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miRNA-Processing Gene Methylation and Cancer Risk
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 27, 2018, 5, S. 550-557 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
|
| Schlagwörter: |
| author_facet |
Joyce, Brian T. Zheng, Yinan Zhang, Zhou Liu, Lei Kocherginsky, Masha Murphy, Robert Achenbach, Chad J. Musa, Jonah Wehbe, Firas Just, Allan Shen, Jincheng Vokonas, Pantel Schwartz, Joel Baccarelli, Andrea A. Hou, Lifang Joyce, Brian T. Zheng, Yinan Zhang, Zhou Liu, Lei Kocherginsky, Masha Murphy, Robert Achenbach, Chad J. Musa, Jonah Wehbe, Firas Just, Allan Shen, Jincheng Vokonas, Pantel Schwartz, Joel Baccarelli, Andrea A. Hou, Lifang |
|---|---|
| author |
Joyce, Brian T. Zheng, Yinan Zhang, Zhou Liu, Lei Kocherginsky, Masha Murphy, Robert Achenbach, Chad J. Musa, Jonah Wehbe, Firas Just, Allan Shen, Jincheng Vokonas, Pantel Schwartz, Joel Baccarelli, Andrea A. Hou, Lifang |
| spellingShingle |
Joyce, Brian T. Zheng, Yinan Zhang, Zhou Liu, Lei Kocherginsky, Masha Murphy, Robert Achenbach, Chad J. Musa, Jonah Wehbe, Firas Just, Allan Shen, Jincheng Vokonas, Pantel Schwartz, Joel Baccarelli, Andrea A. Hou, Lifang Cancer Epidemiology, Biomarkers & Prevention miRNA-Processing Gene Methylation and Cancer Risk Oncology Epidemiology |
| author_sort |
joyce, brian t. |
| spelling |
Joyce, Brian T. Zheng, Yinan Zhang, Zhou Liu, Lei Kocherginsky, Masha Murphy, Robert Achenbach, Chad J. Musa, Jonah Wehbe, Firas Just, Allan Shen, Jincheng Vokonas, Pantel Schwartz, Joel Baccarelli, Andrea A. Hou, Lifang 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-17-0849 <jats:title>Abstract</jats:title> <jats:p>Background: Dysregulation of miRNA and methylation levels are epigenetic hallmarks of cancer, potentially linked via miRNA-processing genes. Studies have found genetic alterations to miRNA-processing genes in cancer cells and human population studies. Our objective was to prospectively examine changes in DNA methylation of miRNA-processing genes and their associations with cancer risk.</jats:p> <jats:p>Methods: We examined cohort data from the Department of Veterans' Affairs Normative Aging Study. Participants were assessed every 3 to 5 years starting in 1999 through 2013 including questionnaires, medical record review, and blood collection. Blood from 686 consenting participants was analyzed using the Illumina 450K BeadChip array to measure methylation at CpG sites throughout the genome. We selected 19 genes based on a literature review, with 519 corresponding CpG sites. We then used Cox proportional hazards models to examine associations with cancer incidence, and generalized estimating equations to examine associations with cancer prevalence. Associations at false discovery rate &lt; 0.05 were considered statistically significant.</jats:p> <jats:p>Results: Methylation of three CpGs (DROSHA: cg23230564, TNRC6B: cg06751583, and TNRC6B: cg21034183) was prospectively associated with time to cancer development (positively for cg06751583, inversely for cg23230564 and cg21034183), whereas methylation of one CpG site (DROSHA: cg16131300) was positively associated with cancer prevalence.</jats:p> <jats:p>Conclusions: DNA methylation of DROSHA, a key miRNA-processing gene, and TNRC6B may play a role in early carcinogenesis.</jats:p> <jats:p>Impact: Changes in miRNA processing may exert multiple effects on cancer development, including protecting against it via altered global miRNAs, and may be a useful early detection biomarker of cancer. Cancer Epidemiol Biomarkers Prev; 27(5); 550–7. ©2018 AACR.</jats:p> miRNA-Processing Gene Methylation and Cancer Risk Cancer Epidemiology, Biomarkers & Prevention |
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10.1158/1055-9965.epi-17-0849 |
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American Association for Cancer Research (AACR), 2018 |
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American Association for Cancer Research (AACR), 2018 |
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1055-9965 1538-7755 |
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1055-9965 1538-7755 |
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American Association for Cancer Research (AACR) |
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Cancer Epidemiology, Biomarkers & Prevention |
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49 |
| title |
miRNA-Processing Gene Methylation and Cancer Risk |
| title_unstemmed |
miRNA-Processing Gene Methylation and Cancer Risk |
| title_full |
miRNA-Processing Gene Methylation and Cancer Risk |
| title_fullStr |
miRNA-Processing Gene Methylation and Cancer Risk |
| title_full_unstemmed |
miRNA-Processing Gene Methylation and Cancer Risk |
| title_short |
miRNA-Processing Gene Methylation and Cancer Risk |
| title_sort |
mirna-processing gene methylation and cancer risk |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-17-0849 |
| publishDate |
2018 |
| physical |
550-557 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Background: Dysregulation of miRNA and methylation levels are epigenetic hallmarks of cancer, potentially linked via miRNA-processing genes. Studies have found genetic alterations to miRNA-processing genes in cancer cells and human population studies. Our objective was to prospectively examine changes in DNA methylation of miRNA-processing genes and their associations with cancer risk.</jats:p>
<jats:p>Methods: We examined cohort data from the Department of Veterans' Affairs Normative Aging Study. Participants were assessed every 3 to 5 years starting in 1999 through 2013 including questionnaires, medical record review, and blood collection. Blood from 686 consenting participants was analyzed using the Illumina 450K BeadChip array to measure methylation at CpG sites throughout the genome. We selected 19 genes based on a literature review, with 519 corresponding CpG sites. We then used Cox proportional hazards models to examine associations with cancer incidence, and generalized estimating equations to examine associations with cancer prevalence. Associations at false discovery rate &lt; 0.05 were considered statistically significant.</jats:p>
<jats:p>Results: Methylation of three CpGs (DROSHA: cg23230564, TNRC6B: cg06751583, and TNRC6B: cg21034183) was prospectively associated with time to cancer development (positively for cg06751583, inversely for cg23230564 and cg21034183), whereas methylation of one CpG site (DROSHA: cg16131300) was positively associated with cancer prevalence.</jats:p>
<jats:p>Conclusions: DNA methylation of DROSHA, a key miRNA-processing gene, and TNRC6B may play a role in early carcinogenesis.</jats:p>
<jats:p>Impact: Changes in miRNA processing may exert multiple effects on cancer development, including protecting against it via altered global miRNAs, and may be a useful early detection biomarker of cancer. Cancer Epidemiol Biomarkers Prev; 27(5); 550–7. ©2018 AACR.</jats:p> |
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| author | Joyce, Brian T., Zheng, Yinan, Zhang, Zhou, Liu, Lei, Kocherginsky, Masha, Murphy, Robert, Achenbach, Chad J., Musa, Jonah, Wehbe, Firas, Just, Allan, Shen, Jincheng, Vokonas, Pantel, Schwartz, Joel, Baccarelli, Andrea A., Hou, Lifang |
| author_facet | Joyce, Brian T., Zheng, Yinan, Zhang, Zhou, Liu, Lei, Kocherginsky, Masha, Murphy, Robert, Achenbach, Chad J., Musa, Jonah, Wehbe, Firas, Just, Allan, Shen, Jincheng, Vokonas, Pantel, Schwartz, Joel, Baccarelli, Andrea A., Hou, Lifang, Joyce, Brian T., Zheng, Yinan, Zhang, Zhou, Liu, Lei, Kocherginsky, Masha, Murphy, Robert, Achenbach, Chad J., Musa, Jonah, Wehbe, Firas, Just, Allan, Shen, Jincheng, Vokonas, Pantel, Schwartz, Joel, Baccarelli, Andrea A., Hou, Lifang |
| author_sort | joyce, brian t. |
| container_issue | 5 |
| container_start_page | 550 |
| container_title | Cancer Epidemiology, Biomarkers & Prevention |
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| description | <jats:title>Abstract</jats:title> <jats:p>Background: Dysregulation of miRNA and methylation levels are epigenetic hallmarks of cancer, potentially linked via miRNA-processing genes. Studies have found genetic alterations to miRNA-processing genes in cancer cells and human population studies. Our objective was to prospectively examine changes in DNA methylation of miRNA-processing genes and their associations with cancer risk.</jats:p> <jats:p>Methods: We examined cohort data from the Department of Veterans' Affairs Normative Aging Study. Participants were assessed every 3 to 5 years starting in 1999 through 2013 including questionnaires, medical record review, and blood collection. Blood from 686 consenting participants was analyzed using the Illumina 450K BeadChip array to measure methylation at CpG sites throughout the genome. We selected 19 genes based on a literature review, with 519 corresponding CpG sites. We then used Cox proportional hazards models to examine associations with cancer incidence, and generalized estimating equations to examine associations with cancer prevalence. Associations at false discovery rate &lt; 0.05 were considered statistically significant.</jats:p> <jats:p>Results: Methylation of three CpGs (DROSHA: cg23230564, TNRC6B: cg06751583, and TNRC6B: cg21034183) was prospectively associated with time to cancer development (positively for cg06751583, inversely for cg23230564 and cg21034183), whereas methylation of one CpG site (DROSHA: cg16131300) was positively associated with cancer prevalence.</jats:p> <jats:p>Conclusions: DNA methylation of DROSHA, a key miRNA-processing gene, and TNRC6B may play a role in early carcinogenesis.</jats:p> <jats:p>Impact: Changes in miRNA processing may exert multiple effects on cancer development, including protecting against it via altered global miRNAs, and may be a useful early detection biomarker of cancer. Cancer Epidemiol Biomarkers Prev; 27(5); 550–7. ©2018 AACR.</jats:p> |
| doi_str_mv | 10.1158/1055-9965.epi-17-0849 |
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| imprint | American Association for Cancer Research (AACR), 2018 |
| imprint_str_mv | American Association for Cancer Research (AACR), 2018 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
| issn | 1055-9965, 1538-7755 |
| issn_str_mv | 1055-9965, 1538-7755 |
| language | English |
| last_indexed | 2024-03-01T17:49:21.213Z |
| match_str | joyce2018mirnaprocessinggenemethylationandcancerrisk |
| mega_collection | American Association for Cancer Research (AACR) (CrossRef) |
| physical | 550-557 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | American Association for Cancer Research (AACR) |
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| series | Cancer Epidemiology, Biomarkers & Prevention |
| source_id | 49 |
| spelling | Joyce, Brian T. Zheng, Yinan Zhang, Zhou Liu, Lei Kocherginsky, Masha Murphy, Robert Achenbach, Chad J. Musa, Jonah Wehbe, Firas Just, Allan Shen, Jincheng Vokonas, Pantel Schwartz, Joel Baccarelli, Andrea A. Hou, Lifang 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-17-0849 <jats:title>Abstract</jats:title> <jats:p>Background: Dysregulation of miRNA and methylation levels are epigenetic hallmarks of cancer, potentially linked via miRNA-processing genes. Studies have found genetic alterations to miRNA-processing genes in cancer cells and human population studies. Our objective was to prospectively examine changes in DNA methylation of miRNA-processing genes and their associations with cancer risk.</jats:p> <jats:p>Methods: We examined cohort data from the Department of Veterans' Affairs Normative Aging Study. Participants were assessed every 3 to 5 years starting in 1999 through 2013 including questionnaires, medical record review, and blood collection. Blood from 686 consenting participants was analyzed using the Illumina 450K BeadChip array to measure methylation at CpG sites throughout the genome. We selected 19 genes based on a literature review, with 519 corresponding CpG sites. We then used Cox proportional hazards models to examine associations with cancer incidence, and generalized estimating equations to examine associations with cancer prevalence. Associations at false discovery rate &lt; 0.05 were considered statistically significant.</jats:p> <jats:p>Results: Methylation of three CpGs (DROSHA: cg23230564, TNRC6B: cg06751583, and TNRC6B: cg21034183) was prospectively associated with time to cancer development (positively for cg06751583, inversely for cg23230564 and cg21034183), whereas methylation of one CpG site (DROSHA: cg16131300) was positively associated with cancer prevalence.</jats:p> <jats:p>Conclusions: DNA methylation of DROSHA, a key miRNA-processing gene, and TNRC6B may play a role in early carcinogenesis.</jats:p> <jats:p>Impact: Changes in miRNA processing may exert multiple effects on cancer development, including protecting against it via altered global miRNAs, and may be a useful early detection biomarker of cancer. Cancer Epidemiol Biomarkers Prev; 27(5); 550–7. ©2018 AACR.</jats:p> miRNA-Processing Gene Methylation and Cancer Risk Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Joyce, Brian T., Zheng, Yinan, Zhang, Zhou, Liu, Lei, Kocherginsky, Masha, Murphy, Robert, Achenbach, Chad J., Musa, Jonah, Wehbe, Firas, Just, Allan, Shen, Jincheng, Vokonas, Pantel, Schwartz, Joel, Baccarelli, Andrea A., Hou, Lifang, Cancer Epidemiology, Biomarkers & Prevention, miRNA-Processing Gene Methylation and Cancer Risk, Oncology, Epidemiology |
| title | miRNA-Processing Gene Methylation and Cancer Risk |
| title_full | miRNA-Processing Gene Methylation and Cancer Risk |
| title_fullStr | miRNA-Processing Gene Methylation and Cancer Risk |
| title_full_unstemmed | miRNA-Processing Gene Methylation and Cancer Risk |
| title_short | miRNA-Processing Gene Methylation and Cancer Risk |
| title_sort | mirna-processing gene methylation and cancer risk |
| title_unstemmed | miRNA-Processing Gene Methylation and Cancer Risk |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-17-0849 |