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Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice
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| Zeitschriftentitel: | Neural Plasticity |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Neural Plasticity, 2016, 2016, S. 1-11 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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| Schlagwörter: |
| author_facet |
Prange-Kiel, Janine Dudzinski, Danuta A. Pröls, Felicitas Glatzel, Markus Matschke, Jakob Rune, Gabriele M. Prange-Kiel, Janine Dudzinski, Danuta A. Pröls, Felicitas Glatzel, Markus Matschke, Jakob Rune, Gabriele M. |
|---|---|
| author |
Prange-Kiel, Janine Dudzinski, Danuta A. Pröls, Felicitas Glatzel, Markus Matschke, Jakob Rune, Gabriele M. |
| spellingShingle |
Prange-Kiel, Janine Dudzinski, Danuta A. Pröls, Felicitas Glatzel, Markus Matschke, Jakob Rune, Gabriele M. Neural Plasticity Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice Neurology (clinical) Neurology |
| author_sort |
prange-kiel, janine |
| spelling |
Prange-Kiel, Janine Dudzinski, Danuta A. Pröls, Felicitas Glatzel, Markus Matschke, Jakob Rune, Gabriele M. 2090-5904 1687-5443 Hindawi Limited Neurology (clinical) Neurology http://dx.doi.org/10.1155/2016/9802086 <jats:p>Numerous studies show that 17<jats:italic>β</jats:italic>-estradiol (E<jats:sub>2</jats:sub>) protects against Alzheimer’s disease (AD) induced neurodegeneration. The E<jats:sub>2</jats:sub>-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is known about the expression of hippocampal aromatase in AD. To better understand the role of hippocampal aromatase in AD, we studied its expression in postmortem material from patients with AD and in a mouse model for AD (5xFAD mice). In human hippocampi, aromatase-immunoreactivity was observed in the vast majority of principal neurons and signal quantification revealed higher expression of aromatase protein in AD patients compared to age- and sex-matched controls. The tissue-specific first exons of aromatase I.f, PII, I.3, and I.6 were detected in hippocampi of controls and AD patients by RT-PCR. In contrast, 3-month-old, female 5xFAD mice showed lower expression of aromatase mRNA and protein (measured by qRT-PCR and semiquantitative immunohistochemistry) than WT controls; no such differences were observed in male mice. Our findings stress the importance of hippocampal aromatase expression in neurodegenerative diseases.</jats:p> Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice Neural Plasticity |
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| title |
Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_unstemmed |
Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_full |
Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_fullStr |
Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_full_unstemmed |
Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_short |
Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_sort |
aromatase expression in the hippocampus of ad patients and 5xfad mice |
| topic |
Neurology (clinical) Neurology |
| url |
http://dx.doi.org/10.1155/2016/9802086 |
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2016 |
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1-11 |
| description |
<jats:p>Numerous studies show that 17<jats:italic>β</jats:italic>-estradiol (E<jats:sub>2</jats:sub>) protects against Alzheimer’s disease (AD) induced neurodegeneration. The E<jats:sub>2</jats:sub>-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is known about the expression of hippocampal aromatase in AD. To better understand the role of hippocampal aromatase in AD, we studied its expression in postmortem material from patients with AD and in a mouse model for AD (5xFAD mice). In human hippocampi, aromatase-immunoreactivity was observed in the vast majority of principal neurons and signal quantification revealed higher expression of aromatase protein in AD patients compared to age- and sex-matched controls. The tissue-specific first exons of aromatase I.f, PII, I.3, and I.6 were detected in hippocampi of controls and AD patients by RT-PCR. In contrast, 3-month-old, female 5xFAD mice showed lower expression of aromatase mRNA and protein (measured by qRT-PCR and semiquantitative immunohistochemistry) than WT controls; no such differences were observed in male mice. Our findings stress the importance of hippocampal aromatase expression in neurodegenerative diseases.</jats:p> |
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| author | Prange-Kiel, Janine, Dudzinski, Danuta A., Pröls, Felicitas, Glatzel, Markus, Matschke, Jakob, Rune, Gabriele M. |
| author_facet | Prange-Kiel, Janine, Dudzinski, Danuta A., Pröls, Felicitas, Glatzel, Markus, Matschke, Jakob, Rune, Gabriele M., Prange-Kiel, Janine, Dudzinski, Danuta A., Pröls, Felicitas, Glatzel, Markus, Matschke, Jakob, Rune, Gabriele M. |
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| description | <jats:p>Numerous studies show that 17<jats:italic>β</jats:italic>-estradiol (E<jats:sub>2</jats:sub>) protects against Alzheimer’s disease (AD) induced neurodegeneration. The E<jats:sub>2</jats:sub>-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is known about the expression of hippocampal aromatase in AD. To better understand the role of hippocampal aromatase in AD, we studied its expression in postmortem material from patients with AD and in a mouse model for AD (5xFAD mice). In human hippocampi, aromatase-immunoreactivity was observed in the vast majority of principal neurons and signal quantification revealed higher expression of aromatase protein in AD patients compared to age- and sex-matched controls. The tissue-specific first exons of aromatase I.f, PII, I.3, and I.6 were detected in hippocampi of controls and AD patients by RT-PCR. In contrast, 3-month-old, female 5xFAD mice showed lower expression of aromatase mRNA and protein (measured by qRT-PCR and semiquantitative immunohistochemistry) than WT controls; no such differences were observed in male mice. Our findings stress the importance of hippocampal aromatase expression in neurodegenerative diseases.</jats:p> |
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| spelling | Prange-Kiel, Janine Dudzinski, Danuta A. Pröls, Felicitas Glatzel, Markus Matschke, Jakob Rune, Gabriele M. 2090-5904 1687-5443 Hindawi Limited Neurology (clinical) Neurology http://dx.doi.org/10.1155/2016/9802086 <jats:p>Numerous studies show that 17<jats:italic>β</jats:italic>-estradiol (E<jats:sub>2</jats:sub>) protects against Alzheimer’s disease (AD) induced neurodegeneration. The E<jats:sub>2</jats:sub>-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is known about the expression of hippocampal aromatase in AD. To better understand the role of hippocampal aromatase in AD, we studied its expression in postmortem material from patients with AD and in a mouse model for AD (5xFAD mice). In human hippocampi, aromatase-immunoreactivity was observed in the vast majority of principal neurons and signal quantification revealed higher expression of aromatase protein in AD patients compared to age- and sex-matched controls. The tissue-specific first exons of aromatase I.f, PII, I.3, and I.6 were detected in hippocampi of controls and AD patients by RT-PCR. In contrast, 3-month-old, female 5xFAD mice showed lower expression of aromatase mRNA and protein (measured by qRT-PCR and semiquantitative immunohistochemistry) than WT controls; no such differences were observed in male mice. Our findings stress the importance of hippocampal aromatase expression in neurodegenerative diseases.</jats:p> Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice Neural Plasticity |
| spellingShingle | Prange-Kiel, Janine, Dudzinski, Danuta A., Pröls, Felicitas, Glatzel, Markus, Matschke, Jakob, Rune, Gabriele M., Neural Plasticity, Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice, Neurology (clinical), Neurology |
| title | Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_full | Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_fullStr | Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_full_unstemmed | Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_short | Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| title_sort | aromatase expression in the hippocampus of ad patients and 5xfad mice |
| title_unstemmed | Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice |
| topic | Neurology (clinical), Neurology |
| url | http://dx.doi.org/10.1155/2016/9802086 |