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Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity
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| Zeitschriftentitel: | Oxidative Medicine and Cellular Longevity |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Oxidative Medicine and Cellular Longevity, 2018, 2018, S. 1-8 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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| Schlagwörter: |
| author_facet |
Valli, Veronica Heilmann, Katharina Danesi, Francesca Bordoni, Alessandra Gerhäuser, Clarissa Valli, Veronica Heilmann, Katharina Danesi, Francesca Bordoni, Alessandra Gerhäuser, Clarissa |
|---|---|
| author |
Valli, Veronica Heilmann, Katharina Danesi, Francesca Bordoni, Alessandra Gerhäuser, Clarissa |
| spellingShingle |
Valli, Veronica Heilmann, Katharina Danesi, Francesca Bordoni, Alessandra Gerhäuser, Clarissa Oxidative Medicine and Cellular Longevity Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity Cell Biology Aging General Medicine Biochemistry |
| author_sort |
valli, veronica |
| spelling |
Valli, Veronica Heilmann, Katharina Danesi, Francesca Bordoni, Alessandra Gerhäuser, Clarissa 1942-0900 1942-0994 Hindawi Limited Cell Biology Aging General Medicine Biochemistry http://dx.doi.org/10.1155/2018/1617202 <jats:p>Obesity is characterized by excess body fat accumulation due to an increase in the size and number of differentiated mature adipocytes. Adipocyte differentiation is regulated by genetic and environmental factors, and its inhibition could represent a strategy for obesity prevention and treatment. The current study was designed with two aims: (i) to evaluate the changes in the expression of adipogenic markers (C/EBP<jats:italic>α</jats:italic>, PPAR<jats:italic>γ</jats:italic>variant 1 and variant 2, and GLUT4) in 3T3-L1 murine preadipocytes at four stages of the differentiation process and (ii) to compare the effectiveness of sulforaphane, genistein, and docosahexaenoic acid in reducing lipid accumulation and modulating C/EBP<jats:italic>α</jats:italic>, PPAR<jats:italic>γ</jats:italic>1, PPAR<jats:italic>γ</jats:italic>2, and GLUT4 mRNA expression in mature adipocytes. All bioactive compounds were shown to suppress adipocyte differentiation, although with different effectiveness. These results set the stage for further studies considering natural food constituents as important agents in preventing or treating obesity.</jats:p> Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity Oxidative Medicine and Cellular Longevity |
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| title |
Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_unstemmed |
Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_full |
Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_fullStr |
Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_full_unstemmed |
Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_short |
Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_sort |
modulation of adipocyte differentiation and proadipogenic gene expression by sulforaphane, genistein, and docosahexaenoic acid as a first step to counteract obesity |
| topic |
Cell Biology Aging General Medicine Biochemistry |
| url |
http://dx.doi.org/10.1155/2018/1617202 |
| publishDate |
2018 |
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1-8 |
| description |
<jats:p>Obesity is characterized by excess body fat accumulation due to an increase in the size and number of differentiated mature adipocytes. Adipocyte differentiation is regulated by genetic and environmental factors, and its inhibition could represent a strategy for obesity prevention and treatment. The current study was designed with two aims: (i) to evaluate the changes in the expression of adipogenic markers (C/EBP<jats:italic>α</jats:italic>, PPAR<jats:italic>γ</jats:italic>variant 1 and variant 2, and GLUT4) in 3T3-L1 murine preadipocytes at four stages of the differentiation process and (ii) to compare the effectiveness of sulforaphane, genistein, and docosahexaenoic acid in reducing lipid accumulation and modulating C/EBP<jats:italic>α</jats:italic>, PPAR<jats:italic>γ</jats:italic>1, PPAR<jats:italic>γ</jats:italic>2, and GLUT4 mRNA expression in mature adipocytes. All bioactive compounds were shown to suppress adipocyte differentiation, although with different effectiveness. These results set the stage for further studies considering natural food constituents as important agents in preventing or treating obesity.</jats:p> |
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| description | <jats:p>Obesity is characterized by excess body fat accumulation due to an increase in the size and number of differentiated mature adipocytes. Adipocyte differentiation is regulated by genetic and environmental factors, and its inhibition could represent a strategy for obesity prevention and treatment. The current study was designed with two aims: (i) to evaluate the changes in the expression of adipogenic markers (C/EBP<jats:italic>α</jats:italic>, PPAR<jats:italic>γ</jats:italic>variant 1 and variant 2, and GLUT4) in 3T3-L1 murine preadipocytes at four stages of the differentiation process and (ii) to compare the effectiveness of sulforaphane, genistein, and docosahexaenoic acid in reducing lipid accumulation and modulating C/EBP<jats:italic>α</jats:italic>, PPAR<jats:italic>γ</jats:italic>1, PPAR<jats:italic>γ</jats:italic>2, and GLUT4 mRNA expression in mature adipocytes. All bioactive compounds were shown to suppress adipocyte differentiation, although with different effectiveness. These results set the stage for further studies considering natural food constituents as important agents in preventing or treating obesity.</jats:p> |
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| spelling | Valli, Veronica Heilmann, Katharina Danesi, Francesca Bordoni, Alessandra Gerhäuser, Clarissa 1942-0900 1942-0994 Hindawi Limited Cell Biology Aging General Medicine Biochemistry http://dx.doi.org/10.1155/2018/1617202 <jats:p>Obesity is characterized by excess body fat accumulation due to an increase in the size and number of differentiated mature adipocytes. Adipocyte differentiation is regulated by genetic and environmental factors, and its inhibition could represent a strategy for obesity prevention and treatment. The current study was designed with two aims: (i) to evaluate the changes in the expression of adipogenic markers (C/EBP<jats:italic>α</jats:italic>, PPAR<jats:italic>γ</jats:italic>variant 1 and variant 2, and GLUT4) in 3T3-L1 murine preadipocytes at four stages of the differentiation process and (ii) to compare the effectiveness of sulforaphane, genistein, and docosahexaenoic acid in reducing lipid accumulation and modulating C/EBP<jats:italic>α</jats:italic>, PPAR<jats:italic>γ</jats:italic>1, PPAR<jats:italic>γ</jats:italic>2, and GLUT4 mRNA expression in mature adipocytes. All bioactive compounds were shown to suppress adipocyte differentiation, although with different effectiveness. These results set the stage for further studies considering natural food constituents as important agents in preventing or treating obesity.</jats:p> Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity Oxidative Medicine and Cellular Longevity |
| spellingShingle | Valli, Veronica, Heilmann, Katharina, Danesi, Francesca, Bordoni, Alessandra, Gerhäuser, Clarissa, Oxidative Medicine and Cellular Longevity, Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity, Cell Biology, Aging, General Medicine, Biochemistry |
| title | Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_full | Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_fullStr | Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_full_unstemmed | Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_short | Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| title_sort | modulation of adipocyte differentiation and proadipogenic gene expression by sulforaphane, genistein, and docosahexaenoic acid as a first step to counteract obesity |
| title_unstemmed | Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity |
| topic | Cell Biology, Aging, General Medicine, Biochemistry |
| url | http://dx.doi.org/10.1155/2018/1617202 |