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Factor V Leiden and Inflammation
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| Zeitschriftentitel: | Thrombosis |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Thrombosis, 2012, 2012, S. 1-10 |
| Format: | E-Article |
| Sprache: | Englisch |
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Hindawi Limited
|
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Perez-Pujol, Silvia Aras, Omer Escolar, Gines Perez-Pujol, Silvia Aras, Omer Escolar, Gines |
|---|---|
| author |
Perez-Pujol, Silvia Aras, Omer Escolar, Gines |
| spellingShingle |
Perez-Pujol, Silvia Aras, Omer Escolar, Gines Thrombosis Factor V Leiden and Inflammation Cardiology and Cardiovascular Medicine Hematology |
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perez-pujol, silvia |
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Perez-Pujol, Silvia Aras, Omer Escolar, Gines 2090-1488 2090-1496 Hindawi Limited Cardiology and Cardiovascular Medicine Hematology http://dx.doi.org/10.1155/2012/594986 <jats:p>Factor V Leiden, is a variant of human factor V (FV), also known as proaccelerin, which leads to a hypercoagulable state. Along these years, factor V Leiden (FVL) has been studied from the pathophysiologic point of view, and research has been focused on finding clinical approaches for the management of the FVL associated to a trombophilic state. Less attention has been paid about the possible role of FVL in inflammatory conditions known to be present in different disorders such as uremia, cirrhosis, liver transplantation, depression as well as sepsis, infection or, inflammatory bowel disease (IBD). Whether platelet FVL will increase the activation of coagulation and/or in which proportion is able to determine the final outcome in the previously mentioned inflammatory conditions is a subject that remains uncertain. This paper will review the association of FVL with inflammation. Specifically, it will analyze the important role of the endothelium and the contribution of other inflammatory components involved at both the immune and vascular levels. This paper will also try to emphasize the importance of being a FVL carrier in associations to diseases where a chronic inflammation occurs, and how this condition may be determinant in the progression and outcome of a specific clinic situation.</jats:p> Factor V Leiden and Inflammation Thrombosis |
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Factor V Leiden and Inflammation |
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Factor V Leiden and Inflammation |
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Factor V Leiden and Inflammation |
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Factor V Leiden and Inflammation |
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Factor V Leiden and Inflammation |
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Factor V Leiden and Inflammation |
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factor v leiden and inflammation |
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Cardiology and Cardiovascular Medicine Hematology |
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http://dx.doi.org/10.1155/2012/594986 |
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2012 |
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1-10 |
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<jats:p>Factor V Leiden, is a variant of human factor V (FV), also known as proaccelerin, which leads to a hypercoagulable state. Along these years, factor V Leiden (FVL) has been studied from the pathophysiologic point of view, and research has been focused on finding clinical approaches for the management of the FVL associated to a trombophilic state. Less attention has been paid about the possible role of FVL in inflammatory conditions known to be present in different disorders such as uremia, cirrhosis, liver transplantation, depression as well as sepsis, infection or, inflammatory bowel disease (IBD). Whether platelet FVL will increase the activation of coagulation and/or in which proportion is able to determine the final outcome in the previously mentioned inflammatory conditions is a subject that remains uncertain. This paper will review the association of FVL with inflammation. Specifically, it will analyze the important role of the endothelium and the contribution of other inflammatory components involved at both the immune and vascular levels. This paper will also try to emphasize the importance of being a FVL carrier in associations to diseases where a chronic inflammation occurs, and how this condition may be determinant in the progression and outcome of a specific clinic situation.</jats:p> |
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| description | <jats:p>Factor V Leiden, is a variant of human factor V (FV), also known as proaccelerin, which leads to a hypercoagulable state. Along these years, factor V Leiden (FVL) has been studied from the pathophysiologic point of view, and research has been focused on finding clinical approaches for the management of the FVL associated to a trombophilic state. Less attention has been paid about the possible role of FVL in inflammatory conditions known to be present in different disorders such as uremia, cirrhosis, liver transplantation, depression as well as sepsis, infection or, inflammatory bowel disease (IBD). Whether platelet FVL will increase the activation of coagulation and/or in which proportion is able to determine the final outcome in the previously mentioned inflammatory conditions is a subject that remains uncertain. This paper will review the association of FVL with inflammation. Specifically, it will analyze the important role of the endothelium and the contribution of other inflammatory components involved at both the immune and vascular levels. This paper will also try to emphasize the importance of being a FVL carrier in associations to diseases where a chronic inflammation occurs, and how this condition may be determinant in the progression and outcome of a specific clinic situation.</jats:p> |
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| spelling | Perez-Pujol, Silvia Aras, Omer Escolar, Gines 2090-1488 2090-1496 Hindawi Limited Cardiology and Cardiovascular Medicine Hematology http://dx.doi.org/10.1155/2012/594986 <jats:p>Factor V Leiden, is a variant of human factor V (FV), also known as proaccelerin, which leads to a hypercoagulable state. Along these years, factor V Leiden (FVL) has been studied from the pathophysiologic point of view, and research has been focused on finding clinical approaches for the management of the FVL associated to a trombophilic state. Less attention has been paid about the possible role of FVL in inflammatory conditions known to be present in different disorders such as uremia, cirrhosis, liver transplantation, depression as well as sepsis, infection or, inflammatory bowel disease (IBD). Whether platelet FVL will increase the activation of coagulation and/or in which proportion is able to determine the final outcome in the previously mentioned inflammatory conditions is a subject that remains uncertain. This paper will review the association of FVL with inflammation. Specifically, it will analyze the important role of the endothelium and the contribution of other inflammatory components involved at both the immune and vascular levels. This paper will also try to emphasize the importance of being a FVL carrier in associations to diseases where a chronic inflammation occurs, and how this condition may be determinant in the progression and outcome of a specific clinic situation.</jats:p> Factor V Leiden and Inflammation Thrombosis |
| spellingShingle | Perez-Pujol, Silvia, Aras, Omer, Escolar, Gines, Thrombosis, Factor V Leiden and Inflammation, Cardiology and Cardiovascular Medicine, Hematology |
| title | Factor V Leiden and Inflammation |
| title_full | Factor V Leiden and Inflammation |
| title_fullStr | Factor V Leiden and Inflammation |
| title_full_unstemmed | Factor V Leiden and Inflammation |
| title_short | Factor V Leiden and Inflammation |
| title_sort | factor v leiden and inflammation |
| title_unstemmed | Factor V Leiden and Inflammation |
| topic | Cardiology and Cardiovascular Medicine, Hematology |
| url | http://dx.doi.org/10.1155/2012/594986 |