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Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome

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Bibliographische Detailangaben
Zeitschriftentitel: Case Reports in Pediatrics
Personen und Körperschaften: Singer, Georg, Kashofer, Karl, Castellani, Christoph, Till, Holger
In: Case Reports in Pediatrics, 2018, 2018, S. 1-6
Format: E-Article
Sprache: Englisch
veröffentlicht:
Hindawi Limited
Schlagwörter:
General Medicine
author_facet Singer, Georg
Kashofer, Karl
Castellani, Christoph
Till, Holger
Singer, Georg
Kashofer, Karl
Castellani, Christoph
Till, Holger
author Singer, Georg
Kashofer, Karl
Castellani, Christoph
Till, Holger
spellingShingle Singer, Georg
Kashofer, Karl
Castellani, Christoph
Till, Holger
Case Reports in Pediatrics
Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
General Medicine
author_sort singer, georg
spelling Singer, Georg Kashofer, Karl Castellani, Christoph Till, Holger 2090-6803 2090-6811 Hindawi Limited General Medicine http://dx.doi.org/10.1155/2018/3292309 <jats:p>Approximately 40% of children with Hirschsprung’s disease (HD) suffer from Hirschsprung’s associated enterocolitis (HAEC) despite correct surgery. Disturbances of the intestinal microbiome may play a role. Treatment with probiotics based on individual analyses of the fecal microbiome has not been published for HD patients with recurrent HAEC yet. A boy with trisomy 21 received transanal pull-through at the age of 6 months for rectosigmoid HD. With four years, he suffered from recurrent episodes of HAEC. The fecal microbiome was measured during three healthy and three HAEC episodes by next-generation sequencing. The patient was started on daily probiotics for 3 months; the fecal microbiome was measured weekly. The fecal microbiome differed significantly between healthy and HAEC episodes. HAEC episodes were associated with significant decreases of Actinobacteria and significant increases of Bacteroidetes and Proteobacteria. Probiotic treatment led to a significant increase of alpha diversity and a significant increase of <jats:italic>Bifidobacterium</jats:italic> and <jats:italic>Streptococcus</jats:italic> as well as decreases of <jats:italic>Rikenellaceae</jats:italic>, <jats:italic>Pseudobutyrivibrio</jats:italic>, <jats:italic>Blautia</jats:italic>, and <jats:italic>Lachnospiraceae</jats:italic>. A longitudinal observation of the microbiome has never been performed following correction of Hirschsprung’s disease. Probiotic treatment significantly changed the fecal microbiome; the alterations were not limited to strains contained in the administered probiotics.</jats:p> Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome Case Reports in Pediatrics
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title Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_unstemmed Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_full Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_fullStr Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_full_unstemmed Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_short Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_sort hirschsprung’s associated enterocolitis (haec) personalized treatment with probiotics based on gene sequencing analysis of the fecal microbiome
topic General Medicine
url http://dx.doi.org/10.1155/2018/3292309
publishDate 2018
physical 1-6
description <jats:p>Approximately 40% of children with Hirschsprung’s disease (HD) suffer from Hirschsprung’s associated enterocolitis (HAEC) despite correct surgery. Disturbances of the intestinal microbiome may play a role. Treatment with probiotics based on individual analyses of the fecal microbiome has not been published for HD patients with recurrent HAEC yet. A boy with trisomy 21 received transanal pull-through at the age of 6 months for rectosigmoid HD. With four years, he suffered from recurrent episodes of HAEC. The fecal microbiome was measured during three healthy and three HAEC episodes by next-generation sequencing. The patient was started on daily probiotics for 3 months; the fecal microbiome was measured weekly. The fecal microbiome differed significantly between healthy and HAEC episodes. HAEC episodes were associated with significant decreases of Actinobacteria and significant increases of Bacteroidetes and Proteobacteria. Probiotic treatment led to a significant increase of alpha diversity and a significant increase of <jats:italic>Bifidobacterium</jats:italic> and <jats:italic>Streptococcus</jats:italic> as well as decreases of <jats:italic>Rikenellaceae</jats:italic>, <jats:italic>Pseudobutyrivibrio</jats:italic>, <jats:italic>Blautia</jats:italic>, and <jats:italic>Lachnospiraceae</jats:italic>. A longitudinal observation of the microbiome has never been performed following correction of Hirschsprung’s disease. Probiotic treatment significantly changed the fecal microbiome; the alterations were not limited to strains contained in the administered probiotics.</jats:p>
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author Singer, Georg, Kashofer, Karl, Castellani, Christoph, Till, Holger
author_facet Singer, Georg, Kashofer, Karl, Castellani, Christoph, Till, Holger, Singer, Georg, Kashofer, Karl, Castellani, Christoph, Till, Holger
author_sort singer, georg
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description <jats:p>Approximately 40% of children with Hirschsprung’s disease (HD) suffer from Hirschsprung’s associated enterocolitis (HAEC) despite correct surgery. Disturbances of the intestinal microbiome may play a role. Treatment with probiotics based on individual analyses of the fecal microbiome has not been published for HD patients with recurrent HAEC yet. A boy with trisomy 21 received transanal pull-through at the age of 6 months for rectosigmoid HD. With four years, he suffered from recurrent episodes of HAEC. The fecal microbiome was measured during three healthy and three HAEC episodes by next-generation sequencing. The patient was started on daily probiotics for 3 months; the fecal microbiome was measured weekly. The fecal microbiome differed significantly between healthy and HAEC episodes. HAEC episodes were associated with significant decreases of Actinobacteria and significant increases of Bacteroidetes and Proteobacteria. Probiotic treatment led to a significant increase of alpha diversity and a significant increase of <jats:italic>Bifidobacterium</jats:italic> and <jats:italic>Streptococcus</jats:italic> as well as decreases of <jats:italic>Rikenellaceae</jats:italic>, <jats:italic>Pseudobutyrivibrio</jats:italic>, <jats:italic>Blautia</jats:italic>, and <jats:italic>Lachnospiraceae</jats:italic>. A longitudinal observation of the microbiome has never been performed following correction of Hirschsprung’s disease. Probiotic treatment significantly changed the fecal microbiome; the alterations were not limited to strains contained in the administered probiotics.</jats:p>
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spelling Singer, Georg Kashofer, Karl Castellani, Christoph Till, Holger 2090-6803 2090-6811 Hindawi Limited General Medicine http://dx.doi.org/10.1155/2018/3292309 <jats:p>Approximately 40% of children with Hirschsprung’s disease (HD) suffer from Hirschsprung’s associated enterocolitis (HAEC) despite correct surgery. Disturbances of the intestinal microbiome may play a role. Treatment with probiotics based on individual analyses of the fecal microbiome has not been published for HD patients with recurrent HAEC yet. A boy with trisomy 21 received transanal pull-through at the age of 6 months for rectosigmoid HD. With four years, he suffered from recurrent episodes of HAEC. The fecal microbiome was measured during three healthy and three HAEC episodes by next-generation sequencing. The patient was started on daily probiotics for 3 months; the fecal microbiome was measured weekly. The fecal microbiome differed significantly between healthy and HAEC episodes. HAEC episodes were associated with significant decreases of Actinobacteria and significant increases of Bacteroidetes and Proteobacteria. Probiotic treatment led to a significant increase of alpha diversity and a significant increase of <jats:italic>Bifidobacterium</jats:italic> and <jats:italic>Streptococcus</jats:italic> as well as decreases of <jats:italic>Rikenellaceae</jats:italic>, <jats:italic>Pseudobutyrivibrio</jats:italic>, <jats:italic>Blautia</jats:italic>, and <jats:italic>Lachnospiraceae</jats:italic>. A longitudinal observation of the microbiome has never been performed following correction of Hirschsprung’s disease. Probiotic treatment significantly changed the fecal microbiome; the alterations were not limited to strains contained in the administered probiotics.</jats:p> Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome Case Reports in Pediatrics
spellingShingle Singer, Georg, Kashofer, Karl, Castellani, Christoph, Till, Holger, Case Reports in Pediatrics, Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome, General Medicine
title Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_full Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_fullStr Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_full_unstemmed Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_short Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
title_sort hirschsprung’s associated enterocolitis (haec) personalized treatment with probiotics based on gene sequencing analysis of the fecal microbiome
title_unstemmed Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
topic General Medicine
url http://dx.doi.org/10.1155/2018/3292309