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Lung mechanics and end-expiratory lung volume during hypoxia in rats
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| Zeitschriftentitel: | Journal of Applied Physiology |
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| Personen und Körperschaften: | , |
| In: | Journal of Applied Physiology, 87, 1999, 1, S. 15-21 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
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| Schlagwörter: |
| Zusammenfassung: | <jats:p> We investigated whether an hypoxia-induced increase in airway resistance mediated by vagal efferents participates in the increase in end-expiratory lung volume (EELV) observed in hypoxia. We also assessed the contribution of the end-expiratory activity of the diaphragm (De) to this phenomenon. Therefore, we measured EELV, total lung resistance (Rl), dynamic lung compliance (Cdyn), De, and minute ventilation (V˙e) in anesthetized rats during normoxia and hypoxia (10% O<jats:sub>2</jats:sub>) before (control) and after administration of atropine or saline. In the control group, hypoxia increased EELV, Cdyn, De, andV˙e but slightly decreased Rl. These changes were unaffected by saline or atropine, except that, in the atropine-treated rats, hypoxia did not change Rl. These results suggest that 1) the increase in EELV observed in hypoxia cannot result from an increase in airway resistance; 2) the increased and persistent activity of inspiratory muscles during expiration is the most likely cause of the increase in EELV during hypoxia; and 3) the decrease in Rl induced by hypoxia could result from the increase in lung volume including EELV. </jats:p> |
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| Umfang: | 15-21 |
| ISSN: |
8750-7587
1522-1601 |
| DOI: | 10.1152/jappl.1999.87.1.15 |