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Oncogene-Induced Senescence: Putting the Brakes on Tumor Development
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| Zeitschriftentitel: | Cancer Research |
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| Personen und Körperschaften: | , |
| In: | Cancer Research, 66, 2006, 6, S. 2881-2884 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Abstract</jats:title> <jats:p>Cellular senescence, a permanent cell cycle arrest, is considered a safeguard mechanism that may prevent aged or abnormal cells from further expansion. Although the term “replicative senescence” stands for the widely accepted model of a terminal growth arrest due to telomere attrition, the significance of “oncogene-inducible senescence” remained an issue of debate over the years. A number of recent studies now show the effect of this acute and telomere-independent form of senescence as a tumor-protective, fail-safe mechanism in vivo that shares conceptual and possibly therapeutic similarities with the genetically encoded apoptosis machinery. (Cancer Res 2006; 66(6): 2881-4)</jats:p> |
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| Umfang: | 2881-2884 |
| ISSN: |
0008-5472
1538-7445 |
| DOI: | 10.1158/0008-5472.can-05-4006 |