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Polymorphisms in thehMSH2Gene and the Risk of Primary Lung Cancer

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Bibliographische Detailangaben
Zeitschriftentitel: Cancer Epidemiology, Biomarkers & Prevention
Personen und Körperschaften: Jung, Chi Young, Choi, Jin Eun, Park, Jung Min, Chae, Myung Hwa, Kang, Hyo-Gyoung, Kim, Kyung Mee, Lee, Su Jeong, Lee, Won Kee, Kam, Sin, Cha, Seung Ick, Kim, Chang Ho, Han, Sung Beom, Jung, Tae Hoon, Jeon, Su Han, Park, Jae Yong
In: Cancer Epidemiology, Biomarkers & Prevention, 15, 2006, 4, S. 762-768
Format: E-Article
Sprache: Englisch
veröffentlicht:
American Association for Cancer Research (AACR)
Schlagwörter:
Oncology
Epidemiology
Details
Zusammenfassung: <jats:title>Abstract</jats:title><jats:p>Polymorphisms in the DNA repair genes may be associated with differences in the capacity to repair DNA damage, and so this can influence an individual's susceptibility to lung cancer. To test this hypothesis, we investigated the association of hMSH2 −118T&amp;gt;C, IVS1+9G&amp;gt;C, IVS10+12A&amp;gt;G, and IVS12−6T&amp;gt;C genotypes and their haplotypes with the risk of lung cancer in a Korean population. The hMSH2 genotypes were determined in 432 lung cancer patients and in 432 healthy controls who were frequency matched for age and gender. The hMSH2 haplotypes were estimated based on a Bayesian algorithm using the Phase program. The presence of at least one IVS10+12G allele was associated with a significantly decreased risk of adenocarcinoma, as compared with the IVS10+12AA genotype [adjusted odds ratio (OR), 0.59; 95% confidence interval (95% CI), 0.40-0.88; P = 0.01], and the presence of at least one IVS12-6C allele was associated with a significantly increased risk of adenocarcinoma, as compared with the IVS12-6TT genotype (adjusted OR, 1.52; 95% CI, 1.02-2.27; P = 0.04). Consistent with the results of the genotyping analysis, the TGGT haplotype with no risk allele was associated with a significantly decreased risk of adenocarcinoma, as compared with the TCAC haplotype with two risk allele [i.e., IVS10+12A and IVS12-6C allele; adjusted OR, 0.49; 95% CI, 0.30-0.78; P = 0.003 and Pc (Bonferroni corrected P value) = 0.012]. The effect of the hMSH2 haplotypes on the risk of adenocarcinoma was statistically significant in the never smokers and younger individuals (adjusted OR, 0.45; 95% CI, 0.27-0.75; P = 0.002 and Pc = 0.004; and adjusted OR, 0.44; 95% CI, 0.23-0.85; P = 0.014 and Pc = 0.028, respectively) but not in the ever-smokers and older individuals. These results suggest that the hMSH2 polymorphisms and their haplotypes may be an important genetic determinant of adenocarcinoma of the lung, particularly in never smokers. (Cancer Epidemiol Biomarkers Prev 2006;15(4):762–8)</jats:p>
Umfang: 762-768
ISSN: 1055-9965
1538-7755
DOI: 10.1158/1055-9965.epi-05-0834