Eintrag weiter verarbeiten
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study
Gespeichert in:
| Zeitschriftentitel: | BioMed Research International |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | BioMed Research International, 2016, 2016, S. 1-16 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Zhang, Ying Feng, Yuanming Ming, Xin Deng, Jun Zhang, Ying Feng, Yuanming Ming, Xin Deng, Jun |
|---|---|
| author |
Zhang, Ying Feng, Yuanming Ming, Xin Deng, Jun |
| spellingShingle |
Zhang, Ying Feng, Yuanming Ming, Xin Deng, Jun BioMed Research International Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
| author_sort |
zhang, ying |
| spelling |
Zhang, Ying Feng, Yuanming Ming, Xin Deng, Jun 2314-6133 2314-6141 Hindawi Limited General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2016/7319843 <jats:p>A novel treatment modality termed energy modulated photon radiotherapy (EMXRT) was investigated. The first step of EMXRT was to determine beam energy for each gantry angle/anatomy configuration from a pool of photon energy beams (2 to 10 MV) with a newly developed energy selector. An inverse planning system using gradient search algorithm was then employed to optimize photon beam intensity of various beam energies based on presimulated Monte Carlo pencil beam dose distributions in patient anatomy. Finally, 3D dose distributions in six patients of different tumor sites were simulated with Monte Carlo method and compared between EMXRT plans and clinical IMRT plans. Compared to current IMRT technique, the proposed EMXRT method could offer a better paradigm for the radiotherapy of lung cancers and pediatric brain tumors in terms of normal tissue sparing and integral dose. For prostate, head and neck, spine, and thyroid lesions, the EMXRT plans were generally comparable to the IMRT plans. Our feasibility study indicated that lower energy (<6 MV) photon beams could be considered in modern radiotherapy treatment planning to achieve a more personalized care for individual patient with dosimetric gains.</jats:p> Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study BioMed Research International |
| doi_str_mv |
10.1155/2016/7319843 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDE2LzczMTk4NDM |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDE2LzczMTk4NDM |
| institution |
DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 |
| imprint |
Hindawi Limited, 2016 |
| imprint_str_mv |
Hindawi Limited, 2016 |
| issn |
2314-6133 2314-6141 |
| issn_str_mv |
2314-6133 2314-6141 |
| language |
English |
| mega_collection |
Hindawi Limited (CrossRef) |
| match_str |
zhang2016energymodulatedphotonradiotherapyamontecarlofeasibilitystudy |
| publishDateSort |
2016 |
| publisher |
Hindawi Limited |
| recordtype |
ai |
| record_format |
ai |
| series |
BioMed Research International |
| source_id |
49 |
| title |
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_unstemmed |
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_full |
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_fullStr |
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_full_unstemmed |
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_short |
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_sort |
energy modulated photon radiotherapy: a monte carlo feasibility study |
| topic |
General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
| url |
http://dx.doi.org/10.1155/2016/7319843 |
| publishDate |
2016 |
| physical |
1-16 |
| description |
<jats:p>A novel treatment modality termed energy modulated photon radiotherapy (EMXRT) was investigated. The first step of EMXRT was to determine beam energy for each gantry angle/anatomy configuration from a pool of photon energy beams (2 to 10 MV) with a newly developed energy selector. An inverse planning system using gradient search algorithm was then employed to optimize photon beam intensity of various beam energies based on presimulated Monte Carlo pencil beam dose distributions in patient anatomy. Finally, 3D dose distributions in six patients of different tumor sites were simulated with Monte Carlo method and compared between EMXRT plans and clinical IMRT plans. Compared to current IMRT technique, the proposed EMXRT method could offer a better paradigm for the radiotherapy of lung cancers and pediatric brain tumors in terms of normal tissue sparing and integral dose. For prostate, head and neck, spine, and thyroid lesions, the EMXRT plans were generally comparable to the IMRT plans. Our feasibility study indicated that lower energy (<6 MV) photon beams could be considered in modern radiotherapy treatment planning to achieve a more personalized care for individual patient with dosimetric gains.</jats:p> |
| container_start_page |
1 |
| container_title |
BioMed Research International |
| container_volume |
2016 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792345812551860238 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:29:23.996Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Energy+Modulated+Photon+Radiotherapy%3A+A+Monte+Carlo+Feasibility+Study&rft.date=2016-01-01&genre=article&issn=2314-6141&volume=2016&spage=1&epage=16&pages=1-16&jtitle=BioMed+Research+International&atitle=Energy+Modulated+Photon+Radiotherapy%3A+A+Monte+Carlo+Feasibility+Study&aulast=Deng&aufirst=Jun&rft_id=info%3Adoi%2F10.1155%2F2016%2F7319843&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792345812551860238 |
| author | Zhang, Ying, Feng, Yuanming, Ming, Xin, Deng, Jun |
| author_facet | Zhang, Ying, Feng, Yuanming, Ming, Xin, Deng, Jun, Zhang, Ying, Feng, Yuanming, Ming, Xin, Deng, Jun |
| author_sort | zhang, ying |
| container_start_page | 1 |
| container_title | BioMed Research International |
| container_volume | 2016 |
| description | <jats:p>A novel treatment modality termed energy modulated photon radiotherapy (EMXRT) was investigated. The first step of EMXRT was to determine beam energy for each gantry angle/anatomy configuration from a pool of photon energy beams (2 to 10 MV) with a newly developed energy selector. An inverse planning system using gradient search algorithm was then employed to optimize photon beam intensity of various beam energies based on presimulated Monte Carlo pencil beam dose distributions in patient anatomy. Finally, 3D dose distributions in six patients of different tumor sites were simulated with Monte Carlo method and compared between EMXRT plans and clinical IMRT plans. Compared to current IMRT technique, the proposed EMXRT method could offer a better paradigm for the radiotherapy of lung cancers and pediatric brain tumors in terms of normal tissue sparing and integral dose. For prostate, head and neck, spine, and thyroid lesions, the EMXRT plans were generally comparable to the IMRT plans. Our feasibility study indicated that lower energy (<6 MV) photon beams could be considered in modern radiotherapy treatment planning to achieve a more personalized care for individual patient with dosimetric gains.</jats:p> |
| doi_str_mv | 10.1155/2016/7319843 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDE2LzczMTk4NDM |
| imprint | Hindawi Limited, 2016 |
| imprint_str_mv | Hindawi Limited, 2016 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
| issn | 2314-6133, 2314-6141 |
| issn_str_mv | 2314-6133, 2314-6141 |
| language | English |
| last_indexed | 2024-03-01T17:29:23.996Z |
| match_str | zhang2016energymodulatedphotonradiotherapyamontecarlofeasibilitystudy |
| mega_collection | Hindawi Limited (CrossRef) |
| physical | 1-16 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher | Hindawi Limited |
| record_format | ai |
| recordtype | ai |
| series | BioMed Research International |
| source_id | 49 |
| spelling | Zhang, Ying Feng, Yuanming Ming, Xin Deng, Jun 2314-6133 2314-6141 Hindawi Limited General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2016/7319843 <jats:p>A novel treatment modality termed energy modulated photon radiotherapy (EMXRT) was investigated. The first step of EMXRT was to determine beam energy for each gantry angle/anatomy configuration from a pool of photon energy beams (2 to 10 MV) with a newly developed energy selector. An inverse planning system using gradient search algorithm was then employed to optimize photon beam intensity of various beam energies based on presimulated Monte Carlo pencil beam dose distributions in patient anatomy. Finally, 3D dose distributions in six patients of different tumor sites were simulated with Monte Carlo method and compared between EMXRT plans and clinical IMRT plans. Compared to current IMRT technique, the proposed EMXRT method could offer a better paradigm for the radiotherapy of lung cancers and pediatric brain tumors in terms of normal tissue sparing and integral dose. For prostate, head and neck, spine, and thyroid lesions, the EMXRT plans were generally comparable to the IMRT plans. Our feasibility study indicated that lower energy (<6 MV) photon beams could be considered in modern radiotherapy treatment planning to achieve a more personalized care for individual patient with dosimetric gains.</jats:p> Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study BioMed Research International |
| spellingShingle | Zhang, Ying, Feng, Yuanming, Ming, Xin, Deng, Jun, BioMed Research International, Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| title | Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_full | Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_fullStr | Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_full_unstemmed | Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_short | Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| title_sort | energy modulated photon radiotherapy: a monte carlo feasibility study |
| title_unstemmed | Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study |
| topic | General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| url | http://dx.doi.org/10.1155/2016/7319843 |