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The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 26, 2017, 2, S. 197-205 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
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| Schlagwörter: |
| author_facet |
Günther, Kathrin Foraita, Ronja Friemel, Juliane Günther, Frauke Bullerdiek, Jörn Nimzyk, Rolf Markowski, Dominique Nadine Behrens, Thomas Ahrens, Wolfgang Günther, Kathrin Foraita, Ronja Friemel, Juliane Günther, Frauke Bullerdiek, Jörn Nimzyk, Rolf Markowski, Dominique Nadine Behrens, Thomas Ahrens, Wolfgang |
|---|---|
| author |
Günther, Kathrin Foraita, Ronja Friemel, Juliane Günther, Frauke Bullerdiek, Jörn Nimzyk, Rolf Markowski, Dominique Nadine Behrens, Thomas Ahrens, Wolfgang |
| spellingShingle |
Günther, Kathrin Foraita, Ronja Friemel, Juliane Günther, Frauke Bullerdiek, Jörn Nimzyk, Rolf Markowski, Dominique Nadine Behrens, Thomas Ahrens, Wolfgang Cancer Epidemiology, Biomarkers & Prevention The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites Oncology Epidemiology |
| author_sort |
günther, kathrin |
| spelling |
Günther, Kathrin Foraita, Ronja Friemel, Juliane Günther, Frauke Bullerdiek, Jörn Nimzyk, Rolf Markowski, Dominique Nadine Behrens, Thomas Ahrens, Wolfgang 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-16-0492 <jats:title>Abstract</jats:title> <jats:p>Background: The transcription factor high-mobility AT-hook 2 (HMGA2) is involved in stem cell renewal and is expressed in many tumor tissues. Head and neck squamous cell carcinomas (HNSCC) comprise tumors of the upper aerodigestive tract and are characterized by high recurrence rates that represent a challenge to patient management. The study addresses the potential of HMGA2 as a molecular biomarker for HNSCC patient survival.</jats:p> <jats:p>Methods: Patients with HNSCC of the larynx, pharynx, tonsils, or oral cavity were recruited in a hospital-based case–control study (n = 202). Quantitative expression of HMGA2 in tumor tissues was measured by RT-PCR. In a 6- to 10-year follow-up, secondary cancers, vital status, and cause of death were ascertained. The HR and 95% confidence intervals (CI) for overall, tumor-specific, and progression-free survival were estimated by Cox proportional hazards with HMGA2 expression level as the independent variable.</jats:p> <jats:p>Results: High HMGA2 expression in tumor tissues of HNSCC patients was significantly correlated with negative HPV status (P = 0.01), and associated with shorter overall survival time. In Cox regression modeling, HMGA2 expression yielded a risk increase for overall and tumor-specific death in subsets of HNSCC patients, that is, laryngeal cancer patients (overall survival: HR = 4.00; 95% CI, 1.18–13.62) and in oral cancer patients (tumor-specific survival: HR = 2.88; 95% CI, 1.06–7.84), but not in patients with pharyngeal and tonsillar HNSCC.</jats:p> <jats:p>Conclusions: HMGA2 expression is associated with a risk increase for adverse outcomes in patients with HNSCC of the larynx and oral cavity.</jats:p> <jats:p>Impact: The understanding of stem cell signaling in HNSCC may offer new strategies for cancer treatment. Cancer Epidemiol Biomarkers Prev; 26(2); 197–205. ©2016 AACR.</jats:p> The Stem Cell Factor <i>HMGA2</i> Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites Cancer Epidemiology, Biomarkers & Prevention |
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American Association for Cancer Research (AACR), 2017 |
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American Association for Cancer Research (AACR), 2017 |
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1538-7755 1055-9965 |
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| title |
The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_unstemmed |
The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_full |
The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_fullStr |
The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_full_unstemmed |
The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_short |
The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_sort |
the stem cell factor <i>hmga2</i> is expressed in non-hpv–associated head and neck squamous cell carcinoma and predicts patient survival of distinct subsites |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-16-0492 |
| publishDate |
2017 |
| physical |
197-205 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Background: The transcription factor high-mobility AT-hook 2 (HMGA2) is involved in stem cell renewal and is expressed in many tumor tissues. Head and neck squamous cell carcinomas (HNSCC) comprise tumors of the upper aerodigestive tract and are characterized by high recurrence rates that represent a challenge to patient management. The study addresses the potential of HMGA2 as a molecular biomarker for HNSCC patient survival.</jats:p>
<jats:p>Methods: Patients with HNSCC of the larynx, pharynx, tonsils, or oral cavity were recruited in a hospital-based case–control study (n = 202). Quantitative expression of HMGA2 in tumor tissues was measured by RT-PCR. In a 6- to 10-year follow-up, secondary cancers, vital status, and cause of death were ascertained. The HR and 95% confidence intervals (CI) for overall, tumor-specific, and progression-free survival were estimated by Cox proportional hazards with HMGA2 expression level as the independent variable.</jats:p>
<jats:p>Results: High HMGA2 expression in tumor tissues of HNSCC patients was significantly correlated with negative HPV status (P = 0.01), and associated with shorter overall survival time. In Cox regression modeling, HMGA2 expression yielded a risk increase for overall and tumor-specific death in subsets of HNSCC patients, that is, laryngeal cancer patients (overall survival: HR = 4.00; 95% CI, 1.18–13.62) and in oral cancer patients (tumor-specific survival: HR = 2.88; 95% CI, 1.06–7.84), but not in patients with pharyngeal and tonsillar HNSCC.</jats:p>
<jats:p>Conclusions: HMGA2 expression is associated with a risk increase for adverse outcomes in patients with HNSCC of the larynx and oral cavity.</jats:p>
<jats:p>Impact: The understanding of stem cell signaling in HNSCC may offer new strategies for cancer treatment. Cancer Epidemiol Biomarkers Prev; 26(2); 197–205. ©2016 AACR.</jats:p> |
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| author | Günther, Kathrin, Foraita, Ronja, Friemel, Juliane, Günther, Frauke, Bullerdiek, Jörn, Nimzyk, Rolf, Markowski, Dominique Nadine, Behrens, Thomas, Ahrens, Wolfgang |
| author_facet | Günther, Kathrin, Foraita, Ronja, Friemel, Juliane, Günther, Frauke, Bullerdiek, Jörn, Nimzyk, Rolf, Markowski, Dominique Nadine, Behrens, Thomas, Ahrens, Wolfgang, Günther, Kathrin, Foraita, Ronja, Friemel, Juliane, Günther, Frauke, Bullerdiek, Jörn, Nimzyk, Rolf, Markowski, Dominique Nadine, Behrens, Thomas, Ahrens, Wolfgang |
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| description | <jats:title>Abstract</jats:title> <jats:p>Background: The transcription factor high-mobility AT-hook 2 (HMGA2) is involved in stem cell renewal and is expressed in many tumor tissues. Head and neck squamous cell carcinomas (HNSCC) comprise tumors of the upper aerodigestive tract and are characterized by high recurrence rates that represent a challenge to patient management. The study addresses the potential of HMGA2 as a molecular biomarker for HNSCC patient survival.</jats:p> <jats:p>Methods: Patients with HNSCC of the larynx, pharynx, tonsils, or oral cavity were recruited in a hospital-based case–control study (n = 202). Quantitative expression of HMGA2 in tumor tissues was measured by RT-PCR. In a 6- to 10-year follow-up, secondary cancers, vital status, and cause of death were ascertained. The HR and 95% confidence intervals (CI) for overall, tumor-specific, and progression-free survival were estimated by Cox proportional hazards with HMGA2 expression level as the independent variable.</jats:p> <jats:p>Results: High HMGA2 expression in tumor tissues of HNSCC patients was significantly correlated with negative HPV status (P = 0.01), and associated with shorter overall survival time. In Cox regression modeling, HMGA2 expression yielded a risk increase for overall and tumor-specific death in subsets of HNSCC patients, that is, laryngeal cancer patients (overall survival: HR = 4.00; 95% CI, 1.18–13.62) and in oral cancer patients (tumor-specific survival: HR = 2.88; 95% CI, 1.06–7.84), but not in patients with pharyngeal and tonsillar HNSCC.</jats:p> <jats:p>Conclusions: HMGA2 expression is associated with a risk increase for adverse outcomes in patients with HNSCC of the larynx and oral cavity.</jats:p> <jats:p>Impact: The understanding of stem cell signaling in HNSCC may offer new strategies for cancer treatment. Cancer Epidemiol Biomarkers Prev; 26(2); 197–205. ©2016 AACR.</jats:p> |
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| imprint | American Association for Cancer Research (AACR), 2017 |
| imprint_str_mv | American Association for Cancer Research (AACR), 2017 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Günther, Kathrin Foraita, Ronja Friemel, Juliane Günther, Frauke Bullerdiek, Jörn Nimzyk, Rolf Markowski, Dominique Nadine Behrens, Thomas Ahrens, Wolfgang 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-16-0492 <jats:title>Abstract</jats:title> <jats:p>Background: The transcription factor high-mobility AT-hook 2 (HMGA2) is involved in stem cell renewal and is expressed in many tumor tissues. Head and neck squamous cell carcinomas (HNSCC) comprise tumors of the upper aerodigestive tract and are characterized by high recurrence rates that represent a challenge to patient management. The study addresses the potential of HMGA2 as a molecular biomarker for HNSCC patient survival.</jats:p> <jats:p>Methods: Patients with HNSCC of the larynx, pharynx, tonsils, or oral cavity were recruited in a hospital-based case–control study (n = 202). Quantitative expression of HMGA2 in tumor tissues was measured by RT-PCR. In a 6- to 10-year follow-up, secondary cancers, vital status, and cause of death were ascertained. The HR and 95% confidence intervals (CI) for overall, tumor-specific, and progression-free survival were estimated by Cox proportional hazards with HMGA2 expression level as the independent variable.</jats:p> <jats:p>Results: High HMGA2 expression in tumor tissues of HNSCC patients was significantly correlated with negative HPV status (P = 0.01), and associated with shorter overall survival time. In Cox regression modeling, HMGA2 expression yielded a risk increase for overall and tumor-specific death in subsets of HNSCC patients, that is, laryngeal cancer patients (overall survival: HR = 4.00; 95% CI, 1.18–13.62) and in oral cancer patients (tumor-specific survival: HR = 2.88; 95% CI, 1.06–7.84), but not in patients with pharyngeal and tonsillar HNSCC.</jats:p> <jats:p>Conclusions: HMGA2 expression is associated with a risk increase for adverse outcomes in patients with HNSCC of the larynx and oral cavity.</jats:p> <jats:p>Impact: The understanding of stem cell signaling in HNSCC may offer new strategies for cancer treatment. Cancer Epidemiol Biomarkers Prev; 26(2); 197–205. ©2016 AACR.</jats:p> The Stem Cell Factor <i>HMGA2</i> Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Günther, Kathrin, Foraita, Ronja, Friemel, Juliane, Günther, Frauke, Bullerdiek, Jörn, Nimzyk, Rolf, Markowski, Dominique Nadine, Behrens, Thomas, Ahrens, Wolfgang, Cancer Epidemiology, Biomarkers & Prevention, The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites, Oncology, Epidemiology |
| title | The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_full | The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_fullStr | The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_full_unstemmed | The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_short | The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| title_sort | the stem cell factor <i>hmga2</i> is expressed in non-hpv–associated head and neck squamous cell carcinoma and predicts patient survival of distinct subsites |
| title_unstemmed | The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-16-0492 |