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Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 25, 2016, 1, S. 114-126 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
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| Schlagwörter: |
| author_facet |
Meulepas, Johanna M. Ronckers, Cécile M. Merks, Johannes Weijerman, Michel E. Lubin, Jay H. Hauptmann, Michael Meulepas, Johanna M. Ronckers, Cécile M. Merks, Johannes Weijerman, Michel E. Lubin, Jay H. Hauptmann, Michael |
|---|---|
| author |
Meulepas, Johanna M. Ronckers, Cécile M. Merks, Johannes Weijerman, Michel E. Lubin, Jay H. Hauptmann, Michael |
| spellingShingle |
Meulepas, Johanna M. Ronckers, Cécile M. Merks, Johannes Weijerman, Michel E. Lubin, Jay H. Hauptmann, Michael Cancer Epidemiology, Biomarkers & Prevention Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes Oncology Epidemiology |
| author_sort |
meulepas, johanna m. |
| spelling |
Meulepas, Johanna M. Ronckers, Cécile M. Merks, Johannes Weijerman, Michel E. Lubin, Jay H. Hauptmann, Michael 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-15-0636 <jats:title>Abstract</jats:title> <jats:p>Background: Recent studies linking radiation exposure from pediatric computed tomography (CT) to increased risks of leukemia and brain tumors lacked data to control for cancer susceptibility syndromes (CSS). These syndromes might be confounders because they are associated with an increased cancer risk and may increase the likelihood of CT scans performed in children.</jats:p> <jats:p>Methods: We identify CSS predisposing to leukemia and brain tumors through a systematic literature search and summarize prevalence and risk estimates. Because there is virtually no empirical evidence in published literature on patterns of CT use for most types of CSS, we estimate confounding bias of relative risks (RR) for categories of radiation exposure based on expert opinion about the current and previous patterns of CT scans among CSS patients.</jats:p> <jats:p>Results: We estimate that radiation-related RRs for leukemia are not meaningfully confounded by Down syndrome, Noonan syndrome, or other CSS. In contrast, RRs for brain tumors may be overestimated due to confounding by tuberous sclerosis complex (TSC) while von Hippel–Lindau disease, neurofibromatosis type 1, or other CSS do not meaningfully confound. Empirical data on the use of CT scans among CSS patients are urgently needed.</jats:p> <jats:p>Conclusions: Our assessment indicates that associations with leukemia reported in previous studies are unlikely to be substantially confounded by unmeasured CSS, whereas brain tumor risks might have been overestimated due to confounding by TSC.</jats:p> <jats:p>Impact: Future studies should identify TSC patients in order to avoid overestimation of brain tumor risks due to radiation exposure from CT scans. Cancer Epidemiol Biomarkers Prev; 25(1); 114–26. ©2015 AACR.</jats:p> Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes Cancer Epidemiology, Biomarkers & Prevention |
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| title |
Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_unstemmed |
Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_full |
Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_fullStr |
Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_full_unstemmed |
Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_short |
Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_sort |
confounding of the association between radiation exposure from ct scans and risk of leukemia and brain tumors by cancer susceptibility syndromes |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-15-0636 |
| publishDate |
2016 |
| physical |
114-126 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Background: Recent studies linking radiation exposure from pediatric computed tomography (CT) to increased risks of leukemia and brain tumors lacked data to control for cancer susceptibility syndromes (CSS). These syndromes might be confounders because they are associated with an increased cancer risk and may increase the likelihood of CT scans performed in children.</jats:p>
<jats:p>Methods: We identify CSS predisposing to leukemia and brain tumors through a systematic literature search and summarize prevalence and risk estimates. Because there is virtually no empirical evidence in published literature on patterns of CT use for most types of CSS, we estimate confounding bias of relative risks (RR) for categories of radiation exposure based on expert opinion about the current and previous patterns of CT scans among CSS patients.</jats:p>
<jats:p>Results: We estimate that radiation-related RRs for leukemia are not meaningfully confounded by Down syndrome, Noonan syndrome, or other CSS. In contrast, RRs for brain tumors may be overestimated due to confounding by tuberous sclerosis complex (TSC) while von Hippel–Lindau disease, neurofibromatosis type 1, or other CSS do not meaningfully confound. Empirical data on the use of CT scans among CSS patients are urgently needed.</jats:p>
<jats:p>Conclusions: Our assessment indicates that associations with leukemia reported in previous studies are unlikely to be substantially confounded by unmeasured CSS, whereas brain tumor risks might have been overestimated due to confounding by TSC.</jats:p>
<jats:p>Impact: Future studies should identify TSC patients in order to avoid overestimation of brain tumor risks due to radiation exposure from CT scans. Cancer Epidemiol Biomarkers Prev; 25(1); 114–26. ©2015 AACR.</jats:p> |
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| author | Meulepas, Johanna M., Ronckers, Cécile M., Merks, Johannes, Weijerman, Michel E., Lubin, Jay H., Hauptmann, Michael |
| author_facet | Meulepas, Johanna M., Ronckers, Cécile M., Merks, Johannes, Weijerman, Michel E., Lubin, Jay H., Hauptmann, Michael, Meulepas, Johanna M., Ronckers, Cécile M., Merks, Johannes, Weijerman, Michel E., Lubin, Jay H., Hauptmann, Michael |
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| description | <jats:title>Abstract</jats:title> <jats:p>Background: Recent studies linking radiation exposure from pediatric computed tomography (CT) to increased risks of leukemia and brain tumors lacked data to control for cancer susceptibility syndromes (CSS). These syndromes might be confounders because they are associated with an increased cancer risk and may increase the likelihood of CT scans performed in children.</jats:p> <jats:p>Methods: We identify CSS predisposing to leukemia and brain tumors through a systematic literature search and summarize prevalence and risk estimates. Because there is virtually no empirical evidence in published literature on patterns of CT use for most types of CSS, we estimate confounding bias of relative risks (RR) for categories of radiation exposure based on expert opinion about the current and previous patterns of CT scans among CSS patients.</jats:p> <jats:p>Results: We estimate that radiation-related RRs for leukemia are not meaningfully confounded by Down syndrome, Noonan syndrome, or other CSS. In contrast, RRs for brain tumors may be overestimated due to confounding by tuberous sclerosis complex (TSC) while von Hippel–Lindau disease, neurofibromatosis type 1, or other CSS do not meaningfully confound. Empirical data on the use of CT scans among CSS patients are urgently needed.</jats:p> <jats:p>Conclusions: Our assessment indicates that associations with leukemia reported in previous studies are unlikely to be substantially confounded by unmeasured CSS, whereas brain tumor risks might have been overestimated due to confounding by TSC.</jats:p> <jats:p>Impact: Future studies should identify TSC patients in order to avoid overestimation of brain tumor risks due to radiation exposure from CT scans. Cancer Epidemiol Biomarkers Prev; 25(1); 114–26. ©2015 AACR.</jats:p> |
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| imprint_str_mv | American Association for Cancer Research (AACR), 2016 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| spelling | Meulepas, Johanna M. Ronckers, Cécile M. Merks, Johannes Weijerman, Michel E. Lubin, Jay H. Hauptmann, Michael 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-15-0636 <jats:title>Abstract</jats:title> <jats:p>Background: Recent studies linking radiation exposure from pediatric computed tomography (CT) to increased risks of leukemia and brain tumors lacked data to control for cancer susceptibility syndromes (CSS). These syndromes might be confounders because they are associated with an increased cancer risk and may increase the likelihood of CT scans performed in children.</jats:p> <jats:p>Methods: We identify CSS predisposing to leukemia and brain tumors through a systematic literature search and summarize prevalence and risk estimates. Because there is virtually no empirical evidence in published literature on patterns of CT use for most types of CSS, we estimate confounding bias of relative risks (RR) for categories of radiation exposure based on expert opinion about the current and previous patterns of CT scans among CSS patients.</jats:p> <jats:p>Results: We estimate that radiation-related RRs for leukemia are not meaningfully confounded by Down syndrome, Noonan syndrome, or other CSS. In contrast, RRs for brain tumors may be overestimated due to confounding by tuberous sclerosis complex (TSC) while von Hippel–Lindau disease, neurofibromatosis type 1, or other CSS do not meaningfully confound. Empirical data on the use of CT scans among CSS patients are urgently needed.</jats:p> <jats:p>Conclusions: Our assessment indicates that associations with leukemia reported in previous studies are unlikely to be substantially confounded by unmeasured CSS, whereas brain tumor risks might have been overestimated due to confounding by TSC.</jats:p> <jats:p>Impact: Future studies should identify TSC patients in order to avoid overestimation of brain tumor risks due to radiation exposure from CT scans. Cancer Epidemiol Biomarkers Prev; 25(1); 114–26. ©2015 AACR.</jats:p> Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Meulepas, Johanna M., Ronckers, Cécile M., Merks, Johannes, Weijerman, Michel E., Lubin, Jay H., Hauptmann, Michael, Cancer Epidemiology, Biomarkers & Prevention, Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes, Oncology, Epidemiology |
| title | Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_full | Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_fullStr | Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_full_unstemmed | Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_short | Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| title_sort | confounding of the association between radiation exposure from ct scans and risk of leukemia and brain tumors by cancer susceptibility syndromes |
| title_unstemmed | Confounding of the Association between Radiation Exposure from CT Scans and Risk of Leukemia and Brain Tumors by Cancer Susceptibility Syndromes |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-15-0636 |