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Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats
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| Zeitschriftentitel: | American Journal of Physiology-Heart and Circulatory Physiology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | American Journal of Physiology-Heart and Circulatory Physiology, 280, 2001, 2, S. H844-H850 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Souza, Hugo C. D. Ballejo, Gustavo Salgado, Maria Cristina O. Dias Da Silva, Valdo J. Salgado, Helio C. Souza, Hugo C. D. Ballejo, Gustavo Salgado, Maria Cristina O. Dias Da Silva, Valdo J. Salgado, Helio C. |
|---|---|
| author |
Souza, Hugo C. D. Ballejo, Gustavo Salgado, Maria Cristina O. Dias Da Silva, Valdo J. Salgado, Helio C. |
| spellingShingle |
Souza, Hugo C. D. Ballejo, Gustavo Salgado, Maria Cristina O. Dias Da Silva, Valdo J. Salgado, Helio C. American Journal of Physiology-Heart and Circulatory Physiology Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats Physiology (medical) Cardiology and Cardiovascular Medicine Physiology |
| author_sort |
souza, hugo c. d. |
| spelling |
Souza, Hugo C. D. Ballejo, Gustavo Salgado, Maria Cristina O. Dias Da Silva, Valdo J. Salgado, Helio C. 0363-6135 1522-1539 American Physiological Society Physiology (medical) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1152/ajpheart.2001.280.2.h844 <jats:p> The present study evaluated the possible changes in the autonomic control of heart rate in the hypertensive model induced by the inhibition of nitric oxide synthase. Rats were treated with N <jats:sup>G</jats:sup>-nitro-l-arginine methyl ester (l-NAME group) in the drinking water during 7 days, whereas control groups were treated with tap water (control group) or with the N <jats:sup>G</jats:sup>-nitro-d-arginine methyl ester (d-NAME group), an inactive isomer of thel-NAME molecule. The l-NAME group developed hypertension and tachycardia. The sequential blockade of the autonomic influences with propranolol and methylatropine indicated that the intrinsic heart rate did not differ among groups and revealed a sympathetic overactivity in the control of heart rate in thel-NAME group. The spectral density power of heart rate, calculated using fast-Fourier transformation, indicated a reduced variability in the low-frequency band (0.20–0.60 Hz) for thel-NAME group. The baroreflex sensitivity was also attenuated in these animals when compared with the normotensive control or d-NAME group. Overall, these data indicate cardiac sympathetic overactivity associated with a decreased baroreflex sensitivity in l-NAME hypertensive rats. </jats:p> Cardiac sympathetic overactivity and decreased baroreflex sensitivity in <scp>l</scp>-NAME hypertensive rats American Journal of Physiology-Heart and Circulatory Physiology |
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American Journal of Physiology-Heart and Circulatory Physiology |
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| title |
Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_unstemmed |
Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_full |
Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_fullStr |
Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_full_unstemmed |
Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_short |
Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_sort |
cardiac sympathetic overactivity and decreased baroreflex sensitivity in <scp>l</scp>-name hypertensive rats |
| topic |
Physiology (medical) Cardiology and Cardiovascular Medicine Physiology |
| url |
http://dx.doi.org/10.1152/ajpheart.2001.280.2.h844 |
| publishDate |
2001 |
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H844-H850 |
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<jats:p> The present study evaluated the possible changes in the autonomic control of heart rate in the hypertensive model induced by the inhibition of nitric oxide synthase. Rats were treated with N <jats:sup>G</jats:sup>-nitro-l-arginine methyl ester (l-NAME group) in the drinking water during 7 days, whereas control groups were treated with tap water (control group) or with the N <jats:sup>G</jats:sup>-nitro-d-arginine methyl ester (d-NAME group), an inactive isomer of thel-NAME molecule. The l-NAME group developed hypertension and tachycardia. The sequential blockade of the autonomic influences with propranolol and methylatropine indicated that the intrinsic heart rate did not differ among groups and revealed a sympathetic overactivity in the control of heart rate in thel-NAME group. The spectral density power of heart rate, calculated using fast-Fourier transformation, indicated a reduced variability in the low-frequency band (0.20–0.60 Hz) for thel-NAME group. The baroreflex sensitivity was also attenuated in these animals when compared with the normotensive control or d-NAME group. Overall, these data indicate cardiac sympathetic overactivity associated with a decreased baroreflex sensitivity in l-NAME hypertensive rats. </jats:p> |
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| author | Souza, Hugo C. D., Ballejo, Gustavo, Salgado, Maria Cristina O., Dias Da Silva, Valdo J., Salgado, Helio C. |
| author_facet | Souza, Hugo C. D., Ballejo, Gustavo, Salgado, Maria Cristina O., Dias Da Silva, Valdo J., Salgado, Helio C., Souza, Hugo C. D., Ballejo, Gustavo, Salgado, Maria Cristina O., Dias Da Silva, Valdo J., Salgado, Helio C. |
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| description | <jats:p> The present study evaluated the possible changes in the autonomic control of heart rate in the hypertensive model induced by the inhibition of nitric oxide synthase. Rats were treated with N <jats:sup>G</jats:sup>-nitro-l-arginine methyl ester (l-NAME group) in the drinking water during 7 days, whereas control groups were treated with tap water (control group) or with the N <jats:sup>G</jats:sup>-nitro-d-arginine methyl ester (d-NAME group), an inactive isomer of thel-NAME molecule. The l-NAME group developed hypertension and tachycardia. The sequential blockade of the autonomic influences with propranolol and methylatropine indicated that the intrinsic heart rate did not differ among groups and revealed a sympathetic overactivity in the control of heart rate in thel-NAME group. The spectral density power of heart rate, calculated using fast-Fourier transformation, indicated a reduced variability in the low-frequency band (0.20–0.60 Hz) for thel-NAME group. The baroreflex sensitivity was also attenuated in these animals when compared with the normotensive control or d-NAME group. Overall, these data indicate cardiac sympathetic overactivity associated with a decreased baroreflex sensitivity in l-NAME hypertensive rats. </jats:p> |
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| imprint_str_mv | American Physiological Society, 2001 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Souza, Hugo C. D. Ballejo, Gustavo Salgado, Maria Cristina O. Dias Da Silva, Valdo J. Salgado, Helio C. 0363-6135 1522-1539 American Physiological Society Physiology (medical) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1152/ajpheart.2001.280.2.h844 <jats:p> The present study evaluated the possible changes in the autonomic control of heart rate in the hypertensive model induced by the inhibition of nitric oxide synthase. Rats were treated with N <jats:sup>G</jats:sup>-nitro-l-arginine methyl ester (l-NAME group) in the drinking water during 7 days, whereas control groups were treated with tap water (control group) or with the N <jats:sup>G</jats:sup>-nitro-d-arginine methyl ester (d-NAME group), an inactive isomer of thel-NAME molecule. The l-NAME group developed hypertension and tachycardia. The sequential blockade of the autonomic influences with propranolol and methylatropine indicated that the intrinsic heart rate did not differ among groups and revealed a sympathetic overactivity in the control of heart rate in thel-NAME group. The spectral density power of heart rate, calculated using fast-Fourier transformation, indicated a reduced variability in the low-frequency band (0.20–0.60 Hz) for thel-NAME group. The baroreflex sensitivity was also attenuated in these animals when compared with the normotensive control or d-NAME group. Overall, these data indicate cardiac sympathetic overactivity associated with a decreased baroreflex sensitivity in l-NAME hypertensive rats. </jats:p> Cardiac sympathetic overactivity and decreased baroreflex sensitivity in <scp>l</scp>-NAME hypertensive rats American Journal of Physiology-Heart and Circulatory Physiology |
| spellingShingle | Souza, Hugo C. D., Ballejo, Gustavo, Salgado, Maria Cristina O., Dias Da Silva, Valdo J., Salgado, Helio C., American Journal of Physiology-Heart and Circulatory Physiology, Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats, Physiology (medical), Cardiology and Cardiovascular Medicine, Physiology |
| title | Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_full | Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_fullStr | Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_full_unstemmed | Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_short | Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| title_sort | cardiac sympathetic overactivity and decreased baroreflex sensitivity in <scp>l</scp>-name hypertensive rats |
| title_unstemmed | Cardiac sympathetic overactivity and decreased baroreflex sensitivity in l-NAME hypertensive rats |
| topic | Physiology (medical), Cardiology and Cardiovascular Medicine, Physiology |
| url | http://dx.doi.org/10.1152/ajpheart.2001.280.2.h844 |