Eintrag weiter verarbeiten
Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma
Gespeichert in:
Zeitschriftentitel: | Cancer Research |
---|---|
Personen und Körperschaften: | , , , , , , , |
In: | Cancer Research, 76, 2016, 21, S. 6241-6252 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
American Association for Cancer Research (AACR)
|
Schlagwörter: |
author_facet |
Takahashi, Naomi Sugaya, Makoto Suga, Hiraku Oka, Tomonori Kawaguchi, Makiko Miyagaki, Tomomitsu Fujita, Hideki Sato, Shinichi Takahashi, Naomi Sugaya, Makoto Suga, Hiraku Oka, Tomonori Kawaguchi, Makiko Miyagaki, Tomomitsu Fujita, Hideki Sato, Shinichi |
---|---|
author |
Takahashi, Naomi Sugaya, Makoto Suga, Hiraku Oka, Tomonori Kawaguchi, Makiko Miyagaki, Tomomitsu Fujita, Hideki Sato, Shinichi |
spellingShingle |
Takahashi, Naomi Sugaya, Makoto Suga, Hiraku Oka, Tomonori Kawaguchi, Makiko Miyagaki, Tomomitsu Fujita, Hideki Sato, Shinichi Cancer Research Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma Cancer Research Oncology |
author_sort |
takahashi, naomi |
spelling |
Takahashi, Naomi Sugaya, Makoto Suga, Hiraku Oka, Tomonori Kawaguchi, Makiko Miyagaki, Tomomitsu Fujita, Hideki Sato, Shinichi 0008-5472 1538-7445 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/0008-5472.can-16-0992 <jats:title>Abstract</jats:title><jats:p>Thymic stromal lymphopoietin (TSLP) activates dendritic cells to induce Th2-mediated inflammation. Periostin, an extracellular matrix protein produced by fibroblasts, induces chronic inflammation by stimulating TSLP production. Recently, a reinforcing cycle linking Th2-type immune responses with periostin-induced keratinocyte activation has been proposed in atopic dermatitis pathogenesis. In this study, we investigated the role of TSLP and periostin in the development of cutaneous T-cell lymphoma (CTCL), where Th2 cytokines and chemokines are also dominant. TSLP and periostin mRNA expression levels were elevated in CTCL lesional skin, both of which correlated with IL4 expression levels. In vitro and ex vivo, IL4 or IL13 stimulated periostin expression by dermal fibroblasts, and fibroblasts from CTCL lesional skin expressed higher levels of periostin than those from control skin. Serum periostin levels of CTCL patients were also significantly higher than those of healthy individuals. Hut78 and MJ, CTCL cell lines, and peripheral blood mononuclear cells from leukemic CTCL patients expressed the TSLP receptor. TSLP induced production of IL4 and IL13 by Hut78 and MJ cells through the activation of STAT5. Moreover, TSLP induced proliferation of CTCL cells both in vitro and in vivo. These data suggest that periostin-mediated TSLP production by keratinocytes directly stimulates CTCL tumor cell growth in addition to inducing a Th2-dominant tumor environment in CTCL. Cancer Res; 76(21); 6241–52. ©2016 AACR.</jats:p> Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma Cancer Research |
doi_str_mv |
10.1158/0008-5472.can-16-0992 |
facet_avail |
Online Free |
finc_class_facet |
Medizin |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8wMDA4LTU0NzIuY2FuLTE2LTA5OTI |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8wMDA4LTU0NzIuY2FuLTE2LTA5OTI |
institution |
DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 |
imprint |
American Association for Cancer Research (AACR), 2016 |
imprint_str_mv |
American Association for Cancer Research (AACR), 2016 |
issn |
0008-5472 1538-7445 |
issn_str_mv |
0008-5472 1538-7445 |
language |
English |
mega_collection |
American Association for Cancer Research (AACR) (CrossRef) |
match_str |
takahashi2016thymicstromalchemokinetslpactsthroughth2cytokineproductiontoinducecutaneoustcelllymphoma |
publishDateSort |
2016 |
publisher |
American Association for Cancer Research (AACR) |
recordtype |
ai |
record_format |
ai |
series |
Cancer Research |
source_id |
49 |
title |
Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_unstemmed |
Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_full |
Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_fullStr |
Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_full_unstemmed |
Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_short |
Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_sort |
thymic stromal chemokine tslp acts through th2 cytokine production to induce cutaneous t-cell lymphoma |
topic |
Cancer Research Oncology |
url |
http://dx.doi.org/10.1158/0008-5472.can-16-0992 |
publishDate |
2016 |
physical |
6241-6252 |
description |
<jats:title>Abstract</jats:title><jats:p>Thymic stromal lymphopoietin (TSLP) activates dendritic cells to induce Th2-mediated inflammation. Periostin, an extracellular matrix protein produced by fibroblasts, induces chronic inflammation by stimulating TSLP production. Recently, a reinforcing cycle linking Th2-type immune responses with periostin-induced keratinocyte activation has been proposed in atopic dermatitis pathogenesis. In this study, we investigated the role of TSLP and periostin in the development of cutaneous T-cell lymphoma (CTCL), where Th2 cytokines and chemokines are also dominant. TSLP and periostin mRNA expression levels were elevated in CTCL lesional skin, both of which correlated with IL4 expression levels. In vitro and ex vivo, IL4 or IL13 stimulated periostin expression by dermal fibroblasts, and fibroblasts from CTCL lesional skin expressed higher levels of periostin than those from control skin. Serum periostin levels of CTCL patients were also significantly higher than those of healthy individuals. Hut78 and MJ, CTCL cell lines, and peripheral blood mononuclear cells from leukemic CTCL patients expressed the TSLP receptor. TSLP induced production of IL4 and IL13 by Hut78 and MJ cells through the activation of STAT5. Moreover, TSLP induced proliferation of CTCL cells both in vitro and in vivo. These data suggest that periostin-mediated TSLP production by keratinocytes directly stimulates CTCL tumor cell growth in addition to inducing a Th2-dominant tumor environment in CTCL. Cancer Res; 76(21); 6241–52. ©2016 AACR.</jats:p> |
container_issue |
21 |
container_start_page |
6241 |
container_title |
Cancer Research |
container_volume |
76 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792347065606471693 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T17:49:21.21Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Thymic+Stromal+Chemokine+TSLP+Acts+through+Th2+Cytokine+Production+to+Induce+Cutaneous+T-cell+Lymphoma&rft.date=2016-11-01&genre=article&issn=1538-7445&volume=76&issue=21&spage=6241&epage=6252&pages=6241-6252&jtitle=Cancer+Research&atitle=Thymic+Stromal+Chemokine+TSLP+Acts+through+Th2+Cytokine+Production+to+Induce+Cutaneous+T-cell+Lymphoma&aulast=Sato&aufirst=Shinichi&rft_id=info%3Adoi%2F10.1158%2F0008-5472.can-16-0992&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792347065606471693 |
author | Takahashi, Naomi, Sugaya, Makoto, Suga, Hiraku, Oka, Tomonori, Kawaguchi, Makiko, Miyagaki, Tomomitsu, Fujita, Hideki, Sato, Shinichi |
author_facet | Takahashi, Naomi, Sugaya, Makoto, Suga, Hiraku, Oka, Tomonori, Kawaguchi, Makiko, Miyagaki, Tomomitsu, Fujita, Hideki, Sato, Shinichi, Takahashi, Naomi, Sugaya, Makoto, Suga, Hiraku, Oka, Tomonori, Kawaguchi, Makiko, Miyagaki, Tomomitsu, Fujita, Hideki, Sato, Shinichi |
author_sort | takahashi, naomi |
container_issue | 21 |
container_start_page | 6241 |
container_title | Cancer Research |
container_volume | 76 |
description | <jats:title>Abstract</jats:title><jats:p>Thymic stromal lymphopoietin (TSLP) activates dendritic cells to induce Th2-mediated inflammation. Periostin, an extracellular matrix protein produced by fibroblasts, induces chronic inflammation by stimulating TSLP production. Recently, a reinforcing cycle linking Th2-type immune responses with periostin-induced keratinocyte activation has been proposed in atopic dermatitis pathogenesis. In this study, we investigated the role of TSLP and periostin in the development of cutaneous T-cell lymphoma (CTCL), where Th2 cytokines and chemokines are also dominant. TSLP and periostin mRNA expression levels were elevated in CTCL lesional skin, both of which correlated with IL4 expression levels. In vitro and ex vivo, IL4 or IL13 stimulated periostin expression by dermal fibroblasts, and fibroblasts from CTCL lesional skin expressed higher levels of periostin than those from control skin. Serum periostin levels of CTCL patients were also significantly higher than those of healthy individuals. Hut78 and MJ, CTCL cell lines, and peripheral blood mononuclear cells from leukemic CTCL patients expressed the TSLP receptor. TSLP induced production of IL4 and IL13 by Hut78 and MJ cells through the activation of STAT5. Moreover, TSLP induced proliferation of CTCL cells both in vitro and in vivo. These data suggest that periostin-mediated TSLP production by keratinocytes directly stimulates CTCL tumor cell growth in addition to inducing a Th2-dominant tumor environment in CTCL. Cancer Res; 76(21); 6241–52. ©2016 AACR.</jats:p> |
doi_str_mv | 10.1158/0008-5472.can-16-0992 |
facet_avail | Online, Free |
finc_class_facet | Medizin |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8wMDA4LTU0NzIuY2FuLTE2LTA5OTI |
imprint | American Association for Cancer Research (AACR), 2016 |
imprint_str_mv | American Association for Cancer Research (AACR), 2016 |
institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
issn | 0008-5472, 1538-7445 |
issn_str_mv | 0008-5472, 1538-7445 |
language | English |
last_indexed | 2024-03-01T17:49:21.21Z |
match_str | takahashi2016thymicstromalchemokinetslpactsthroughth2cytokineproductiontoinducecutaneoustcelllymphoma |
mega_collection | American Association for Cancer Research (AACR) (CrossRef) |
physical | 6241-6252 |
publishDate | 2016 |
publishDateSort | 2016 |
publisher | American Association for Cancer Research (AACR) |
record_format | ai |
recordtype | ai |
series | Cancer Research |
source_id | 49 |
spelling | Takahashi, Naomi Sugaya, Makoto Suga, Hiraku Oka, Tomonori Kawaguchi, Makiko Miyagaki, Tomomitsu Fujita, Hideki Sato, Shinichi 0008-5472 1538-7445 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/0008-5472.can-16-0992 <jats:title>Abstract</jats:title><jats:p>Thymic stromal lymphopoietin (TSLP) activates dendritic cells to induce Th2-mediated inflammation. Periostin, an extracellular matrix protein produced by fibroblasts, induces chronic inflammation by stimulating TSLP production. Recently, a reinforcing cycle linking Th2-type immune responses with periostin-induced keratinocyte activation has been proposed in atopic dermatitis pathogenesis. In this study, we investigated the role of TSLP and periostin in the development of cutaneous T-cell lymphoma (CTCL), where Th2 cytokines and chemokines are also dominant. TSLP and periostin mRNA expression levels were elevated in CTCL lesional skin, both of which correlated with IL4 expression levels. In vitro and ex vivo, IL4 or IL13 stimulated periostin expression by dermal fibroblasts, and fibroblasts from CTCL lesional skin expressed higher levels of periostin than those from control skin. Serum periostin levels of CTCL patients were also significantly higher than those of healthy individuals. Hut78 and MJ, CTCL cell lines, and peripheral blood mononuclear cells from leukemic CTCL patients expressed the TSLP receptor. TSLP induced production of IL4 and IL13 by Hut78 and MJ cells through the activation of STAT5. Moreover, TSLP induced proliferation of CTCL cells both in vitro and in vivo. These data suggest that periostin-mediated TSLP production by keratinocytes directly stimulates CTCL tumor cell growth in addition to inducing a Th2-dominant tumor environment in CTCL. Cancer Res; 76(21); 6241–52. ©2016 AACR.</jats:p> Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma Cancer Research |
spellingShingle | Takahashi, Naomi, Sugaya, Makoto, Suga, Hiraku, Oka, Tomonori, Kawaguchi, Makiko, Miyagaki, Tomomitsu, Fujita, Hideki, Sato, Shinichi, Cancer Research, Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma, Cancer Research, Oncology |
title | Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_full | Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_fullStr | Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_full_unstemmed | Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_short | Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
title_sort | thymic stromal chemokine tslp acts through th2 cytokine production to induce cutaneous t-cell lymphoma |
title_unstemmed | Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma |
topic | Cancer Research, Oncology |
url | http://dx.doi.org/10.1158/0008-5472.can-16-0992 |