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Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 27, 2018, 3, S. 285-294 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
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| Schlagwörter: |
| author_facet |
Sandler, Jason E. Huang, Huang Zhao, Nan Wu, Weiwei Liu, Fangfang Ma, Shuangge Udelsman, Robert Zhang, Yawei Sandler, Jason E. Huang, Huang Zhao, Nan Wu, Weiwei Liu, Fangfang Ma, Shuangge Udelsman, Robert Zhang, Yawei |
|---|---|
| author |
Sandler, Jason E. Huang, Huang Zhao, Nan Wu, Weiwei Liu, Fangfang Ma, Shuangge Udelsman, Robert Zhang, Yawei |
| spellingShingle |
Sandler, Jason E. Huang, Huang Zhao, Nan Wu, Weiwei Liu, Fangfang Ma, Shuangge Udelsman, Robert Zhang, Yawei Cancer Epidemiology, Biomarkers & Prevention Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer Oncology Epidemiology |
| author_sort |
sandler, jason e. |
| spelling |
Sandler, Jason E. Huang, Huang Zhao, Nan Wu, Weiwei Liu, Fangfang Ma, Shuangge Udelsman, Robert Zhang, Yawei 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-17-0319 <jats:title>Abstract</jats:title> <jats:p>Background: Radiation exposure is a well-documented risk factor for thyroid cancer; diagnostic imaging represents an increasing source of exposure. Germline variations in DNA repair genes could increase risk of developing thyroid cancer following diagnostic radiation exposure. No studies have directly tested for interaction between germline mutations and radiation exposure.</jats:p> <jats:p>Methods: Using data and DNA samples from a Connecticut population–based case–control study performed in 2010 to 2011, we genotyped 440 cases of incident thyroid cancer and 465 population-based controls for 296 SNPs in 52 DNA repair genes. We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genotype–environment interaction between each SNP and ionizing radiation.</jats:p> <jats:p>Results: Three SNPs were associated with increased risk of thyroid cancer and with thyroid microcarcinoma: HUS rs2708896, HUS rs10951937, and MGMT rs12769288. No SNPs were associated with increased risk of larger tumor (&gt;10 mm) in the additive model. The gene–environment interaction analysis yielded 24 SNPs with Pinteraction &lt; 0.05 for all thyroid cancer, 12 SNPs with Pinteraction &lt; 0.05 for thyroid microcarcinoma, and 5 SNPs with Pinteraction &lt; 0.05 for larger tumors.</jats:p> <jats:p>Conclusions: Germline variants in DNA repair genes are associated with thyroid cancer risk and are differentially associated with thyroid microcarcinoma and large tumor size. Our study provides the first evidence that germline genetic variations modify the association between diagnostic radiation and thyroid cancer risk.</jats:p> <jats:p>Impact: Thyroid microcarcinoma may represent a distinct subset of thyroid cancer. The effect of diagnostic radiation on thyroid cancer risk varies by germline polymorphism. Cancer Epidemiol Biomarkers Prev; 27(3); 285–94. ©2017 AACR.</jats:p> Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer Cancer Epidemiology, Biomarkers & Prevention |
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10.1158/1055-9965.epi-17-0319 |
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American Association for Cancer Research (AACR), 2018 |
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American Association for Cancer Research (AACR), 2018 |
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1055-9965 1538-7755 |
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American Association for Cancer Research (AACR) |
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Cancer Epidemiology, Biomarkers & Prevention |
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| title |
Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_unstemmed |
Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_full |
Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_fullStr |
Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_full_unstemmed |
Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_short |
Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_sort |
germline variants in dna repair genes, diagnostic radiation, and risk of thyroid cancer |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-17-0319 |
| publishDate |
2018 |
| physical |
285-294 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Background: Radiation exposure is a well-documented risk factor for thyroid cancer; diagnostic imaging represents an increasing source of exposure. Germline variations in DNA repair genes could increase risk of developing thyroid cancer following diagnostic radiation exposure. No studies have directly tested for interaction between germline mutations and radiation exposure.</jats:p>
<jats:p>Methods: Using data and DNA samples from a Connecticut population–based case–control study performed in 2010 to 2011, we genotyped 440 cases of incident thyroid cancer and 465 population-based controls for 296 SNPs in 52 DNA repair genes. We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genotype–environment interaction between each SNP and ionizing radiation.</jats:p>
<jats:p>Results: Three SNPs were associated with increased risk of thyroid cancer and with thyroid microcarcinoma: HUS rs2708896, HUS rs10951937, and MGMT rs12769288. No SNPs were associated with increased risk of larger tumor (&gt;10 mm) in the additive model. The gene–environment interaction analysis yielded 24 SNPs with Pinteraction &lt; 0.05 for all thyroid cancer, 12 SNPs with Pinteraction &lt; 0.05 for thyroid microcarcinoma, and 5 SNPs with Pinteraction &lt; 0.05 for larger tumors.</jats:p>
<jats:p>Conclusions: Germline variants in DNA repair genes are associated with thyroid cancer risk and are differentially associated with thyroid microcarcinoma and large tumor size. Our study provides the first evidence that germline genetic variations modify the association between diagnostic radiation and thyroid cancer risk.</jats:p>
<jats:p>Impact: Thyroid microcarcinoma may represent a distinct subset of thyroid cancer. The effect of diagnostic radiation on thyroid cancer risk varies by germline polymorphism. Cancer Epidemiol Biomarkers Prev; 27(3); 285–94. ©2017 AACR.</jats:p> |
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| _version_ | 1792347442468880393 |
| author | Sandler, Jason E., Huang, Huang, Zhao, Nan, Wu, Weiwei, Liu, Fangfang, Ma, Shuangge, Udelsman, Robert, Zhang, Yawei |
| author_facet | Sandler, Jason E., Huang, Huang, Zhao, Nan, Wu, Weiwei, Liu, Fangfang, Ma, Shuangge, Udelsman, Robert, Zhang, Yawei, Sandler, Jason E., Huang, Huang, Zhao, Nan, Wu, Weiwei, Liu, Fangfang, Ma, Shuangge, Udelsman, Robert, Zhang, Yawei |
| author_sort | sandler, jason e. |
| container_issue | 3 |
| container_start_page | 285 |
| container_title | Cancer Epidemiology, Biomarkers & Prevention |
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| description | <jats:title>Abstract</jats:title> <jats:p>Background: Radiation exposure is a well-documented risk factor for thyroid cancer; diagnostic imaging represents an increasing source of exposure. Germline variations in DNA repair genes could increase risk of developing thyroid cancer following diagnostic radiation exposure. No studies have directly tested for interaction between germline mutations and radiation exposure.</jats:p> <jats:p>Methods: Using data and DNA samples from a Connecticut population–based case–control study performed in 2010 to 2011, we genotyped 440 cases of incident thyroid cancer and 465 population-based controls for 296 SNPs in 52 DNA repair genes. We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genotype–environment interaction between each SNP and ionizing radiation.</jats:p> <jats:p>Results: Three SNPs were associated with increased risk of thyroid cancer and with thyroid microcarcinoma: HUS rs2708896, HUS rs10951937, and MGMT rs12769288. No SNPs were associated with increased risk of larger tumor (&gt;10 mm) in the additive model. The gene–environment interaction analysis yielded 24 SNPs with Pinteraction &lt; 0.05 for all thyroid cancer, 12 SNPs with Pinteraction &lt; 0.05 for thyroid microcarcinoma, and 5 SNPs with Pinteraction &lt; 0.05 for larger tumors.</jats:p> <jats:p>Conclusions: Germline variants in DNA repair genes are associated with thyroid cancer risk and are differentially associated with thyroid microcarcinoma and large tumor size. Our study provides the first evidence that germline genetic variations modify the association between diagnostic radiation and thyroid cancer risk.</jats:p> <jats:p>Impact: Thyroid microcarcinoma may represent a distinct subset of thyroid cancer. The effect of diagnostic radiation on thyroid cancer risk varies by germline polymorphism. Cancer Epidemiol Biomarkers Prev; 27(3); 285–94. ©2017 AACR.</jats:p> |
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| imprint | American Association for Cancer Research (AACR), 2018 |
| imprint_str_mv | American Association for Cancer Research (AACR), 2018 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229 |
| issn | 1055-9965, 1538-7755 |
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| publisher | American Association for Cancer Research (AACR) |
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| series | Cancer Epidemiology, Biomarkers & Prevention |
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| spelling | Sandler, Jason E. Huang, Huang Zhao, Nan Wu, Weiwei Liu, Fangfang Ma, Shuangge Udelsman, Robert Zhang, Yawei 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-17-0319 <jats:title>Abstract</jats:title> <jats:p>Background: Radiation exposure is a well-documented risk factor for thyroid cancer; diagnostic imaging represents an increasing source of exposure. Germline variations in DNA repair genes could increase risk of developing thyroid cancer following diagnostic radiation exposure. No studies have directly tested for interaction between germline mutations and radiation exposure.</jats:p> <jats:p>Methods: Using data and DNA samples from a Connecticut population–based case–control study performed in 2010 to 2011, we genotyped 440 cases of incident thyroid cancer and 465 population-based controls for 296 SNPs in 52 DNA repair genes. We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genotype–environment interaction between each SNP and ionizing radiation.</jats:p> <jats:p>Results: Three SNPs were associated with increased risk of thyroid cancer and with thyroid microcarcinoma: HUS rs2708896, HUS rs10951937, and MGMT rs12769288. No SNPs were associated with increased risk of larger tumor (&gt;10 mm) in the additive model. The gene–environment interaction analysis yielded 24 SNPs with Pinteraction &lt; 0.05 for all thyroid cancer, 12 SNPs with Pinteraction &lt; 0.05 for thyroid microcarcinoma, and 5 SNPs with Pinteraction &lt; 0.05 for larger tumors.</jats:p> <jats:p>Conclusions: Germline variants in DNA repair genes are associated with thyroid cancer risk and are differentially associated with thyroid microcarcinoma and large tumor size. Our study provides the first evidence that germline genetic variations modify the association between diagnostic radiation and thyroid cancer risk.</jats:p> <jats:p>Impact: Thyroid microcarcinoma may represent a distinct subset of thyroid cancer. The effect of diagnostic radiation on thyroid cancer risk varies by germline polymorphism. Cancer Epidemiol Biomarkers Prev; 27(3); 285–94. ©2017 AACR.</jats:p> Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Sandler, Jason E., Huang, Huang, Zhao, Nan, Wu, Weiwei, Liu, Fangfang, Ma, Shuangge, Udelsman, Robert, Zhang, Yawei, Cancer Epidemiology, Biomarkers & Prevention, Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer, Oncology, Epidemiology |
| title | Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_full | Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_fullStr | Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_full_unstemmed | Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_short | Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| title_sort | germline variants in dna repair genes, diagnostic radiation, and risk of thyroid cancer |
| title_unstemmed | Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-17-0319 |