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Regional nonuniformity of normal adult human left ventricle
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| Zeitschriftentitel: | American Journal of Physiology-Heart and Circulatory Physiology |
|---|---|
| Personen und Körperschaften: | , |
| In: | American Journal of Physiology-Heart and Circulatory Physiology, 280, 2001, 2, S. H610-H620 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Bogaert, Jan Rademakers, Frank E. Bogaert, Jan Rademakers, Frank E. |
|---|---|
| author |
Bogaert, Jan Rademakers, Frank E. |
| spellingShingle |
Bogaert, Jan Rademakers, Frank E. American Journal of Physiology-Heart and Circulatory Physiology Regional nonuniformity of normal adult human left ventricle Physiology (medical) Cardiology and Cardiovascular Medicine Physiology |
| author_sort |
bogaert, jan |
| spelling |
Bogaert, Jan Rademakers, Frank E. 0363-6135 1522-1539 American Physiological Society Physiology (medical) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1152/ajpheart.2001.280.2.h610 <jats:p> Regional nonuniformity is a feature of both diseased and normal left ventricles (LV). With the use of magnetic resonance (MR) myocardial tagging, we performed three-dimensional strain analysis on 87 healthy adults in local cardiac and fiber coordinate systems (radial, circumferential, longitudinal, and fiber strains) to characterize normal nonuniformities and to test the validity of wall thickening as a parameter of regional function. Regional morphology included wall thickness and radii of curvature measurements. With respect to transmural nonuniformity, subendocardial strains exceeded subepicardial strains. Going from base to apex, wall thickness and circumferential radii of curvature decreased, whereas longitudinal radii of curvature increased. All of the strains increased from LV base to apex, resulting in a higher ejection fraction (EF) at the apex than at the base (70.9 ± 0.4 vs. 62.4 ± 0.4%; means ± SE, P < 0.0001). When we looked around the circumference of the ventricle, the anterior part of the LV was the flattest and thinnest and showed the largest wall thickening (46.6 ± 1.2%) but the lowest EF (64.7 ± 0.5%). The posterior LV wall was thicker, more curved, and showed a lower wall thickening (32.8 ± 1.0%) but a higher EF (71.3 ± 0.5%). The regional contribution of the LV wall to the ejection of blood is thus highly variable and is not fully characterized by wall thickening alone. Differences in regional LV architecture and probably local stress are possible explanations for this marked functional nonuniformity. </jats:p> Regional nonuniformity of normal adult human left ventricle American Journal of Physiology-Heart and Circulatory Physiology |
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| title |
Regional nonuniformity of normal adult human left ventricle |
| title_unstemmed |
Regional nonuniformity of normal adult human left ventricle |
| title_full |
Regional nonuniformity of normal adult human left ventricle |
| title_fullStr |
Regional nonuniformity of normal adult human left ventricle |
| title_full_unstemmed |
Regional nonuniformity of normal adult human left ventricle |
| title_short |
Regional nonuniformity of normal adult human left ventricle |
| title_sort |
regional nonuniformity of normal adult human left ventricle |
| topic |
Physiology (medical) Cardiology and Cardiovascular Medicine Physiology |
| url |
http://dx.doi.org/10.1152/ajpheart.2001.280.2.h610 |
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2001 |
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H610-H620 |
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<jats:p> Regional nonuniformity is a feature of both diseased and normal left ventricles (LV). With the use of magnetic resonance (MR) myocardial tagging, we performed three-dimensional strain analysis on 87 healthy adults in local cardiac and fiber coordinate systems (radial, circumferential, longitudinal, and fiber strains) to characterize normal nonuniformities and to test the validity of wall thickening as a parameter of regional function. Regional morphology included wall thickness and radii of curvature measurements. With respect to transmural nonuniformity, subendocardial strains exceeded subepicardial strains. Going from base to apex, wall thickness and circumferential radii of curvature decreased, whereas longitudinal radii of curvature increased. All of the strains increased from LV base to apex, resulting in a higher ejection fraction (EF) at the apex than at the base (70.9 ± 0.4 vs. 62.4 ± 0.4%; means ± SE, P < 0.0001). When we looked around the circumference of the ventricle, the anterior part of the LV was the flattest and thinnest and showed the largest wall thickening (46.6 ± 1.2%) but the lowest EF (64.7 ± 0.5%). The posterior LV wall was thicker, more curved, and showed a lower wall thickening (32.8 ± 1.0%) but a higher EF (71.3 ± 0.5%). The regional contribution of the LV wall to the ejection of blood is thus highly variable and is not fully characterized by wall thickening alone. Differences in regional LV architecture and probably local stress are possible explanations for this marked functional nonuniformity. </jats:p> |
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| author | Bogaert, Jan, Rademakers, Frank E. |
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| description | <jats:p> Regional nonuniformity is a feature of both diseased and normal left ventricles (LV). With the use of magnetic resonance (MR) myocardial tagging, we performed three-dimensional strain analysis on 87 healthy adults in local cardiac and fiber coordinate systems (radial, circumferential, longitudinal, and fiber strains) to characterize normal nonuniformities and to test the validity of wall thickening as a parameter of regional function. Regional morphology included wall thickness and radii of curvature measurements. With respect to transmural nonuniformity, subendocardial strains exceeded subepicardial strains. Going from base to apex, wall thickness and circumferential radii of curvature decreased, whereas longitudinal radii of curvature increased. All of the strains increased from LV base to apex, resulting in a higher ejection fraction (EF) at the apex than at the base (70.9 ± 0.4 vs. 62.4 ± 0.4%; means ± SE, P < 0.0001). When we looked around the circumference of the ventricle, the anterior part of the LV was the flattest and thinnest and showed the largest wall thickening (46.6 ± 1.2%) but the lowest EF (64.7 ± 0.5%). The posterior LV wall was thicker, more curved, and showed a lower wall thickening (32.8 ± 1.0%) but a higher EF (71.3 ± 0.5%). The regional contribution of the LV wall to the ejection of blood is thus highly variable and is not fully characterized by wall thickening alone. Differences in regional LV architecture and probably local stress are possible explanations for this marked functional nonuniformity. </jats:p> |
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| spelling | Bogaert, Jan Rademakers, Frank E. 0363-6135 1522-1539 American Physiological Society Physiology (medical) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1152/ajpheart.2001.280.2.h610 <jats:p> Regional nonuniformity is a feature of both diseased and normal left ventricles (LV). With the use of magnetic resonance (MR) myocardial tagging, we performed three-dimensional strain analysis on 87 healthy adults in local cardiac and fiber coordinate systems (radial, circumferential, longitudinal, and fiber strains) to characterize normal nonuniformities and to test the validity of wall thickening as a parameter of regional function. Regional morphology included wall thickness and radii of curvature measurements. With respect to transmural nonuniformity, subendocardial strains exceeded subepicardial strains. Going from base to apex, wall thickness and circumferential radii of curvature decreased, whereas longitudinal radii of curvature increased. All of the strains increased from LV base to apex, resulting in a higher ejection fraction (EF) at the apex than at the base (70.9 ± 0.4 vs. 62.4 ± 0.4%; means ± SE, P < 0.0001). When we looked around the circumference of the ventricle, the anterior part of the LV was the flattest and thinnest and showed the largest wall thickening (46.6 ± 1.2%) but the lowest EF (64.7 ± 0.5%). The posterior LV wall was thicker, more curved, and showed a lower wall thickening (32.8 ± 1.0%) but a higher EF (71.3 ± 0.5%). The regional contribution of the LV wall to the ejection of blood is thus highly variable and is not fully characterized by wall thickening alone. Differences in regional LV architecture and probably local stress are possible explanations for this marked functional nonuniformity. </jats:p> Regional nonuniformity of normal adult human left ventricle American Journal of Physiology-Heart and Circulatory Physiology |
| spellingShingle | Bogaert, Jan, Rademakers, Frank E., American Journal of Physiology-Heart and Circulatory Physiology, Regional nonuniformity of normal adult human left ventricle, Physiology (medical), Cardiology and Cardiovascular Medicine, Physiology |
| title | Regional nonuniformity of normal adult human left ventricle |
| title_full | Regional nonuniformity of normal adult human left ventricle |
| title_fullStr | Regional nonuniformity of normal adult human left ventricle |
| title_full_unstemmed | Regional nonuniformity of normal adult human left ventricle |
| title_short | Regional nonuniformity of normal adult human left ventricle |
| title_sort | regional nonuniformity of normal adult human left ventricle |
| title_unstemmed | Regional nonuniformity of normal adult human left ventricle |
| topic | Physiology (medical), Cardiology and Cardiovascular Medicine, Physiology |
| url | http://dx.doi.org/10.1152/ajpheart.2001.280.2.h610 |