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Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2
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| Zeitschriftentitel: | Oxidative Medicine and Cellular Longevity |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Oxidative Medicine and Cellular Longevity, 2017, 2017, S. 1-12 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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| Schlagwörter: |
| author_facet |
Wang, Yonggang Wu, Hao Xin, Ying Bai, Yang Kong, Lili Tan, Yi Liu, Feng Cai, Lu Wang, Yonggang Wu, Hao Xin, Ying Bai, Yang Kong, Lili Tan, Yi Liu, Feng Cai, Lu |
|---|---|
| author |
Wang, Yonggang Wu, Hao Xin, Ying Bai, Yang Kong, Lili Tan, Yi Liu, Feng Cai, Lu |
| spellingShingle |
Wang, Yonggang Wu, Hao Xin, Ying Bai, Yang Kong, Lili Tan, Yi Liu, Feng Cai, Lu Oxidative Medicine and Cellular Longevity Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 Cell Biology Aging General Medicine Biochemistry |
| author_sort |
wang, yonggang |
| spelling |
Wang, Yonggang Wu, Hao Xin, Ying Bai, Yang Kong, Lili Tan, Yi Liu, Feng Cai, Lu 1942-0900 1942-0994 Hindawi Limited Cell Biology Aging General Medicine Biochemistry http://dx.doi.org/10.1155/2017/5374897 <jats:p>Although angiotensin II (Ang II) was reported to facilitate sperm motility and intratesticular sperm transport, recent findings shed light on the efficacy of Ang II in stimulating inflammatory events in testicular peritubular cells, effect of which may play a role in male infertility. It is still unknown whether Ang II can induce testicular apoptotic cell death, which may be a more direct action of Ang II in male infertility. Therefore, the present study aims to determine whether Ang II can induce testicular apoptotic cell death and whether this action can be prevented by sulforaphane (SFN) via activating nuclear factor (erythroid-derived 2)-like 2 (NRF2), the governor of antioxidant-redox signalling. Eight-week-old male C57BL/6J wild type (WT) and<jats:italic> Nrf2</jats:italic> gene knockout mice were treated with Ang II, in the presence or absence of SFN. In WT mice, SFN activated testicular NRF2 expression and function, along with a marked attenuation in Ang II-induced testicular oxidative stress, inflammation, endoplasmic reticulum stress, and apoptotic cell death. Deletion of the<jats:italic> Nrf2</jats:italic> gene led to a complete abolishment of these efficacies of SFN. The present study indicated that Ang II may result in testicular apoptotic cell death, which can be prevented by SFN via the activation of NRF2.</jats:p> Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 Oxidative Medicine and Cellular Longevity |
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| title |
Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_unstemmed |
Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_full |
Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_fullStr |
Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_full_unstemmed |
Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_short |
Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_sort |
sulforaphane prevents angiotensin ii-induced testicular cell death via activation of nrf2 |
| topic |
Cell Biology Aging General Medicine Biochemistry |
| url |
http://dx.doi.org/10.1155/2017/5374897 |
| publishDate |
2017 |
| physical |
1-12 |
| description |
<jats:p>Although angiotensin II (Ang II) was reported to facilitate sperm motility and intratesticular sperm transport, recent findings shed light on the efficacy of Ang II in stimulating inflammatory events in testicular peritubular cells, effect of which may play a role in male infertility. It is still unknown whether Ang II can induce testicular apoptotic cell death, which may be a more direct action of Ang II in male infertility. Therefore, the present study aims to determine whether Ang II can induce testicular apoptotic cell death and whether this action can be prevented by sulforaphane (SFN) via activating nuclear factor (erythroid-derived 2)-like 2 (NRF2), the governor of antioxidant-redox signalling. Eight-week-old male C57BL/6J wild type (WT) and<jats:italic> Nrf2</jats:italic> gene knockout mice were treated with Ang II, in the presence or absence of SFN. In WT mice, SFN activated testicular NRF2 expression and function, along with a marked attenuation in Ang II-induced testicular oxidative stress, inflammation, endoplasmic reticulum stress, and apoptotic cell death. Deletion of the<jats:italic> Nrf2</jats:italic> gene led to a complete abolishment of these efficacies of SFN. The present study indicated that Ang II may result in testicular apoptotic cell death, which can be prevented by SFN via the activation of NRF2.</jats:p> |
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| author | Wang, Yonggang, Wu, Hao, Xin, Ying, Bai, Yang, Kong, Lili, Tan, Yi, Liu, Feng, Cai, Lu |
| author_facet | Wang, Yonggang, Wu, Hao, Xin, Ying, Bai, Yang, Kong, Lili, Tan, Yi, Liu, Feng, Cai, Lu, Wang, Yonggang, Wu, Hao, Xin, Ying, Bai, Yang, Kong, Lili, Tan, Yi, Liu, Feng, Cai, Lu |
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| description | <jats:p>Although angiotensin II (Ang II) was reported to facilitate sperm motility and intratesticular sperm transport, recent findings shed light on the efficacy of Ang II in stimulating inflammatory events in testicular peritubular cells, effect of which may play a role in male infertility. It is still unknown whether Ang II can induce testicular apoptotic cell death, which may be a more direct action of Ang II in male infertility. Therefore, the present study aims to determine whether Ang II can induce testicular apoptotic cell death and whether this action can be prevented by sulforaphane (SFN) via activating nuclear factor (erythroid-derived 2)-like 2 (NRF2), the governor of antioxidant-redox signalling. Eight-week-old male C57BL/6J wild type (WT) and<jats:italic> Nrf2</jats:italic> gene knockout mice were treated with Ang II, in the presence or absence of SFN. In WT mice, SFN activated testicular NRF2 expression and function, along with a marked attenuation in Ang II-induced testicular oxidative stress, inflammation, endoplasmic reticulum stress, and apoptotic cell death. Deletion of the<jats:italic> Nrf2</jats:italic> gene led to a complete abolishment of these efficacies of SFN. The present study indicated that Ang II may result in testicular apoptotic cell death, which can be prevented by SFN via the activation of NRF2.</jats:p> |
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| spelling | Wang, Yonggang Wu, Hao Xin, Ying Bai, Yang Kong, Lili Tan, Yi Liu, Feng Cai, Lu 1942-0900 1942-0994 Hindawi Limited Cell Biology Aging General Medicine Biochemistry http://dx.doi.org/10.1155/2017/5374897 <jats:p>Although angiotensin II (Ang II) was reported to facilitate sperm motility and intratesticular sperm transport, recent findings shed light on the efficacy of Ang II in stimulating inflammatory events in testicular peritubular cells, effect of which may play a role in male infertility. It is still unknown whether Ang II can induce testicular apoptotic cell death, which may be a more direct action of Ang II in male infertility. Therefore, the present study aims to determine whether Ang II can induce testicular apoptotic cell death and whether this action can be prevented by sulforaphane (SFN) via activating nuclear factor (erythroid-derived 2)-like 2 (NRF2), the governor of antioxidant-redox signalling. Eight-week-old male C57BL/6J wild type (WT) and<jats:italic> Nrf2</jats:italic> gene knockout mice were treated with Ang II, in the presence or absence of SFN. In WT mice, SFN activated testicular NRF2 expression and function, along with a marked attenuation in Ang II-induced testicular oxidative stress, inflammation, endoplasmic reticulum stress, and apoptotic cell death. Deletion of the<jats:italic> Nrf2</jats:italic> gene led to a complete abolishment of these efficacies of SFN. The present study indicated that Ang II may result in testicular apoptotic cell death, which can be prevented by SFN via the activation of NRF2.</jats:p> Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 Oxidative Medicine and Cellular Longevity |
| spellingShingle | Wang, Yonggang, Wu, Hao, Xin, Ying, Bai, Yang, Kong, Lili, Tan, Yi, Liu, Feng, Cai, Lu, Oxidative Medicine and Cellular Longevity, Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2, Cell Biology, Aging, General Medicine, Biochemistry |
| title | Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_full | Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_fullStr | Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_full_unstemmed | Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_short | Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| title_sort | sulforaphane prevents angiotensin ii-induced testicular cell death via activation of nrf2 |
| title_unstemmed | Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 |
| topic | Cell Biology, Aging, General Medicine, Biochemistry |
| url | http://dx.doi.org/10.1155/2017/5374897 |