNA in cancer development and progression has been well established, the association between genetic variants in miRNA biogenesis pathway genes and breast cancer risk has been yet unclear.</jats:p> <jats:p>Methods: We analyzed data from two genome-wide association studies conducted in East Asian women including 5,066 cases and 4,337 controls. Among the single-nucleotide polymorphisms (SNP), which were directly genotyped or imputed, we selected 237 SNPs in 32 genes involved in miRNA biogenesis pathway and its regulation.</jats:p> <jats:p>Results: Although eight SNPs were nominally associated with breast cancer risk in combined samples (P &lt; 0.05), none of them were significant after adjustment for multiple comparisons.</jats:p> <jats:p>Conclusions: The common genetic variants in miRNA biogenesis pathway genes may not be associated with breast cancer risk.</jats:p> <jats:p>Impact: This study suggests no association between the polymorphisms in miRNA biogenesis pathway genes and breast cancer risk. Studies with large sample size and more genetic variants should be warranted to adequately evaluate the potential association. Cancer Epidemiol Biomarkers Prev; 21(8); 1385–7. ©2012 AACR.</jats:p> |
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| imprint | American Association for Cancer Research (AACR), 2012 |
| imprint_str_mv | American Association for Cancer Research (AACR), 2012 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
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| spelling | Sung, Hyuna Zhang, Ben Choi, Ji-Yeob Long, Jirong Park, Sue K. Yoo, Keun-Young Noh, Dong-Young Ahn, Sei-Hyun Zheng, Wei Kang, Daehee 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-12-0600 <jats:title>Abstract</jats:title> <jats:p>Background: Although the role of miRNA in cancer development and progression has been well established, the association between genetic variants in miRNA biogenesis pathway genes and breast cancer risk has been yet unclear.</jats:p> <jats:p>Methods: We analyzed data from two genome-wide association studies conducted in East Asian women including 5,066 cases and 4,337 controls. Among the single-nucleotide polymorphisms (SNP), which were directly genotyped or imputed, we selected 237 SNPs in 32 genes involved in miRNA biogenesis pathway and its regulation.</jats:p> <jats:p>Results: Although eight SNPs were nominally associated with breast cancer risk in combined samples (P &lt; 0.05), none of them were significant after adjustment for multiple comparisons.</jats:p> <jats:p>Conclusions: The common genetic variants in miRNA biogenesis pathway genes may not be associated with breast cancer risk.</jats:p> <jats:p>Impact: This study suggests no association between the polymorphisms in miRNA biogenesis pathway genes and breast cancer risk. Studies with large sample size and more genetic variants should be warranted to adequately evaluate the potential association. Cancer Epidemiol Biomarkers Prev; 21(8); 1385–7. ©2012 AACR.</jats:p> Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Sung, Hyuna, Zhang, Ben, Choi, Ji-Yeob, Long, Jirong, Park, Sue K., Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Zheng, Wei, Kang, Daehee, Cancer Epidemiology, Biomarkers & Prevention, Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women, Oncology, Epidemiology |
| title | Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_full | Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_fullStr | Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_full_unstemmed | Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_short | Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| title_sort | common genetic variants in the microrna biogenesis pathway are not associated with breast cancer risk in asian women |
| title_unstemmed | Common Genetic Variants in the MicroRNA Biogenesis Pathway Are Not Associated with Breast Cancer Risk in Asian Women |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-12-0600 |