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Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

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Bibliographische Detailangaben
Zeitschriftentitel: Cancer Research
Personen und Körperschaften: Patel, Vivek L., Busch, Evan L., Friebel, Tara M., Cronin, Angel, Leslie, Goska, McGuffog, Lesley, Adlard, Julian, Agata, Simona, Agnarsson, Bjarni A., Ahmed, Munaza, Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L., Arason, Adalgeir, Arnold, Norbert, Artioli, Grazia, Arver, Brita, Auber, Bernd, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B., Barnes, Daniel R., Barroso, Alicia, Barrowdale, Daniel, Belotti, Muriel, Benitez, Javier, Bertelsen, Birgitte, Blok, Marinus J., Bodrogi, Istvan, Bonadona, Valérie, Bonanni, Bernardo, Bondavalli, Davide, Boonen, Susanne E., Borde, Julika, Borg, Ake, Bradbury, Angela R., Brady, Angela, Brewer, Carole, Brunet, Joan, Buecher, Bruno, Buys, Saundra S., Cabezas-Camarero, Santiago, Caldés, Trinidad, Caliebe, Almuth, Caligo, Maria A., Calvello, Mariarosaria, Campbell, Ian G., Carnevali, Ileana, Carrasco, Estela, Chan, Tsun L., Chu, Annie T.W., Chung, Wendy K., Claes, Kathleen B.M., Collaborators, GEMO Study, Collaborators, EMBRACE, Cook, Jackie, Cortesi, Laura, Couch, Fergus J., Daly, Mary B., Damante, Giuseppe, Darder, Esther, Davidson, Rosemarie, de la Hoya, Miguel, Puppa, Lara Della, Dennis, Joe, Díez, Orland, Ding, Yuan Chun, Ditsch, Nina, Domchek, Susan M., Donaldson, Alan, Dworniczak, Bernd, Easton, Douglas F., Eccles, Diana M., Eeles, Rosalind A., Ehrencrona, Hans, Ejlertsen, Bent, Engel, Christoph, Evans, D. Gareth, Faivre, Laurence, Faust, Ulrike, Feliubadaló, Lídia, Foretova, Lenka, Fostira, Florentia, Fountzilas, George, Frost, Debra, García-Barberán, Vanesa, Garre, Pilar, Gauthier-Villars, Marion, Géczi, Lajos, Gehrig, Andrea, Gerdes, Anne-Marie, Gesta, Paul, Giannini, Giuseppe, Glendon, Gord, Godwin, Andrew K., Goldgar, David E., Greene, Mark H., Gutierrez-Barrera, Angelica M., Hahnen, Eric, Hamann, Ute, Hauke, Jan, Herold, Natalie, Hogervorst, Frans B.L., Honisch, Ellen, Hopper, John L., Hulick, Peter J., Investigators, KConFab, Investigators, HEBON, Izatt, Louise, Jager, Agnes, James, Paul, Janavicius, Ramunas, Jensen, Uffe Birk, Jensen, Thomas Dyrso, Johannsson, Oskar Th., John, Esther M., Joseph, Vijai, Kang, Eunyoung, Kast, Karin, Kiiski, Johanna I., Kim, Sung-Won, Kim, Zisun, Ko, Kwang-Pil, Konstantopoulou, Irene, Kramer, Gero, Krogh, Lotte, Kruse, Torben A., Kwong, Ava, Larsen, Mirjam, Lasset, Christine, Lautrup, Charlotte, Lazaro, Conxi, Lee, Jihyoun, Lee, Jong Won, Lee, Min Hyuk, Lemke, Johannes, Lesueur, Fabienne, Liljegren, Annelie, Lindblom, Annika, Llovet, Patricia, Lopez-Fernández, Adria, Lopez-Perolio, Irene, Lorca, Victor, Loud, Jennifer T., Ma, Edmond S.K., Mai, Phuong L., Manoukian, Siranoush, Mari, Veronique, Martin, Lynn, Matricardi, Laura, Mebirouk, Noura, Medici, Veronica, Meijers-Heijboer, Hanne E.J., Meindl, Alfons, Mensenkamp, Arjen R., Miller, Clare, Gomes, Denise Molina, Montagna, Marco, Mooij, Thea M., Moserle, Lidia, Mouret-Fourme, Emmanuelle, Mulligan, Anna Marie, Nathanson, Katherine L., Navratilova, Marie, Nevanlinna, Heli, Niederacher, Dieter, Nielsen, Finn C. Cilius, Nikitina-Zake, Liene, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Ong, Kai-Ren, Osorio, Ana, Ott, Claus-Eric, Palli, Domenico, Park, Sue K., Parsons, Michael T., Pedersen, Inge Sokilde, Peissel, Bernard, Peixoto, Ana, Pérez-Segura, Pedro, Peterlongo, Paolo, Petersen, Annabeth Høgh, Porteous, Mary E., Pujana, Miguel Angel, Radice, Paolo, Ramser, Juliane, Rantala, Johanna, Rashid, Muhammad U., Rhiem, Kerstin, Rizzolo, Piera, Robson, Mark E., Rookus, Matti A., Rossing, Caroline M., Ruddy, Kathryn J., Santos, Catarina, Saule, Claire, Scarpitta, Rosa, Schmutzler, Rita K., Schuster, Hélène, Senter, Leigha, Seynaeve, Caroline M., Shah, Payal D., Sharma, Priyanka, Shin, Vivian Y., Silvestri, Valentina, Simard, Jacques, Singer, Christian F., Skytte, Anne-Bine, Snape, Katie, Solano, Angela R., Soucy, Penny, Southey, Melissa C., Spurdle, Amanda B., Steele, Linda, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Stradella, Agostina, Sunde, Lone, Sutter, Christian, Tan, Yen Y., Teixeira, Manuel R., Teo, Soo Hwang, Thomassen, Mads, Tibiletti, Maria Grazia, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda E., Tommasi, Stefania, Torres, Diana, Toss, Angela, Trainer, Alison H., Tung, Nadine, van Asperen, Christi J., van der Baan, Frederieke H., van der Kolk, Lizet E., van der Luijt, Rob B., van Hest, Liselotte P., Varesco, Liliana, Varon-Mateeva, Raymonda, Viel, Alessandra, Vierstraete, Jeroen, Villa, Roberta, von Wachenfeldt, Anna, Wagner, Philipp, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weitzel, Jeffrey N., Wieme, Greet, Yadav, Siddhartha, Yannoukakos, Drakoulis, Yoon, Sook-Yee, Zanzottera, Cristina, Zorn, Kristin K., D'Amico, Anthony V., Freedman, Matthew L., Pomerantz, Mark M., Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L., Ottini, Laura, Nielsen, Henriette Roed, Rebbeck, Timothy R.
In: Cancer Research, 80, 2020, 3, S. 624-638
Format: E-Article
Sprache: Englisch
veröffentlicht:
American Association for Cancer Research (AACR)
Schlagwörter:
author_facet Patel, Vivek L.
Busch, Evan L.
Friebel, Tara M.
Cronin, Angel
Leslie, Goska
McGuffog, Lesley
Adlard, Julian
Agata, Simona
Agnarsson, Bjarni A.
Ahmed, Munaza
Aittomäki, Kristiina
Alducci, Elisa
Andrulis, Irene L.
Arason, Adalgeir
Arnold, Norbert
Artioli, Grazia
Arver, Brita
Auber, Bernd
Azzollini, Jacopo
Balmaña, Judith
Barkardottir, Rosa B.
Barnes, Daniel R.
Barroso, Alicia
Barrowdale, Daniel
Belotti, Muriel
Benitez, Javier
Bertelsen, Birgitte
Blok, Marinus J.
Bodrogi, Istvan
Bonadona, Valérie
Bonanni, Bernardo
Bondavalli, Davide
Boonen, Susanne E.
Borde, Julika
Borg, Ake
Bradbury, Angela R.
Brady, Angela
Brewer, Carole
Brunet, Joan
Buecher, Bruno
Buys, Saundra S.
Cabezas-Camarero, Santiago
Caldés, Trinidad
Caliebe, Almuth
Caligo, Maria A.
Calvello, Mariarosaria
Campbell, Ian G.
Carnevali, Ileana
Carrasco, Estela
Chan, Tsun L.
Chu, Annie T.W.
Chung, Wendy K.
Claes, Kathleen B.M.
Collaborators, GEMO Study
Collaborators, EMBRACE
Cook, Jackie
Cortesi, Laura
Couch, Fergus J.
Daly, Mary B.
Damante, Giuseppe
Darder, Esther
Davidson, Rosemarie
de la Hoya, Miguel
Puppa, Lara Della
Dennis, Joe
Díez, Orland
Ding, Yuan Chun
Ditsch, Nina
Domchek, Susan M.
Donaldson, Alan
Dworniczak, Bernd
Easton, Douglas F.
Eccles, Diana M.
Eeles, Rosalind A.
Ehrencrona, Hans
Ejlertsen, Bent
Engel, Christoph
Evans, D. Gareth
Faivre, Laurence
Faust, Ulrike
Feliubadaló, Lídia
Foretova, Lenka
Fostira, Florentia
Fountzilas, George
Frost, Debra
García-Barberán, Vanesa
Garre, Pilar
Gauthier-Villars, Marion
Géczi, Lajos
Gehrig, Andrea
Gerdes, Anne-Marie
Gesta, Paul
Giannini, Giuseppe
Glendon, Gord
Godwin, Andrew K.
Goldgar, David E.
Greene, Mark H.
Gutierrez-Barrera, Angelica M.
Hahnen, Eric
Hamann, Ute
Hauke, Jan
Herold, Natalie
Hogervorst, Frans B.L.
Honisch, Ellen
Hopper, John L.
Hulick, Peter J.
Investigators, KConFab
Investigators, HEBON
Izatt, Louise
Jager, Agnes
James, Paul
Janavicius, Ramunas
Jensen, Uffe Birk
Jensen, Thomas Dyrso
Johannsson, Oskar Th.
John, Esther M.
Joseph, Vijai
Kang, Eunyoung
Kast, Karin
Kiiski, Johanna I.
Kim, Sung-Won
Kim, Zisun
Ko, Kwang-Pil
Konstantopoulou, Irene
Kramer, Gero
Krogh, Lotte
Kruse, Torben A.
Kwong, Ava
Larsen, Mirjam
Lasset, Christine
Lautrup, Charlotte
Lazaro, Conxi
Lee, Jihyoun
Lee, Jong Won
Lee, Min Hyuk
Lemke, Johannes
Lesueur, Fabienne
Liljegren, Annelie
Lindblom, Annika
Llovet, Patricia
Lopez-Fernández, Adria
Lopez-Perolio, Irene
Lorca, Victor
Loud, Jennifer T.
Ma, Edmond S.K.
Mai, Phuong L.
Manoukian, Siranoush
Mari, Veronique
Martin, Lynn
Matricardi, Laura
Mebirouk, Noura
Medici, Veronica
Meijers-Heijboer, Hanne E.J.
Meindl, Alfons
Mensenkamp, Arjen R.
Miller, Clare
Gomes, Denise Molina
Montagna, Marco
Mooij, Thea M.
Moserle, Lidia
Mouret-Fourme, Emmanuelle
Mulligan, Anna Marie
Nathanson, Katherine L.
Navratilova, Marie
Nevanlinna, Heli
Niederacher, Dieter
Nielsen, Finn C. Cilius
Nikitina-Zake, Liene
Offit, Kenneth
Olah, Edith
Olopade, Olufunmilayo I.
Ong, Kai-Ren
Osorio, Ana
Ott, Claus-Eric
Palli, Domenico
Park, Sue K.
Parsons, Michael T.
Pedersen, Inge Sokilde
Peissel, Bernard
Peixoto, Ana
Pérez-Segura, Pedro
Peterlongo, Paolo
Petersen, Annabeth Høgh
Porteous, Mary E.
Pujana, Miguel Angel
Radice, Paolo
Ramser, Juliane
Rantala, Johanna
Rashid, Muhammad U.
Rhiem, Kerstin
Rizzolo, Piera
Robson, Mark E.
Rookus, Matti A.
Rossing, Caroline M.
Ruddy, Kathryn J.
Santos, Catarina
Saule, Claire
Scarpitta, Rosa
Schmutzler, Rita K.
Schuster, Hélène
Senter, Leigha
Seynaeve, Caroline M.
Shah, Payal D.
Sharma, Priyanka
Shin, Vivian Y.
Silvestri, Valentina
Simard, Jacques
Singer, Christian F.
Skytte, Anne-Bine
Snape, Katie
Solano, Angela R.
Soucy, Penny
Southey, Melissa C.
Spurdle, Amanda B.
Steele, Linda
Steinemann, Doris
Stoppa-Lyonnet, Dominique
Stradella, Agostina
Sunde, Lone
Sutter, Christian
Tan, Yen Y.
Teixeira, Manuel R.
Teo, Soo Hwang
Thomassen, Mads
Tibiletti, Maria Grazia
Tischkowitz, Marc
Tognazzo, Silvia
Toland, Amanda E.
Tommasi, Stefania
Torres, Diana
Toss, Angela
Trainer, Alison H.
Tung, Nadine
van Asperen, Christi J.
van der Baan, Frederieke H.
van der Kolk, Lizet E.
van der Luijt, Rob B.
van Hest, Liselotte P.
Varesco, Liliana
Varon-Mateeva, Raymonda
Viel, Alessandra
Vierstraete, Jeroen
Villa, Roberta
von Wachenfeldt, Anna
Wagner, Philipp
Wang-Gohrke, Shan
Wappenschmidt, Barbara
Weitzel, Jeffrey N.
Wieme, Greet
Yadav, Siddhartha
Yannoukakos, Drakoulis
Yoon, Sook-Yee
Zanzottera, Cristina
Zorn, Kristin K.
D'Amico, Anthony V.
Freedman, Matthew L.
Pomerantz, Mark M.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Neuhausen, Susan L.
Ottini, Laura
Nielsen, Henriette Roed
Rebbeck, Timothy R.
Patel, Vivek L.
Busch, Evan L.
Friebel, Tara M.
Cronin, Angel
Leslie, Goska
McGuffog, Lesley
Adlard, Julian
Agata, Simona
Agnarsson, Bjarni A.
Ahmed, Munaza
Aittomäki, Kristiina
Alducci, Elisa
Andrulis, Irene L.
Arason, Adalgeir
Arnold, Norbert
Artioli, Grazia
Arver, Brita
Auber, Bernd
Azzollini, Jacopo
Balmaña, Judith
Barkardottir, Rosa B.
Barnes, Daniel R.
Barroso, Alicia
Barrowdale, Daniel
Belotti, Muriel
Benitez, Javier
Bertelsen, Birgitte
Blok, Marinus J.
Bodrogi, Istvan
Bonadona, Valérie
Bonanni, Bernardo
Bondavalli, Davide
Boonen, Susanne E.
Borde, Julika
Borg, Ake
Bradbury, Angela R.
Brady, Angela
Brewer, Carole
Brunet, Joan
Buecher, Bruno
Buys, Saundra S.
Cabezas-Camarero, Santiago
Caldés, Trinidad
Caliebe, Almuth
Caligo, Maria A.
Calvello, Mariarosaria
Campbell, Ian G.
Carnevali, Ileana
Carrasco, Estela
Chan, Tsun L.
Chu, Annie T.W.
Chung, Wendy K.
Claes, Kathleen B.M.
Collaborators, GEMO Study
Collaborators, EMBRACE
Cook, Jackie
Cortesi, Laura
Couch, Fergus J.
Daly, Mary B.
Damante, Giuseppe
Darder, Esther
Davidson, Rosemarie
de la Hoya, Miguel
Puppa, Lara Della
Dennis, Joe
Díez, Orland
Ding, Yuan Chun
Ditsch, Nina
Domchek, Susan M.
Donaldson, Alan
Dworniczak, Bernd
Easton, Douglas F.
Eccles, Diana M.
Eeles, Rosalind A.
Ehrencrona, Hans
Ejlertsen, Bent
Engel, Christoph
Evans, D. Gareth
Faivre, Laurence
Faust, Ulrike
Feliubadaló, Lídia
Foretova, Lenka
Fostira, Florentia
Fountzilas, George
Frost, Debra
García-Barberán, Vanesa
Garre, Pilar
Gauthier-Villars, Marion
Géczi, Lajos
Gehrig, Andrea
Gerdes, Anne-Marie
Gesta, Paul
Giannini, Giuseppe
Glendon, Gord
Godwin, Andrew K.
Goldgar, David E.
Greene, Mark H.
Gutierrez-Barrera, Angelica M.
Hahnen, Eric
Hamann, Ute
Hauke, Jan
Herold, Natalie
Hogervorst, Frans B.L.
Honisch, Ellen
Hopper, John L.
Hulick, Peter J.
Investigators, KConFab
Investigators, HEBON
Izatt, Louise
Jager, Agnes
James, Paul
Janavicius, Ramunas
Jensen, Uffe Birk
Jensen, Thomas Dyrso
Johannsson, Oskar Th.
John, Esther M.
Joseph, Vijai
Kang, Eunyoung
Kast, Karin
Kiiski, Johanna I.
Kim, Sung-Won
Kim, Zisun
Ko, Kwang-Pil
Konstantopoulou, Irene
Kramer, Gero
Krogh, Lotte
Kruse, Torben A.
Kwong, Ava
Larsen, Mirjam
Lasset, Christine
Lautrup, Charlotte
Lazaro, Conxi
Lee, Jihyoun
Lee, Jong Won
Lee, Min Hyuk
Lemke, Johannes
Lesueur, Fabienne
Liljegren, Annelie
Lindblom, Annika
Llovet, Patricia
Lopez-Fernández, Adria
Lopez-Perolio, Irene
Lorca, Victor
Loud, Jennifer T.
Ma, Edmond S.K.
Mai, Phuong L.
Manoukian, Siranoush
Mari, Veronique
Martin, Lynn
Matricardi, Laura
Mebirouk, Noura
Medici, Veronica
Meijers-Heijboer, Hanne E.J.
Meindl, Alfons
Mensenkamp, Arjen R.
Miller, Clare
Gomes, Denise Molina
Montagna, Marco
Mooij, Thea M.
Moserle, Lidia
Mouret-Fourme, Emmanuelle
Mulligan, Anna Marie
Nathanson, Katherine L.
Navratilova, Marie
Nevanlinna, Heli
Niederacher, Dieter
Nielsen, Finn C. Cilius
Nikitina-Zake, Liene
Offit, Kenneth
Olah, Edith
Olopade, Olufunmilayo I.
Ong, Kai-Ren
Osorio, Ana
Ott, Claus-Eric
Palli, Domenico
Park, Sue K.
Parsons, Michael T.
Pedersen, Inge Sokilde
Peissel, Bernard
Peixoto, Ana
Pérez-Segura, Pedro
Peterlongo, Paolo
Petersen, Annabeth Høgh
Porteous, Mary E.
Pujana, Miguel Angel
Radice, Paolo
Ramser, Juliane
Rantala, Johanna
Rashid, Muhammad U.
Rhiem, Kerstin
Rizzolo, Piera
Robson, Mark E.
Rookus, Matti A.
Rossing, Caroline M.
Ruddy, Kathryn J.
Santos, Catarina
Saule, Claire
Scarpitta, Rosa
Schmutzler, Rita K.
Schuster, Hélène
Senter, Leigha
Seynaeve, Caroline M.
Shah, Payal D.
Sharma, Priyanka
Shin, Vivian Y.
Silvestri, Valentina
Simard, Jacques
Singer, Christian F.
Skytte, Anne-Bine
Snape, Katie
Solano, Angela R.
Soucy, Penny
Southey, Melissa C.
Spurdle, Amanda B.
Steele, Linda
Steinemann, Doris
Stoppa-Lyonnet, Dominique
Stradella, Agostina
Sunde, Lone
Sutter, Christian
Tan, Yen Y.
Teixeira, Manuel R.
Teo, Soo Hwang
Thomassen, Mads
Tibiletti, Maria Grazia
Tischkowitz, Marc
Tognazzo, Silvia
Toland, Amanda E.
Tommasi, Stefania
Torres, Diana
Toss, Angela
Trainer, Alison H.
Tung, Nadine
van Asperen, Christi J.
van der Baan, Frederieke H.
van der Kolk, Lizet E.
van der Luijt, Rob B.
van Hest, Liselotte P.
Varesco, Liliana
Varon-Mateeva, Raymonda
Viel, Alessandra
Vierstraete, Jeroen
Villa, Roberta
von Wachenfeldt, Anna
Wagner, Philipp
Wang-Gohrke, Shan
Wappenschmidt, Barbara
Weitzel, Jeffrey N.
Wieme, Greet
Yadav, Siddhartha
Yannoukakos, Drakoulis
Yoon, Sook-Yee
Zanzottera, Cristina
Zorn, Kristin K.
D'Amico, Anthony V.
Freedman, Matthew L.
Pomerantz, Mark M.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Neuhausen, Susan L.
Ottini, Laura
Nielsen, Henriette Roed
Rebbeck, Timothy R.
author Patel, Vivek L.
Busch, Evan L.
Friebel, Tara M.
Cronin, Angel
Leslie, Goska
McGuffog, Lesley
Adlard, Julian
Agata, Simona
Agnarsson, Bjarni A.
Ahmed, Munaza
Aittomäki, Kristiina
Alducci, Elisa
Andrulis, Irene L.
Arason, Adalgeir
Arnold, Norbert
Artioli, Grazia
Arver, Brita
Auber, Bernd
Azzollini, Jacopo
Balmaña, Judith
Barkardottir, Rosa B.
Barnes, Daniel R.
Barroso, Alicia
Barrowdale, Daniel
Belotti, Muriel
Benitez, Javier
Bertelsen, Birgitte
Blok, Marinus J.
Bodrogi, Istvan
Bonadona, Valérie
Bonanni, Bernardo
Bondavalli, Davide
Boonen, Susanne E.
Borde, Julika
Borg, Ake
Bradbury, Angela R.
Brady, Angela
Brewer, Carole
Brunet, Joan
Buecher, Bruno
Buys, Saundra S.
Cabezas-Camarero, Santiago
Caldés, Trinidad
Caliebe, Almuth
Caligo, Maria A.
Calvello, Mariarosaria
Campbell, Ian G.
Carnevali, Ileana
Carrasco, Estela
Chan, Tsun L.
Chu, Annie T.W.
Chung, Wendy K.
Claes, Kathleen B.M.
Collaborators, GEMO Study
Collaborators, EMBRACE
Cook, Jackie
Cortesi, Laura
Couch, Fergus J.
Daly, Mary B.
Damante, Giuseppe
Darder, Esther
Davidson, Rosemarie
de la Hoya, Miguel
Puppa, Lara Della
Dennis, Joe
Díez, Orland
Ding, Yuan Chun
Ditsch, Nina
Domchek, Susan M.
Donaldson, Alan
Dworniczak, Bernd
Easton, Douglas F.
Eccles, Diana M.
Eeles, Rosalind A.
Ehrencrona, Hans
Ejlertsen, Bent
Engel, Christoph
Evans, D. Gareth
Faivre, Laurence
Faust, Ulrike
Feliubadaló, Lídia
Foretova, Lenka
Fostira, Florentia
Fountzilas, George
Frost, Debra
García-Barberán, Vanesa
Garre, Pilar
Gauthier-Villars, Marion
Géczi, Lajos
Gehrig, Andrea
Gerdes, Anne-Marie
Gesta, Paul
Giannini, Giuseppe
Glendon, Gord
Godwin, Andrew K.
Goldgar, David E.
Greene, Mark H.
Gutierrez-Barrera, Angelica M.
Hahnen, Eric
Hamann, Ute
Hauke, Jan
Herold, Natalie
Hogervorst, Frans B.L.
Honisch, Ellen
Hopper, John L.
Hulick, Peter J.
Investigators, KConFab
Investigators, HEBON
Izatt, Louise
Jager, Agnes
James, Paul
Janavicius, Ramunas
Jensen, Uffe Birk
Jensen, Thomas Dyrso
Johannsson, Oskar Th.
John, Esther M.
Joseph, Vijai
Kang, Eunyoung
Kast, Karin
Kiiski, Johanna I.
Kim, Sung-Won
Kim, Zisun
Ko, Kwang-Pil
Konstantopoulou, Irene
Kramer, Gero
Krogh, Lotte
Kruse, Torben A.
Kwong, Ava
Larsen, Mirjam
Lasset, Christine
Lautrup, Charlotte
Lazaro, Conxi
Lee, Jihyoun
Lee, Jong Won
Lee, Min Hyuk
Lemke, Johannes
Lesueur, Fabienne
Liljegren, Annelie
Lindblom, Annika
Llovet, Patricia
Lopez-Fernández, Adria
Lopez-Perolio, Irene
Lorca, Victor
Loud, Jennifer T.
Ma, Edmond S.K.
Mai, Phuong L.
Manoukian, Siranoush
Mari, Veronique
Martin, Lynn
Matricardi, Laura
Mebirouk, Noura
Medici, Veronica
Meijers-Heijboer, Hanne E.J.
Meindl, Alfons
Mensenkamp, Arjen R.
Miller, Clare
Gomes, Denise Molina
Montagna, Marco
Mooij, Thea M.
Moserle, Lidia
Mouret-Fourme, Emmanuelle
Mulligan, Anna Marie
Nathanson, Katherine L.
Navratilova, Marie
Nevanlinna, Heli
Niederacher, Dieter
Nielsen, Finn C. Cilius
Nikitina-Zake, Liene
Offit, Kenneth
Olah, Edith
Olopade, Olufunmilayo I.
Ong, Kai-Ren
Osorio, Ana
Ott, Claus-Eric
Palli, Domenico
Park, Sue K.
Parsons, Michael T.
Pedersen, Inge Sokilde
Peissel, Bernard
Peixoto, Ana
Pérez-Segura, Pedro
Peterlongo, Paolo
Petersen, Annabeth Høgh
Porteous, Mary E.
Pujana, Miguel Angel
Radice, Paolo
Ramser, Juliane
Rantala, Johanna
Rashid, Muhammad U.
Rhiem, Kerstin
Rizzolo, Piera
Robson, Mark E.
Rookus, Matti A.
Rossing, Caroline M.
Ruddy, Kathryn J.
Santos, Catarina
Saule, Claire
Scarpitta, Rosa
Schmutzler, Rita K.
Schuster, Hélène
Senter, Leigha
Seynaeve, Caroline M.
Shah, Payal D.
Sharma, Priyanka
Shin, Vivian Y.
Silvestri, Valentina
Simard, Jacques
Singer, Christian F.
Skytte, Anne-Bine
Snape, Katie
Solano, Angela R.
Soucy, Penny
Southey, Melissa C.
Spurdle, Amanda B.
Steele, Linda
Steinemann, Doris
Stoppa-Lyonnet, Dominique
Stradella, Agostina
Sunde, Lone
Sutter, Christian
Tan, Yen Y.
Teixeira, Manuel R.
Teo, Soo Hwang
Thomassen, Mads
Tibiletti, Maria Grazia
Tischkowitz, Marc
Tognazzo, Silvia
Toland, Amanda E.
Tommasi, Stefania
Torres, Diana
Toss, Angela
Trainer, Alison H.
Tung, Nadine
van Asperen, Christi J.
van der Baan, Frederieke H.
van der Kolk, Lizet E.
van der Luijt, Rob B.
van Hest, Liselotte P.
Varesco, Liliana
Varon-Mateeva, Raymonda
Viel, Alessandra
Vierstraete, Jeroen
Villa, Roberta
von Wachenfeldt, Anna
Wagner, Philipp
Wang-Gohrke, Shan
Wappenschmidt, Barbara
Weitzel, Jeffrey N.
Wieme, Greet
Yadav, Siddhartha
Yannoukakos, Drakoulis
Yoon, Sook-Yee
Zanzottera, Cristina
Zorn, Kristin K.
D'Amico, Anthony V.
Freedman, Matthew L.
Pomerantz, Mark M.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Neuhausen, Susan L.
Ottini, Laura
Nielsen, Henriette Roed
Rebbeck, Timothy R.
spellingShingle Patel, Vivek L.
Busch, Evan L.
Friebel, Tara M.
Cronin, Angel
Leslie, Goska
McGuffog, Lesley
Adlard, Julian
Agata, Simona
Agnarsson, Bjarni A.
Ahmed, Munaza
Aittomäki, Kristiina
Alducci, Elisa
Andrulis, Irene L.
Arason, Adalgeir
Arnold, Norbert
Artioli, Grazia
Arver, Brita
Auber, Bernd
Azzollini, Jacopo
Balmaña, Judith
Barkardottir, Rosa B.
Barnes, Daniel R.
Barroso, Alicia
Barrowdale, Daniel
Belotti, Muriel
Benitez, Javier
Bertelsen, Birgitte
Blok, Marinus J.
Bodrogi, Istvan
Bonadona, Valérie
Bonanni, Bernardo
Bondavalli, Davide
Boonen, Susanne E.
Borde, Julika
Borg, Ake
Bradbury, Angela R.
Brady, Angela
Brewer, Carole
Brunet, Joan
Buecher, Bruno
Buys, Saundra S.
Cabezas-Camarero, Santiago
Caldés, Trinidad
Caliebe, Almuth
Caligo, Maria A.
Calvello, Mariarosaria
Campbell, Ian G.
Carnevali, Ileana
Carrasco, Estela
Chan, Tsun L.
Chu, Annie T.W.
Chung, Wendy K.
Claes, Kathleen B.M.
Collaborators, GEMO Study
Collaborators, EMBRACE
Cook, Jackie
Cortesi, Laura
Couch, Fergus J.
Daly, Mary B.
Damante, Giuseppe
Darder, Esther
Davidson, Rosemarie
de la Hoya, Miguel
Puppa, Lara Della
Dennis, Joe
Díez, Orland
Ding, Yuan Chun
Ditsch, Nina
Domchek, Susan M.
Donaldson, Alan
Dworniczak, Bernd
Easton, Douglas F.
Eccles, Diana M.
Eeles, Rosalind A.
Ehrencrona, Hans
Ejlertsen, Bent
Engel, Christoph
Evans, D. Gareth
Faivre, Laurence
Faust, Ulrike
Feliubadaló, Lídia
Foretova, Lenka
Fostira, Florentia
Fountzilas, George
Frost, Debra
García-Barberán, Vanesa
Garre, Pilar
Gauthier-Villars, Marion
Géczi, Lajos
Gehrig, Andrea
Gerdes, Anne-Marie
Gesta, Paul
Giannini, Giuseppe
Glendon, Gord
Godwin, Andrew K.
Goldgar, David E.
Greene, Mark H.
Gutierrez-Barrera, Angelica M.
Hahnen, Eric
Hamann, Ute
Hauke, Jan
Herold, Natalie
Hogervorst, Frans B.L.
Honisch, Ellen
Hopper, John L.
Hulick, Peter J.
Investigators, KConFab
Investigators, HEBON
Izatt, Louise
Jager, Agnes
James, Paul
Janavicius, Ramunas
Jensen, Uffe Birk
Jensen, Thomas Dyrso
Johannsson, Oskar Th.
John, Esther M.
Joseph, Vijai
Kang, Eunyoung
Kast, Karin
Kiiski, Johanna I.
Kim, Sung-Won
Kim, Zisun
Ko, Kwang-Pil
Konstantopoulou, Irene
Kramer, Gero
Krogh, Lotte
Kruse, Torben A.
Kwong, Ava
Larsen, Mirjam
Lasset, Christine
Lautrup, Charlotte
Lazaro, Conxi
Lee, Jihyoun
Lee, Jong Won
Lee, Min Hyuk
Lemke, Johannes
Lesueur, Fabienne
Liljegren, Annelie
Lindblom, Annika
Llovet, Patricia
Lopez-Fernández, Adria
Lopez-Perolio, Irene
Lorca, Victor
Loud, Jennifer T.
Ma, Edmond S.K.
Mai, Phuong L.
Manoukian, Siranoush
Mari, Veronique
Martin, Lynn
Matricardi, Laura
Mebirouk, Noura
Medici, Veronica
Meijers-Heijboer, Hanne E.J.
Meindl, Alfons
Mensenkamp, Arjen R.
Miller, Clare
Gomes, Denise Molina
Montagna, Marco
Mooij, Thea M.
Moserle, Lidia
Mouret-Fourme, Emmanuelle
Mulligan, Anna Marie
Nathanson, Katherine L.
Navratilova, Marie
Nevanlinna, Heli
Niederacher, Dieter
Nielsen, Finn C. Cilius
Nikitina-Zake, Liene
Offit, Kenneth
Olah, Edith
Olopade, Olufunmilayo I.
Ong, Kai-Ren
Osorio, Ana
Ott, Claus-Eric
Palli, Domenico
Park, Sue K.
Parsons, Michael T.
Pedersen, Inge Sokilde
Peissel, Bernard
Peixoto, Ana
Pérez-Segura, Pedro
Peterlongo, Paolo
Petersen, Annabeth Høgh
Porteous, Mary E.
Pujana, Miguel Angel
Radice, Paolo
Ramser, Juliane
Rantala, Johanna
Rashid, Muhammad U.
Rhiem, Kerstin
Rizzolo, Piera
Robson, Mark E.
Rookus, Matti A.
Rossing, Caroline M.
Ruddy, Kathryn J.
Santos, Catarina
Saule, Claire
Scarpitta, Rosa
Schmutzler, Rita K.
Schuster, Hélène
Senter, Leigha
Seynaeve, Caroline M.
Shah, Payal D.
Sharma, Priyanka
Shin, Vivian Y.
Silvestri, Valentina
Simard, Jacques
Singer, Christian F.
Skytte, Anne-Bine
Snape, Katie
Solano, Angela R.
Soucy, Penny
Southey, Melissa C.
Spurdle, Amanda B.
Steele, Linda
Steinemann, Doris
Stoppa-Lyonnet, Dominique
Stradella, Agostina
Sunde, Lone
Sutter, Christian
Tan, Yen Y.
Teixeira, Manuel R.
Teo, Soo Hwang
Thomassen, Mads
Tibiletti, Maria Grazia
Tischkowitz, Marc
Tognazzo, Silvia
Toland, Amanda E.
Tommasi, Stefania
Torres, Diana
Toss, Angela
Trainer, Alison H.
Tung, Nadine
van Asperen, Christi J.
van der Baan, Frederieke H.
van der Kolk, Lizet E.
van der Luijt, Rob B.
van Hest, Liselotte P.
Varesco, Liliana
Varon-Mateeva, Raymonda
Viel, Alessandra
Vierstraete, Jeroen
Villa, Roberta
von Wachenfeldt, Anna
Wagner, Philipp
Wang-Gohrke, Shan
Wappenschmidt, Barbara
Weitzel, Jeffrey N.
Wieme, Greet
Yadav, Siddhartha
Yannoukakos, Drakoulis
Yoon, Sook-Yee
Zanzottera, Cristina
Zorn, Kristin K.
D'Amico, Anthony V.
Freedman, Matthew L.
Pomerantz, Mark M.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Neuhausen, Susan L.
Ottini, Laura
Nielsen, Henriette Roed
Rebbeck, Timothy R.
Cancer Research
Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
Cancer Research
Oncology
author_sort patel, vivek l.
spelling Patel, Vivek L. Busch, Evan L. Friebel, Tara M. Cronin, Angel Leslie, Goska McGuffog, Lesley Adlard, Julian Agata, Simona Agnarsson, Bjarni A. Ahmed, Munaza Aittomäki, Kristiina Alducci, Elisa Andrulis, Irene L. Arason, Adalgeir Arnold, Norbert Artioli, Grazia Arver, Brita Auber, Bernd Azzollini, Jacopo Balmaña, Judith Barkardottir, Rosa B. Barnes, Daniel R. Barroso, Alicia Barrowdale, Daniel Belotti, Muriel Benitez, Javier Bertelsen, Birgitte Blok, Marinus J. Bodrogi, Istvan Bonadona, Valérie Bonanni, Bernardo Bondavalli, Davide Boonen, Susanne E. Borde, Julika Borg, Ake Bradbury, Angela R. Brady, Angela Brewer, Carole Brunet, Joan Buecher, Bruno Buys, Saundra S. Cabezas-Camarero, Santiago Caldés, Trinidad Caliebe, Almuth Caligo, Maria A. Calvello, Mariarosaria Campbell, Ian G. Carnevali, Ileana Carrasco, Estela Chan, Tsun L. Chu, Annie T.W. Chung, Wendy K. Claes, Kathleen B.M. Collaborators, GEMO Study Collaborators, EMBRACE Cook, Jackie Cortesi, Laura Couch, Fergus J. Daly, Mary B. Damante, Giuseppe Darder, Esther Davidson, Rosemarie de la Hoya, Miguel Puppa, Lara Della Dennis, Joe Díez, Orland Ding, Yuan Chun Ditsch, Nina Domchek, Susan M. Donaldson, Alan Dworniczak, Bernd Easton, Douglas F. Eccles, Diana M. Eeles, Rosalind A. Ehrencrona, Hans Ejlertsen, Bent Engel, Christoph Evans, D. Gareth Faivre, Laurence Faust, Ulrike Feliubadaló, Lídia Foretova, Lenka Fostira, Florentia Fountzilas, George Frost, Debra García-Barberán, Vanesa Garre, Pilar Gauthier-Villars, Marion Géczi, Lajos Gehrig, Andrea Gerdes, Anne-Marie Gesta, Paul Giannini, Giuseppe Glendon, Gord Godwin, Andrew K. Goldgar, David E. Greene, Mark H. Gutierrez-Barrera, Angelica M. Hahnen, Eric Hamann, Ute Hauke, Jan Herold, Natalie Hogervorst, Frans B.L. Honisch, Ellen Hopper, John L. Hulick, Peter J. Investigators, KConFab Investigators, HEBON Izatt, Louise Jager, Agnes James, Paul Janavicius, Ramunas Jensen, Uffe Birk Jensen, Thomas Dyrso Johannsson, Oskar Th. John, Esther M. Joseph, Vijai Kang, Eunyoung Kast, Karin Kiiski, Johanna I. Kim, Sung-Won Kim, Zisun Ko, Kwang-Pil Konstantopoulou, Irene Kramer, Gero Krogh, Lotte Kruse, Torben A. Kwong, Ava Larsen, Mirjam Lasset, Christine Lautrup, Charlotte Lazaro, Conxi Lee, Jihyoun Lee, Jong Won Lee, Min Hyuk Lemke, Johannes Lesueur, Fabienne Liljegren, Annelie Lindblom, Annika Llovet, Patricia Lopez-Fernández, Adria Lopez-Perolio, Irene Lorca, Victor Loud, Jennifer T. Ma, Edmond S.K. Mai, Phuong L. Manoukian, Siranoush Mari, Veronique Martin, Lynn Matricardi, Laura Mebirouk, Noura Medici, Veronica Meijers-Heijboer, Hanne E.J. Meindl, Alfons Mensenkamp, Arjen R. Miller, Clare Gomes, Denise Molina Montagna, Marco Mooij, Thea M. Moserle, Lidia Mouret-Fourme, Emmanuelle Mulligan, Anna Marie Nathanson, Katherine L. Navratilova, Marie Nevanlinna, Heli Niederacher, Dieter Nielsen, Finn C. Cilius Nikitina-Zake, Liene Offit, Kenneth Olah, Edith Olopade, Olufunmilayo I. Ong, Kai-Ren Osorio, Ana Ott, Claus-Eric Palli, Domenico Park, Sue K. Parsons, Michael T. Pedersen, Inge Sokilde Peissel, Bernard Peixoto, Ana Pérez-Segura, Pedro Peterlongo, Paolo Petersen, Annabeth Høgh Porteous, Mary E. Pujana, Miguel Angel Radice, Paolo Ramser, Juliane Rantala, Johanna Rashid, Muhammad U. Rhiem, Kerstin Rizzolo, Piera Robson, Mark E. Rookus, Matti A. Rossing, Caroline M. Ruddy, Kathryn J. Santos, Catarina Saule, Claire Scarpitta, Rosa Schmutzler, Rita K. Schuster, Hélène Senter, Leigha Seynaeve, Caroline M. Shah, Payal D. Sharma, Priyanka Shin, Vivian Y. Silvestri, Valentina Simard, Jacques Singer, Christian F. Skytte, Anne-Bine Snape, Katie Solano, Angela R. Soucy, Penny Southey, Melissa C. Spurdle, Amanda B. Steele, Linda Steinemann, Doris Stoppa-Lyonnet, Dominique Stradella, Agostina Sunde, Lone Sutter, Christian Tan, Yen Y. Teixeira, Manuel R. Teo, Soo Hwang Thomassen, Mads Tibiletti, Maria Grazia Tischkowitz, Marc Tognazzo, Silvia Toland, Amanda E. Tommasi, Stefania Torres, Diana Toss, Angela Trainer, Alison H. Tung, Nadine van Asperen, Christi J. van der Baan, Frederieke H. van der Kolk, Lizet E. van der Luijt, Rob B. van Hest, Liselotte P. Varesco, Liliana Varon-Mateeva, Raymonda Viel, Alessandra Vierstraete, Jeroen Villa, Roberta von Wachenfeldt, Anna Wagner, Philipp Wang-Gohrke, Shan Wappenschmidt, Barbara Weitzel, Jeffrey N. Wieme, Greet Yadav, Siddhartha Yannoukakos, Drakoulis Yoon, Sook-Yee Zanzottera, Cristina Zorn, Kristin K. D'Amico, Anthony V. Freedman, Matthew L. Pomerantz, Mark M. Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. Ottini, Laura Nielsen, Henriette Roed Rebbeck, Timothy R. 0008-5472 1538-7445 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/0008-5472.can-19-1840 <jats:title>Abstract</jats:title> <jats:sec> <jats:title /> <jats:p>Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3′ region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25–2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63–5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71–4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12–11.54; P = 0.0002). No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Significance:</jats:title> <jats:p>Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.</jats:p> </jats:sec> Association of Genomic Domains in <i>BRCA1</i> and <i>BRCA2</i> with Prostate Cancer Risk and Aggressiveness Cancer Research
doi_str_mv 10.1158/0008-5472.can-19-1840
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recordtype ai
record_format ai
series Cancer Research
source_id 49
title Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_unstemmed Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_full Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_fullStr Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_full_unstemmed Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_short Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_sort association of genomic domains in <i>brca1</i> and <i>brca2</i> with prostate cancer risk and aggressiveness
topic Cancer Research
Oncology
url http://dx.doi.org/10.1158/0008-5472.can-19-1840
publishDate 2020
physical 624-638
description <jats:title>Abstract</jats:title> <jats:sec> <jats:title /> <jats:p>Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3′ region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25–2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63–5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71–4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12–11.54; P = 0.0002). No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Significance:</jats:title> <jats:p>Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.</jats:p> </jats:sec>
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author Patel, Vivek L., Busch, Evan L., Friebel, Tara M., Cronin, Angel, Leslie, Goska, McGuffog, Lesley, Adlard, Julian, Agata, Simona, Agnarsson, Bjarni A., Ahmed, Munaza, Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L., Arason, Adalgeir, Arnold, Norbert, Artioli, Grazia, Arver, Brita, Auber, Bernd, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B., Barnes, Daniel R., Barroso, Alicia, Barrowdale, Daniel, Belotti, Muriel, Benitez, Javier, Bertelsen, Birgitte, Blok, Marinus J., Bodrogi, Istvan, Bonadona, Valérie, Bonanni, Bernardo, Bondavalli, Davide, Boonen, Susanne E., Borde, Julika, Borg, Ake, Bradbury, Angela R., Brady, Angela, Brewer, Carole, Brunet, Joan, Buecher, Bruno, Buys, Saundra S., Cabezas-Camarero, Santiago, Caldés, Trinidad, Caliebe, Almuth, Caligo, Maria A., Calvello, Mariarosaria, Campbell, Ian G., Carnevali, Ileana, Carrasco, Estela, Chan, Tsun L., Chu, Annie T.W., Chung, Wendy K., Claes, Kathleen B.M., Collaborators, GEMO Study, Collaborators, EMBRACE, Cook, Jackie, Cortesi, Laura, Couch, Fergus J., Daly, Mary B., Damante, Giuseppe, Darder, Esther, Davidson, Rosemarie, de la Hoya, Miguel, Puppa, Lara Della, Dennis, Joe, Díez, Orland, Ding, Yuan Chun, Ditsch, Nina, Domchek, Susan M., Donaldson, Alan, Dworniczak, Bernd, Easton, Douglas F., Eccles, Diana M., Eeles, Rosalind A., Ehrencrona, Hans, Ejlertsen, Bent, Engel, Christoph, Evans, D. Gareth, Faivre, Laurence, Faust, Ulrike, Feliubadaló, Lídia, Foretova, Lenka, Fostira, Florentia, Fountzilas, George, Frost, Debra, García-Barberán, Vanesa, Garre, Pilar, Gauthier-Villars, Marion, Géczi, Lajos, Gehrig, Andrea, Gerdes, Anne-Marie, Gesta, Paul, Giannini, Giuseppe, Glendon, Gord, Godwin, Andrew K., Goldgar, David E., Greene, Mark H., Gutierrez-Barrera, Angelica M., Hahnen, Eric, Hamann, Ute, Hauke, Jan, Herold, Natalie, Hogervorst, Frans B.L., Honisch, Ellen, Hopper, John L., Hulick, Peter J., Investigators, KConFab, Investigators, HEBON, Izatt, Louise, Jager, Agnes, James, Paul, Janavicius, Ramunas, Jensen, Uffe Birk, Jensen, Thomas Dyrso, Johannsson, Oskar Th., John, Esther M., Joseph, Vijai, Kang, Eunyoung, Kast, Karin, Kiiski, Johanna I., Kim, Sung-Won, Kim, Zisun, Ko, Kwang-Pil, Konstantopoulou, Irene, Kramer, Gero, Krogh, Lotte, Kruse, Torben A., Kwong, Ava, Larsen, Mirjam, Lasset, Christine, Lautrup, Charlotte, Lazaro, Conxi, Lee, Jihyoun, Lee, Jong Won, Lee, Min Hyuk, Lemke, Johannes, Lesueur, Fabienne, Liljegren, Annelie, Lindblom, Annika, Llovet, Patricia, Lopez-Fernández, Adria, Lopez-Perolio, Irene, Lorca, Victor, Loud, Jennifer T., Ma, Edmond S.K., Mai, Phuong L., Manoukian, Siranoush, Mari, Veronique, Martin, Lynn, Matricardi, Laura, Mebirouk, Noura, Medici, Veronica, Meijers-Heijboer, Hanne E.J., Meindl, Alfons, Mensenkamp, Arjen R., Miller, Clare, Gomes, Denise Molina, Montagna, Marco, Mooij, Thea M., Moserle, Lidia, Mouret-Fourme, Emmanuelle, Mulligan, Anna Marie, Nathanson, Katherine L., Navratilova, Marie, Nevanlinna, Heli, Niederacher, Dieter, Nielsen, Finn C. Cilius, Nikitina-Zake, Liene, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Ong, Kai-Ren, Osorio, Ana, Ott, Claus-Eric, Palli, Domenico, Park, Sue K., Parsons, Michael T., Pedersen, Inge Sokilde, Peissel, Bernard, Peixoto, Ana, Pérez-Segura, Pedro, Peterlongo, Paolo, Petersen, Annabeth Høgh, Porteous, Mary E., Pujana, Miguel Angel, Radice, Paolo, Ramser, Juliane, Rantala, Johanna, Rashid, Muhammad U., Rhiem, Kerstin, Rizzolo, Piera, Robson, Mark E., Rookus, Matti A., Rossing, Caroline M., Ruddy, Kathryn J., Santos, Catarina, Saule, Claire, Scarpitta, Rosa, Schmutzler, Rita K., Schuster, Hélène, Senter, Leigha, Seynaeve, Caroline M., Shah, Payal D., Sharma, Priyanka, Shin, Vivian Y., Silvestri, Valentina, Simard, Jacques, Singer, Christian F., Skytte, Anne-Bine, Snape, Katie, Solano, Angela R., Soucy, Penny, Southey, Melissa C., Spurdle, Amanda B., Steele, Linda, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Stradella, Agostina, Sunde, Lone, Sutter, Christian, Tan, Yen Y., Teixeira, Manuel R., Teo, Soo Hwang, Thomassen, Mads, Tibiletti, Maria Grazia, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda E., Tommasi, Stefania, Torres, Diana, Toss, Angela, Trainer, Alison H., Tung, Nadine, van Asperen, Christi J., van der Baan, Frederieke H., van der Kolk, Lizet E., van der Luijt, Rob B., van Hest, Liselotte P., Varesco, Liliana, Varon-Mateeva, Raymonda, Viel, Alessandra, Vierstraete, Jeroen, Villa, Roberta, von Wachenfeldt, Anna, Wagner, Philipp, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weitzel, Jeffrey N., Wieme, Greet, Yadav, Siddhartha, Yannoukakos, Drakoulis, Yoon, Sook-Yee, Zanzottera, Cristina, Zorn, Kristin K., D'Amico, Anthony V., Freedman, Matthew L., Pomerantz, Mark M., Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L., Ottini, Laura, Nielsen, Henriette Roed, Rebbeck, Timothy R.
author_facet Patel, Vivek L., Busch, Evan L., Friebel, Tara M., Cronin, Angel, Leslie, Goska, McGuffog, Lesley, Adlard, Julian, Agata, Simona, Agnarsson, Bjarni A., Ahmed, Munaza, Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L., Arason, Adalgeir, Arnold, Norbert, Artioli, Grazia, Arver, Brita, Auber, Bernd, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B., Barnes, Daniel R., Barroso, Alicia, Barrowdale, Daniel, Belotti, Muriel, Benitez, Javier, Bertelsen, Birgitte, Blok, Marinus J., Bodrogi, Istvan, Bonadona, Valérie, Bonanni, Bernardo, Bondavalli, Davide, Boonen, Susanne E., Borde, Julika, Borg, Ake, Bradbury, Angela R., Brady, Angela, Brewer, Carole, Brunet, Joan, Buecher, Bruno, Buys, Saundra S., Cabezas-Camarero, Santiago, Caldés, Trinidad, Caliebe, Almuth, Caligo, Maria A., Calvello, Mariarosaria, Campbell, Ian G., Carnevali, Ileana, Carrasco, Estela, Chan, Tsun L., Chu, Annie T.W., Chung, Wendy K., Claes, Kathleen B.M., Collaborators, GEMO Study, Collaborators, EMBRACE, Cook, Jackie, Cortesi, Laura, Couch, Fergus J., Daly, Mary B., Damante, Giuseppe, Darder, Esther, Davidson, Rosemarie, de la Hoya, Miguel, Puppa, Lara Della, Dennis, Joe, Díez, Orland, Ding, Yuan Chun, Ditsch, Nina, Domchek, Susan M., Donaldson, Alan, Dworniczak, Bernd, Easton, Douglas F., Eccles, Diana M., Eeles, Rosalind A., Ehrencrona, Hans, Ejlertsen, Bent, Engel, Christoph, Evans, D. Gareth, Faivre, Laurence, Faust, Ulrike, Feliubadaló, Lídia, Foretova, Lenka, Fostira, Florentia, Fountzilas, George, Frost, Debra, García-Barberán, Vanesa, Garre, Pilar, Gauthier-Villars, Marion, Géczi, Lajos, Gehrig, Andrea, Gerdes, Anne-Marie, Gesta, Paul, Giannini, Giuseppe, Glendon, Gord, Godwin, Andrew K., Goldgar, David E., Greene, Mark H., Gutierrez-Barrera, Angelica M., Hahnen, Eric, Hamann, Ute, Hauke, Jan, Herold, Natalie, Hogervorst, Frans B.L., Honisch, Ellen, Hopper, John L., Hulick, Peter J., Investigators, KConFab, Investigators, HEBON, Izatt, Louise, Jager, Agnes, James, Paul, Janavicius, Ramunas, Jensen, Uffe Birk, Jensen, Thomas Dyrso, Johannsson, Oskar Th., John, Esther M., Joseph, Vijai, Kang, Eunyoung, Kast, Karin, Kiiski, Johanna I., Kim, Sung-Won, Kim, Zisun, Ko, Kwang-Pil, Konstantopoulou, Irene, Kramer, Gero, Krogh, Lotte, Kruse, Torben A., Kwong, Ava, Larsen, Mirjam, Lasset, Christine, Lautrup, Charlotte, Lazaro, Conxi, Lee, Jihyoun, Lee, Jong Won, Lee, Min Hyuk, Lemke, Johannes, Lesueur, Fabienne, Liljegren, Annelie, Lindblom, Annika, Llovet, Patricia, Lopez-Fernández, Adria, Lopez-Perolio, Irene, Lorca, Victor, Loud, Jennifer T., Ma, Edmond S.K., Mai, Phuong L., Manoukian, Siranoush, Mari, Veronique, Martin, Lynn, Matricardi, Laura, Mebirouk, Noura, Medici, Veronica, Meijers-Heijboer, Hanne E.J., Meindl, Alfons, Mensenkamp, Arjen R., Miller, Clare, Gomes, Denise Molina, Montagna, Marco, Mooij, Thea M., Moserle, Lidia, Mouret-Fourme, Emmanuelle, Mulligan, Anna Marie, Nathanson, Katherine L., Navratilova, Marie, Nevanlinna, Heli, Niederacher, Dieter, Nielsen, Finn C. Cilius, Nikitina-Zake, Liene, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Ong, Kai-Ren, Osorio, Ana, Ott, Claus-Eric, Palli, Domenico, Park, Sue K., Parsons, Michael T., Pedersen, Inge Sokilde, Peissel, Bernard, Peixoto, Ana, Pérez-Segura, Pedro, Peterlongo, Paolo, Petersen, Annabeth Høgh, Porteous, Mary E., Pujana, Miguel Angel, Radice, Paolo, Ramser, Juliane, Rantala, Johanna, Rashid, Muhammad U., Rhiem, Kerstin, Rizzolo, Piera, Robson, Mark E., Rookus, Matti A., Rossing, Caroline M., Ruddy, Kathryn J., Santos, Catarina, Saule, Claire, Scarpitta, Rosa, Schmutzler, Rita K., Schuster, Hélène, Senter, Leigha, Seynaeve, Caroline M., Shah, Payal D., Sharma, Priyanka, Shin, Vivian Y., Silvestri, Valentina, Simard, Jacques, Singer, Christian F., Skytte, Anne-Bine, Snape, Katie, Solano, Angela R., Soucy, Penny, Southey, Melissa C., Spurdle, Amanda B., Steele, Linda, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Stradella, Agostina, Sunde, Lone, Sutter, Christian, Tan, Yen Y., Teixeira, Manuel R., Teo, Soo Hwang, Thomassen, Mads, Tibiletti, Maria Grazia, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda E., Tommasi, Stefania, Torres, Diana, Toss, Angela, Trainer, Alison H., Tung, Nadine, van Asperen, Christi J., van der Baan, Frederieke H., van der Kolk, Lizet E., van der Luijt, Rob B., van Hest, Liselotte P., Varesco, Liliana, Varon-Mateeva, Raymonda, Viel, Alessandra, Vierstraete, Jeroen, Villa, Roberta, von Wachenfeldt, Anna, Wagner, Philipp, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weitzel, Jeffrey N., Wieme, Greet, Yadav, Siddhartha, Yannoukakos, Drakoulis, Yoon, Sook-Yee, Zanzottera, Cristina, Zorn, Kristin K., D'Amico, Anthony V., Freedman, Matthew L., Pomerantz, Mark M., Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L., Ottini, Laura, Nielsen, Henriette Roed, Rebbeck, Timothy R., Patel, Vivek L., Busch, Evan L., Friebel, Tara M., Cronin, Angel, Leslie, Goska, McGuffog, Lesley, Adlard, Julian, Agata, Simona, Agnarsson, Bjarni A., Ahmed, Munaza, Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L., Arason, Adalgeir, Arnold, Norbert, Artioli, Grazia, Arver, Brita, Auber, Bernd, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B., Barnes, Daniel R., Barroso, Alicia, Barrowdale, Daniel, Belotti, Muriel, Benitez, Javier, Bertelsen, Birgitte, Blok, Marinus J., Bodrogi, Istvan, Bonadona, Valérie, Bonanni, Bernardo, Bondavalli, Davide, Boonen, Susanne E., Borde, Julika, Borg, Ake, Bradbury, Angela R., Brady, Angela, Brewer, Carole, Brunet, Joan, Buecher, Bruno, Buys, Saundra S., Cabezas-Camarero, Santiago, Caldés, Trinidad, Caliebe, Almuth, Caligo, Maria A., Calvello, Mariarosaria, Campbell, Ian G., Carnevali, Ileana, Carrasco, Estela, Chan, Tsun L., Chu, Annie T.W., Chung, Wendy K., Claes, Kathleen B.M., Collaborators, GEMO Study, Collaborators, EMBRACE, Cook, Jackie, Cortesi, Laura, Couch, Fergus J., Daly, Mary B., Damante, Giuseppe, Darder, Esther, Davidson, Rosemarie, de la Hoya, Miguel, Puppa, Lara Della, Dennis, Joe, Díez, Orland, Ding, Yuan Chun, Ditsch, Nina, Domchek, Susan M., Donaldson, Alan, Dworniczak, Bernd, Easton, Douglas F., Eccles, Diana M., Eeles, Rosalind A., Ehrencrona, Hans, Ejlertsen, Bent, Engel, Christoph, Evans, D. Gareth, Faivre, Laurence, Faust, Ulrike, Feliubadaló, Lídia, Foretova, Lenka, Fostira, Florentia, Fountzilas, George, Frost, Debra, García-Barberán, Vanesa, Garre, Pilar, Gauthier-Villars, Marion, Géczi, Lajos, Gehrig, Andrea, Gerdes, Anne-Marie, Gesta, Paul, Giannini, Giuseppe, Glendon, Gord, Godwin, Andrew K., Goldgar, David E., Greene, Mark H., Gutierrez-Barrera, Angelica M., Hahnen, Eric, Hamann, Ute, Hauke, Jan, Herold, Natalie, Hogervorst, Frans B.L., Honisch, Ellen, Hopper, John L., Hulick, Peter J., Investigators, KConFab, Investigators, HEBON, Izatt, Louise, Jager, Agnes, James, Paul, Janavicius, Ramunas, Jensen, Uffe Birk, Jensen, Thomas Dyrso, Johannsson, Oskar Th., John, Esther M., Joseph, Vijai, Kang, Eunyoung, Kast, Karin, Kiiski, Johanna I., Kim, Sung-Won, Kim, Zisun, Ko, Kwang-Pil, Konstantopoulou, Irene, Kramer, Gero, Krogh, Lotte, Kruse, Torben A., Kwong, Ava, Larsen, Mirjam, Lasset, Christine, Lautrup, Charlotte, Lazaro, Conxi, Lee, Jihyoun, Lee, Jong Won, Lee, Min Hyuk, Lemke, Johannes, Lesueur, Fabienne, Liljegren, Annelie, Lindblom, Annika, Llovet, Patricia, Lopez-Fernández, Adria, Lopez-Perolio, Irene, Lorca, Victor, Loud, Jennifer T., Ma, Edmond S.K., Mai, Phuong L., Manoukian, Siranoush, Mari, Veronique, Martin, Lynn, Matricardi, Laura, Mebirouk, Noura, Medici, Veronica, Meijers-Heijboer, Hanne E.J., Meindl, Alfons, Mensenkamp, Arjen R., Miller, Clare, Gomes, Denise Molina, Montagna, Marco, Mooij, Thea M., Moserle, Lidia, Mouret-Fourme, Emmanuelle, Mulligan, Anna Marie, Nathanson, Katherine L., Navratilova, Marie, Nevanlinna, Heli, Niederacher, Dieter, Nielsen, Finn C. Cilius, Nikitina-Zake, Liene, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Ong, Kai-Ren, Osorio, Ana, Ott, Claus-Eric, Palli, Domenico, Park, Sue K., Parsons, Michael T., Pedersen, Inge Sokilde, Peissel, Bernard, Peixoto, Ana, Pérez-Segura, Pedro, Peterlongo, Paolo, Petersen, Annabeth Høgh, Porteous, Mary E., Pujana, Miguel Angel, Radice, Paolo, Ramser, Juliane, Rantala, Johanna, Rashid, Muhammad U., Rhiem, Kerstin, Rizzolo, Piera, Robson, Mark E., Rookus, Matti A., Rossing, Caroline M., Ruddy, Kathryn J., Santos, Catarina, Saule, Claire, Scarpitta, Rosa, Schmutzler, Rita K., Schuster, Hélène, Senter, Leigha, Seynaeve, Caroline M., Shah, Payal D., Sharma, Priyanka, Shin, Vivian Y., Silvestri, Valentina, Simard, Jacques, Singer, Christian F., Skytte, Anne-Bine, Snape, Katie, Solano, Angela R., Soucy, Penny, Southey, Melissa C., Spurdle, Amanda B., Steele, Linda, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Stradella, Agostina, Sunde, Lone, Sutter, Christian, Tan, Yen Y., Teixeira, Manuel R., Teo, Soo Hwang, Thomassen, Mads, Tibiletti, Maria Grazia, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda E., Tommasi, Stefania, Torres, Diana, Toss, Angela, Trainer, Alison H., Tung, Nadine, van Asperen, Christi J., van der Baan, Frederieke H., van der Kolk, Lizet E., van der Luijt, Rob B., van Hest, Liselotte P., Varesco, Liliana, Varon-Mateeva, Raymonda, Viel, Alessandra, Vierstraete, Jeroen, Villa, Roberta, von Wachenfeldt, Anna, Wagner, Philipp, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weitzel, Jeffrey N., Wieme, Greet, Yadav, Siddhartha, Yannoukakos, Drakoulis, Yoon, Sook-Yee, Zanzottera, Cristina, Zorn, Kristin K., D'Amico, Anthony V., Freedman, Matthew L., Pomerantz, Mark M., Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L., Ottini, Laura, Nielsen, Henriette Roed, Rebbeck, Timothy R.
author_sort patel, vivek l.
container_issue 3
container_start_page 624
container_title Cancer Research
container_volume 80
description <jats:title>Abstract</jats:title> <jats:sec> <jats:title /> <jats:p>Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3′ region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25–2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63–5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71–4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12–11.54; P = 0.0002). No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Significance:</jats:title> <jats:p>Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.</jats:p> </jats:sec>
doi_str_mv 10.1158/0008-5472.can-19-1840
facet_avail Online, Free
finc_class_facet Medizin
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format_de14 Article, E-Article
format_de15 Article, E-Article
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format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
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format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
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geogr_code not assigned
geogr_code_person not assigned
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8wMDA4LTU0NzIuY2FuLTE5LTE4NDA
imprint American Association for Cancer Research (AACR), 2020
imprint_str_mv American Association for Cancer Research (AACR), 2020
institution DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161
issn 0008-5472, 1538-7445
issn_str_mv 0008-5472, 1538-7445
language English
last_indexed 2024-03-01T18:08:43.599Z
match_str patel2020associationofgenomicdomainsinbrca1andbrca2withprostatecancerriskandaggressiveness
mega_collection American Association for Cancer Research (AACR) (CrossRef)
physical 624-638
publishDate 2020
publishDateSort 2020
publisher American Association for Cancer Research (AACR)
record_format ai
recordtype ai
series Cancer Research
source_id 49
spelling Patel, Vivek L. Busch, Evan L. Friebel, Tara M. Cronin, Angel Leslie, Goska McGuffog, Lesley Adlard, Julian Agata, Simona Agnarsson, Bjarni A. Ahmed, Munaza Aittomäki, Kristiina Alducci, Elisa Andrulis, Irene L. Arason, Adalgeir Arnold, Norbert Artioli, Grazia Arver, Brita Auber, Bernd Azzollini, Jacopo Balmaña, Judith Barkardottir, Rosa B. Barnes, Daniel R. Barroso, Alicia Barrowdale, Daniel Belotti, Muriel Benitez, Javier Bertelsen, Birgitte Blok, Marinus J. Bodrogi, Istvan Bonadona, Valérie Bonanni, Bernardo Bondavalli, Davide Boonen, Susanne E. Borde, Julika Borg, Ake Bradbury, Angela R. Brady, Angela Brewer, Carole Brunet, Joan Buecher, Bruno Buys, Saundra S. Cabezas-Camarero, Santiago Caldés, Trinidad Caliebe, Almuth Caligo, Maria A. Calvello, Mariarosaria Campbell, Ian G. Carnevali, Ileana Carrasco, Estela Chan, Tsun L. Chu, Annie T.W. Chung, Wendy K. Claes, Kathleen B.M. Collaborators, GEMO Study Collaborators, EMBRACE Cook, Jackie Cortesi, Laura Couch, Fergus J. Daly, Mary B. Damante, Giuseppe Darder, Esther Davidson, Rosemarie de la Hoya, Miguel Puppa, Lara Della Dennis, Joe Díez, Orland Ding, Yuan Chun Ditsch, Nina Domchek, Susan M. Donaldson, Alan Dworniczak, Bernd Easton, Douglas F. Eccles, Diana M. Eeles, Rosalind A. Ehrencrona, Hans Ejlertsen, Bent Engel, Christoph Evans, D. Gareth Faivre, Laurence Faust, Ulrike Feliubadaló, Lídia Foretova, Lenka Fostira, Florentia Fountzilas, George Frost, Debra García-Barberán, Vanesa Garre, Pilar Gauthier-Villars, Marion Géczi, Lajos Gehrig, Andrea Gerdes, Anne-Marie Gesta, Paul Giannini, Giuseppe Glendon, Gord Godwin, Andrew K. Goldgar, David E. Greene, Mark H. Gutierrez-Barrera, Angelica M. Hahnen, Eric Hamann, Ute Hauke, Jan Herold, Natalie Hogervorst, Frans B.L. Honisch, Ellen Hopper, John L. Hulick, Peter J. Investigators, KConFab Investigators, HEBON Izatt, Louise Jager, Agnes James, Paul Janavicius, Ramunas Jensen, Uffe Birk Jensen, Thomas Dyrso Johannsson, Oskar Th. John, Esther M. Joseph, Vijai Kang, Eunyoung Kast, Karin Kiiski, Johanna I. Kim, Sung-Won Kim, Zisun Ko, Kwang-Pil Konstantopoulou, Irene Kramer, Gero Krogh, Lotte Kruse, Torben A. Kwong, Ava Larsen, Mirjam Lasset, Christine Lautrup, Charlotte Lazaro, Conxi Lee, Jihyoun Lee, Jong Won Lee, Min Hyuk Lemke, Johannes Lesueur, Fabienne Liljegren, Annelie Lindblom, Annika Llovet, Patricia Lopez-Fernández, Adria Lopez-Perolio, Irene Lorca, Victor Loud, Jennifer T. Ma, Edmond S.K. Mai, Phuong L. Manoukian, Siranoush Mari, Veronique Martin, Lynn Matricardi, Laura Mebirouk, Noura Medici, Veronica Meijers-Heijboer, Hanne E.J. Meindl, Alfons Mensenkamp, Arjen R. Miller, Clare Gomes, Denise Molina Montagna, Marco Mooij, Thea M. Moserle, Lidia Mouret-Fourme, Emmanuelle Mulligan, Anna Marie Nathanson, Katherine L. Navratilova, Marie Nevanlinna, Heli Niederacher, Dieter Nielsen, Finn C. Cilius Nikitina-Zake, Liene Offit, Kenneth Olah, Edith Olopade, Olufunmilayo I. Ong, Kai-Ren Osorio, Ana Ott, Claus-Eric Palli, Domenico Park, Sue K. Parsons, Michael T. Pedersen, Inge Sokilde Peissel, Bernard Peixoto, Ana Pérez-Segura, Pedro Peterlongo, Paolo Petersen, Annabeth Høgh Porteous, Mary E. Pujana, Miguel Angel Radice, Paolo Ramser, Juliane Rantala, Johanna Rashid, Muhammad U. Rhiem, Kerstin Rizzolo, Piera Robson, Mark E. Rookus, Matti A. Rossing, Caroline M. Ruddy, Kathryn J. Santos, Catarina Saule, Claire Scarpitta, Rosa Schmutzler, Rita K. Schuster, Hélène Senter, Leigha Seynaeve, Caroline M. Shah, Payal D. Sharma, Priyanka Shin, Vivian Y. Silvestri, Valentina Simard, Jacques Singer, Christian F. Skytte, Anne-Bine Snape, Katie Solano, Angela R. Soucy, Penny Southey, Melissa C. Spurdle, Amanda B. Steele, Linda Steinemann, Doris Stoppa-Lyonnet, Dominique Stradella, Agostina Sunde, Lone Sutter, Christian Tan, Yen Y. Teixeira, Manuel R. Teo, Soo Hwang Thomassen, Mads Tibiletti, Maria Grazia Tischkowitz, Marc Tognazzo, Silvia Toland, Amanda E. Tommasi, Stefania Torres, Diana Toss, Angela Trainer, Alison H. Tung, Nadine van Asperen, Christi J. van der Baan, Frederieke H. van der Kolk, Lizet E. van der Luijt, Rob B. van Hest, Liselotte P. Varesco, Liliana Varon-Mateeva, Raymonda Viel, Alessandra Vierstraete, Jeroen Villa, Roberta von Wachenfeldt, Anna Wagner, Philipp Wang-Gohrke, Shan Wappenschmidt, Barbara Weitzel, Jeffrey N. Wieme, Greet Yadav, Siddhartha Yannoukakos, Drakoulis Yoon, Sook-Yee Zanzottera, Cristina Zorn, Kristin K. D'Amico, Anthony V. Freedman, Matthew L. Pomerantz, Mark M. Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. Ottini, Laura Nielsen, Henriette Roed Rebbeck, Timothy R. 0008-5472 1538-7445 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/0008-5472.can-19-1840 <jats:title>Abstract</jats:title> <jats:sec> <jats:title /> <jats:p>Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3′ region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25–2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63–5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71–4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12–11.54; P = 0.0002). No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Significance:</jats:title> <jats:p>Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.</jats:p> </jats:sec> Association of Genomic Domains in <i>BRCA1</i> and <i>BRCA2</i> with Prostate Cancer Risk and Aggressiveness Cancer Research
spellingShingle Patel, Vivek L., Busch, Evan L., Friebel, Tara M., Cronin, Angel, Leslie, Goska, McGuffog, Lesley, Adlard, Julian, Agata, Simona, Agnarsson, Bjarni A., Ahmed, Munaza, Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L., Arason, Adalgeir, Arnold, Norbert, Artioli, Grazia, Arver, Brita, Auber, Bernd, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B., Barnes, Daniel R., Barroso, Alicia, Barrowdale, Daniel, Belotti, Muriel, Benitez, Javier, Bertelsen, Birgitte, Blok, Marinus J., Bodrogi, Istvan, Bonadona, Valérie, Bonanni, Bernardo, Bondavalli, Davide, Boonen, Susanne E., Borde, Julika, Borg, Ake, Bradbury, Angela R., Brady, Angela, Brewer, Carole, Brunet, Joan, Buecher, Bruno, Buys, Saundra S., Cabezas-Camarero, Santiago, Caldés, Trinidad, Caliebe, Almuth, Caligo, Maria A., Calvello, Mariarosaria, Campbell, Ian G., Carnevali, Ileana, Carrasco, Estela, Chan, Tsun L., Chu, Annie T.W., Chung, Wendy K., Claes, Kathleen B.M., Collaborators, GEMO Study, Collaborators, EMBRACE, Cook, Jackie, Cortesi, Laura, Couch, Fergus J., Daly, Mary B., Damante, Giuseppe, Darder, Esther, Davidson, Rosemarie, de la Hoya, Miguel, Puppa, Lara Della, Dennis, Joe, Díez, Orland, Ding, Yuan Chun, Ditsch, Nina, Domchek, Susan M., Donaldson, Alan, Dworniczak, Bernd, Easton, Douglas F., Eccles, Diana M., Eeles, Rosalind A., Ehrencrona, Hans, Ejlertsen, Bent, Engel, Christoph, Evans, D. 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title Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_full Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_fullStr Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_full_unstemmed Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_short Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
title_sort association of genomic domains in <i>brca1</i> and <i>brca2</i> with prostate cancer risk and aggressiveness
title_unstemmed Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
topic Cancer Research, Oncology
url http://dx.doi.org/10.1158/0008-5472.can-19-1840